serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (SERPINF1) - coding DNA reference sequence

(used for variant description)

(last modified May 12, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_002615.5 in the SERPINF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering SERPINF1 transcript NM_002615.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5037
                        ggtcgctttaagaaaggagtagctgtaatctgaagcc       c.-121

 .         .         .         .         .         .                g.5097
 tgctggacgctggattagaaggcagcaaaaaaagctctgtgctggctggagccccctcag       c.-61

 .         .         .         .         .         .  | 02          g.9946
 tgtgcaggcttagagggactaggctgggtgtggagctgcagcgtatccacag | gccccagg    c.-1

          .         .         .         .         .         .       g.10006
 ATGCAGGCCCTGGTGCTACTCCTCTGCATTGGAGCCCTCCTCGGGCACAGCAGCTGCCAG       c.60
 M  Q  A  L  V  L  L  L  C  I  G  A  L  L  G  H  S  S  C  Q         p.20

          .         .     | 03   .         .         .         .    g.12923
 AACCCTGCCAGCCCCCCGGAGGAG | GGCTCCCCAGACCCCGACAGCACAGGGGCGCTGGTG    c.120
 N  P  A  S  P  P  E  E   | G  S  P  D  P  D  S  T  G  A  L  V      p.40

          .         .         .         .         .         .       g.12983
 GAGGAGGAGGATCCTTTCTTCAAAGTCCCCGTGAACAAGCTGGCAGCGGCTGTCTCCAAC       c.180
 E  E  E  D  P  F  F  K  V  P  V  N  K  L  A  A  A  V  S  N         p.60

          .         .         .         .         .         .       g.13043
 TTCGGCTATGACCTGTACCGGGTGCGATCCAGCACGAGCCCCACGACCAACGTGCTCCTG       c.240
 F  G  Y  D  L  Y  R  V  R  S  S  T  S  P  T  T  N  V  L  L         p.80

          .         .         .         .    | 04    .         .    g.14081
 TCTCCTCTCAGTGTGGCCACGGCCCTCTCGGCCCTCTCGCTGG | GAGCGGAGCAGCGAACA    c.300
 S  P  L  S  V  A  T  A  L  S  A  L  S  L  G |   A  E  Q  R  T      p.100

          .         .         .         .         .         .       g.14141
 GAATCCATCATTCACCGGGCTCTCTACTATGACTTGATCAGCAGCCCAGACATCCATGGT       c.360
 E  S  I  I  H  R  A  L  Y  Y  D  L  I  S  S  P  D  I  H  G         p.120

          .         .         .         .         .         .       g.14201
 ACCTATAAGGAGCTCCTTGACACGGTCACTGCCCCCCAGAAGAACCTCAAGAGTGCCTCC       c.420
 T  Y  K  E  L  L  D  T  V  T  A  P  Q  K  N  L  K  S  A  S         p.140

          .          | 05        .         .         .         .    g.14948
 CGGATCGTCTTTGAGAAGA | AGCTGCGCATAAAATCCAGCTTTGTGGCACCTCTGGAAAAG    c.480
 R  I  V  F  E  K  K |   L  R  I  K  S  S  F  V  A  P  L  E  K      p.160

          .         .         .         .         .         .       g.15008
 TCATATGGGACCAGGCCCAGAGTCCTGACGGGCAACCCTCGCTTGGACCTGCAAGAGATC       c.540
 S  Y  G  T  R  P  R  V  L  T  G  N  P  R  L  D  L  Q  E  I         p.180

          .         .         .         .         .         .       g.15068
 AACAACTGGGTGCAGGCGCAGATGAAAGGGAAGCTCGCCAGGTCCACAAAGGAAATTCCC       c.600
 N  N  W  V  Q  A  Q  M  K  G  K  L  A  R  S  T  K  E  I  P         p.200

          .         .         .         .    | 06    .         .    g.18110
 GATGAGATCAGCATTCTCCTTCTCGGTGTGGCGCACTTCAAGG | GGCAGTGGGTAACAAAG    c.660
 D  E  I  S  I  L  L  L  G  V  A  H  F  K  G |   Q  W  V  T  K      p.220

          .         .         .         .         .         .       g.18170
 TTTGACTCCAGAAAGACTTCCCTCGAGGATTTCTACTTGGATGAAGAGAGGACCGTGAGG       c.720
 F  D  S  R  K  T  S  L  E  D  F  Y  L  D  E  E  R  T  V  R         p.240

          .         .         .         .         .         .       g.18230
 GTCCCCATGATGTCGGACCCTAAGGCTGTTTTACGCTATGGCTTGGATTCAGATCTCAGC       c.780
 V  P  M  M  S  D  P  K  A  V  L  R  Y  G  L  D  S  D  L  S         p.260

        | 07 .         .         .         .         .         .    g.19621
 TGCAAG | ATTGCCCAGCTGCCCTTGACCGGAAGCATGAGTATCATCTTCTTCCTGCCCCTG    c.840
 C  K   | I  A  Q  L  P  L  T  G  S  M  S  I  I  F  F  L  P  L      p.280

          .         .         .         .         .         .       g.19681
 AAAGTGACCCAGAATTTGACCTTGATAGAGGAGAGCCTCACCTCCGAGTTCATTCATGAC       c.900
 K  V  T  Q  N  L  T  L  I  E  E  S  L  T  S  E  F  I  H  D         p.300

          .         .         .         .         .         .       g.19741
 ATAGACCGAGAACTGAAGACCGTGCAGGCGGTCCTCACTGTCCCCAAGCTGAAGCTGAGT       c.960
 I  D  R  E  L  K  T  V  Q  A  V  L  T  V  P  K  L  K  L  S         p.320

          .         .         .        | 08.         .         .    g.20245
 TATGAAGGCGAAGTCACCAAGTCCCTGCAGGAGATGA | AGCTGCAATCCTTGTTTGATTCA    c.1020
 Y  E  G  E  V  T  K  S  L  Q  E  M  K |   L  Q  S  L  F  D  S      p.340

          .         .         .         .         .         .       g.20305
 CCAGACTTTAGCAAGATCACAGGCAAACCCATCAAGCTGACTCAGGTGGAACACCGGGCT       c.1080
 P  D  F  S  K  I  T  G  K  P  I  K  L  T  Q  V  E  H  R  A         p.360

          .         .         .         .         .         .       g.20365
 GGCTTTGAGTGGAACGAGGATGGGGCGGGAACCACCCCCAGCCCAGGGCTGCAGCCTGCC       c.1140
 G  F  E  W  N  E  D  G  A  G  T  T  P  S  P  G  L  Q  P  A         p.380

          .         .         .         .         .         .       g.20425
 CACCTCACCTTCCCGCTGGACTATCACCTTAACCAGCCTTTCATCTTCGTACTGAGGGAC       c.1200
 H  L  T  F  P  L  D  Y  H  L  N  Q  P  F  I  F  V  L  R  D         p.400

          .         .         .         .         .                 g.20482
 ACAGACACAGGGGCCCTTCTCTTCATTGGCAAGATTCTGGACCCCAGGGGCCCCTAA          c.1257
 T  D  T  G  A  L  L  F  I  G  K  I  L  D  P  R  G  P  X            p.418

          .         .         .         .         .         .       g.20542
 tatcccagtttaatattccaataccctagaagaaaacccgagggacagcagattccacag       c.*60

          .         .         .         .         .                 g.20601
 gacacgaaggctgcccctgtaaggtttcaatgcatacaataaaagagctttatccctaa        c.*119

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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