surfactant protein B (SFTPB) - coding DNA reference sequence

(used for variant description)

(last modified May 24, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_000542.3 in the SFTPB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering SFTPB transcript NM_000542.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     tgtaaatgctcttctgactaatgcaaaccatgtgtccata       c.-61

 .         .         .        | 02.         .         .             g.5522
 gaaccagaagatttttccaggggaaaag | agcccccacgccccgcccagctataaggggcc    c.-1

          .         .         .         .         .         .       g.5582
 ATGCACCAAGCAGGGTACCCAGGCTGCAGAGGTGCCATGGCTGAGTCACACCTGCTGCAG       c.60
 M  H  Q  A  G  Y  P  G  C  R  G  A  M  A  E  S  H  L  L  Q         p.20

          .         .         .         .    | 03    .         .    g.5952
 TGGCTGCTGCTGCTGCTGCCCACGCTCTGTGGCCCAGGCACTG | CTGCCTGGACCACCTCA    c.120
 W  L  L  L  L  L  P  T  L  C  G  P  G  T  A |   A  W  T  T  S      p.40

          .         .         .         .         .         .       g.6012
 TCCTTGGCCTGTGCCCAGGGCCCTGAGTTCTGGTGCCAAAGCCTGGAGCAAGCATTGCAG       c.180
 S  L  A  C  A  Q  G  P  E  F  W  C  Q  S  L  E  Q  A  L  Q         p.60

          .         .         .         .         .  | 04      .    g.6573
 TGCAGAGCCCTAGGGCATTGCCTACAGGAAGTCTGGGGACATGTGGGAGCC | GATGACCTA    c.240
 C  R  A  L  G  H  C  L  Q  E  V  W  G  H  V  G  A   | D  D  L      p.80

          .         .         .         .         .         .       g.6633
 TGCCAAGAGTGTGAGGACATCGTCCACATCCTTAACAAGATGGCCAAGGAGGCCATTTTC       c.300
 C  Q  E  C  E  D  I  V  H  I  L  N  K  M  A  K  E  A  I  F         p.100

     | 05    .         .         .         .         .         .    g.7056
 CAG | GACACGATGAGGAAGTTCCTGGAGCAGGAGTGCAACGTCCTCCCCTTGAAGCTGCTC    c.360
 Q   | D  T  M  R  K  F  L  E  Q  E  C  N  V  L  P  L  K  L  L      p.120

          .         .         .         .         .         .       g.7116
 ATGCCCCAGTGCAACCAAGTGCTTGACGACTACTTCCCCCTGGTCATCGACTACTTCCAG       c.420
 M  P  Q  C  N  Q  V  L  D  D  Y  F  P  L  V  I  D  Y  F  Q         p.140

           | 06        .         .         .         .         .    g.7998
 AACCAGACT | GACTCAAACGGCATCTGTATGCACCTGGGCCTGTGCAAATCCCGGCAGCCA    c.480
 N  Q  T   | D  S  N  G  I  C  M  H  L  G  L  C  K  S  R  Q  P      p.160

          .         .         .         .         .         .       g.8058
 GAGCCAGAGCAGGAGCCAGGGATGTCAGACCCCCTGCCCAAACCTCTGCGGGACCCTCTG       c.540
 E  P  E  Q  E  P  G  M  S  D  P  L  P  K  P  L  R  D  P  L         p.180

          .         .         .         .         .         .       g.8118
 CCAGACCCTCTGCTGGACAAGCTCGTCCTCCCTGTGCTGCCCGGGGCCCTCCAGGCGAGG       c.600
 P  D  P  L  L  D  K  L  V  L  P  V  L  P  G  A  L  Q  A  R         p.200

          .         | 07         .         .         .         .    g.8405
 CCTGGGCCTCACACACAG | GATCTCTCCGAGCAGCAATTCCCCATTCCTCTCCCCTATTGC    c.660
 P  G  P  H  T  Q   | D  L  S  E  Q  Q  F  P  I  P  L  P  Y  C      p.220

          .         .         .         .         | 08         .    g.9906
 TGGCTCTGCAGGGCTCTGATCAAGCGGATCCAAGCCATGATTCCCAAG | GGTGCGCTAGCT    c.720
 W  L  C  R  A  L  I  K  R  I  Q  A  M  I  P  K   | G  A  L  A      p.240

          .         .         .         .         .         .       g.9966
 GTGGCAGTGGCCCAGGTGTGCCGCGTGGTACCTCTGGTGGCGGGCGGCATCTGCCAGTGC       c.780
 V  A  V  A  Q  V  C  R  V  V  P  L  V  A  G  G  I  C  Q  C         p.260

          .         .         .         .         .         .       g.10026
 CTGGCTGAGCGCTACTCCGTCATCCTGCTCGACACGCTGCTGGGCCGCATGCTGCCCCAG       c.840
 L  A  E  R  Y  S  V  I  L  L  D  T  L  L  G  R  M  L  P  Q         p.280

          .         .         .         .         .   | 09     .    g.10258
 CTGGTCTGCCGCCTCGTCCTCCGGTGCTCCATGGATGACAGCGCTGGCCCAA | GGTCGCCG    c.900
 L  V  C  R  L  V  L  R  C  S  M  D  D  S  A  G  P  R |   S  P      p.300

          .         .         .         .         .         .       g.10318
 ACAGGAGAATGGCTGCCGCGAGACTCTGAGTGCCACCTCTGCATGTCCGTGACCACCCAG       c.960
 T  G  E  W  L  P  R  D  S  E  C  H  L  C  M  S  V  T  T  Q         p.320

          .         .         .         .         .         .       g.10378
 GCCGGGAACAGCAGCGAGCAGGCCATACCACAGGCAATGCTCCAGGCCTGTGTTGGCTCC       c.1020
 A  G  N  S  S  E  Q  A  I  P  Q  A  M  L  Q  A  C  V  G  S         p.340

          .         | 10         .         .         .         .    g.11674
 TGGCTGGACAGGGAAAAG | TGCAAGCAATTTGTGGAGCAGCACACGCCCCAGCTGCTGACC    c.1080
 W  L  D  R  E  K   | C  K  Q  F  V  E  Q  H  T  P  Q  L  L  T      p.360

          .         .         .          | 11        .         .    g.12227
 CTGGTGCCCAGGGGCTGGGATGCCCACACCACCTGCCAG | GCCCTCGGGGTGTGTGGGACC    c.1140
 L  V  P  R  G  W  D  A  H  T  T  C  Q   | A  L  G  V  C  G  T      p.380

          .         .         .         .                           g.12269
 ATGTCCAGCCCTCTCCAGTGTATCCACAGCCCCGACCTTTGA                         c.1182
 M  S  S  P  L  Q  C  I  H  S  P  D  L  X                           p.393

          .          | 12        .         .         .         .    g.14100
 tgagaactcagctgtccag | ctgcaaaggaaaagccaagtgagacgggctctgggaccatg    c.*60

          .         .         .         .         .         .       g.14160
 gtgaccaggctcttcccctgctccctggccctcgccagctgccaggctgaaaagaagcct       c.*120

          .         .         .         .         .         .       g.14220
 cagctcccacaccgccctcctcaccgcccttcctcggcagtcacttccactggtggacca       c.*180

          .         .         .         .         .         .       g.14280
 cgggcccccagccctgtgtcggccttgtctgtctcagctcaaccacagtctgacaccaga       c.*240

          .         .         .         .         .         .       g.14340
 gcccacttccatcctctctggtgtgaggcacagcgagggcagcatctggaggagctctgc       c.*300

          .         .         .         .         .         .       g.14400
 agcctccacacctaccacgacctcccagggctgggctcaggaaaaaccagccactgcttt       c.*360

          .         .         .         .         .         .       g.14460
 acaggacagggggttgaagctgagccccgcctcacacccacccccatgcactcaaagatt       c.*420

          .         .         .         .         .         .       g.14520
 ggattttacagctacttgcaattcaaaattcagaagaataaaaaatgggaacatacagaa       c.*480

          .         .         .         .         .         .       g.14580
 ctctaaaagatagacatcagaaattgttaagttaagctttttcaaaaaatcagcaattcc       c.*540

          .         .         .         .         .         .       g.14640
 ccagcgtagtcaagggtggacactgcacgctctggcatgatgggatggcgaccgggcaag       c.*600

          .         .         .         .         .         .       g.14700
 ctttcttcctcgagatgctctgctgcttgagagctattgctttgttaagatataaaaagg       c.*660

          .         .         .         .         .         .       g.14760
 ggtttctttttgtctttctgtaaggtggacttccagcttttgattgaaagtcctagggtg       c.*720

          .         .         .         .         .         .       g.14820
 attctatttctgctgtgatttatctgctgaaagctcagctggggttgtgcaagctaggga       c.*780

          .         .         .         .         .         .       g.14880
 cccattcctgtgtaatacaatgtctgcaccaatgctaataaagtcctattctcttttatg       c.*840

          .         .         .         .         .         .       g.14940
 agaaagaaaaagacaccgtcctttaaagtgctgcagtatggccagacgtggtggctcaca       c.*900

          .         .         .         .         .         .       g.15000
 cctgcaatcccagcaccttaggaggccgaggcaggaggatccttgaggtcaggagttcga       c.*960

          .         .         .         .         .         .       g.15060
 gaccagcctcgccaacatggtgaaaccccatttctactaaaaatacaaaaaattagccaa       c.*1020

          .         .         .         .         .         .       g.15120
 gtgtggtggcatatgcctgtaatcccaactactcagaaggccgaggcaggagaattactt       c.*1080

          .         .         .         .         .         .       g.15180
 gaacgcaggagaatcactgcagcccaggaggcagaggttgcagtgagccgagattgcacc       c.*1140

          .         .         .         .         .         .       g.15240
 actgcactccagcctgggtgacagagcaagactccatctcagtaaataaataaataaata       c.*1200

          .         .         .         .         .         .       g.15300
 aaaagcgctgcagtagctgtggcctcaccctgaagtcagcgggcccaggcctacctcact       c.*1260

          .         .         .         .         .         .       g.15360
 ctctcccttggcagagaagcagacgtccatagctcctctccctcacaagcgctcccagcc       c.*1320

          .         .         .         .         .         .       g.15420
 tgccctccagctgctgctctcccctcccagtctctactcactgggatgaggttaggtcat       c.*1380

          .         .         .         .         .         .       g.15480
 gaggacaccaaaaacctaaaaataaacaaaaagccaaacaagccttagcttttcttaaag       c.*1440

          .         .         .         .         .         .       g.15540
 actgaaatgcctggaagtgtccctttatttataaaataacttttgtcatatttcttatac       c.*1500

          .         .         .         .         .         .       g.15600
 atgtttcttgtaagaaattcagaaactacagacaaagagagtggaaattacccactgtca       c.*1560

          .         .         .         .         .         .       g.15660
 ggcctctgagcccaagctaagccatcatatcccctgtgccctgcacgtatacacccagat       c.*1620

          .         .         .         .         .         .       g.15720
 ggcctgaagcaactgaagatccacaaaagaagtgaaaatagccagttcctgccttaactg       c.*1680

          .         .         .         .         .         .       g.15780
 atgacattccaccattgtgatttgttcctgccccaccctaactgatcaattgaccttgtg       c.*1740

          .         .         .         .         .         .       g.15840
 acaatacaccttccccacccttgagaaggtgctttgtaatattctccccacccaccccac       c.*1800

          .         .         .         .         .         .       g.15900
 gcccgcacccccgcacccttaagaaggtattttgtaatattctctccgccattgagaatg       c.*1860

          .         .         .         .         .         .       g.15960
 tgctttgtaagatccaccccctgcccacaaaaaattgctcctaactccaccgcctatccc       c.*1920

          .         .         .         .         .         .       g.16020
 aaacctacaagaactaatgataatcccaccaccctttgctgactctttttggactcagcc       c.*1980

          .         .         .         .         .         .       g.16080
 cacctgcacccaggtgattaaaaagctttattgttcacacaaagcctgtttggtagtctc       c.*2040

          .         .         .         .         .         .       g.16140
 ttcacagggaagcatgtgacacccacaatcccacctagcccaggagagagctacggcagg       c.*2100

          .         .         .         .         .         .       g.16200
 gtgtgtgttttgacactgagcttggggctttttccatcttctccccacagcctctggctc       c.*2160

          .         .         .         .         .         .       g.16260
 cacacctccaccgttcaagcgccagaaagagctgtctatgcagcctgctcttgggcctgg       c.*2220

          .         .         .         .         .         .       g.16320
 ggatgagacacacaattcattggctcctggattttaagtagacatttgtaaatctatagc       c.*2280

          .         .         .         .         .         .       g.16380
 taactactgtccttaaagccattgtttccattacaaaatccaactctctgagagaaaagg       c.*2340

          .         .         .         .                           g.16425
 gtgttttaaatttaaaaaaataaaaacaaaaaagtttgattgaga                      c.*2385

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Surfactant protein B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 29
©2004-2023 Leiden University Medical Center