SIN3 transcription regulator homolog B (yeast) (SIN3B) - coding DNA reference sequence

(used for variant description)

(last modified May 9, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_015260.2 in the SIN3B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering SIN3B transcript NM_015260.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      ggggcgcagctccgacttcggac       c.-1

          .         .         .         .         .         .       g.5083
 ATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGG       c.60
 M  A  H  A  G  G  G  S  G  G  S  G  A  G  G  P  A  G  R  G         p.20

          .         .         .         .         .         .       g.5143
 CTGAGCGGCGCCCGCTGGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCAC       c.120
 L  S  G  A  R  W  G  R  S  G  S  A  G  H  E  K  L  P  V  H         p.40

  | 02       .         .         .         .         .         .    g.5453
  | GTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTGGCAGCGACCCTGCC    c.180
  | V  E  D  A  L  T  Y  L  D  Q  V  K  I  R  F  G  S  D  P  A      p.60

          .         .         .         .        | 03.         .    g.7109
 ACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAG | CATCGATACTCCT    c.240
 T  Y  N  G  F  L  E  I  M  K  E  F  K  S  Q  S  |  I  D  T  P      p.80

          .         .         .         .         .         .       g.7169
 GGAGTCATCAGACGTGTCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTC       c.300
 G  V  I  R  R  V  S  Q  L  F  H  E  H  P  D  L  I  V  G  F         p.100

          .         .         .         .         .         .       g.7229
 AACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATGGCAAGTTAAACATA       c.360
 N  A  F  L  P  L  G  Y  R  I  D  I  P  K  N  G  K  L  N  I         p.120

          .         .  | 04      .         .         .         .    g.17409
 CAGTCGCCTCTGACAAGCCAG | GAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTC    c.420
 Q  S  P  L  T  S  Q   | E  N  S  H  N  H  G  D  G  A  E  D  F      p.140

          .         .         .         .         .         .       g.17469
 AAGCAGCAGGTGCCGTATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTG       c.480
 K  Q  Q  V  P  Y  K  E  D  K  P  Q  V  P  L  E  S  D  S  V         p.160

          .         .         .         .         .         .       g.17529
 GAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCTTCCTAGACCACCCA       c.540
 E  F  N  N  A  I  S  Y  V  N  K  I  K  T  R  F  L  D  H  P         p.180

          .         .         .         .   | 05     .         .    g.22590
 GAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAG | AAGGAGCAGCTGAACACG    c.600
 E  I  Y  R  S  F  L  E  I  L  H  T  Y  Q   | K  E  Q  L  N  T      p.200

          .         .         .         .         .         .       g.22650
 AGGGGCCGGCCATTCCGAGGCATGTCTGAAGAGGAGGTGTTCACCGAGGTGGCCAACCTC       c.660
 R  G  R  P  F  R  G  M  S  E  E  E  V  F  T  E  V  A  N  L         p.220

          .         .         .         .         .         .       g.22710
 TTCCGGGGCCAGGAGGACCTGCTCTCAGAGTTTGGACAGTTCCTGCCCGAAGCCAAGCGG       c.720
 F  R  G  Q  E  D  L  L  S  E  F  G  Q  F  L  P  E  A  K  R         p.240

        | 06 .         .         .         .         .         .    g.27068
 TCTCTG | TTCACAGGAAACGGGCCGTGCGAGATGCACAGCGTGCAGAAGAACGAGCACGAC    c.780
 S  L   | F  T  G  N  G  P  C  E  M  H  S  V  Q  K  N  E  H  D      p.260

          .         .         .         .         .         .       g.27128
 AAGACCCCGGAGCACAGCAGGAAGCGCTCCCGGCCCTCGCTCCTCCGCCCCGTGTCTGCA       c.840
 K  T  P  E  H  S  R  K  R  S  R  P  S  L  L  R  P  V  S  A         p.280

           | 07        .         .         .         .         .    g.28722
 CCCGCCAAG | AAAAAAATGAAACTTCGTGGTACCAAAGACCTGTCCATCGCTGCAGTGGGG    c.900
 P  A  K   | K  K  M  K  L  R  G  T  K  D  L  S  I  A  A  V  G      p.300

          .         .         .          | 08        .         .    g.29766
 AAGTACGGGACTCTGCAGGAATTTTCTTTCTTTGACAAG | GTCCGCCGGGTGCTGAAGAGC    c.960
 K  Y  G  T  L  Q  E  F  S  F  F  D  K   | V  R  R  V  L  K  S      p.320

          .         .         .         .         .         .       g.29826
 CAGGAGGTGTATGAAAACTTCCTCCGCTGCATCGCACTCTTCAACCAGGAGCTGGTGTCT       c.1020
 Q  E  V  Y  E  N  F  L  R  C  I  A  L  F  N  Q  E  L  V  S         p.340

          .         .         .         | 09         .         .    g.37976
 GGCTCTGAGCTCCTGCAGCTCGTCAGCCCATTTCTGGG | GAAATTTCCAGAACTCTTTGCA    c.1080
 G  S  E  L  L  Q  L  V  S  P  F  L  G  |  K  F  P  E  L  F  A      p.360

          .         .         .         .         .         .       g.38036
 CAGTTCAAGTCCTTCCTGGGGGTAAAAGAGCTGTCCTTCGCGCCACCCATGAGCGACAGA       c.1140
 Q  F  K  S  F  L  G  V  K  E  L  S  F  A  P  P  M  S  D  R         p.380

          .         .         .         .         .         .       g.38096
 TCCGGGGACGGGATAAGCCGGGAAATTGATTATGCATCCTGCAAGCGCATAGGATCCAGC       c.1200
 S  G  D  G  I  S  R  E  I  D  Y  A  S  C  K  R  I  G  S  S         p.400

          .         .         .         .         .         .       g.38156
 TACCGGGCACTCCCCAAAACCTACCAGCAGCCCAAGTGCAGTGGGAGGACAGCCATCTGC       c.1260
 Y  R  A  L  P  K  T  Y  Q  Q  P  K  C  S  G  R  T  A  I  C         p.420

        | 10 .         .         .         .         .         .    g.38540
 AAGGAG | CTTGACCATTGGACACTTCTCCAGGGTTCGTGGACAGACGATTACTGCATGTCC    c.1320
 K  E   | L  D  H  W  T  L  L  Q  G  S  W  T  D  D  Y  C  M  S      p.440

          .         .         .         .   | 11     .         .    g.39300
 AAGTTCAAGAATACCTGCTGGATTCCAGGATATAGTGCAGGG | GTACTGAACGACACCTGG    c.1380
 K  F  K  N  T  C  W  I  P  G  Y  S  A  G   | V  L  N  D  T  W      p.460

          .         .         .         .         .         .       g.39360
 GTCTCCTTCCCTTCCTGGTCTGAGGACTCCACGTTCGTCAGCTCCAAGAAGACACCGTAC       c.1440
 V  S  F  P  S  W  S  E  D  S  T  F  V  S  S  K  K  T  P  Y         p.480

          .         .         .          | 12        .         .    g.41033
 GAGGAGCAGCTTCACCGCTGTGAGGACGAGCGCTTCGAG | TTAGACGTTGTCCTGGAGACG    c.1500
 E  E  Q  L  H  R  C  E  D  E  R  F  E   | L  D  V  V  L  E  T      p.500

          .         .         .         .         .         .       g.41093
 AACCTGGCCACAATCCGTGTGTTGGAAAGTGTGCAGAAGAAGCTATCTCGGATGGCGCCG       c.1560
 N  L  A  T  I  R  V  L  E  S  V  Q  K  K  L  S  R  M  A  P         p.520

          .         .         .         .         .         .       g.41153
 GAAGACCAGGAGAAGTTCCGGCTGGACGACTCCCTGGGAGGCACGTCGGAGGTGATCCAG       c.1620
 E  D  Q  E  K  F  R  L  D  D  S  L  G  G  T  S  E  V  I  Q         p.540

          .         .         .         .         .         .       g.41213
 CGCCGTGCCATTTATCGCATCTATGGCGACAAGGCCCCGGAGATCATCGAGAGCCTCAAG       c.1680
 R  R  A  I  Y  R  I  Y  G  D  K  A  P  E  I  I  E  S  L  K         p.560

          .         .         .         | 13         .         .    g.41997
 AAGAACCCTGTCACCGCTGTCCCCGTTGTCCTGAAAAG | ACTGAAGGCCAAGGAAGAGGAG    c.1740
 K  N  P  V  T  A  V  P  V  V  L  K  R  |  L  K  A  K  E  E  E      p.580

          .         .         .         .         .         .       g.42057
 TGGCGGGAGGCCCAGCAGGGCTTCAACAAGATCTGGCGGGAGCAGTATGAGAAGGCGTAC       c.1800
 W  R  E  A  Q  Q  G  F  N  K  I  W  R  E  Q  Y  E  K  A  Y         p.600

          .         .         .         .         .         .       g.42117
 CTCAAGTCCCTTGACCACCAGGCTGTGAACTTCAAGCAGAACGACACCAAGGCCCTGCGC       c.1860
 L  K  S  L  D  H  Q  A  V  N  F  K  Q  N  D  T  K  A  L  R         p.620

          .         .         .         .   | 14     .         .    g.45080
 TCCAAGAGCTTGCTCAACGAGATCGAGAGCGTCTACGACGAG | CACCAGGAGCAGCACTCG    c.1920
 S  K  S  L  L  N  E  I  E  S  V  Y  D  E   | H  Q  E  Q  H  S      p.640

          .         .         .         .         .         .       g.45140
 GAGGGCCGCAGTGCCCCCTCTAGCGAGCCGCACCTCATCTTTGTGTACGAGGACCGGCAG       c.1980
 E  G  R  S  A  P  S  S  E  P  H  L  I  F  V  Y  E  D  R  Q         p.660

          .         .         .         .         .         .       g.45200
 ATCCTGGAGGACGCAGCAGCGCTCATCAGCTACTACGTGAAGCGGCAGCCGGCCATCCAG       c.2040
 I  L  E  D  A  A  A  L  I  S  Y  Y  V  K  R  Q  P  A  I  Q         p.680

          .         .         .         .         .         .       g.45260
 AAGGAGGACCAGGGCACCATCCACCAGCTGCTGCACCAGTTCGTGCCCAGCCTCTTCTTC       c.2100
 K  E  D  Q  G  T  I  H  Q  L  L  H  Q  F  V  P  S  L  F  F         p.700

          .         .         .         .         .         .       g.45320
 TCTCAGCAGCTGGACCTGGGCGCCTCCGAGGAGTCAGCTGATGAGGACCGGGACAGCCCC       c.2160
 S  Q  Q  L  D  L  G  A  S  E  E  S  A  D  E  D  R  D  S  P         p.720

          .         .         .         .         .         .       g.45380
 CAGGGGCAGACCACAGACCCCAGTGAGCGGAAGAAGCCGGCGCCAGGACCCCACAGTAGC       c.2220
 Q  G  Q  T  T  D  P  S  E  R  K  K  P  A  P  G  P  H  S  S         p.740

          .         .         .         .         .         .       g.45440
 CCCCCAGAGGAGAAGGGGGCCTTCGGGGATGCCCCGGCCACTGAGCAGCCACCCCTGCCG       c.2280
 P  P  E  E  K  G  A  F  G  D  A  P  A  T  E  Q  P  P  L  P         p.760

          .         .         .         .         .         .       g.45500
 CCCCCAGCCCCGCACAAGCCCCTGGACGATGTCTACAGCCTATTTTTTGCCAACAACAAC       c.2340
 P  P  A  P  H  K  P  L  D  D  V  Y  S  L  F  F  A  N  N  N         p.780

          .         .         .         .         .         .       g.45560
 TGGTACTTCTTCCTGCGCCTGCACCAGACCCTGTGCTCCAGGCTGCTGAAGATCTACCGC       c.2400
 W  Y  F  F  L  R  L  H  Q  T  L  C  S  R  L  L  K  I  Y  R         p.800

          .         .         .         .         .         .       g.45620
 CAGGCGCAGAAGCAGCTTCTGGAGTATCGGACCGAGAAGGAGCGGGAGAAGCTGCTGTGT       c.2460
 Q  A  Q  K  Q  L  L  E  Y  R  T  E  K  E  R  E  K  L  L  C         p.820

          .         .         .         .         .         | 15    g.46833
 GAGGGCCGCAGGGAGAAGGGCAGCGACCCCGCCATGGAGCTGCGGCTGAAGCAGCCCA | GT    c.2520
 E  G  R  R  E  K  G  S  D  P  A  M  E  L  R  L  K  Q  P  S |       p.840

          .         .         .         .         .         .       g.46893
 GAAGTGGAGCTGGAGGAGTACTACCCGGCCTTCCTGGACATGGTGCGGAGCCTGCTGGAG       c.2580
 E  V  E  L  E  E  Y  Y  P  A  F  L  D  M  V  R  S  L  L  E         p.860

          .         .         .         .         .         .       g.46953
 GGCAGCATCGACCCCACGCAGTACGAGGACACCCTACGCGAGATGTTCACCATCCATGCC       c.2640
 G  S  I  D  P  T  Q  Y  E  D  T  L  R  E  M  F  T  I  H  A         p.880

          .         .         .         .         | 16         .    g.51669
 TACGTGGGCTTCACCATGGACAAGCTGGTGCAGAACATTGCGCGGCAG | CTGCACCACCTC    c.2700
 Y  V  G  F  T  M  D  K  L  V  Q  N  I  A  R  Q   | L  H  H  L      p.900

          .         .         .         .         .         .       g.51729
 GTGAGCGATGACGTCTGCCTGAAGGTGGTGGAGCTCTACCTGAACGAGAAGAAGCGGGGT       c.2760
 V  S  D  D  V  C  L  K  V  V  E  L  Y  L  N  E  K  K  R  G         p.920

          .         .         .         .         .         .       g.51789
 GCCGCTGGTGGGAACCTGTCCTCCCGCTGCGTCCGCGCTGCTAGGGAGACCAGCTACCAG       c.2820
 A  A  G  G  N  L  S  S  R  C  V  R  A  A  R  E  T  S  Y  Q         p.940

          .         .         .         .   | 17     .         .    g.52106
 TGGAAGGCTGAGCGCTGCATGGCCGACGAGAACTGCTTCAAG | GTGATGTTCCTGCAGCGC    c.2880
 W  K  A  E  R  C  M  A  D  E  N  C  F  K   | V  M  F  L  Q  R      p.960

          .         .         .         .         .         .       g.52166
 AAAGGGCAGGTGATCATGACCATCGAGCTCCTGGACACCGAGGAGGCCCAGACGGAGGAC       c.2940
 K  G  Q  V  I  M  T  I  E  L  L  D  T  E  E  A  Q  T  E  D         p.980

          .      | 18  .         .         .         .         .    g.53192
 CCTGTGGAGGTCCAG | CACCTGGCTCGGTACGTGGAGCAGTATGTGGGGACCGAGGGCGCG    c.3000
 P  V  E  V  Q   | H  L  A  R  Y  V  E  Q  Y  V  G  T  E  G  A      p.1000

          .         .         .         .         . | 19       .    g.53795
 TCCAGCTCGCCCACTGAGGGCTTCCTCCTGAAACCTGTGTTCCTGCAGAG | GAACCTCAAG    c.3060
 S  S  S  P  T  E  G  F  L  L  K  P  V  F  L  Q  R  |  N  L  K      p.1020

          .         .         .         .         .         .       g.53855
 AAGTTCCGCCGCCGGTGGCAGAGCGAGCAGGCGCGGGCCCTGCGCGGTGAGGCCAGGAGC       c.3120
 K  F  R  R  R  W  Q  S  E  Q  A  R  A  L  R  G  E  A  R  S         p.1040

          .         .         .         .         .         .       g.53915
 TCCTGGAAGCGGCTGGTGGGCGTGGAGAGCGCCTGCGACGTGGACTGCCGCTTCAAGCTC       c.3180
 S  W  K  R  L  V  G  V  E  S  A  C  D  V  D  C  R  F  K  L         p.1060

          .         .         .         .         .         .       g.53975
 AGCACTCACAAGATGGTGTTCATCGTGAACTCCGAGGACTACATGTACCGTCGCGGGACC       c.3240
 S  T  H  K  M  V  F  I  V  N  S  E  D  Y  M  Y  R  R  G  T         p.1080

          .         | 20         .         .         .         .    g.54141
 CTCTGCCGGGCCAAGCAG | GTGCAGCCCCTGGTCCTGCTCCGCCACCACCAGCACTTTGAG    c.3300
 L  C  R  A  K  Q   | V  Q  P  L  V  L  L  R  H  H  Q  H  F  E      p.1100

          .         .         .         .         .         .       g.54201
 GAGTGGCACAGCCGCTGGCTGGAGGACAATGTGACGGTGGAGGCGGCTAGCCTGGTGCAG       c.3360
 E  W  H  S  R  W  L  E  D  N  V  T  V  E  A  A  S  L  V  Q         p.1120

          .         .         .         .         .         .       g.54261
 GACTGGCTGATGGGTGAGGAGGACGAGGACATGGTACCCTGCAAGACGCTGTGTGAGACA       c.3420
 D  W  L  M  G  E  E  D  E  D  M  V  P  C  K  T  L  C  E  T         p.1140

          .         .         .         .         .         .       g.54321
 GTGCACGTGCACGGCCTGCCCGTGACCCGCTACCGCGTGCAGTACAGCCGCCGCCCGGCC       c.3480
 V  H  V  H  G  L  P  V  T  R  Y  R  V  Q  Y  S  R  R  P  A         p.1160

                                                                    g.54330
 TCGCCCTGA                                                          c.3489
 S  P  X                                                            p.1162

          .         .         .         .         .         .       g.54390
 cccgccctcatgggcaccgggcaggcgcctcacagagcacagacgtgccctcggccttgg       c.*60

          .         .         .         .         .         .       g.54450
 tcgtgtcggggccgttttcttgaacgacgtgagaggcatctcccagcccctctgctgccg       c.*120

          .         .         .         .         .         .       g.54510
 gacagcgcactccagggcaggacgccgcccccgtggctcccggtctcctgtgggcctgct       c.*180

          .         .         .         .         .         .       g.54570
 gtgtgccaaacctgagctacctgcacccgagccctggggctcagccccaccacaggggcg       c.*240

          .         .         .         .         .         .       g.54630
 ggtggacgtgctggccgaggaacaagcaatcatgtttgcgtccccgtccgtcacatgtgc       c.*300

          .         .         .         .         .         .       g.54690
 caaatccctggcaggcagatggctcctgccccatattcttgccgtgtcttggaaaagtca       c.*360

          .         .         .         .         .         .       g.54750
 caggtgacagccctcctgaggcccacactttggagggggtccatgtccaagagaccctga       c.*420

          .         .         .         .         .         .       g.54810
 caaggaaggagttgagccctgggtaggcttgcttgaaaagtgagtccttccagaatattc       c.*480

          .         .         .         .         .         .       g.54870
 tcagagctgccagaaacatcatctgagggtttgggcatcagctctgcctggctggtgttc       c.*540

          .         .         .         .         .         .       g.54930
 aggccctcagtcactttggaagtgagaagaacccttcagccaaacctttgggatcccatt       c.*600

          .         .         .         .         .         .       g.54990
 ttgaagtccagagctggagcaggcgggcagtgccctgggagaccccgctctggataagac       c.*660

          .         .         .         .         .         .       g.55050
 acccaaccccaactccagcagctggactctgggcccacaaggggagggaccccagccagt       c.*720

          .         .         .         .         .         .       g.55110
 attccctcagagccggcacgaccctgctgtggggcggcgggcccagtcgtgttcctgcag       c.*780

          .         .         .         .         .         .       g.55170
 tgggcaccctaggcgtatgtgtatacacgcacagatatttattcctttcgcttttagtgg       c.*840

          .         .         .         .         .         .       g.55230
 ttgttatttctgtagcagccaagtcctgcggctccctggggctgagatctccctttgtgg       c.*900

          .         .         .         .         .         .       g.55290
 aactccgagagccgccctgacagtcccagccgccacccaaggagccccatccgcccaccc       c.*960

          .         .         .         .         .         .       g.55350
 accctgggacccacgcggccactccagggatcattgttgtccttttgtgaggggctgagg       c.*1020

          .         .         .         .         .         .       g.55410
 cgactgtcccatggaggcatccaaggctttctgtgccaagaatcccaagtgactggggct       c.*1080

          .         .         .         .         .         .       g.55470
 ggggaccacttctccaggcctctctccccgaccatgagagcccctggccctggcccctgc       c.*1140

          .         .         .         .         .         .       g.55530
 acaccagtaggcccagaataaccgccacccttgccatcctgcaacagctggactcaagtt       c.*1200

          .         .         .         .         .         .       g.55590
 tccaggaagtggagatgtgtttctagaagtttcctgtggaacctggaggctcctgatgcc       c.*1260

          .         .         .         .         .         .       g.55650
 tttgactccaggctgggcgattccgatgctgacccgtcctcctgggctccccacccccgc       c.*1320

          .         .         .         .         .         .       g.55710
 tccccaagtgtcacacaggcactttgtacacatcctggttttctaagaagggaacttgcc       c.*1380

          .         .         .         .         .         .       g.55770
 atcaagattcctgtaccaggcccacggccgtctcgggcagagccacctgggccccgggtg       c.*1440

          .         .         .         .         .         .       g.55830
 cagccggagaccccgccgagcccctcctcccagtattcccatccccgcatgcttctaggg       c.*1500

          .         .         .         .         .         .       g.55890
 agcgcctcttttccgttcttgaggaatttctgttctggggcttgtccttcctttgcagct       c.*1560

          .         .         .         .         .         .       g.55950
 gttttgaatgtagttttccttttctatttatttgcacattaaagttaataattgaatatt       c.*1620

                                                                    g.55956
 gacatc                                                             c.*1626

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SIN3 transcription regulator homolog B (yeast) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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