serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) (SERPINH1) - coding DNA reference sequence

(used for variant description)

(last modified May 12, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001207014.1 in the SERPINH1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering SERPINH1 transcript NM_001207014.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   agtaggacccaggggccgggaggcgccggcagagggaggggc       c.-301

 .         .         .         .         .         .                g.5102
 cgggggccggggaggttttgagggaggtctttggctttttttggcggagctggggcgccc       c.-241

 .         .         .         .         .         .                g.5162
 tccggaagcgtttccaactttccagaagtttctcgggacgggcaggagggggtggggact       c.-181

 .         .         .         .         .         .                g.5222
 gccatatatagatcccgggagcaggggagcgggctaagagtagaatcgtgtcgcggctcg       c.-121

 .         .         .         .         .  | 02      .             g.6689
 agagcgagagtcacgtcccggcgctagcccagcccgacccag | aatgaaaaaggcaggcat    c.-61

 .         .         .      | 03  .         .         .             g.9294
 tgacctccctctgaggcagtttccag | gcccaccgtggtgcacgcaaaccacttcctggcc    c.-1

          .         .         .         .         .         .       g.9354
 ATGCGCTCCCTCCTGCTTCTCAGCGCCTTCTGCCTCCTGGAGGCGGCCCTGGCCGCCGAG       c.60
 M  R  S  L  L  L  L  S  A  F  C  L  L  E  A  A  L  A  A  E         p.20

          .         .         .         .         .         .       g.9414
 GTGAAGAAACCTGCAGCCGCAGCAGCTCCTGGCACTGCGGAGAAGTTGAGCCCCAAGGCG       c.120
 V  K  K  P  A  A  A  A  A  P  G  T  A  E  K  L  S  P  K  A         p.40

          .         .         .         .         .         .       g.9474
 GCCACGCTTGCCGAGCGCAGCGCCGGCCTGGCCTTCAGCTTGTACCAGGCCATGGCCAAG       c.180
 A  T  L  A  E  R  S  A  G  L  A  F  S  L  Y  Q  A  M  A  K         p.60

          .         .         .         .         .         .       g.9534
 GACCAGGCAGTGGAGAACATCCTGGTGTCACCCGTGGTGGTGGCCTCGTCGCTAGGGCTC       c.240
 D  Q  A  V  E  N  I  L  V  S  P  V  V  V  A  S  S  L  G  L         p.80

          .         .         .         .         .         .       g.9594
 GTGTCGCTGGGCGGCAAGGCGACCACGGCGTCGCAGGCCAAGGCAGTGCTGAGCGCCGAG       c.300
 V  S  L  G  G  K  A  T  T  A  S  Q  A  K  A  V  L  S  A  E         p.100

          .         .         .         .         .         .       g.9654
 CAGCTGCGCGACGAGGAGGTGCACGCCGGCCTGGGCGAGCTGCTGCGCTCACTCAGCAAC       c.360
 Q  L  R  D  E  E  V  H  A  G  L  G  E  L  L  R  S  L  S  N         p.120

          .         .         .         .         .         .       g.9714
 TCCACGGCGCGCAACGTGACCTGGAAGCTGGGCAGCCGACTGTACGGACCCAGCTCAGTG       c.420
 S  T  A  R  N  V  T  W  K  L  G  S  R  L  Y  G  P  S  S  V         p.140

          .         .         .         .         .         .       g.9774
 AGCTTCGCTGATGACTTCGTGCGCAGCAGCAAGCAGCACTACAACTGCGAGCACTCCAAG       c.480
 S  F  A  D  D  F  V  R  S  S  K  Q  H  Y  N  C  E  H  S  K         p.160

          .         .         .         .         .         .       g.9834
 ATCAACTTCCGCGACAAGCGCAGCGCGCTGCAGTCCATCAACGAGTGGGCCGCGCAGACC       c.540
 I  N  F  R  D  K  R  S  A  L  Q  S  I  N  E  W  A  A  Q  T         p.180

          .         .         .         .         .         .       g.9894
 ACCGACGGCAAGCTGCCCGAGGTCACCAAGGACGTGGAGCGCACGGACGGCGCCCTGCTA       c.600
 T  D  G  K  L  P  E  V  T  K  D  V  E  R  T  D  G  A  L  L         p.200

          .         .   | 04     .         .         .         .    g.11713
 GTCAACGCCATGTTCTTCAAGC | CACACTGGGATGAGAAATTCCACCACAAGATGGTGGAC    c.660
 V  N  A  M  F  F  K  P |   H  W  D  E  K  F  H  H  K  M  V  D      p.220

          .         .         .         .         .         .       g.11773
 AACCGTGGCTTCATGGTGACTCGGTCCTATACCGTGGGTGTCATGATGATGCACCGGACA       c.720
 N  R  G  F  M  V  T  R  S  Y  T  V  G  V  M  M  M  H  R  T         p.240

   | 05      .         .         .         .         .         .    g.11942
 G | GCCTCTACAACTACTACGACGACGAGAAGGAAAAGCTGCAAATCGTGGAGATGCCCCTG    c.780
 G |   L  Y  N  Y  Y  D  D  E  K  E  K  L  Q  I  V  E  M  P  L      p.260

          .         .         .         .         .         .       g.12002
 GCCCACAAGCTCTCCAGCCTCATCATCCTCATGCCCCATCACGTGGAGCCTCTCGAGCGC       c.840
 A  H  K  L  S  S  L  I  I  L  M  P  H  H  V  E  P  L  E  R         p.280

          .         .         .         .         .         .       g.12062
 CTTGAAAAGCTGCTAACCAAAGAGCAGCTGAAGATCTGGATGGGGAAGATGCAGAAGAAG       c.900
 L  E  K  L  L  T  K  E  Q  L  K  I  W  M  G  K  M  Q  K  K         p.300

          .         .         .         .         .     | 06   .    g.14731
 GCTGTTGCCATCTCCTTGCCCAAGGGTGTGGTGGAGGTGACCCATGACCTGCAG | AAACAC    c.960
 A  V  A  I  S  L  P  K  G  V  V  E  V  T  H  D  L  Q   | K  H      p.320

          .         .         .         .         .         .       g.14791
 CTGGCTGGGCTGGGCCTGACTGAGGCCATTGACAAGAACAAGGCCGACTTGTCACGCATG       c.1020
 L  A  G  L  G  L  T  E  A  I  D  K  N  K  A  D  L  S  R  M         p.340

          .         .         .         .         .         .       g.14851
 TCAGGCAAGAAGGACCTGTACCTGGCCAGCGTGTTCCACGCCACCGCCTTTGAGTTGGAC       c.1080
 S  G  K  K  D  L  Y  L  A  S  V  F  H  A  T  A  F  E  L  D         p.360

          .         .         .         .         .         .       g.14911
 ACAGATGGCAACCCCTTTGACCAGGACATCTACGGGCGCGAGGAGCTGCGCAGCCCCAAG       c.1140
 T  D  G  N  P  F  D  Q  D  I  Y  G  R  E  E  L  R  S  P  K         p.380

          .         .         .         .         .         .       g.14971
 CTGTTCTACGCCGACCACCCCTTCATCTTCCTAGTGCGGGACACCCAAAGCGGCTCCCTG       c.1200
 L  F  Y  A  D  H  P  F  I  F  L  V  R  D  T  Q  S  G  S  L         p.400

          .         .         .         .         .                 g.15028
 CTATTCATTGGGCGCCTGGTCCGGCCTAAGGGTGACAAGATGCGAGACGAGTTATAG          c.1257
 L  F  I  G  R  L  V  R  P  K  G  D  K  M  R  D  E  L  X            p.418

          .         .         .         .         .         .       g.15088
 ggcctcagggtgcacacaggatggcaggaggcatccaaaggctcctgagacacatgggtg       c.*60

          .         .         .         .         .         .       g.15148
 ctattggggttgggggggaggtgaggtaccagccttggatactccatggggtgggggtgg       c.*120

          .         .         .         .         .         .       g.15208
 aaaaacagaccggggttcccgtgtgcctgagcggaccttcccagctagaattcactccac       c.*180

          .         .         .         .         .         .       g.15268
 ttggacatgggccccagataccatgatgctgagcccggaaactccacatcctgtgggacc       c.*240

          .         .         .         .         .         .       g.15328
 tgggccatagtcattctgcctgccctgaaagtcccagatcaagcctgcctcaatcagtat       c.*300

          .         .         .         .         .         .       g.15388
 tcatatttatagccaggtaccttctcacctgtgagaccaaattgagctaggggggtcagc       c.*360

          .         .         .         .         .         .       g.15448
 cagccctcttctgacactaaaacacctcagctgcctccccagctctatcccaacctctcc       c.*420

          .         .         .         .         .         .       g.15508
 caactataaaactaggtgctgcagcccctgggaccaggcacccccagaatgacctggccg       c.*480

          .         .         .         .         .         .       g.15568
 cagtgaggcggattgagaaggagctcccaggaggggcttctgggcagactctggtcaaga       c.*540

          .         .         .         .         .         .       g.15628
 agcatcgtgtctggcgttgtggggatgaactttttgttttgtttcttccttttttagttc       c.*600

          .         .         .         .         .         .       g.15688
 ttcaaagatagggagggaagggggaacatgagcctttgttgctatcaatccaagaactta       c.*660

          .         .         .         .         .         .       g.15748
 tttgtacattttttttttcaataaaacttttccaatgacattttgttggagcgtggaaga       c.*720

                                                                    g.15749
 a                                                                  c.*721

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 26c
©2004-2021 Leiden University Medical Center