small G protein signaling modulator 3 (SGSM3) - coding DNA reference sequence

(used for variant description)

(last modified February 25, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_015705.4 in the SGSM3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering SGSM3 transcript NM_015705.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                gccacgcgtgcgcttaggcgccgctgagc       c.-181

 .         .         .         .         .         .                g.5089
 gctgactgggtgcgagtggggaagctgctaacccgacccggattggcgctgaggtggccc       c.-121

 .         | 02         .         .         .         .             g.35156
 gtggggcag | ggcagatgattctggaccagatgaagcctgaggagccttccagctctaaga    c.-61

 .         .         .         .         .         .                g.35216
 tagcaggataggagacttctaagattggagctgcagaagacttgccagcccaccagcaca       c.-1

         | 03.         .         .         .         .         .    g.36055
 ATGTCAG | GAAGCCATACACCTGCCTGTGGCCCTTTCTCAGCCCTGACTCCGAGCATATGG    c.60
 M  S  G |   S  H  T  P  A  C  G  P  F  S  A  L  T  P  S  I  W      p.20

          .         .         . | 04       .         .         .    g.36578
 CCCCAGGAGATCTTGGCCAAGTACACGCAG | AAGGAAGAGTCAGCAGAGCAACCAGAGTTC    c.120
 P  Q  E  I  L  A  K  Y  T  Q   | K  E  E  S  A  E  Q  P  E  F      p.40

          .         .         .        | 05.         .         .    g.38679
 TACTACGATGAGTTTGGTTTCCGTGTGTACAAGGAAG | AAGGTGATGAGCCTGGCTCCAGT    c.180
 Y  Y  D  E  F  G  F  R  V  Y  K  E  E |   G  D  E  P  G  S  S      p.60

          .         .         .         .         .         .       g.38739
 CTGCTGGCGAACTCCCCTCTGATGGAGGATGCTCCACAGAGGCTGCGGTGGCAGGCCCAC       c.240
 L  L  A  N  S  P  L  M  E  D  A  P  Q  R  L  R  W  Q  A  H         p.80

          .         .         .         .         .         .       g.38799
 CTGGAGTTCACCCATAACCACGATGTGGGGGATCTCACCTGGGACAAGATTGCCGTCTCC       c.300
 L  E  F  T  H  N  H  D  V  G  D  L  T  W  D  K  I  A  V  S         p.100

          .         .         .         .         .         .       g.38859
 CTACCCCGCTCTGAGAAGCTCCGCTCCCTGGTGCTGGCCGGCATCCCACATGGCATGAGG       c.360
 L  P  R  S  E  K  L  R  S  L  V  L  A  G  I  P  H  G  M  R         p.120

        | 06 .         .         .         .         .         .    g.39020
 CCACAG | CTGTGGATGCGGCTCTCTGGGGCCCTGCAGAAGAAGAGGAACTCTGAGCTGTCC    c.420
 P  Q   | L  W  M  R  L  S  G  A  L  Q  K  K  R  N  S  E  L  S      p.140

          .         .         .         .         .     | 07   .    g.39556
 TACCGCGAGATTGTGAAGAACAGCTCCAACGATGAGACCATCGCTGCCAAGCAG | ATCGAG    c.480
 Y  R  E  I  V  K  N  S  S  N  D  E  T  I  A  A  K  Q   | I  E      p.160

          .         .         .         .         .         .       g.39616
 AAGGACCTGCTCCGCACCATGCCCAGCAACGCCTGCTTCGCCAGCATGGGTAGCATCGGG       c.540
 K  D  L  L  R  T  M  P  S  N  A  C  F  A  S  M  G  S  I  G         p.180

          .         .         .         .         .         .       g.39676
 GTGCCCCGCCTGCGCAGGGTGCTCCGGGCCCTGGCCTGGCTCTACCCAGAGATCGGCTAC       c.600
 V  P  R  L  R  R  V  L  R  A  L  A  W  L  Y  P  E  I  G  Y         p.200

          .         | 08         .         .         .         .    g.40100
 TGCCAGGGCACCGGCATG | GTGGCCGCCTGCCTCCTGCTGTTCCTGGAGGAGGAGGACGCC    c.660
 C  Q  G  T  G  M   | V  A  A  C  L  L  L  F  L  E  E  E  D  A      p.220

          .         .         .         .         .         .       g.40160
 TTCTGGATGATGTCTGCCATCATCGAGGACCTGCTCCCCGCCTCCTACTTCAGCACCACC       c.720
 F  W  M  M  S  A  I  I  E  D  L  L  P  A  S  Y  F  S  T  T         p.240

          .         .         .         .         .         .       g.40220
 CTGCTGGGTGTCCAGACTGACCAGCGGGTCCTGCGCCACCTCATTGTCCAGTACCTGCCT       c.780
 L  L  G  V  Q  T  D  Q  R  V  L  R  H  L  I  V  Q  Y  L  P         p.260

          .         .         .     | 09   .         .         .    g.40513
 CGCCTGGACAAGCTGCTCCAGGAGCATGACATTG | AGCTGTCCCTGATCACACTGCACTGG    c.840
 R  L  D  K  L  L  Q  E  H  D  I  E |   L  S  L  I  T  L  H  W      p.280

          .         .         .         .         .         .       g.40573
 TTCCTCACGGCCTTCGCCAGCGTGGTGGACATCAAGCTGCTCCTGCGCATCTGGGACCTG       c.900
 F  L  T  A  F  A  S  V  V  D  I  K  L  L  L  R  I  W  D  L         p.300

          .         .         .         .         .         .       g.40633
 TTTTTCTACGAGGGCTCCCGGGTGCTGTTCCAGCTCACGCTGGGCATGCTGCACCTCAAG       c.960
 F  F  Y  E  G  S  R  V  L  F  Q  L  T  L  G  M  L  H  L  K         p.320

  | 10       .         .         .         .         .         .    g.40907
  | GAGGAAGAGCTGATCCAGTCAGAGAACTCGGCCTCCATCTTCAACACGCTATCGGATATC    c.1020
  | E  E  E  L  I  Q  S  E  N  S  A  S  I  F  N  T  L  S  D  I      p.340

          .         .         .         .         .         .       g.40967
 CCGTCGCAGATGGAGGACGCGGAGCTGCTTCTGGGGGTGGCCATGCGGCTGGCCGGCTCC       c.1080
 P  S  Q  M  E  D  A  E  L  L  L  G  V  A  M  R  L  A  G  S         p.360

          .         .         .         .         .         .       g.41027
 CTCACCGATGTGGCCGTGGAGACTCAGCGCCGCAAGCACCTGGCCTATCTCATTGCAGAC       c.1140
 L  T  D  V  A  V  E  T  Q  R  R  K  H  L  A  Y  L  I  A  D         p.380

          .         .         .         .      | 11  .         .    g.41441
 CAGGGCCAGCTCCTGGGGGCCGGCACCCTCACCAACCTCTCTCAG | GTTGTTCGCCGCAGG    c.1200
 Q  G  Q  L  L  G  A  G  T  L  T  N  L  S  Q   | V  V  R  R  R      p.400

          .         .         .         . | 12       .         .    g.41630
 ACCCAGCGGAGGAAGTCCACCATCACTGCTCTGCTCTTCG | GGGAGGATGACCTGGAGGCA    c.1260
 T  Q  R  R  K  S  T  I  T  A  L  L  F  G |   E  D  D  L  E  A      p.420

          .         .         .         .         .         .       g.41690
 CTCAAGGCCAAGAACATCAAGCAGACGGAACTGGTGGCTGACCTCCGGGAAGCCATCCTG       c.1320
 L  K  A  K  N  I  K  Q  T  E  L  V  A  D  L  R  E  A  I  L         p.440

          .         .         .         .         | 13         .    g.41834
 CGCGTGGCACGCCACTTCCAGTGCACAGACCCCAAAAACTGCAGCGTG | GAGCTGACTCCA    c.1380
 R  V  A  R  H  F  Q  C  T  D  P  K  N  C  S  V   | E  L  T  P      p.460

          .         .         .         .         .         .       g.41894
 GACTATAGCATGGAGAGCCACCAGCGGGACCACGAGAACTACGTGGCGTGCTCACGCAGC       c.1440
 D  Y  S  M  E  S  H  Q  R  D  H  E  N  Y  V  A  C  S  R  S         p.480

          .         .         .         .         .         .       g.41954
 CACCGGCGCCGAGCCAAGGCCCTGCTGGACTTTGAGCGGCACGACGACGACGAGCTGGGC       c.1500
 H  R  R  R  A  K  A  L  L  D  F  E  R  H  D  D  D  E  L  G         p.500

          .         .     | 14   .         .         .         .    g.42234
 TTCCGCAAGAACGACATCATCACA | ATCGTGTCTCAGAAGGACGAGCACTGCTGGGTGGGG    c.1560
 F  R  K  N  D  I  I  T   | I  V  S  Q  K  D  E  H  C  W  V  G      p.520

          .          | 15        .         .         .         .    g.42521
 GAGCTCAACGGCCTGCGAG | GCTGGTTTCCAGCCAAGTTCGTGGAAGTCCTGGATGAGCGC    c.1620
 E  L  N  G  L  R  G |   W  F  P  A  K  F  V  E  V  L  D  E  R      p.540

           | 16        .         .         .         .         .    g.42737
 AGCAAAGAG | TACTCCATCGCGGGGGATGACTCGGTGACGGAGGGGGTCACAGACCTCGTG    c.1680
 S  K  E   | Y  S  I  A  G  D  D  S  V  T  E  G  V  T  D  L  V      p.560

          .         .         .         .         .         .       g.42797
 CGAGGGACCCTCTGCCCGGCCCTTAAGGCCCTGTTCGAACATGGACTGAAGAAGCCATCC       c.1740
 R  G  T  L  C  P  A  L  K  A  L  F  E  H  G  L  K  K  P  S         p.580

          .         .         .         .   | 17     .         .    g.43054
 CTGCTTGGGGGCGCCTGCCACCCCTGGCTGTTTATCGAGGAG | GCTGCAGGCCGGGAGGTC    c.1800
 L  L  G  G  A  C  H  P  W  L  F  I  E  E   | A  A  G  R  E  V      p.600

          .         .         .         .         .    | 18    .    g.43210
 GAGAGAGACTTTGCCTCCGTGTATTCCCGTCTGGTGCTCTGTAAGACCTTCAG | GTTGGAT    c.1860
 E  R  D  F  A  S  V  Y  S  R  L  V  L  C  K  T  F  R  |  L  D      p.620

          .         .         .         .   | 19     .         .    g.43360
 GAAGATGGCAAAGTCCTGACCCCGGAGGAGCTGCTCTACCGG | GCTGTGCAGTCTGTGAAC    c.1920
 E  D  G  K  V  L  T  P  E  E  L  L  Y  R   | A  V  Q  S  V  N      p.640

          .         .         .         .         .         .       g.43420
 GTGACCCACGATGCAGTGCATGCACAAATGGATGTGAAGCTCCGCTCACTGATCTGCGTG       c.1980
 V  T  H  D  A  V  H  A  Q  M  D  V  K  L  R  S  L  I  C  V         p.660

          | 20         .         .         .         .         .    g.43711
 GGGCTCAA | TGAGCAGGTGCTGCACCTGTGGCTGGAGGTGCTCTGCTCCAGCCTGCCCACC    c.2040
 G  L  N  |  E  Q  V  L  H  L  W  L  E  V  L  C  S  S  L  P  T      p.680

          .         .         .         .         .         .       g.43771
 GTGGAGAAGTGGTACCAGCCCTGGTCCTTCCTGCGCAGCCCGGGCTGGGTCCAGATCAAG       c.2100
 V  E  K  W  Y  Q  P  W  S  F  L  R  S  P  G  W  V  Q  I  K         p.700

          .  | 21      .         .         .         .         .    g.43923
 TGTGAGCTCCG | AGTCCTCTGCTGCTTTGCCTTCAGCCTCTCCCAGGACTGGGAGCTCCCT    c.2160
 C  E  L  R  |  V  L  C  C  F  A  F  S  L  S  Q  D  W  E  L  P      p.720

          .   | 22     .         .         .         .         .    g.44139
 GCGAAGAGAGAG | GCGCAGCAGCCCCTGAAGGAGGGCGTCCGGGACATGCTGGTGAAGCAC    c.2220
 A  K  R  E   | A  Q  Q  P  L  K  E  G  V  R  D  M  L  V  K  H      p.740

          .         .         .                                     g.44169
 CACCTCTTCAGCTGGGATGTGGACGGGTGA                                     c.2250
 H  L  F  S  W  D  V  D  G  X                                       p.749

          .         .         .         .         .         .       g.44229
 ccccctcctccccagcccaacctcgggcctgcgtctgaggtggcccaggaccccaagctg       c.*60

          .         .         .         .         .         .       g.44289
 cagagcccagggaagagcagctccagagccctggccggggccgcgggatatcaatatcag       c.*120

          .         .         .         .         .         .       g.44349
 gctgccccactccacgttccccagcacatcccaggtggtgggagcagagggtaccctgcc       c.*180

          .         .         .         .         .         .       g.44409
 ccaccagggtccttagggatgctctaggccaaaccacagtttgtaccaaaaaccttgtga       c.*240

          .         .         .         .         .         .       g.44469
 ggaggtgggggagccatgtctgtgctcaggaagagggaaggggatgggggtggctagtag       c.*300

          .         .         .         .         .         .       g.44529
 gctcctggcctctttggtttataaataaactgtgtctgtctttgagaaagcacctacctg       c.*360

          .         .         .         .         .         .       g.44589
 tcttctgtgcagctagggctgcagagctgtattcaggtccaaggttctgcccttccttga       c.*420

          .         .         .         .         .         .       g.44649
 gtggtctagaaggcactgcgtggcccctcagatgctgggacacaacagacccgggaccca       c.*480

          .         .         .         .         .                 g.44699
 gctgtgctacccaccccttccatggactgaataagatggactaacaggcc                 c.*530

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Small G protein signaling modulator 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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