SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae) (SIL1) - coding DNA reference sequence

(used for variant description)

(last modified November 7, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_001037633.1 in the SIL1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008112.1, covering SIL1 transcript NM_001037633.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   accggctcagacggtcgccgccgcgt       c.-181

 .         .         .         .         .         .                g.5086
 ttgcgcagggggagctggtcgccgccgcggccgcctggaattgtgggagttgtgtctgcc       c.-121

 .         .         .  | 02      .         .         .             g.6886
 actcggctgccggaggccgaag | gccagctattacttctctactgaggccaactgtgagcc    c.-61

 .         .         .         .         .          | 03            g.75533
 ctggtgtgtttcattggcaggagaagaggctaattaagtgaaactgaaag | gtccctgact    c.-1

          .         .         .         .         .         .       g.75593
 ATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTCTGGGCATGCTGCTTGGGCTG       c.60
 M  A  P  Q  S  L  P  S  S  R  M  A  P  L  G  M  L  L  G  L         p.20

          .         .         .         .      | 04  .         .    g.82218
 CTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTG | AAGGAGTTTGCCCTG    c.120
 L  M  A  A  C  F  T  F  C  L  S  H  Q  N  L   | K  E  F  A  L      p.40

          .         .         .         .         .         .       g.82278
 ACCAACCCAGAGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAG       c.180
 T  N  P  E  K  S  S  T  K  E  T  E  R  K  E  T  K  A  E  E         p.60

          .         .         .         .         .         .       g.82338
 GAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGCATGAGTGGCAGGCCCTTCAG       c.240
 E  L  D  A  E  V  L  E  V  F  H  P  T  H  E  W  Q  A  L  Q         p.80

      | 05   .         .         .         .         .         .    g.152386
 CCAG | GGCAGGCTGTCCCTGCAGGATCCCACGTACGGCTGAATCTTCAGACTGGGGAAAGA    c.300
 P  G |   Q  A  V  P  A  G  S  H  V  R  L  N  L  Q  T  G  E  R      p.100

          .         .         .         .         .    | 06    .    g.160664
 GAGGCAAAACTCCAATATGAGGACAAGTTCCGAAATAATTTGAAAGGCAAAAG | GCTGGAT    c.360
 E  A  K  L  Q  Y  E  D  K  F  R  N  N  L  K  G  K  R  |  L  D      p.120

          .         .         .         .         .         .       g.160724
 ATCAACACCAACACCTACACATCTCAGGATCTCAAGAGTGCACTGGCAAAATTCAAGGAG       c.420
 I  N  T  N  T  Y  T  S  Q  D  L  K  S  A  L  A  K  F  K  E         p.140

          .         .         .    | 07    .         .         .    g.176411
 GGGGCAGAGATGGAGAGTTCAAAGGAAGACAAG | GCAAGGCAGGCTGAGGTAAAGCGGCTC    c.480
 G  A  E  M  E  S  S  K  E  D  K   | A  R  Q  A  E  V  K  R  L      p.160

          .         .         .         .         .         .       g.176471
 TTCCGCCCCATTGAGGAACTGAAGAAAGACTTTGATGAGCTGAATGTTGTCATTGAGACT       c.540
 F  R  P  I  E  E  L  K  K  D  F  D  E  L  N  V  V  I  E  T         p.180

          .         .         .         .         .         .       g.176531
 GACATGCAGATCATGGTACGGCTGATCAACAAGTTCAATAGTTCCAGCTCCAGTTTGGAA       c.600
 D  M  Q  I  M  V  R  L  I  N  K  F  N  S  S  S  S  S  L  E         p.200

          .         .         .         .      | 08  .         .    g.182099
 GAGAAGATTGCTGCGCTCTTTGATCTTGAATATTATGTCCATCAG | ATGGACAATGCGCAG    c.660
 E  K  I  A  A  L  F  D  L  E  Y  Y  V  H  Q   | M  D  N  A  Q      p.220

          .         .         .         .         .         .       g.182159
 GACCTGCTTTCCTTTGGTGGTCTTCAAGTGGTGATCAATGGGCTGAACAGCACAGAGCCC       c.720
 D  L  L  S  F  G  G  L  Q  V  V  I  N  G  L  N  S  T  E  P         p.240

          .         .         .         .        | 09.         .    g.251505
 CTCGTGAAGGAGTATGCTGCGTTTGTGCTGGGCGCTGCCTTTTCCAG | CAACCCCAAGGTC    c.780
 L  V  K  E  Y  A  A  F  V  L  G  A  A  F  S  S  |  N  P  K  V      p.260

          .         .         .         .         .         .       g.251565
 CAGGTGGAGGCCATCGAAGGGGGAGCCCTGCAGAAGCTGCTGGTCATCCTGGCCACGGAG       c.840
 Q  V  E  A  I  E  G  G  A  L  Q  K  L  L  V  I  L  A  T  E         p.280

          .         .     | 10   .         .         .         .    g.252077
 CAGCCGCTCACTGCAAAGAAGAAG | GTCCTGTTTGCACTGTGCTCCCTGCTGCGCCACTTC    c.900
 Q  P  L  T  A  K  K  K   | V  L  F  A  L  C  S  L  L  R  H  F      p.300

          .         .         .         .         .         .       g.252137
 CCCTATGCCCAGCGGCAGTTCCTGAAGCTCGGGGGGCTGCAGGTCCTGAGGACCCTGGTG       c.960
 P  Y  A  Q  R  Q  F  L  K  L  G  G  L  Q  V  L  R  T  L  V         p.320

          .         .         .         .         .         .       g.252197
 CAGGAGAAGGGCACGGAGGTGCTCGCCGTGCGCGTGGTCACACTGCTCTACGACCTGGTC       c.1020
 Q  E  K  G  T  E  V  L  A  V  R  V  V  T  L  L  Y  D  L  V         p.340

           | 11        .         .         .         .         .    g.255954
 ACGGAGAAG | ATGTTCGCCGAGGAGGAGGCTGAGCTGACCCAGGAGATGTCCCCAGAGAAG    c.1080
 T  E  K   | M  F  A  E  E  E  A  E  L  T  Q  E  M  S  P  E  K      p.360

          .         .         .         .         .         .       g.256014
 CTGCAGCAGTATCGCCAGGTACACCTCCTGCCAGGCCTGTGGGAACAGGGCTGGTGCGAG       c.1140
 L  Q  Q  Y  R  Q  V  H  L  L  P  G  L  W  E  Q  G  W  C  E         p.380

          .         .         .         .         .         .       g.256074
 ATCACGGCCCACCTCCTGGCGCTGCCCGAGCATGATGCCCGTGAGAAGGTGCTGCAGACA       c.1200
 I  T  A  H  L  L  A  L  P  E  H  D  A  R  E  K  V  L  Q  T         p.400

          .         .         .         .         .         .       g.256134
 CTGGGCGTCCTCCTGACCACCTGCCGGGACCGCTACCGTCAGGACCCCCAGCTCGGCAGG       c.1260
 L  G  V  L  L  T  T  C  R  D  R  Y  R  Q  D  P  Q  L  G  R         p.420

          .         .         .         .         .         .       g.256194
 ACACTGGCCAGCCTGCAGGCTGAGTACCAGGTGCTGGCCAGCCTGGAGCTGCAGGATGGT       c.1320
 T  L  A  S  L  Q  A  E  Y  Q  V  L  A  S  L  E  L  Q  D  G         p.440

          .         .         .         .         .         .       g.256254
 GAGGACGAGGGCTACTTCCAGGAGCTGCTGGGCTCTGTCAACAGCTTGCTGAAGGAGCTG       c.1380
 E  D  E  G  Y  F  Q  E  L  L  G  S  V  N  S  L  L  K  E  L         p.460

                                                                    g.256260
 AGATGA                                                             c.1386
 R  X                                                               p.461

          .         .         .         .         .         .       g.256320
 ggccccacaccaggactggactgggatgccgctagtgaggctgaggggtgccagcgtggg       c.*60

          .         .         .         .         .         .       g.256380
 tgggcttctcaggcaggaggacatcttggcagtgctggcttggccattaaatggaaacct       c.*120

          .         .         .         .         .         .       g.256440
 gaaggccatcctctttctgctgtgtgtctgtgtagactgggcacagccctgtggccgggg       c.*180

          .         .         .         .         .         .       g.256500
 ggtcaggtgagtggttgggtgatgggctctgctgacgtgcagggctcagcccagggcatc       c.*240

          .         .         .         .         .         .       g.256560
 caggaacaggctccagggcaggaacctgggcccaggagttgcaagtctctgcttcttacc       c.*300

          .         .         .         .         .         .       g.256620
 aagcagcagctctgtaccttgggaagtcgcttaattgctctgagcttgtttcctcatctg       c.*360

          .         .         .                                     g.256657
 tcaggagtgccattaaaggagaaaaatcacgtagaaa                              c.*397

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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