serine active site containing 1 (SERAC1) - coding DNA reference sequence

(used for variant description)

(last modified March 10, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_032861.3 in the SERAC1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032889.1, covering SERAC1 transcript NM_032861.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       agagcgggccgagggggcgggg       c.-121

 .         .         .         .         .         .                g.5082
 tcacgagccgccagccgccgggtggagggtcccggccgggagccgcggaaagagtagggc       c.-61

 .         .         .         .         .         .         | 02    g.14917
 tccccagacaacggggtccgacgagcagttgggcacgggctgagtccgcctgccggcag | a    c.-1

          .         .         .         .         .         .       g.14977
 ATGTCCCTGGCTGCTTATTGCGTCATCTGTTGCAGAAGAATAGGAACCTCTACTTCCCCA       c.60
 M  S  L  A  A  Y  C  V  I  C  C  R  R  I  G  T  S  T  S  P         p.20

          .         .         .  | 03      .         .         .    g.17958
 CCAAAAAGTGGCACACACTGGAGAGATATCA | GAAATATAATAAAGTTTACTGGATCACTT    c.120
 P  K  S  G  T  H  W  R  D  I  R |   N  I  I  K  F  T  G  S  L      p.40

          | 04         .         .         .         .         .    g.22743
 ATTTTAGG | AGGTTCTTTATTTCTTACATATGAAGTTCTGGCCCTGAAGAAGGCTGTGACA    c.180
 I  L  G  |  G  S  L  F  L  T  Y  E  V  L  A  L  K  K  A  V  T      p.60

          .         .         .         .         .         .       g.22803
 TTAGATACTCAAGTGGTAGAACGAGAAAAAATGAAGTCATATATATATGTGCACACAGTT       c.240
 L  D  T  Q  V  V  E  R  E  K  M  K  S  Y  I  Y  V  H  T  V         p.80

          .         .      | 05  .         .         .         .    g.24361
 TCTTTAGACAAAGGAGAAAATCATG | GTATTGCCTGGCAGGCAAGAAAAGAACTTCACAAA    c.300
 S  L  D  K  G  E  N  H  G |   I  A  W  Q  A  R  K  E  L  H  K      p.100

          .         .         .         .         .      | 06  .    g.26372
 GCAGTAAGAAAAGTATTGGCAACATCAGCCAAGATACTGCGGAATCCATTTGCTG | ATCCT    c.360
 A  V  R  K  V  L  A  T  S  A  K  I  L  R  N  P  F  A  D |   P      p.120

          .         .         .         .         .         .       g.26432
 TTTAGTACAGTTGATATAGAAGATCATGAGTGTGCTGTGTGGCTGCTCCTACGGAAGAGC       c.420
 F  S  T  V  D  I  E  D  H  E  C  A  V  W  L  L  L  R  K  S         p.140

          .         .         .         .         .         .       g.26492
 AAGTCAGATGACAAAACCACGCGACTCGAGGCTGTGCGGGAAATGTCGGAGACCCATCAC       c.480
 K  S  D  D  K  T  T  R  L  E  A  V  R  E  M  S  E  T  H  H         p.160

         | 07.         .         .         .         .         .    g.28913
 TGGCATG | ATTACCAGTATAGGATAATTGCTCAAGCCTGTGATCCGAAAACTCTTATTGGT    c.540
 W  H  D |   Y  Q  Y  R  I  I  A  Q  A  C  D  P  K  T  L  I  G      p.180

          .         .         .         .         .         .       g.28973
 TTGGCACGAAGCGAAGAGAGTGATCTTCGCTTTTTTCTCCTACCACCTCCTTTGCCATCT       c.600
 L  A  R  S  E  E  S  D  L  R  F  F  L  L  P  P  P  L  P  S         p.200

           | 08        .         .         .         .         .    g.30147
 TTAAAAGAA | GATTCTTCCACTGAAGAAGAGCTCAGACAGTTGCTGGCTTCCTTACCTCAA    c.660
 L  K  E   | D  S  S  T  E  E  E  L  R  Q  L  L  A  S  L  P  Q      p.220

          .         .         .         .         .         .       g.30207
 ACAGAGCTAGATGAGTGTATCCAGTATTTTACATCTTTGGCTCTTAGTGAAAGCAGTCAG       c.720
 T  E  L  D  E  C  I  Q  Y  F  T  S  L  A  L  S  E  S  S  Q         p.240

          .         | 09         .         .         .         .    g.42836
 AGTCTAGCTGCTCAGAAG | GGTGGTTTATGGTGTTTTGGAGGAAATGGACTTCCTTATGCT    c.780
 S  L  A  A  Q  K   | G  G  L  W  C  F  G  G  N  G  L  P  Y  A      p.260

          .         .         .         .         .         .       g.42896
 GAAAGTTTTGGAGAAGTTCCTTCAGCAACAGTGGAAATGTTCTGTTTAGAAGCTATAGTA       c.840
 E  S  F  G  E  V  P  S  A  T  V  E  M  F  C  L  E  A  I  V         p.280

          .   | 10     .         .         .         .         .    g.45058
 AAACATTCTGAG | ATATCCACACATTGTGATAAAATCGAAGCAAATGGAGGCCTGCAGCTA    c.900
 K  H  S  E   | I  S  T  H  C  D  K  I  E  A  N  G  G  L  Q  L      p.300

          .         .         .         .         .         .       g.45118
 CTTCAGAGGCTGTACCGACTTCACAAGGACTGCCCTAAAGTACAGAGAAATATAATGCGT       c.960
 L  Q  R  L  Y  R  L  H  K  D  C  P  K  V  Q  R  N  I  M  R         p.320

          .         .         .         .         .      | 11  .    g.52710
 GTCATTGGAAATATGGCTTTGAATGAACATCTTCATTCTTCTATAGTTCGCTCAG | GCTGG    c.1020
 V  I  G  N  M  A  L  N  E  H  L  H  S  S  I  V  R  S  G |   W      p.340

          .         .         .         .         .         .       g.52770
 GTTTCCATCATGGCAGAAGCAATGAAATCTCCCCACATTATGGAGTCCTCACACGCTGCC       c.1080
 V  S  I  M  A  E  A  M  K  S  P  H  I  M  E  S  S  H  A  A         p.360

          .         .         .         .         .         .       g.52830
 AGAATCCTGGCAAATCTAGACCGAGAAACTGTGCAAGAAAAATATCAGGATGGCGTATAT       c.1140
 R  I  L  A  N  L  D  R  E  T  V  Q  E  K  Y  Q  D  G  V  Y         p.380

          .         .       | 12 .         .         .         .    g.54144
 GTGCTGCATCCCCAATATCGAACAAG | TCAGCCCATTAAAGCAGATGTCCTTTTTATTCAT    c.1200
 V  L  H  P  Q  Y  R  T  S  |  Q  P  I  K  A  D  V  L  F  I  H      p.400

          .         .         .         .         .         .       g.54204
 GGCCTTATGGGAGCAGCATTCAAAACATGGCGCCAGCAGGACAGTGAGCAGGCTGTAATT       c.1260
 G  L  M  G  A  A  F  K  T  W  R  Q  Q  D  S  E  Q  A  V  I         p.420

          .         .         .         .         | 13         .    g.55471
 GAAAAACCTATGGAGGATGAAGACAGATATACGACGTGCTGGCCCAAG | ACATGGTTAGCA    c.1320
 E  K  P  M  E  D  E  D  R  Y  T  T  C  W  P  K   | T  W  L  A      p.440

          .         .         .         .         .         .       g.55531
 AAAGACTGTCCTGCTCTCCGAATTATATCTGTGGAGTATGACACCAGCCTCAGCGACTGG       c.1380
 K  D  C  P  A  L  R  I  I  S  V  E  Y  D  T  S  L  S  D  W         p.460

          .         .    | 14    .         .         .         .    g.57035
 AGAGCAAGGTGCCCTATGGAAAG | AAAGTCCATTGCATTCAGAAGCAACGAACTTCTTAGG    c.1440
 R  A  R  C  P  M  E  R  |  K  S  I  A  F  R  S  N  E  L  L  R      p.480

          .         .         .         .         .         .       g.57095
 AAGCTCAGAGCTGCTGGTGTTGGGGATAGGCCAGTGGTTTGGATATCACATAGCATGGGA       c.1500
 K  L  R  A  A  G  V  G  D  R  P  V  V  W  I  S  H  S  M  G         p.500

   | 15      .         .         .         .         .         .    g.58368
 G | GTCTTCTTGTCAAAAAGATGCTGTTGGAAGCCTCTACGAAGCCAGAAATGAGTACTGTT    c.1560
 G |   L  L  V  K  K  M  L  L  E  A  S  T  K  P  E  M  S  T  V      p.520

          .         .         .         .         .         .       g.58428
 ATCAACAATACCAGAGGAATAATTTTTTATAGTGTCCCTCATCATGGATCACGTTTGGCT       c.1620
 I  N  N  T  R  G  I  I  F  Y  S  V  P  H  H  G  S  R  L  A         p.540

          .         .         .         .         .         .       g.58488
 GAATACTCTGTTAATATTCGCTATCTTCTCTTCCCCTCGTTGGAAGTCAAAGAACTCAGC       c.1680
 E  Y  S  V  N  I  R  Y  L  L  F  P  S  L  E  V  K  E  L  S         p.560

      | 16   .         .         .         .         .         .    g.59744
 AAGG | ATTCTCCTGCACTTAAAACACTACAAGATGACTTTCTGGAGTTTGCTAAAGACAAA    c.1740
 K  D |   S  P  A  L  K  T  L  Q  D  D  F  L  E  F  A  K  D  K      p.580

          .         .         .         .         .         .       g.59804
 AACTTCCAGGTGCTGAATTTTGTGGAAACACTACCAACCTACATTGGCAGCATGATTAAG       c.1800
 N  F  Q  V  L  N  F  V  E  T  L  P  T  Y  I  G  S  M  I  K         p.600

          .         .         | 17         .         .         .    g.61810
 CTCCATGTGGTACCTGTGGAATCAGCAG | ATTTAGGCATTGGAGATCTAATTCCTGTGGAT    c.1860
 L  H  V  V  P  V  E  S  A  D |   L  G  I  G  D  L  I  P  V  D      p.620

          .         .         .         .         .         .       g.61870
 GTTAACCATTTGAACATTTGTAAGCCAAAGAAAAAGGATGCTTTTTTGTACCAGCGTACT       c.1920
 V  N  H  L  N  I  C  K  P  K  K  K  D  A  F  L  Y  Q  R  T         p.640

          .         .         .         .                           g.61915
 TTACAATTCATTCGTGAAGCTTTAGCCAAAGACCTTGAAAACTAA                      c.1965
 L  Q  F  I  R  E  A  L  A  K  D  L  E  N  X                        p.654

          .         .         .         .         .         .       g.61975
 cagttgtgctcttccagttttcatatgtgaattcagtgcaagaaacttggtgttctgttt       c.*60

          .         .         .         .         .         .       g.62035
 cttcttttaagctctatgcaatcatgcaaacatagtgatcatagcgtcaacatggtctgg       c.*120

          .         .         .         .         .         .       g.62095
 agtgtgttgcagactacagaacattgttctcccttcaagcgctgtaaagcaccaacccgg       c.*180

          .         .         .         .         .         .       g.62155
 aagtggcaggcacagaaggaagggctggattgggcccctttggtgtaaagaagtccctgt       c.*240

          .         .         .         .         .         .       g.62215
 gtgctgctttatggttcgcagtgttgggcttggtgactggagcaaagctgctgtgagaga       c.*300

          .         .         .         .         .         .       g.62275
 gtgtcctttcccatctgtgactttcctggtgcatccaggaggggcacggcaggttctgag       c.*360

          .         .         .         .         .         .       g.62335
 gtaactcaacttaccataaaaatgccattaagagagtacctaaaatggagagaagaatga       c.*420

          .         .         .         .         .         .       g.62395
 actagaacattcaagactcttttacttctgggtattgatttgctgtacatttttaaagtt       c.*480

          .         .         .         .         .         .       g.62455
 tgagtttttagctcagttctaccttttatctgacacattattactagtgttaactttgtt       c.*540

          .         .         .         .         .         .       g.62515
 agacttattgtcatgtctgggtcagttccttgtatctattttcgtattcctgagaacaaa       c.*600

          .         .         .         .         .         .       g.62575
 tctttttcttagaaaaattctagcttataataattcttttcagactgtagctgcctatgc       c.*660

          .         .         .         .         .         .       g.62635
 ttggaatttgtcctagataaggataaagtagctaatccattattgatcacagtatgaagt       c.*720

          .         .         .         .         .         .       g.62695
 aaaactattctaagccattatatgaattagcaattcttagtatcaagattctcagattct       c.*780

          .         .         .         .         .         .       g.62755
 ctttggctaaataaacctttcttcttccttgctcatttgcaagtggtattaattgacctc       c.*840

          .         .         .         .         .         .       g.62815
 tatagcatgtgagtagtagataatcatgtcgatgacctttttttctttagagtaacagca       c.*900

          .         .         .         .         .         .       g.62875
 ttattgagatataatttacataccataagattcacccttttaaattatacaattcatttt       c.*960

          .         .         .         .         .         .       g.62935
 tgttttgttttgtttgtttagagacagggtctgactctgttgcccaagctggagtgcagt       c.*1020

          .         .         .         .         .         .       g.62995
 ggcatgatcatagctcattgtaacctcaaactcctgggctcaagagatccttttgcttca       c.*1080

          .         .         .         .         .         .       g.63055
 gcctcccaagcagctaggactacaggcacatgccaccacacttgggtaattaaaaaataa       c.*1140

          .         .         .         .         .         .       g.63115
 ataaatacttttttgtagagacagggtctcactgtgttgcccaggtctcaaactcccgat       c.*1200

          .         .         .         .         .         .       g.63175
 ctcaagccaccctcccaaaatgctgtgattataggccagagccattgttcccaggctcaa       c.*1260

          .         .         .         .         .         .       g.63235
 ttcattggtttttagtatagttcactgagttgtgcaacatcattgctatttaatttcagg       c.*1320

          .         .         .         .         .         .       g.63295
 ctatttcatcatccccaaaagaaccccatacccatgagcagtcagttcccacctctgctt       c.*1380

          .         .         .         .         .         .       g.63355
 tcccaagcctgcggtaaacactaatctgttttctgtctctatggatttgggaattttatg       c.*1440

          .         .         .         .         .         .       g.63415
 taaatggaatcatacaatatgtggccctctctgccttcttccttctattagcatgttttc       c.*1500

          .         .         .         .         .         .       g.63475
 aaggttcattcatgatatagcatgtatcagtactacttcatttctttttatggccgaaat       c.*1560

          .         .         .         .         .         .       g.63535
 tactccattgtatgatatgccatgtttctttatccattcatcagctgatggacatctagg       c.*1620

          .         .         .         .         .         .       g.63595
 ttctgttcatttttgtctatgataaataatgctaccatgatcatttgtgtacaaatttat       c.*1680

          .         .         .         .         .         .       g.63655
 gtgtggatagatgtttttgattctcttgggtggaattgctggtcaaatggtaagtctatg       c.*1740

          .         .         .         .         .         .       g.63715
 tttaaattttgaagatggtgaacttttgtagaatgagatagtcgaagctaaaactggagt       c.*1800

          .         .         .         .         .         .       g.63775
 atggcatctgaaggtaaatggctcatcaataaactcgatatcaacaattaattgtttcat       c.*1860

                                                                    g.63777
 tg                                                                 c.*1862

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Serine active site containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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