solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (SLC12A1) - coding DNA reference sequence

(used for variant description)

(last modified April 12, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_000338.2 in the SLC12A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering SLC12A1 transcript NM_000338.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .    | 02        g.6239
                         tacatttcctcagaagaaggctccttggtg | ctttga    c.-181

 .         .         .         .         .         .                g.6299
 agaacatcctgaagattatatcggagacaatatatcaagaatctatttattgaatcatct       c.-121

 .         .         .         .         .         .                g.6359
 agaacaaaagccaggagctccctaatggaagcacattagtgtttattttgatgaagaaat       c.-61

 .         .         .         .         .         .                g.6419
 atatagattttttaaaacaaccacaaagtagatagctcagtaaaaaatcaattttggaag       c.-1

          .         .         .         .         .         .       g.6479
 ATGTCACTGAACAACTCTTCCAATGTATTTCTGGATTCAGTGCCCAGTAATACCAATCGC       c.60
 M  S  L  N  N  S  S  N  V  F  L  D  S  V  P  S  N  T  N  R         p.20

          .         .         .         .         .         .       g.6539
 TTTCAAGTTAGTGTCATAAATGAGAACCATGAGAGCAGTGCAGCTGCAGATGACAATACT       c.120
 F  Q  V  S  V  I  N  E  N  H  E  S  S  A  A  A  D  D  N  T         p.40

          .         .         .         .         .         .       g.6599
 GACCCACCACATTATGAAGAAACCTCTTTTGGGGATGAAGCTCAGAAAAGACTCAGAATC       c.180
 D  P  P  H  Y  E  E  T  S  F  G  D  E  A  Q  K  R  L  R  I         p.60

          .         .         .         .         .         .       g.6659
 AGCTTTAGGCCTGGGAATCAGGAGTGCTATGACAATTTCCTCCAAAGTGGAGAAACTGCT       c.240
 S  F  R  P  G  N  Q  E  C  Y  D  N  F  L  Q  S  G  E  T  A         p.80

          .         .         .         .         .         .       g.6719
 AAAACAGATGCCAGTTTTCACGCTTATGATTCTCACACAAACACATACTATCTACAAACT       c.300
 K  T  D  A  S  F  H  A  Y  D  S  H  T  N  T  Y  Y  L  Q  T         p.100

          .         .         .         .         .         .       g.6779
 TTTGGCCACAACACCATGGATGCCGTTCCCAAGATAGAGTACTATCGTAACACCGGCAGC       c.360
 F  G  H  N  T  M  D  A  V  P  K  I  E  Y  Y  R  N  T  G  S         p.120

          .         .         .         .         .         .       g.6839
 ATCAGTGGGCCCAAGGTCAACCGACCCAGCCTGCTTGAGATTCACGAGCAACTCGCAAAG       c.420
 I  S  G  P  K  V  N  R  P  S  L  L  E  I  H  E  Q  L  A  K         p.140

  | 03       .         .         .         .         .         .    g.19393
  | AATGTGGCAGTCACCCCAAGTTCAGCTGACAGAGTTGCTAACGGTGATGGGATACCTGGA    c.480
  | N  V  A  V  T  P  S  S  A  D  R  V  A  N  G  D  G  I  P  G      p.160

          .         .         .         .         .         .       g.19453
 GATGAACAAGCTGAAAATAAGGAAGATGATCAAGCTGGTGTTGTGAAGTTTGGATGGGTG       c.540
 D  E  Q  A  E  N  K  E  D  D  Q  A  G  V  V  K  F  G  W  V         p.180

          .   | 04     .         .         .         .         .    g.19668
 AAAGGTGTGCTG | GTAAGATGCATGCTGAACATCTGGGGAGTCATGCTCTTCATTCGCCTC    c.600
 K  G  V  L   | V  R  C  M  L  N  I  W  G  V  M  L  F  I  R  L      p.200

          .         .         | 05         .         .         .    g.25207
 TCCTGGATTGTTGGAGAAGCTGGAATTG | GTCTTGGAGTTCTCATAATTCTTCTTTCCACC    c.660
 S  W  I  V  G  E  A  G  I  G |   L  G  V  L  I  I  L  L  S  T      p.220

          .         .         .         .         .         .       g.25267
 ATGGTAACTTCTATTACTGGGTTGTCAACTTCTGCGATAGCAACTAACGGGTTTGTTCGT       c.720
 M  V  T  S  I  T  G  L  S  T  S  A  I  A  T  N  G  F  V  R         p.240

      | 06   .         .         .         .         .         .    g.27944
 GGAG | GTGGGGCCTACTATCTTATTTCCAGAAGTTTAGGGCCCGAGTTCGGTGGGTCAATA    c.780
 G  G |   G  A  Y  Y  L  I  S  R  S  L  G  P  E  F  G  G  S  I      p.260

          .         .         .         .         .         .       g.28004
 GGCCTGATCTTTGCTTTTGCTAATGCAGTGGCTGTTGCTATGTATGTGGTGGGATTTGCT       c.840
 G  L  I  F  A  F  A  N  A  V  A  V  A  M  Y  V  V  G  F  A         p.280

          .         .     | 07   .         .         .         .    g.29128
 GAGACTGTAGTAGATCTTCTTAAG | GAGAGTGATTCGATGATGGTGGATCCAACCAATGAC    c.900
 E  T  V  V  D  L  L  K   | E  S  D  S  M  M  V  D  P  T  N  D      p.300

          .         .         .         .         .         .       g.29188
 ATCCGGATTATAGGCTCCATCACAGTGGTGATTCTTCTAGGAATTTCAGTAGCTGGAATG       c.960
 I  R  I  I  G  S  I  T  V  V  I  L  L  G  I  S  V  A  G  M         p.320

          .      | 08  .         .         .         .         .    g.31471
 GAATGGGAGGCAAAG | GCCCAAGTCATTCTTCTGGTCATTCTTCTAATTGCTATTGCAAAC    c.1020
 E  W  E  A  K   | A  Q  V  I  L  L  V  I  L  L  I  A  I  A  N      p.340

          .         .         .         .         .         .       g.31531
 TTCTTCATTGGAACTGTCATTCCATCCAACAATGAGAAAAAGTCCAGAGGTTTCTTTAAT       c.1080
 F  F  I  G  T  V  I  P  S  N  N  E  K  K  S  R  G  F  F  N         p.360

         | 09.         .         .         .         .         .    g.33629
 TACCAAG | CATCAATATTTGCAGAAAACTTTGGGCCACGCTTCACAAAGGGTGAAGGCTTC    c.1140
 Y  Q  A |   S  I  F  A  E  N  F  G  P  R  F  T  K  G  E  G  F      p.380

          .         .         .         .         .         .       g.33689
 TTCTCTGTCTTTGCCATTTTTTTCCCAGCAGCTACTGGGATTCTTGCTGGTGCCAATATC       c.1200
 F  S  V  F  A  I  F  F  P  A  A  T  G  I  L  A  G  A  N  I         p.400

          .      | 10  .         .         .         .         .    g.40259
 TCAGGAGATTTGGAG | GATCCCCAAGATGCCATCCCCAGAGGAACCATGCTGGCCATTTTC    c.1260
 S  G  D  L  E   | D  P  Q  D  A  I  P  R  G  T  M  L  A  I  F      p.420

          .         .         .         . | 11       .         .    g.43472
 ATCACCACTGTTGCCTACTTAGGGGTTGCAATTTGTGTAG | GGGCCTGTGTGGTCCGAGAT    c.1320
 I  T  T  V  A  Y  L  G  V  A  I  C  V  G |   A  C  V  V  R  D      p.440

          .         .         .         .         .         .       g.43532
 GCCACCGGGAACATGAATGACACCATCATTTCTGGGATGAACTGCAATGGTTCAGCAGCA       c.1380
 A  T  G  N  M  N  D  T  I  I  S  G  M  N  C  N  G  S  A  A         p.460

          .         .         .         .         .         .       g.43592
 TGTGGGTTGGGCTATGACTTCTCAAGATGTCGACATGAACCATGTCAGTACGGGCTGATG       c.1440
 C  G  L  G  Y  D  F  S  R  C  R  H  E  P  C  Q  Y  G  L  M         p.480

          .   | 12     .         .         .         .         .    g.45656
 AACAATTTCCAG | GTCATGAGCATGGTATCAGGGTTCGGCCCCCTCATCACTGCGGGAATC    c.1500
 N  N  F  Q   | V  M  S  M  V  S  G  F  G  P  L  I  T  A  G  I      p.500

          .         .         .         .         .         .       g.45716
 TTTTCTGCAACACTCTCCTCCGCCCTGGCCTCCCTTGTCAGCGCACCCAAAGTGTTCCAG       c.1560
 F  S  A  T  L  S  S  A  L  A  S  L  V  S  A  P  K  V  F  Q         p.520

  | 13       .         .         .         .         .         .    g.46096
  | GCTCTGTGCAAGGACAACATCTACAAAGCCCTGCAGTTTTTTGCAAAGGGATATGGGAAA    c.1620
  | A  L  C  K  D  N  I  Y  K  A  L  Q  F  F  A  K  G  Y  G  K      p.540

          .         .         .         .         .         .       g.46156
 AACAATGAACCCCTGAGAGGATATATTCTCACTTTTCTTATAGCCATGGCATTTATTCTT       c.1680
 N  N  E  P  L  R  G  Y  I  L  T  F  L  I  A  M  A  F  I  L         p.560

      | 14   .         .         .         .         .         .    g.48330
 ATTG | CGGAACTGAACACCATTGCTCCCATCATCTCCAACTTTTTCCTGGCCTCATATGCA    c.1740
 I  A |   E  L  N  T  I  A  P  I  I  S  N  F  F  L  A  S  Y  A      p.580

          .         .         .         .       | 15 .         .    g.50328
 CTTATTAATTTCTCCTGCTTCCATGCCTCTTATGCCAAATCTCCAG | GATGGAGACCTGCG    c.1800
 L  I  N  F  S  C  F  H  A  S  Y  A  K  S  P  G |   W  R  P  A      p.600

          .         .         .         .         .         .       g.50388
 TATGGAATTTACAACATGTGGGTATCTCTTTTTGGAGCTGTTTTGTGCTGTGCAGTCATG       c.1860
 Y  G  I  Y  N  M  W  V  S  L  F  G  A  V  L  C  C  A  V  M         p.620

          .         .         .         .         .         .       g.50448
 TTTGTCATCAACTGGTGGGCAGCTGTCATCACCTATGTCATTGAATTCTTCCTTTACGTC       c.1920
 F  V  I  N  W  W  A  A  V  I  T  Y  V  I  E  F  F  L  Y  V         p.640

          .         .   | 16     .         .         .         .    g.54548
 TATGTGACTTGTAAGAAGCCAG | ATGTGAACTGGGGCTCCTCCACACAGGCTCTTTCCTAC    c.1980
 Y  V  T  C  K  K  P  D |   V  N  W  G  S  S  T  Q  A  L  S  Y      p.660

          .         .         .         .         .         .       g.54608
 GTGAGTGCTTTAGACAATGCTCTGGAATTAACCACAGTGGAAGACCACGTAAAAAACTTC       c.2040
 V  S  A  L  D  N  A  L  E  L  T  T  V  E  D  H  V  K  N  F         p.680

    | 17     .         .         .         .         .         .    g.57957
 AG | GCCCCAGTGCATTGTCTTAACAGGGGGACCCATGACAAGACCTGCTCTCCTGGACATA    c.2100
 R  |  P  Q  C  I  V  L  T  G  G  P  M  T  R  P  A  L  L  D  I      p.700

          .         .         .         .         .     | 18   .    g.66266
 ACTCACGCCTTTACCAAGAACAGTGGCCTTTGCATCTGCTGTGAAGTCTTTGTG | GGACCG    c.2160
 T  H  A  F  T  K  N  S  G  L  C  I  C  C  E  V  F  V   | G  P      p.720

          .         .         .         .         .         .       g.66326
 CGCAAACTGTGTGTTAAGGAGATGAACAGTGGCATGGCGAAAAAACAGGCCTGGCTTATA       c.2220
 R  K  L  C  V  K  E  M  N  S  G  M  A  K  K  Q  A  W  L  I         p.740

          .         .         .         .         .         .       g.66386
 AAGAACAAAATCAAGGCTTTTTATGCTGCAGTGGCGGCAGACTGTTTCAGGGATGGTGTC       c.2280
 K  N  K  I  K  A  F  Y  A  A  V  A  A  D  C  F  R  D  G  V         p.760

          .      | 19  .         .         .         .         .    g.68402
 CGAAGTCTTCTTCAG | GCCTCAGGCTTAGGAAGAATGAAACCAAACACTCTGGTGATTGGA    c.2340
 R  S  L  L  Q   | A  S  G  L  G  R  M  K  P  N  T  L  V  I  G      p.780

          .         .         .         .         .         .       g.68462
 TATAAGAAAAACTGGAGGAAAGCTCCCTTGACAGAGATTGAGAACTACGTGGGAATCATA       c.2400
 Y  K  K  N  W  R  K  A  P  L  T  E  I  E  N  Y  V  G  I  I         p.800

    | 20     .         .         .         .         .         .    g.73328
 CA | TGATGCATTTGATTTTGAGATTGGCGTGGTTATAGTCAGAATCAGCCAAGGATTTGAC    c.2460
 H  |  D  A  F  D  F  E  I  G  V  V  I  V  R  I  S  Q  G  F  D      p.820

          .         .      | 21  .         .         .         .    g.83840
 ATCTCTCAGGTTCTTCAGGTGCAAG | AGGAATTAGAGAGATTAGAACAGGAGAGACTAGCA    c.2520
 I  S  Q  V  L  Q  V  Q  E |   E  L  E  R  L  E  Q  E  R  L  A      p.840

          .         .         .         .         .         .       g.83900
 TTGGAAGCGACTATCAAAGATAATGAGTGTGAAGAGGAAAGTGGAGGCATCCGAGGCTTG       c.2580
 L  E  A  T  I  K  D  N  E  C  E  E  E  S  G  G  I  R  G  L         p.860

          .         .         .         .          | 22        .    g.86753
 TTTAAAAAAGCTGGCAAGTTGAACATTACTAAGACAACGCCTAAAAAAG | ATGGCAGCATT    c.2640
 F  K  K  A  G  K  L  N  I  T  K  T  T  P  K  K  D |   G  S  I      p.880

          .         .         .         .         .         .       g.86813
 AACACAAGCCAGTCGATGCATGTGGGAGAGTTCAACCAGAAACTGGTGGAAGCCAGCACT       c.2700
 N  T  S  Q  S  M  H  V  G  E  F  N  Q  K  L  V  E  A  S  T         p.900

          .         .         .         .         .         .       g.86873
 CAATTTAAAAAGAAACAAGAAAAAGGCACAATTGATGTTTGGTGGTTGTTTGATGATGGA       c.2760
 Q  F  K  K  K  Q  E  K  G  T  I  D  V  W  W  L  F  D  D  G         p.920

   | 23      .         .         .         .         .         .    g.87163
 G | GGTTAACACTTCTTATCCCCTATATCTTAACTCTCAGAAAAAAATGGAAAGACTGTAAA    c.2820
 G |   L  T  L  L  I  P  Y  I  L  T  L  R  K  K  W  K  D  C  K      p.940

          .         .         .         .         .    | 24    .    g.90484
 TTAAGAATCTATGTGGGAGGGAAGATCAACCGCATTGAAGAAGAAAAAATTGT | AATGGCT    c.2880
 L  R  I  Y  V  G  G  K  I  N  R  I  E  E  E  K  I  V  |  M  A      p.960

          .         .         .         .         .         .       g.90544
 TCCCTTCTGAGCAAATTTAGGATAAAATTTGCAGACATCCATATCATCGGTGACATCAAC       c.2940
 S  L  L  S  K  F  R  I  K  F  A  D  I  H  I  I  G  D  I  N         p.980

          .         . | 25       .         .         .         .    g.97879
 ATTAGGCCAAACAAAGAGAG | CTGGAAAGTCTTTGAAGAGATGATTGAACCATATCGTCTC    c.3000
 I  R  P  N  K  E  S  |  W  K  V  F  E  E  M  I  E  P  Y  R  L      p.1000

          .         .         .         .         .         .       g.97939
 CATGAAAGCTGCAAAGATTTAACAACTGCTGAGAAATTAAAAAGAGAAACTCCGTGGAAA       c.3060
 H  E  S  C  K  D  L  T  T  A  E  K  L  K  R  E  T  P  W  K         p.1020

          .         .         .       | 26 .         .         .    g.100038
 ATTACAGATGCAGAACTGGAAGCAGTCAAGGAAAAG | AGTTACCGCCAAGTTCGACTGAAT    c.3120
 I  T  D  A  E  L  E  A  V  K  E  K   | S  Y  R  Q  V  R  L  N      p.1040

          .         .         .         .     | 27   .         .    g.101465
 GAACTCTTACAGGAGCACTCCAGAGCTGCTAATCTCATTGTCCT | GAGCCTTCCCGTGGCA    c.3180
 E  L  L  Q  E  H  S  R  A  A  N  L  I  V  L  |  S  L  P  V  A      p.1060

          .         .         .         .         .         .       g.101525
 AGAAAGGGATCCATATCGGATTTGTTGTATATGGCTTGGTTGGAAATCCTCACAAAGAAC       c.3240
 R  K  G  S  I  S  D  L  L  Y  M  A  W  L  E  I  L  T  K  N         p.1080

          .         .         .         .         .         .       g.101585
 CTCCCACCTGTCTTACTAGTTAGAGGAAATCACAAAAATGTCTTGACATTTTACTCTTAA       c.3300
 L  P  P  V  L  L  V  R  G  N  H  K  N  V  L  T  F  Y  S  X         p.1099

          .         .         .         .         .         .       g.101645
 aacatgaaagattggaatacattttaacttaatgtaatgcataattaagaaacatgttcc       c.*60

          .         .         .         .         .         .       g.101705
 agtactttatgttgtaaatctgatctatggatatgcaaacctctggagaggatcctacca       c.*120

          .         .         .         .         .         .       g.101765
 gattctacatacattgcataatttttatcagttaatgcgagcttttttttctcttctcag       c.*180

          .         .         .         .         .         .       g.101825
 cttaaggggttgtcaaagccaatgttatccctagaaaaacatttttgtcactgctgttga       c.*240

          .         .         .         .         .         .       g.101885
 taaacaagaaaatcaaggaaactcatgttggcttatgctcatgaaaaccaccaatgtgat       c.*300

          .         .         .         .         .         .       g.101945
 tgtaaacttctccagacaaacttaaccttttgtttcttaattttttgttttgagtgtttg       c.*360

          .         .         .         .         .         .       g.102005
 cttctcagccctggtataggtctcagccccacagcaggatctcaataaatgcttattgac       c.*420

          .         .         .         .         .         .       g.102065
 aggctggcatagtaaccacaggtggttatcaaaggaaaagaccaataggctggggaacat       c.*480

          .         .         .         .         .         .       g.102125
 aattatgcttggccccctcagaggcttatacctccaaagcagatttaaaaatcagtaact       c.*540

          .         .         .         .         .         .       g.102185
 caaaactttaagaagtagttgagtctacaaaatattcaaagcagttacctaaataaggtt       c.*600

          .         .         .         .         .         .       g.102245
 atttaatgtaacagattatatacttaaagtgatctgagcaatcattgataacatatggct       c.*660

          .         .         .         .         .         .       g.102305
 taaatttgctgctgcctgaaaagtatattaactagattagaagacaccatatactccaat       c.*720

          .         .         .         .         .         .       g.102365
 aaaatgaaatatattctattctcaatatataaactttaattgtactccctatcaaatatt       c.*780

          .         .         .         .         .         .       g.102425
 ttgaaatttccatcacggcattactttgcatatttttttctaattaaatggttagtacag       c.*840

          .         .         .         .         .         .       g.102485
 atgaaatctttatagatgactacttgaaaactaagtgctacaaattttcaaaccattatt       c.*900

          .         .         .         .         .         .       g.102545
 aagaaatatatcctgaatcatatatttagttactttctatagtgattgtatggatttaaa       c.*960

          .         .         .         .         .         .       g.102605
 agaataattaaaatgtgaagttgaaaaacttgtaaaatttggaatatacagatactgatt       c.*1020

          .         .         .         .         .         .       g.102665
 tttttcatttttgttagtatacctataatacataatcacattgacaaaccaatgaaaata       c.*1080

          .         .         .         .         .         .       g.102725
 ttgattttctgatgaatggcttgatttttctccttgacatgttttgactgttcattctaa       c.*1140

          .         .         .         .         .                 g.102778
 ctgaaaacatatatgggaaaatatgaacctgaaataaaagcactcaaattcaa              c.*1193

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 12 (sodium/potassium/chloride transporters), member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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