v-ski sarcoma viral oncogene homolog (avian) (SKI) - coding DNA reference sequence

(used for variant description)

(last modified October 12, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_003036.3 in the SKI gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013084.1, covering SKI transcript NM_003036.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5012
                                                 cggggcggcggc       c.-61

 .         .         .         .         .         .                g.5072
 gggggccgggggggcccgggcgcgcgggagcgggagcggccgggggagccggagcgcacc       c.-1

          .         .         .         .         .         .       g.5132
 ATGGAGGCGGCGGCAGGCGGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACG       c.60
 M  E  A  A  A  G  G  R  G  C  F  Q  P  H  P  G  L  Q  K  T         p.20

          .         .         .         .         .         .       g.5192
 CTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCCGCTTTCTCGGCG       c.120
 L  E  Q  F  H  L  S  S  M  S  S  L  G  G  P  A  A  F  S  A         p.40

          .         .         .         .         .         .       g.5252
 CGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTG       c.180
 R  W  A  Q  E  A  Y  K  K  E  S  A  K  E  A  G  A  A  A  V         p.60

          .         .         .         .         .         .       g.5312
 CCGGCGCCGGTGCCCGCAGCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAG       c.240
 P  A  P  V  P  A  A  T  E  P  P  P  V  L  H  L  P  A  I  Q         p.80

          .         .         .         .         .         .       g.5372
 CCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGCTCCACCGAGCGC       c.300
 P  P  P  P  V  L  P  G  P  F  F  M  P  S  D  R  S  T  E  R         p.100

          .         .         .         .         .         .       g.5432
 TGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGC       c.360
 C  E  T  V  L  E  G  E  T  I  S  C  F  V  V  G  G  E  K  R         p.120

          .         .         .         .         .         .       g.5492
 CTGTGTCTGCCGCAGATTCTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAAC       c.420
 L  C  L  P  Q  I  L  N  S  V  L  R  D  F  S  L  Q  Q  I  N         p.140

          .         .         .         .         .         .       g.5552
 GCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGACCAGCTGGAGATC       c.480
 A  V  C  D  E  L  H  I  Y  C  S  R  C  T  A  D  Q  L  E  I         p.160

          .         .         .         .         .         .       g.5612
 CTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACG       c.540
 L  K  V  M  G  I  L  P  F  S  A  P  S  C  G  L  I  T  K  T         p.180

          .         .         .         .         .         .       g.5672
 GACGCCGAGCGCCTGTGCAACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAG       c.600
 D  A  E  R  L  C  N  A  L  L  Y  G  G  A  Y  P  P  P  C  K         p.200

          .         .         .         .         .         .       g.5732
 AAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGCAGCGTCCGCGTG       c.660
 K  E  L  A  A  S  L  A  L  G  L  E  L  S  E  R  S  V  R  V         p.220

          .         .         .         .         .         .       g.5792
 TACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCG       c.720
 Y  H  E  C  F  G  K  C  K  G  L  L  V  P  E  L  Y  S  S  P         p.240

          .         .         .         .         .         .       g.5852
 AGCGCCGCCTGCATCCAGTGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTG       c.780
 S  A  A  C  I  Q  C  L  D  C  R  L  M  Y  P  P  H  K  F  V         p.260

          .         .         .         .         .         .       g.5912
 GTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTCGACTCGGCCAAC       c.840
 V  H  S  H  K  A  L  E  N  R  T  C  H  W  G  F  D  S  A  N         p.280

          .         .         .         .         .         .       g.5972
 TGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTC       c.900
 W  R  A  Y  I  L  L  S  Q  D  Y  T  G  K  E  E  Q  A  R  L         p.300

          .         .         .         .         .         .       g.6032
 GGCCGCTGCCTGGACGACGTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGG       c.960
 G  R  C  L  D  D  V  K  E  K  F  D  Y  G  N  K  Y  K  R  R         p.320

           | 02        .         .         .         .         .    g.79334
 GTGCCCCGG | GTCTCCTCTGAGCCTCCGGCCTCCATAAGACCCAAAACAGATGACACCTCT    c.1020
 V  P  R   | V  S  S  E  P  P  A  S  I  R  P  K  T  D  D  T  S      p.340

          .         .         .         .         .         .       g.79394
 TCCCAGTCCCCCGCGCCTTCCGAAAAGGACAAGCCGTCCAGCTGGCTGCGGACCTTGGCC       c.1080
 S  Q  S  P  A  P  S  E  K  D  K  P  S  S  W  L  R  T  L  A         p.360

          .      | 03  .         .         .         .         .    g.79635
 GGCTCTTCCAATAAG | AGCCTGGGCTGTGTTCACCCTCGCCAGCGCCTCTCTGCTTTCCGA    c.1140
 G  S  S  N  K   | S  L  G  C  V  H  P  R  Q  R  L  S  A  F  R      p.380

          .         .         .         .         .         .       g.79695
 CCCTGGTCCCCCGCAGTGTCAGCGAGTGAGAAAGAGCTCTCCCCACACCTCCCGGCCCTC       c.1200
 P  W  S  P  A  V  S  A  S  E  K  E  L  S  P  H  L  P  A  L         p.400

          .  | 04      .         .         .         .         .    g.80194
 ATCCGAGACAG | CTTCTACTCCTACAAGAGCTTTGAGACAGCCGTGGCGCCCAACGTGGCC    c.1260
 I  R  D  S  |  F  Y  S  Y  K  S  F  E  T  A  V  A  P  N  V  A      p.420

          .         .         .         .         .         .       g.80254
 CTCGCACCGCCGGCCCAGCAGAAGGTTGTGAGCAGCCCTCCGTGTGCCGCCGCCGTCTCC       c.1320
 L  A  P  P  A  Q  Q  K  V  V  S  S  P  P  C  A  A  A  V  S         p.440

          .         .         .         .         .         .       g.80314
 CGGGCCCCCGAGCCTCTCGCCACTTGCACCCAGCCTCGGAAGCGGAAGCTGACTGTGGAC       c.1380
 R  A  P  E  P  L  A  T  C  T  Q  P  R  K  R  K  L  T  V  D         p.460

          .         .         .         .         .         .       g.80374
 ACCCCAGGAGCCCCAGAGACGCTGGCGCCCGTGGCTGCCCCAGAGGAGGACAAGGACTCG       c.1440
 T  P  G  A  P  E  T  L  A  P  V  A  A  P  E  E  D  K  D  S         p.480

          .         .         .     | 05   .         .         .    g.80624
 GAGGCGGAGGTGGAAGTTGAAAGCAGGGAGGAAT | TCACCTCCTCCTTGTCCTCGCTCTCT    c.1500
 E  A  E  V  E  V  E  S  R  E  E  F |   T  S  S  L  S  S  L  S      p.500

          .         .         .         .         .         .       g.80684
 TCCCCGTCCTTTACCTCATCCAGCTCCGCCAAGGACCTGGGCTCCCCGGGTGCGCGTGCC       c.1560
 S  P  S  F  T  S  S  S  S  A  K  D  L  G  S  P  G  A  R  A         p.520

          .         .         .         .         .         .       g.80744
 CTGCCCTCGGCCGTCCCTGATGCTGCGGCCCCTGCCGACGCCCCCAGTGGGCTGGAGGCG       c.1620
 L  P  S  A  V  P  D  A  A  A  P  A  D  A  P  S  G  L  E  A         p.540

          .         .         .         .         .         .       g.80804
 GAGCTGGAGCACCTGCGGCAGGCACTGGAGGGCGGCCTGGACACCAAGGAAGCCAAAGAG       c.1680
 E  L  E  H  L  R  Q  A  L  E  G  G  L  D  T  K  E  A  K  E         p.560

          .         .         .         .         .         .       g.80864
 AAGTTCCTGCATGAGGTGGTCAAGATGCGCGTGAAGCAGGAGGAGAAGCTCAGCGCAGCC       c.1740
 K  F  L  H  E  V  V  K  M  R  V  K  Q  E  E  K  L  S  A  A         p.580

          .         .        | 06.         .         .         .    g.82358
 CTGCAGGCCAAGCGCAGCCTCCACCAG | GAGCTGGAGTTCCTACGCGTGGCCAAGAAGGAG    c.1800
 L  Q  A  K  R  S  L  H  Q   | E  L  E  F  L  R  V  A  K  K  E      p.600

          .         .         .         .         .         .       g.82418
 AAGCTGCGGGAGGCCACGGAGGCCAAGCGTAACCTGCGGAAGGAGATCGAGCGTCTCCGC       c.1860
 K  L  R  E  A  T  E  A  K  R  N  L  R  K  E  I  E  R  L  R         p.620

          .         .         .         .         .         .       g.82478
 GCCGAGAACGAGAAGAAGATGAAAGAGGCCAACGAGTCACGGCTGCGCCTGAAGCGGGAG       c.1920
 A  E  N  E  K  K  M  K  E  A  N  E  S  R  L  R  L  K  R  E         p.640

          .         .         .         .         .         .       g.82538
 CTGGAGCAGGCGCGGCAGGCCCGGGTGTGCGACAAGGGCTGCGAGGCGGGCCGCCTGCGC       c.1980
 L  E  Q  A  R  Q  A  R  V  C  D  K  G  C  E  A  G  R  L  R         p.660

          .         | 07         .         .         .         .    g.82924
 GCCAAGTACTCGGCCCAG | ATCGAAGACCTGCAGGTGAAGCTGCAGCACGCGGAGGCGGAC    c.2040
 A  K  Y  S  A  Q   | I  E  D  L  Q  V  K  L  Q  H  A  E  A  D      p.680

          .         .         .         .         .         .       g.82984
 CGGGAGCAGCTGCGGGCCGACCTGCTGCGGGAGCGCGAGGCCCGGGAGCACCTGGAGAAG       c.2100
 R  E  Q  L  R  A  D  L  L  R  E  R  E  A  R  E  H  L  E  K         p.700

          .         .         .         .         .         .       g.83044
 GTGGTGAAGGAGCTGCAGGAACAGCTGTGGCCGCGGGCCCGCCCCGAGGCTGCGGGCAGC       c.2160
 V  V  K  E  L  Q  E  Q  L  W  P  R  A  R  P  E  A  A  G  S         p.720

          .         .                                               g.83071
 GAGGGCGCTGCGGAGCTGGAGCCGTAG                                        c.2187
 E  G  A  A  E  L  E  P  X                                          p.728

          .         .         .         .         .         .       g.83131
 attccgtgcctgccgccgcagcgccgccgacaacgcgggtgcaggggggcgcggctgggc       c.*60

          .         .         .         .         .         .       g.83191
 ggtgcagctccgcccggctccgcccctgcagcccacacagcacaacgtcttaccgtgcct       c.*120

          .         .         .         .         .         .       g.83251
 attaccaagcgagtgtttgtaaccatgtagttttggaacccactgcaaaattttctactg       c.*180

          .         .         .         .         .         .       g.83311
 gccaagttcaagtgagtaagccgcgtcccccaactacagctggagacggggccagctcgg       c.*240

          .         .         .         .         .         .       g.83371
 cggcctgctggtcctctgcttgctggaacattctaacatttacacttttgttataagcta       c.*300

          .         .         .         .         .         .       g.83431
 tttaaaaccagtaaggagacttgaaattcagaaaatcaacacatttttaaatgactaact       c.*360

          .         .         .         .         .         .       g.83491
 tctaaaagccccaacacatgacgccatctgaagacccgcaacggagtgggggtggcggcc       c.*420

          .         .         .         .         .         .       g.83551
 gccccaccctccccacccggggaagccatcacagctcatctgcccgcggctgcgtgagga       c.*480

          .         .         .         .         .         .       g.83611
 cagcaggggtttttcttcagagtctattttttcagcgacaaggacccaggtcttcctgct       c.*540

          .         .         .         .         .         .       g.83671
 gctgccagggagagcagggacagtgccgcgtgcgagatgagctcgaacactgcccgcctt       c.*600

          .         .         .         .         .         .       g.83731
 actgccgcctaccccgcccgccacgccgccgtcgatgccagcgctgtccccacgggtacc       c.*660

          .         .         .         .         .         .       g.83791
 aggaagtgcagagccgcacaggagctgccccggagctgaggggacggtcttcggctcctc       c.*720

          .         .         .         .         .         .       g.83851
 tgcaccccgtgattctgcccacgctcctccaccacgaggcactgacctgcgtcgggtggt       c.*780

          .         .         .         .         .         .       g.83911
 gaccgtggctggcggtcacgccctcagcccctccgggcacacgtgccgcctgaccgggcg       c.*840

          .         .         .         .         .         .       g.83971
 acccttttcagttcggcaaacgtcgctcccttcattttgggactgaggctgcagcattgg       c.*900

          .         .         .         .         .         .       g.84031
 aacaaaagagcattatttcaatttttctttctttttttttgttcgttcatttaaacgtat       c.*960

          .         .         .         .         .         .       g.84091
 atttagaactgcactttgtccacaaccttcccttctctttctattccccagtgaactgag       c.*1020

          .         .         .         .         .         .       g.84151
 gtttttaccgatttatagagcagtcaaatccgaagtgctcgagtgcttagaaaccccctc       c.*1080

          .         .         .         .         .         .       g.84211
 tggtgcttggttgaacaagggaatcacaagaaaacgaaaatgcaaaaactgaacttcggg       c.*1140

          .         .         .         .         .         .       g.84271
 ggtcgttctgtgccttccagcatcttgtacagcaaatcctgactcgtgtctttttacccc       c.*1200

          .         .         .         .         .         .       g.84331
 caagatatctgtcttcagtagcgactgaatctgccactctcagaataagttccttgcatt       c.*1260

          .         .         .         .         .         .       g.84391
 tattccaaataatctcgtttactctcacctgtttatgcaaattgtataaggtttcttatg       c.*1320

          .         .         .         .         .         .       g.84451
 cccaagcttgaaaaatgatttcccagtagacaagaggcggctacctatcctacagttacg       c.*1380

          .         .         .         .         .         .       g.84511
 gtatttatttacataagaagatcttacaggagttctttgcttgaatccgttctaacaccc       c.*1440

          .         .         .         .         .         .       g.84571
 gcggcagctgcacgcgctcacagaaggtggaggttacttgcccaggtacagacgacctcg       c.*1500

          .         .         .         .         .         .       g.84631
 gggcagtgacgagcaaagaccagagactgctgagccctcgcatctgggtggcggaattgc       c.*1560

          .         .         .         .         .         .       g.84691
 ctgcggggttttgcccttggtttactgaggggggtcttggttgctgctgaagccccccac       c.*1620

          .         .         .         .         .         .       g.84751
 cccttctaaagtgcaatgcaaaagggacatcatgtatatgcagcgtttgtttggaatttt       c.*1680

          .         .         .         .         .         .       g.84811
 ctttgcttttgttttctttgcggttgttctgtgtgcatggattccacacctctgccgtag       c.*1740

          .         .         .         .         .         .       g.84871
 gtagatccgtcagcgggcattattaccgtgtcttgtaaagggtcggttttgttatgcaac       c.*1800

          .         .         .         .         .         .       g.84931
 atgcagaatgctgtttttagccttgttttaccagagttgttttttttttcagttatttct       c.*1860

          .         .         .         .         .         .       g.84991
 tcaagggaaactaaatgatttagttggagcaaagctttaagtgtgttggcgtgcttctgt       c.*1920

          .         .         .         .         .         .       g.85051
 gtggctgtcctgtgtcgccaggtcgaagatcacagtgaggtagaggccctgccccatccc       c.*1980

          .         .         .         .         .         .       g.85111
 cagggccgccaggcttgctccgtttgctttgagtttttagaccccagagggagatgagct       c.*2040

          .         .         .         .         .         .       g.85171
 tttccaagctgtgtctgggccagagcctctccttgcccttgctccatcccgacggtcacc       c.*2100

          .         .         .         .         .         .       g.85231
 gttgggtccacgcctccaccgccccatcttgccccaaacggaaagcgctgtatctgcagt       c.*2160

          .         .         .         .         .         .       g.85291
 ggcagcccttccccacttcggctctgggagggtccagccagtgtcacctgggcccaccct       c.*2220

          .         .         .         .         .         .       g.85351
 ttcctgcagctgccaggcccgtgcggtcagtgggacccggacgtgggcaggcgagctcgg       c.*2280

          .         .         .         .         .         .       g.85411
 gaccctcccaggcagttcccacagctcttgcctcggctcaccagggtcacttccactgtc       c.*2340

          .         .         .         .         .         .       g.85471
 aggggcctgagggggcagctgtggctgcagggctgctctggactgaggggtcccaggccc       c.*2400

          .         .         .         .         .         .       g.85531
 cgaggggtgcacgcctggctccccttggcacaggtgcgagtccgtttcttttcagcagaa       c.*2460

          .         .         .         .         .         .       g.85591
 gggggaagaggtgtccgctgtgtgggctgctgactcctctgtgtgtgaggcccttcatct       c.*2520

          .         .         .         .         .         .       g.85651
 aagtgattgtgtattcagtttaattctcattatatttctatactgaaagaagatttttaa       c.*2580

          .         .         .         .         .         .       g.85711
 cgaagggaaaaacaacagcaataacattcatatctctggagcagctaactcatacacgta       c.*2640

          .         .         .         .         .         .       g.85771
 atgtctgcttttcgtacagaactagccaatgtaaaaacagttcacctgtaaatacttttt       c.*2700

          .         .         .         .         .         .       g.85831
 cctttttcaccgttgtattatacatgtatatgctgggtcctttttcagaaactcttttct       c.*2760

          .         .         .         .         .         .       g.85891
 tacctgagagttgtcttgttttctgggctgtttttaactgaggaaaaaaaaaatgctttc       c.*2820

          .         .         .         .         .         .       g.85951
 ctgccggggggcaggggagacggagaaacccatgtgcgtttcccatgtgaccccctcctc       c.*2880

          .         .         .         .         .         .       g.86011
 cctgtgggtctgagccccggccccccccacctcctcctccctgtgggtccgaaccccggc       c.*2940

          .         .         .         .         .         .       g.86071
 ccccccaccccctcctccctgtgggtccgaaccccggcccccccaccccctcctccctgt       c.*3000

          .         .         .         .         .         .       g.86131
 gggtccgatccccggccccccccaccccctcctccctgtgggtccgaaccccggcccccc       c.*3060

          .         .         .         .         .         .       g.86191
 ccccaccccctcctccctgtgggtccgaaccccggcccccccacccctccctcagcccac       c.*3120

          .         .         .         .         .         .       g.86251
 cagggtccagggagatgttcgttctcgctttaagtcaggagtcacaaatgactttttttt       c.*3180

          .         .         .         .         .         .       g.86311
 ttcaattaaggaaaaagctccatctctacctttaacatcacccagacccccgcccctgcc       c.*3240

          .         .         .         .         .         .       g.86371
 cgtgccccacgctgctgctaacgacagtatgatgcttactctgctactcggaaactattt       c.*3300

          .         .         .         .         .         .       g.86431
 ttatgtaattaatgtatgctttcttgtttataaatgcctgatttaaaaagaaaagagctt       c.*3360

          .         .         .         .         .         .       g.86491
 ggcatatttatctatttcgctgtgtacctgttagtccttccccgaccccgaaacagatga       c.*3420

          .         .                                               g.86519
 cattgtacaataaaggactttgagagga                                       c.*3448

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The V-ski sarcoma viral oncogene homolog (avian) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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