SIX homeobox 5 (SIX5) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_175875.4 in the SIX5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012745.1, covering SIX5 transcript NM_175875.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5035
                          gagacggaggcgtgcagaagctcagtctcggggcg       c.-361

 .         .         .         .         .         .                g.5095
 gaggcttcgcgcccttagtcctcctggacggcccgttaccttctgcgttgtcccgatggg       c.-301

 .         .         .         .         .         .                g.5155
 gaaactgaggccctgagccagaagcacacgctggggggaggcagaaagcgcggccagagg       c.-241

 .         .         .         .         .         .                g.5215
 cggagggaaaacaaagggagaatcacagacagacgggagggggacggacacacacaaggg       c.-181

 .         .         .         .         .         .                g.5275
 gacagagacccgagtggagagctggatctcgccttcccggcgtggggcgcagggtcggcc       c.-121

 .         .         .         .         .         .                g.5335
 agaaagaagatcgagaagagcggggagtgggggcgaaaaggggggacaggtgggggagga       c.-61

 .         .         .         .         .         .                g.5395
 ggctggggaaagcccgagggaggaagagagggagggaggaacttcccaaagttgcaaaac       c.-1

          .         .         .         .         .         .       g.5455
 ATGGCTACCTTGCCTGCGGAGCCGAGCGCGGGGCCGGCGGCTGGGGGGGAGGCGGTGGCG       c.60
 M  A  T  L  P  A  E  P  S  A  G  P  A  A  G  G  E  A  V  A         p.20

          .         .         .         .         .         .       g.5515
 GCGGCGGCGGCGACCGAAGAGGAGGAGGAGGAAGCGCGCCAGCTCTTGCAGACTTTGCAG       c.120
 A  A  A  A  T  E  E  E  E  E  E  A  R  Q  L  L  Q  T  L  Q         p.40

          .         .         .         .         .         .       g.5575
 GCGGCCGAGGGTGAGGCGGCGGCGGCGGCCGGGGCCGGGGCGGGCGCAGCGGCTGCGGGA       c.180
 A  A  E  G  E  A  A  A  A  A  G  A  G  A  G  A  A  A  A  G         p.60

          .         .         .         .         .         .       g.5635
 GCTGAGGGCCCGGGATCCCCGGGCGTCCCCGGGTCGCCCCCCGAGGCCGCTTCCGAACCG       c.240
 A  E  G  P  G  S  P  G  V  P  G  S  P  P  E  A  A  S  E  P         p.80

          .         .         .         .         .         .       g.5695
 CCCACGGGCCTCCGCTTCTCGCCCGAGCAGGTGGCGTGCGTCTGCGAGGCGCTGCTCCAG       c.300
 P  T  G  L  R  F  S  P  E  Q  V  A  C  V  C  E  A  L  L  Q         p.100

          .         .         .         .         .         .       g.5755
 GCGGGCCACGCCGGCCGCTTGAGCCGCTTCCTGGGCGCACTGCCCCCGGCCGAGCGCCTA       c.360
 A  G  H  A  G  R  L  S  R  F  L  G  A  L  P  P  A  E  R  L         p.120

          .         .         .         .         .         .       g.5815
 CGTGGCAGCGACCCGGTGTTGCGCGCGCGGGCCCTGGTGGCCTTCCAGCGGGGCGAGTAC       c.420
 R  G  S  D  P  V  L  R  A  R  A  L  V  A  F  Q  R  G  E  Y         p.140

          .         .         .         .         .         .       g.5875
 GCCGAGCTCTACCGGCTACTCGAGAGCCGCCCCTTCCCCGCCGCCCACCACGCCTTCCTG       c.480
 A  E  L  Y  R  L  L  E  S  R  P  F  P  A  A  H  H  A  F  L         p.160

          .         .         .         .         .         .       g.5935
 CAGGACCTCTACCTGCGCGCGCGCTACCATGAGGCCGAGCGGGCCCGCGGCCGCGCGCTT       c.540
 Q  D  L  Y  L  R  A  R  Y  H  E  A  E  R  A  R  G  R  A  L         p.180

          .         .         .         .         .         .       g.5995
 GGCGCAGTGGACAAGTATCGACTGCGCAAGAAGTTCCCGCTGCCCAAGACCATCTGGGAC       c.600
 G  A  V  D  K  Y  R  L  R  K  K  F  P  L  P  K  T  I  W  D         p.200

          .         .         .         .         .         .       g.6055
 GGCGAGGAGACAGTCTACTGCTTCAAGGAGCGCTCCCGCGCAGCGCTCAAGGCCTGCTAC       c.660
 G  E  E  T  V  Y  C  F  K  E  R  S  R  A  A  L  K  A  C  Y         p.220

          .         .         .         .         .         .       g.6115
 CGCGGCAACCGCTACCCCACGCCGGACGAGAAGCGCCGCCTGGCCACACTCACCGGCCTG       c.720
 R  G  N  R  Y  P  T  P  D  E  K  R  R  L  A  T  L  T  G  L         p.240

          .         .         .         .         .         .       g.6175
 TCGCTCACGCAGGTCAGCAACTGGTTCAAGAACCGGCGACAGCGCGACCGGACCGGGGCC       c.780
 S  L  T  Q  V  S  N  W  F  K  N  R  R  Q  R  D  R  T  G  A         p.260

          .         .    | 02    .         .         .         .    g.7121
 GGAGGCGGCGCGCCCTGCAAGAG | CGAGTCTGATGGGAATCCCACGACTGAGGACGAGTCC    c.840
 G  G  G  A  P  C  K  S  |  E  S  D  G  N  P  T  T  E  D  E  S      p.280

          .         .         .         .         .         .       g.7181
 AGCCGAAGTCCTGAGGACCTGGAGAGAGGGGCGGCCCCAGTGTCCGCCGAGGCCGCTGCC       c.900
 S  R  S  P  E  D  L  E  R  G  A  A  P  V  S  A  E  A  A  A         p.300

          .         .         .         .         .         .       g.7241
 CAGGGCTCCATATTCCTGGCAGGGACCGGCCCTCCCGCGCCTTGCCCGGCTTCCTCCTCC       c.960
 Q  G  S  I  F  L  A  G  T  G  P  P  A  P  C  P  A  S  S  S         p.320

          .         .         .         .         .         .       g.7301
 ATCCTGGTGAACGGGAGCTTCCTGGCAGCCAGCGGCTCCCCAGCAGTGCTCCTCAACGGG       c.1020
 I  L  V  N  G  S  F  L  A  A  S  G  S  P  A  V  L  L  N  G         p.340

          .         .         .         .         .         .       g.7361
 GGCCCCGTCATCATCAACGGCCTGGCCCTGGGCGAGGCCTCCAGCCTGGGCCCGCTGCTG       c.1080
 G  P  V  I  I  N  G  L  A  L  G  E  A  S  S  L  G  P  L  L         p.360

          .         .         .         .         .         .       g.7421
 CTCACTGGGGGCGGGGGTGCCCCTCCACCGCAGCCCAGCCCTCAGGGGGCCAGCGAGACC       c.1140
 L  T  G  G  G  G  A  P  P  P  Q  P  S  P  Q  G  A  S  E  T         p.380

          .         .         .         .         .         .       g.7481
 AAGACCTCTCTGGTCCTGGACCCTCAGACAGGGGAGGTGCGGCTGGAGGAGGCTCAGTCG       c.1200
 K  T  S  L  V  L  D  P  Q  T  G  E  V  R  L  E  E  A  Q  S         p.400

          .         .         .         .         .         .       g.7541
 GAGGCCCCTGAGACCAAAGGGGCCCAGGTGGCTGCTCCGGGACCAGCCCTTGGAGAGGAG       c.1260
 E  A  P  E  T  K  G  A  Q  V  A  A  P  G  P  A  L  G  E  E         p.420

          .         .         .         .         .         .       g.7601
 GTCCTGGGGCCCCTGGCCCAAGTGGTGCCTGGCCCCCCGACGGCTGCCACCTTTCCTCTG       c.1320
 V  L  G  P  L  A  Q  V  V  P  G  P  P  T  A  A  T  F  P  L         p.440

          .         .         .         .         .         .       g.7661
 CCCCCGGGGCCAGTGCCTGCTGTGGCTGCCCCACAAGTGGTACCGCTCTCCCCACCCCCG       c.1380
 P  P  G  P  V  P  A  V  A  A  P  Q  V  V  P  L  S  P  P  P         p.460

          .         .         .         .         .         .       g.7721
 GGGTATCCCACGGGCCTGAGCCCCACCTCCCCACTATTGAACCTGCCCCAGGTAGTACCC       c.1440
 G  Y  P  T  G  L  S  P  T  S  P  L  L  N  L  P  Q  V  V  P         p.480

          .         .         .         .         .         .       g.7781
 ACCTCACAGGTGGTGACCCTGCCCCAGGCTGTGGGGCCCCTGCAGCTGTTGGCAGCCGGG       c.1500
 T  S  Q  V  V  T  L  P  Q  A  V  G  P  L  Q  L  L  A  A  G         p.500

          .         .         .         .         .         .       g.7841
 CCAGGCAGCCCTGTGAAGGTGGCAGCTGCAGCAGGCCCTGCCAATGTGCACCTCATCAAC       c.1560
 P  G  S  P  V  K  V  A  A  A  A  G  P  A  N  V  H  L  I  N         p.520

          .         .         .         .          | 03        .    g.8139
 TCCGGGGTGGGCGTGACTGCCCTGCAGCTGCCTTCGGCCACTGCCCCAG | GAAACTTCCTC    c.1620
 S  G  V  G  V  T  A  L  Q  L  P  S  A  T  A  P  G |   N  F  L      p.540

          .         .         .         .         .         .       g.8199
 CTGGCCAACCCTGTGTCTGGCAGCCCCATCGTGACGGGTGTGGCCGTGCAGCAGGGCAAG       c.1680
 L  A  N  P  V  S  G  S  P  I  V  T  G  V  A  V  Q  Q  G  K         p.560

          .         .         .         .         .         .       g.8259
 ATCATCCTCACCGCCACCTTCCCCACCAGCATGCTCGTCTCCCAGGTCCTGCCGCCAGCC       c.1740
 I  I  L  T  A  T  F  P  T  S  M  L  V  S  Q  V  L  P  P  A         p.580

          .         .         .         .         .         .       g.8319
 CCCGGCCTGGCCCTGCCACTGAAGCCAGAGACGGCCATCTCCGTGCCTGAGGGAGGCCTC       c.1800
 P  G  L  A  L  P  L  K  P  E  T  A  I  S  V  P  E  G  G  L         p.600

          .         .         .         .         .         .       g.8379
 CCGGTGGCCCCCAGCCCTGCTCTCCCAGAGGCTCACGCCCTAGGCACCCTTTCTGCACAG       c.1860
 P  V  A  P  S  P  A  L  P  E  A  H  A  L  G  T  L  S  A  Q         p.620

          .         .         .         .         .         .       g.8439
 CAGCCACCCCCCGCCGCTGCCACCACCTCCAGCACCAGCCTGCCCTTCTCCCCTGACTCC       c.1920
 Q  P  P  P  A  A  A  T  T  S  S  T  S  L  P  F  S  P  D  S         p.640

          .         .         .         .         .         .       g.8499
 CCTGGCCTCCTGCCCAACTTCCCGGCGCCCCCACCAGAGGGGCTGATGTTGTCACCCGCG       c.1980
 P  G  L  L  P  N  F  P  A  P  P  P  E  G  L  M  L  S  P  A         p.660

          .         .         .         .         .         .       g.8559
 GCCGTGCCTGTCTGGTCAGCAGGGCTGGAACTAAGCGCAGGAACAGAGGGGCTGCTGGAA       c.2040
 A  V  P  V  W  S  A  G  L  E  L  S  A  G  T  E  G  L  L  E         p.680

          .         .         .         .         .         .       g.8619
 GCGGAAAAGGGGCTGGGGACACAGGCCCCCCACACCGTGCTGAGGCTGCCAGACCCCGAC       c.2100
 A  E  K  G  L  G  T  Q  A  P  H  T  V  L  R  L  P  D  P  D         p.700

          .         .         .         .         .         .       g.8679
 CCTGAGGGGCTGCTCCTGGGGGCCACCGCAGGGGGTGAGGTTGACGAGGGGTTGGAAGCT       c.2160
 P  E  G  L  L  L  G  A  T  A  G  G  E  V  D  E  G  L  E  A         p.720

          .         .         .         .         .         .       g.8739
 GAGGCCAAGGTTCTGACCCAGCTCCAGTCGGTGCCTGTGGAGGAGCCCTTGGAACTGTGA       c.2220
 E  A  K  V  L  T  Q  L  Q  S  V  P  V  E  E  P  L  E  L  X         p.739

          .         .         .         .         .         .       g.8799
 cccagtgtggccccgtggcctctcccgacattggtgctgaagacgcagggacaggaatgg       c.*60

          .         .         .         .         .         .       g.8859
 gaggggggagccccagaaatgcggttgctgaagaccccagtcaccacatccttctgcctg       c.*120

          .         .         .         .         .         .       g.8919
 ggtggcctctccaagccctggtggtgctgggggttgtatccccggccacctcctgtccag       c.*180

          .         .         .         .         .         .       g.8979
 gtctccatccccctttggatgggaggcctctctgttacagccctccccatgctgtgccct       c.*240

          .         .         .         .         .         .       g.9039
 gccatatacgtgggggactcagggtcctgactcaggggccctgccccctccacttggtac       c.*300

          .         .         .         .         .         .       g.9099
 tagctgtaagcggaacaccctgccccagggccggacttccagcccccagagccctctccc       c.*360

          .         .         .         .         .         .       g.9159
 tgtcactccctgaaacactattaatagctctgccgatagctggtgttgtcacaactgcct       c.*420

          .         .         .         .         .         .       g.9219
 ggaatccgaaggtggaggacaggcagccccgcgcccctgagactggagaccctccccagt       c.*480

          .         .         .         .         .         .       g.9279
 gtggcatttcctgccaggggcggggggtggggcagctgtggggagacgggggtcttcctt       c.*540

          .         .         .         .         .         .       g.9339
 caccagctcccctcgactcaagcccttgtcctcattatccggcccagaccaaagattccc       c.*600

          .         .         .         .         .         .       g.9399
 tcatccctgggggcagccctgccgctgtgtctcctttgtatcctaaatctttatttttct       c.*660

          .         .         .         .         .                 g.9455
 aggacatgttatgcctccattttcaattaaaataaagttatcggattacaccacca           c.*716

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SIX homeobox 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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