solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000339.2 in the SLC12A3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009386.2, covering SLC12A3 transcript NM_000339.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                ctggcccctccctggacacccaggcgaca       c.-1

          .         .         .         .         .         .       g.5089
 ATGGCAGAACTGCCCACAACAGAGACGCCTGGGGACGCCACTTTGTGCAGCGGGCGCTTC       c.60
 M  A  E  L  P  T  T  E  T  P  G  D  A  T  L  C  S  G  R  F         p.20

          .         .         .         .         .         .       g.5149
 ACCATCAGCACACTGCTGAGCAGTGATGAGCCCTCTCCACCAGCTGCCTATGACAGCAGC       c.120
 T  I  S  T  L  L  S  S  D  E  P  S  P  P  A  A  Y  D  S  S         p.40

          .         .         .         .         .         .       g.5209
 CACCCCAGCCACCTGACCCACAGCAGCACCTTCTGCATGCGCACCTTTGGCTACAACACG       c.180
 H  P  S  H  L  T  H  S  S  T  F  C  M  R  T  F  G  Y  N  T         p.60

          .         .         .         .         .         .       g.5269
 ATCGATGTGGTGCCCACATATGAGCACTATGCCAACAGCACCCAGCCTGGTGAGCCCCGG       c.240
 I  D  V  V  P  T  Y  E  H  Y  A  N  S  T  Q  P  G  E  P  R         p.80

          .         .         .         .   | 02     .         .    g.6881
 AAGGTCCGGCCCACACTGGCTGACCTGCACTCCTTCCTCAAG | CAGGAAGGCAGACACCTG    c.300
 K  V  R  P  T  L  A  D  L  H  S  F  L  K   | Q  E  G  R  H  L      p.100

          .         .         .         .         .         .       g.6941
 CATGCCCTGGCCTTTGACAGCCGGCCCAGCCACGAGATGACTGATGGGCTGGTGGAGGGC       c.360
 H  A  L  A  F  D  S  R  P  S  H  E  M  T  D  G  L  V  E  G         p.120

          .         .         .         .         .         .       g.7001
 GAGGCAGGCACCAGCAGCGAGAAGAACCCCGAGGAGCCAGTGCGCTTCGGCTGGGTCAAG       c.420
 E  A  G  T  S  S  E  K  N  P  E  E  P  V  R  F  G  W  V  K         p.140

           | 03        .         .         .         .         .    g.8141
 GGGGTGATG | ATTCGTTGCATGCTCAACATTTGGGGCGTGATCCTCTACCTGCGGCTGCCC    c.480
 G  V  M   | I  R  C  M  L  N  I  W  G  V  I  L  Y  L  R  L  P      p.160

          .         .      | 04  .         .         .         .    g.9557
 TGGATTACGGCCCAGGCAGGCATCG | TCCTGACCTGGATCATCATCCTGCTGTCGGTCACG    c.540
 W  I  T  A  Q  A  G  I  V |   L  T  W  I  I  I  L  L  S  V  T      p.180

          .         .         .         .         .         .       g.9617
 GTGACCTCCATCACAGGCCTCTCCATCTCAGCCATCTCCACCAATGGCAAGGTCAAGTCA       c.600
 V  T  S  I  T  G  L  S  I  S  A  I  S  T  N  G  K  V  K  S         p.200

   | 05      .         .         .         .         .         .    g.9948
 G | GTGGCACCTACTTCCTCATCTCCCGGAGTCTGGGCCCAGAGCTTGGGGGCTCCATCGGC    c.660
 G |   G  T  Y  F  L  I  S  R  S  L  G  P  E  L  G  G  S  I  G      p.220

          .         .         .         .         .         .       g.10008
 CTCATTTTCGCTTTCGCCAATGCCGTGGGTGTGGCCATGCACACGGTGGGCTTTGCAGAG       c.720
 L  I  F  A  F  A  N  A  V  G  V  A  M  H  T  V  G  F  A  E         p.240

          .         .  | 06      .         .         .         .    g.10458
 ACCGTGCGGGACCTGCTCCAG | GAGTATGGGGCACCCATCGTGGACCCCATTAACGACATC    c.780
 T  V  R  D  L  L  Q   | E  Y  G  A  P  I  V  D  P  I  N  D  I      p.260

          .         .         .         .         .         .       g.10518
 CGCATCATTGCCGTGGTCTCGGTCACTGTGCTGCTGGCCATCTCCCTGGCTGGCATGGAG       c.840
 R  I  I  A  V  V  S  V  T  V  L  L  A  I  S  L  A  G  M  E         p.280

          .   | 07     .         .         .         .         .    g.12192
 TGGGAGTCCAAG | GCCCAGGTGCTGTTCTTCCTTGTCATCATGGTCTCCTTTGCCAACTAT    c.900
 W  E  S  K   | A  Q  V  L  F  F  L  V  I  M  V  S  F  A  N  Y      p.300

          .         .         .         .         .         .       g.12252
 TTAGTGGGGACGCTGATCCCCCCATCTGAGGACAAGGCCTCCAAAGGCTTCTTCAGCTAC       c.960
 L  V  G  T  L  I  P  P  S  E  D  K  A  S  K  G  F  F  S  Y         p.320

      | 08   .         .         .         .         .         .    g.12505
 CGGG | CGGACATTTTTGTCCAGAACTTGGTGCCTGACTGGCGGGGTCCAGATGGCACCTTC    c.1020
 R  A |   D  I  F  V  Q  N  L  V  P  D  W  R  G  P  D  G  T  F      p.340

          .         .         .         .         .         .       g.12565
 TTCGGAATGTTCTCCATCTTCTTCCCCTCGGCCACAGGCATCCTGGCAGGGGCCAACATA       c.1080
 F  G  M  F  S  I  F  F  P  S  A  T  G  I  L  A  G  A  N  I         p.360

          .      | 09  .         .         .         .         .    g.17915
 TCTGGTGACCTCAAG | GACCCTGCTATAGCCATCCCCAAGGGGACCCTCATGGCCATTTTC    c.1140
 S  G  D  L  K   | D  P  A  I  A  I  P  K  G  T  L  M  A  I  F      p.380

          .         .         .         . | 10       .         .    g.18886
 TGGACGACCATTTCCTACCTGGCCATCTCAGCCACCATTG | GCTCCTGCGTGGTGCGTGAT    c.1200
 W  T  T  I  S  Y  L  A  I  S  A  T  I  G |   S  C  V  V  R  D      p.400

          .         .         .         .         .         .       g.18946
 GCCTCTGGGGTCCTGAATGACACAGTGACCCCTGGCTGGGGTGCCTGCGAGGGGCTGGCC       c.1260
 A  S  G  V  L  N  D  T  V  T  P  G  W  G  A  C  E  G  L  A         p.420

          .         .         .         .         .         .       g.19006
 TGCAGCTATGGCTGGAACTTCACCGAGTGCACCCAGCAGCACAGCTGCCACTACGGCCTC       c.1320
 C  S  Y  G  W  N  F  T  E  C  T  Q  Q  H  S  C  H  Y  G  L         p.440

          .      | 11  .         .         .         .         .    g.19380
 ATCAACTATTACCAG | ACCATGAGCATGGTGTCAGGCTTCGCGCCCCTGATCACGGCTGGC    c.1380
 I  N  Y  Y  Q   | T  M  S  M  V  S  G  F  A  P  L  I  T  A  G      p.460

          .         .         .         .         .         .       g.19440
 ATCTTCGGGGCCACCCTCTCCTCTGCCCTGGCCTGCCTTGTCTCTGCTGCCAAAGTCTTC       c.1440
 I  F  G  A  T  L  S  S  A  L  A  C  L  V  S  A  A  K  V  F         p.480

     | 12    .         .         .         .         .         .    g.19980
 CAG | TGCCTTTGCGAGGACCAGCTGTACCCACTGATCGGCTTCTTCGGCAAAGGCTATGGC    c.1500
 Q   | C  L  C  E  D  Q  L  Y  P  L  I  G  F  F  G  K  G  Y  G      p.500

          .         .         .         .         .         .       g.20040
 AAGAACAAGGAGCCCGTGCGTGGCTACCTGCTGGCCTACGCCATCGCTGTGGCCTTCATC       c.1560
 K  N  K  E  P  V  R  G  Y  L  L  A  Y  A  I  A  V  A  F  I         p.520

         | 13.         .         .         .         .         .    g.22242
 ATCATCG | CTGAGCTCAACACCATAGCCCCCATCATTTCCAACTTCTTCCTCTGCTCCTAT    c.1620
 I  I  A |   E  L  N  T  I  A  P  I  I  S  N  F  F  L  C  S  Y      p.540

          .         .         .         .          | 14        .    g.23853
 GCCCTCATCAACTTCAGCTGCTTCCACGCCTCCATCACCAACTCGCCTG | GGTGGAGACCT    c.1680
 A  L  I  N  F  S  C  F  H  A  S  I  T  N  S  P  G |   W  R  P      p.560

          .         .         .         .         .         .       g.23913
 TCATTCCAATACTACAACAAGTGGGCGGCGCTGTTTGGGGCTATCATCTCCGTGGTCATC       c.1740
 S  F  Q  Y  Y  N  K  W  A  A  L  F  G  A  I  I  S  V  V  I         p.580

          .         .         .         .         .         .       g.23973
 ATGTTCCTCCTCACCTGGTGGGCGGCCCTCATCGCCATTGGCGTGGTGCTCTTCCTCCTG       c.1800
 M  F  L  L  T  W  W  A  A  L  I  A  I  G  V  V  L  F  L  L         p.600

          .         .      | 15  .         .         .         .    g.25093
 CTCTATGTCATCTACAAGAAGCCAG | AGGTAAATTGGGGCTCCTCGGTACAGGCTGGCTCC    c.1860
 L  Y  V  I  Y  K  K  P  E |   V  N  W  G  S  S  V  Q  A  G  S      p.620

          .         .         .         .         .         .       g.25153
 TACAACCTGGCCCTCAGCTACTCGGTGGGCCTCAATGAGGTGGAAGACCACATCAAGAAC       c.1920
 Y  N  L  A  L  S  Y  S  V  G  L  N  E  V  E  D  H  I  K  N         p.640

       | 16  .         .         .         .         .         .    g.26212
 TACCG | CCCCCAGTGCCTGGTGCTCACGGGGCCCCCCAACTTCCGCCCGGCCCTGGTGGAC    c.1980
 Y  R  |  P  Q  C  L  V  L  T  G  P  P  N  F  R  P  A  L  V  D      p.660

          .         .         .         .         .        | 17.    g.26749
 TTTGTGGGCACCTTCACCCGGAACCTCAGCCTGATGATCTGTGGCCACGTGCTCATC | GGA    c.2040
 F  V  G  T  F  T  R  N  L  S  L  M  I  C  G  H  V  L  I   | G      p.680

          .         .         .         .         .         .       g.26809
 CCCCACAAGCAGAGGATGCCTGAGCTCCAGCTCATCGCCAACGGGCACACCAAGTGGCTG       c.2100
 P  H  K  Q  R  M  P  E  L  Q  L  I  A  N  G  H  T  K  W  L         p.700

          .         .         .         .         .         .       g.26869
 AACAAGAGGAAGATCAAGGCCTTCTACTCGGATGTCATTGCCGAGGACCTCCGCAGAGGC       c.2160
 N  K  R  K  I  K  A  F  Y  S  D  V  I  A  E  D  L  R  R  G         p.720

          .         | 18         .         .         .         .    g.27760
 GTCCAGATCCTCATGCAG | GCCGCAGGTCTCGGGAGAATGAAGCCCAACATTCTGGTGGTT    c.2220
 V  Q  I  L  M  Q   | A  A  G  L  G  R  M  K  P  N  I  L  V  V      p.740

          .         .         .         .         .         .       g.27820
 GGGTTCAAGAAGAACTGGCAGTCGGCTCACCCGGCCACAGTGGAAGACTACATTGGCATC       c.2280
 G  F  K  K  N  W  Q  S  A  H  P  A  T  V  E  D  Y  I  G  I         p.760

       | 19  .         .         .         .         .         .    g.30122
 CTCCA | TGATGCCTTTGATTTCAACTATGGCGTGTGTGTCATGAGGATGCGGGAGGGACTC    c.2340
 L  H  |  D  A  F  D  F  N  Y  G  V  C  V  M  R  M  R  E  G  L      p.780

          .         .         | 20         .         .         .    g.31908
 AACGTGTCCAAGATGATGCAGGCGCACA | TTAACCCCGTGTTTGACCCAGCGGAGGACGGG    c.2400
 N  V  S  K  M  M  Q  A  H  I |   N  P  V  F  D  P  A  E  D  G      p.800

          .         .         .         .       | 21 .         .    g.32760
 AAGGAAGCCAGCGCCAGAGGTGCCAGGCCATCAGTCTCTGGCGCTT | TGGACCCCAAGGCC    c.2460
 K  E  A  S  A  R  G  A  R  P  S  V  S  G  A  L |   D  P  K  A      p.820

          .         .         .         .         .         .       g.32820
 CTGGTGAAGGAGGAGCAGGCCACCACCATCTTCCAGTCGGAGCAGGGCAAGAAGACCATA       c.2520
 L  V  K  E  E  Q  A  T  T  I  F  Q  S  E  Q  G  K  K  T  I         p.840

          .         .         | 22         .         .         .    g.34356
 GACATCTACTGGCTCTTTGACGATGGAG | GCCTCACCCTCCTCATTCCCTATCTCCTTGGC    c.2580
 D  I  Y  W  L  F  D  D  G  G |   L  T  L  L  I  P  Y  L  L  G      p.860

          .         .         .         .         .         .       g.34416
 CGCAAGAGGAGGTGGAGCAAATGCAAGATCCGTGTGTTCGTAGGCGGCCAGATTAACAGG       c.2640
 R  K  R  R  W  S  K  C  K  I  R  V  F  V  G  G  Q  I  N  R         p.880

          .         . | 23       .         .         .         .    g.39363
 ATGGACCAGGAGAGAAAGGC | GATCATTTCTCTGCTGAGCAAGTTCCGACTGGGATTCCAT    c.2700
 M  D  Q  E  R  K  A  |  I  I  S  L  L  S  K  F  R  L  G  F  H      p.900

          .         .         .         .        | 24.         .    g.42179
 GAAGTCCACATCCTCCCTGACATCAACCAGAACCCTCGGGCTGAGCA | CACCAAGAGGTTT    c.2760
 E  V  H  I  L  P  D  I  N  Q  N  P  R  A  E  H  |  T  K  R  F      p.920

          .         .         .         .         .         .       g.42239
 GAGGACATGATTGCACCCTTCCGTCTGAATGATGGCTTCAAGGATGAGGCCACTGTCAAC       c.2820
 E  D  M  I  A  P  F  R  L  N  D  G  F  K  D  E  A  T  V  N         p.940

          .         .         .         .         .         .       g.42299
 GAGATGCGGCGGGACTGCCCCTGGAAGATCTCAGATGAGGAGATTACGAAGAACAGAGTC       c.2880
 E  M  R  R  D  C  P  W  K  I  S  D  E  E  I  T  K  N  R  V         p.960

     | 25    .         .         .         .         .         .    g.44245
 AAG | TCCCTTCGGCAGGTGAGGCTGAATGAGATTGTGCTGGATTACTCCCGAGACGCTGCT    c.2940
 K   | S  L  R  Q  V  R  L  N  E  I  V  L  D  Y  S  R  D  A  A      p.980

          .  | 26      .         .         .         .         .    g.53106
 CTCATCGTCAT | CACTTTGCCCATAGGGAGGAAGGGGAAGTGCCCCAGCTCGCTGTACATG    c.3000
 L  I  V  I  |  T  L  P  I  G  R  K  G  K  C  P  S  S  L  Y  M      p.1000

          .         .         .         .         .         .       g.53166
 GCCTGGCTGGAGACCCTGTCCCAGGACCTCAGACCTCCAGTCATCCTGATCCGAGGAAAC       c.3060
 A  W  L  E  T  L  S  Q  D  L  R  P  P  V  I  L  I  R  G  N         p.1020

          .         .         .                                     g.53199
 CAGGAAAACGTGCTCACCTTTTACTGCCAGTAA                                  c.3093
 Q  E  N  V  L  T  F  Y  C  Q  X                                    p.1030

          .         .         .         .         .         .       g.53259
 ctccaggctttgacatccctgtccacagctctgagtgtgtgggataagttggaacttgat       c.*60

          .         .         .         .         .         .       g.53319
 tgcctctagtccacagggatgagactcatgttctgttgcactttaagtggcagcatctga       c.*120

          .         .         .         .         .         .       g.53379
 tgatctcaccgaaaaagatggtagatttccaaatctggctggactccacttccatgggac       c.*180

          .         .         .         .         .         .       g.53439
 acattccctgggtcttgtgtttataggctagagaaatagcagatggagctgcaaggaaaa       c.*240

          .         .         .         .         .         .       g.53499
 ctctctaaagcatcctattccttttaaaggatttcttttgattttgatgaccattaatta       c.*300

          .         .         .         .         .         .       g.53559
 agagttcagtctttgatttgtatgcaaattggagtcccaatgctgggcgtgaatcttgac       c.*360

          .         .         .         .         .         .       g.53619
 agtttctacagaccttcctgggtgaaagttcctaaatcatgccctgcttcctccaatagg       c.*420

          .         .         .         .         .         .       g.53679
 agaatgggagcctcacctgtaggacctacaggctctctaaggaatgcaggtctctctctg       c.*480

          .         .         .         .         .         .       g.53739
 agcctccacagccaggcaaatacatatatatatattttttttttagatgaagttttttct       c.*540

          .         .         .         .         .         .       g.53799
 cttgttgcccaggctagggtgtaatggcatgatctcaggtcactgcaacctcctcccggg       c.*600

          .         .         .         .         .         .       g.53859
 ttcaagcatttcttctgtctcagcctcccgaatagctgggattacaggcacctgccatca       c.*660

          .         .         .         .         .         .       g.53919
 cacgagctaatttttgtatttttagtagagatggggtttcaccatgttgaccaggctggt       c.*720

          .         .         .         .         .         .       g.53979
 gttgagctcctgacctcaggtgatccacccacctcggtctcccaaagtgctggggttaca       c.*780

          .         .         .         .         .         .       g.54039
 ggcctgagccactgcgcccggcccaggcaaatttcttgaaccacttctcactcccgtcac       c.*840

          .         .         .         .         .         .       g.54099
 tttcaataaggggtctttgatgtcttcactggttctttggacgagggacttttcgaactt       c.*900

          .         .         .         .         .         .       g.54159
 ttttggttgcaacacacagtaagaaatatacttcacactgagacttgcagcgcacacaca       c.*960

          .         .         .         .         .         .       g.54219
 cggaaacgaccaaaacaaaaatgtcacaaaacaatacttacccttccctgggggacgtcc       c.*1020

          .         .         .         .         .         .       g.54279
 tccagtatgttctgttctgtttatttttcactgttggttgcaatccaataaaatgacttt       c.*1080

          .         .         .         .         .         .       g.54339
 gggatccactcatgggtggggacccacacatttgaaaggcatggccacctttctgttgtg       c.*1140

          .         .         .         .         .         .       g.54399
 ccttgcatttgtccacacacagggagtctggctgagctggggaaaggccacggctgggtg       c.*1200

          .         .         .         .         .         .       g.54459
 tcattgccattttcccagctcatctcaccgggaagaaaagcagattgacagaacacgtga       c.*1260

          .         .         .         .         .         .       g.54519
 ggaggggtattgatggcaggagagtcaaaaaagagttttaaagaaggggcaaggttgaag       c.*1320

          .         .         .         .         .         .       g.54579
 gagtctagtggcaagggtaagatttcaggcatggttaagaacagacgacaaggatgtcag       c.*1380

          .         .         .         .         .         .       g.54639
 gaatgaagatgtggagaggggtgtagagatggcaaggttggcaaggaacagataggcagg       c.*1440

          .         .         .         .         .         .       g.54699
 agcaggtccaagccaagcctagcccaagaccaggtgaaaggagaggggaggaggagccac       c.*1500

          .         .         .         .         .         .       g.54759
 ctgcaagagatggaaagagcaggcggcagagggggctggcagggaggggctgttaagagt       c.*1560

          .         .         .         .         .         .       g.54819
 ggggttggaggtgggagagaagctaggacaagggagatggagaaaggacctatacctggc       c.*1620

          .         .         .         .         .         .       g.54879
 tcacggaaggccttcaggtcactacacgttgaacatccccagtgtttgagcccccaaagc       c.*1680

          .         .         .         .         .         .       g.54939
 tagggtgcaagagcactgccatcgaatgccagtgggtgaggccaagtgagggtatttgca       c.*1740

          .         .         .         .         .         .       g.54999
 gctctagacataaccaagaagcgtaaaggtgagttgtttggtggtacgactgcctgtgcc       c.*1800

          .         .         .         .         .         .       g.55059
 ttcttccgatggcactggggtggctgaaggaacagacatctttgggtttcatcagcctcc       c.*1860

          .         .         .         .         .         .       g.55119
 tccaagactgctgcagtgcctacactttagacttcagaaggagactaaagacttctagaa       c.*1920

          .         .         .         .         .         .       g.55179
 tttagaaggagatctgaagtctcctttctggagttacaacccaaaggatgttagcatttc       c.*1980

          .         .         .         .         .         .       g.55239
 tcaggtcatcccactgcaaagcccagaaggcttggggctcccaggctgctctgaagcccc       c.*2040

          .         .         .         .         .         .       g.55299
 actgtctgaccgcctcagggcttgctacgagggactggggcacggccaagctgactagga       c.*2100

          .         .         .         .         .         .       g.55359
 acagctctcgtgctcctgagggacctggaggatgggcctgcctcccagccattgagctgg       c.*2160

          .         .         .         .         .         .       g.55419
 attctgggataattcttaactcgaaataaggggaagcatccatcagggaatgctggcctt       c.*2220

          .         .         .         .         .         .       g.55479
 tctagagccacgtagaaaacaattttctggttcttcaaacctcaaagagtccttggtcca       c.*2280

          .         .         .         .         .         .       g.55539
 aaaaacagaatgttttggcttcgggtgtcaaaaaaaaaattttcacgatgtcagaaatag       c.*2340

          .         .         .         .         .         .       g.55599
 tatgtttttaacaatagtaatagctttgtaaaaaaataaaaagctttaacagcgaggcca       c.*2400

          .         .         .         .                           g.55644
 taaacaatgaaatgaataaaaacggtggtcattcagtcaacggaa                      c.*2445

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 12 (sodium/chloride transporters), member 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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