solute carrier family 19, member 3 (SLC19A3) - coding DNA reference sequence

(used for variant description)

(last modified March 9, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_025243.3 in the SLC19A3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016359.1, covering SLC19A3 transcript NM_025243.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                caagagcgcctggatccatccgacagccg       c.-61

 .         .         .         .         .         .        | 02    g.20711
 cgggtgcgtggtcgtgcggcaagtgagcgatttggtgaacagacactcccttctgtag | cc    c.-1

          .         .         .         .         .         .       g.20771
 ATGGATTGTTACAGAACTTCACTAAGCAGTTCCTGGATTTACCCCACTGTGATCCTCTGC       c.60
 M  D  C  Y  R  T  S  L  S  S  S  W  I  Y  P  T  V  I  L  C         p.20

          .         .         .         .         .         .       g.20831
 TTATTTGGTTTTTTCTCCATGATGAGACCCTCAGAACCATTCCTTATCCCATATTTATCT       c.120
 L  F  G  F  F  S  M  M  R  P  S  E  P  F  L  I  P  Y  L  S         p.40

          .         .         . | 03       .         .         .    g.23495
 GGACCAGATAAAAACCTGACCAGTGCAGAG | ATAACAAATGAGATCTTCCCCGTTTGGACA    c.180
 G  P  D  K  N  L  T  S  A  E   | I  T  N  E  I  F  P  V  W  T      p.60

          .         .         .         .         .         .       g.23555
 TACTCCTACCTGGTGCTGCTGCTGCCTGTGTTTGTCCTCACCGATTATGTCCGCTACAAG       c.240
 Y  S  Y  L  V  L  L  L  P  V  F  V  L  T  D  Y  V  R  Y  K         p.80

          .         .         .         .         .         .       g.23615
 CCAGTCATCATCTTGCAAGGTATCAGTTTCATCATTACCTGGCTGCTGCTGTTGTTTGGC       c.300
 P  V  I  I  L  Q  G  I  S  F  I  I  T  W  L  L  L  L  F  G         p.100

          .         .         .         .         .         .       g.23675
 CAAGGAGTGAAGACCATGCAGGTTGTAGAGTTCTTCTATGGGATGGTCACCGCCGCCGAG       c.360
 Q  G  V  K  T  M  Q  V  V  E  F  F  Y  G  M  V  T  A  A  E         p.120

          .         .         .         .         .         .       g.23735
 GTGGCCTACTACGCCTACATATACAGCGTGGTCAGCCCCGAGCACTACCAGAGAGTGAGC       c.420
 V  A  Y  Y  A  Y  I  Y  S  V  V  S  P  E  H  Y  Q  R  V  S         p.140

          .         .         .         .         .         .       g.23795
 GGCTACTGCAGGAGCGTCACGCTGGCCGCCTACACAGCAGGGTCGGTGCTGGCTCAACTC       c.480
 G  Y  C  R  S  V  T  L  A  A  Y  T  A  G  S  V  L  A  Q  L         p.160

          .         .         .         .         .         .       g.23855
 TTGGTATCCCTGGCGAACATGTCGTACTTTTACCTCAACGTCATATCCTTGGCCTCTGTC       c.540
 L  V  S  L  A  N  M  S  Y  F  Y  L  N  V  I  S  L  A  S  V         p.180

          .         .         .         .         .         .       g.23915
 TCCGTGGCTTTCCTTTTCTCACTTTTCCTACCAATGCCCAAGAAAAGCATGTTTTTTCAT       c.600
 S  V  A  F  L  F  S  L  F  L  P  M  P  K  K  S  M  F  F  H         p.200

          .         .         .         .         .         .       g.23975
 GCAAAACCCAGCAGAGAAATAAAGAAGTCATCAAGCGTGAATCCAGTATTAGAGGAAACT       c.660
 A  K  P  S  R  E  I  K  K  S  S  S  V  N  P  V  L  E  E  T         p.220

          .         .         .         .         .         .       g.24035
 CACGAAGGTGAAGCACCAGGCTGTGAAGAGCAGAAACCCACATCAGAAATACTCAGCACT       c.720
 H  E  G  E  A  P  G  C  E  E  Q  K  P  T  S  E  I  L  S  T         p.240

          .         .         .         .         .         .       g.24095
 TCAGGGAAGCTGAATAAGGGCCAGCTGAACAGCCTGAAACCAAGCAATGTGACTGTGGAC       c.780
 S  G  K  L  N  K  G  Q  L  N  S  L  K  P  S  N  V  T  V  D         p.260

          .         .         .         .         .         .       g.24155
 GTTTTTGTGCAGTGGTTCCAAGATTTGAAGGAGTGCTACTCCTCAAAACGTCTTTTCTAC       c.840
 V  F  V  Q  W  F  Q  D  L  K  E  C  Y  S  S  K  R  L  F  Y         p.280

          .         .         .         .         .         .       g.24215
 TGGTCTCTATGGTGGGCTTTCGCCACAGCAGGTTTTAACCAGGTTTTGAACTATGTTCAA       c.900
 W  S  L  W  W  A  F  A  T  A  G  F  N  Q  V  L  N  Y  V  Q         p.300

          .         .         .         .         .         .       g.24275
 ATCCTGTGGGATTACAAGGCGCCATCCCAAGATTCTTCCATCTATAATGGGGCCGTAGAA       c.960
 I  L  W  D  Y  K  A  P  S  Q  D  S  S  I  Y  N  G  A  V  E         p.320

          .          | 04        .         .         .         .    g.26989
 GCTATTGCAACCTTTGGAG | GGGCTGTGGCTGCCTTTGCAGTGGGTTATGTGAAAGTCAAC    c.1020
 A  I  A  T  F  G  G |   A  V  A  A  F  A  V  G  Y  V  K  V  N      p.340

          .         .         .         .         .         .       g.27049
 TGGGACCTTCTGGGAGAGCTGGCTCTGGTGGTCTTCTCAGTTGTCAATGCCGGTTCTTTA       c.1080
 W  D  L  L  G  E  L  A  L  V  V  F  S  V  V  N  A  G  S  L         p.360

          .         .         .         .         .         .       g.27109
 TTTCTCATGCATTACACAGCCAATATCTGGGCGTGCTATGCTGGCTATTTGATATTCAAG       c.1140
 F  L  M  H  Y  T  A  N  I  W  A  C  Y  A  G  Y  L  I  F  K         p.380

          .         .         .   | 05     .         .         .    g.34750
 TCCAGCTATATGCTTCTTATAACCATAGCAGT | ATTTCAGATTGCAGTTAATCTGAATGTG    c.1200
 S  S  Y  M  L  L  I  T  I  A  V  |  F  Q  I  A  V  N  L  N  V      p.400

          .         .         .         .         .         .       g.34810
 GAACGCTATGCCTTGGTATTTGGAATCAACACCTTTATTGCCTTGGTGATTCAGACCATC       c.1260
 E  R  Y  A  L  V  F  G  I  N  T  F  I  A  L  V  I  Q  T  I         p.420

          .         .         .         .         .     | 06   .    g.35462
 ATGACTGTGATTGTAGTAGATCAGAGAGGGCTCAACTTGCCAGTCAGCATTCAG | TTTTTA    c.1320
 M  T  V  I  V  V  D  Q  R  G  L  N  L  P  V  S  I  Q   | F  L      p.440

          .         .         .         .         .         .       g.35522
 GTTTATGGGAGCTATTTTGCAGTAATTGCTGGAATTTTCCTAATGAGAAGCATGTATATT       c.1380
 V  Y  G  S  Y  F  A  V  I  A  G  I  F  L  M  R  S  M  Y  I         p.460

          .         .         .         .         .         .       g.35582
 ACCTACTCAACCAAATCCCAGAAGGATGTACAGAGCCCTGCTCCAAGTGAGAATCCAGAT       c.1440
 T  Y  S  T  K  S  Q  K  D  V  Q  S  P  A  P  S  E  N  P  D         p.480

          .         .         .         .         .                 g.35633
 GTGTCTCACCCAGAGGAAGAGAGTAATATCATCATGTCAACAAAACTCTAA                c.1491
 V  S  H  P  E  E  E  S  N  I  I  M  S  T  K  L  X                  p.496

          .         .         .         .         .         .       g.35693
 cctcatcgcaacaaacgcaacagtggctttcaaagttatgcaataataaggaaagatttt       c.*60

          .         .         .         .         .         .       g.35753
 gagatgggtggcatatgttttgccataacttgacatgctttgcaaatctggattccaatg       c.*120

          .         .         .         .         .         .       g.35813
 gacctttcaaaaccacaacaaaacctcagttttagatgagttctctatgtgaccaatttt       c.*180

          .         .         .         .         .         .       g.35873
 actggatgcaattgacaggacccgtcatcataattaaacaacccatattggggaccccct       c.*240

          .         .         .         .         .         .       g.35933
 gtgactagtagcagctggaaaattctggtttttatcacttgtaaagacatgcagatggcg       c.*300

          .         .         .         .         .         .       g.35993
 tggaaccaaaccatgagaaaactccagccatcctggagttgatattcaccatttgtgagg       c.*360

          .         .         .         .         .         .       g.36053
 agaaatactaactggactgaccctattgctaggcttaaatacttatttgatcttaccaaa       c.*420

          .         .         .         .         .         .       g.36113
 gaagtcaacacatgggacctttgtgtcacatgaaccattttctttcctcttctattaagt       c.*480

          .         .         .         .         .         .       g.36173
 gtatttctgtttaagttacagttctctaagagaattacaatgtttgtcccatttctaagg       c.*540

          .         .         .         .         .         .       g.36233
 gcttctcttcaactctaataacagcattattcacgttatgatttgatagtattattattt       c.*600

          .         .         .         .         .         .       g.36293
 aatttttttatgattattttccattttgtgctctgagttttgctgttgaaagtctccctc       c.*660

          .         .         .         .         .         .       g.36353
 aagaatagcttcagatcctcttgtgtatttgcagaatacacaaggtcatttcccagtggc       c.*720

          .         .         .         .         .         .       g.36413
 ctgggagaggcagtgagccttctctccaccaccatagacaggtgttaatgcatctatggg       c.*780

          .         .         .         .         .         .       g.36473
 ccaggtgcagtggctcactcctgtaatccgagcaatttgggaggccaaggtgggagtttt       c.*840

          .         .         .         .         .         .       g.36533
 gcttgaggccagaggttcaagaccagcctgggcaacacagtgacacctgactctactaaa       c.*900

          .         .         .         .         .         .       g.36593
 aaattaaaaaattagctgggcagcgtggtgtgtgcctgtagtctcagctacttgggaggc       c.*960

          .         .         .         .         .         .       g.36653
 catggtgggaggatgggttgagcacaggagtcagaggctacagtgagctatgattgcacc       c.*1020

          .         .         .         .         .         .       g.36713
 attgcactccagcctgggcaacagagtaagactctcatccccctcctcccaaaaaagagc       c.*1080

          .         .         .         .         .         .       g.36773
 acctgtgtggtgtctgtctaaaataggaaaacttaaaggaggtttctagaagtattagaa       c.*1140

          .         .         .         .         .         .       g.36833
 ataagaaaacactgatggggggagtggaataaaacacctgattttgttttgttttggttt       c.*1200

          .         .         .         .         .         .       g.36893
 ttgagacagtctcgctctctcacccaggctggaatgcaatggcgtgatcttggctcactg       c.*1260

          .         .         .         .         .         .       g.36953
 caaacttcacctcctgagttcaagccattctcctacctcagcctcccaagtagctgggac       c.*1320

          .         .         .         .         .         .       g.37013
 tatgggtgcacaccaccacgcctggctaatttttgtatttttagtggagatggggtttca       c.*1380

          .         .         .         .         .         .       g.37073
 caatgttggccaggctggtctcaaactcctgacttcaggtgatctgtctgcctcggcctc       c.*1440

          .         .         .         .         .         .       g.37133
 ccaaagagctgagattacaggcgtgagccaccatgcctggccaaaacacctgatttttaa       c.*1500

          .         .         .         .         .         .       g.37193
 atggtagcaattgtgctaaataaaatgtgtaaaaattttaaagagttgttaacatttttt       c.*1560

          .         .         .         .         .         .       g.37253
 gatgaattctgctgaaaattatctgaacatacctgtttttcgaaacttcaagaaacttca       c.*1620

          .         .         .         .         .         .       g.37313
 ataagggatgcattgagcagtctgacagtgagaataaagaatgctgagtcaagatttata       c.*1680

          .         .         .         .         .         .       g.37373
 ttaaggctggaagctgtggctcacacctgtaatcccagcattttgggaggctgaagtgag       c.*1740

          .         .         .         .         .         .       g.37433
 aggttaatttgagggtaggggtatgagaccatcttggccaatatagcaagaccctgtgtc       c.*1800

          .         .         .         .         .         .       g.37493
 taaaacaaacaaaaaaatttttaattggattttgatatggtttggatctgtgtccccacc       c.*1860

          .         .         .         .         .         .       g.37553
 aaatctcacgttgaagtgtaatccccaatgttagaggtggggccggctgggaggcgactg       c.*1920

          .         .         .         .         .         .       g.37613
 gatcatgggtgtgaagccttcatgaatggtttggcaccgtcccctcagtgctggtctcat       c.*1980

          .         .         .         .         .         .       g.37673
 gacagtgagttatcgtgagatctggtagtttaaaagtgtgtagcacctccccactctctc       c.*2040

          .         .         .         .         .         .       g.37733
 tttctcctgctttggccacgtgaagatgcctgctcccactttgccttctgccatgagtaa       c.*2100

          .         .         .         .         .         .       g.37793
 aaattccccgaggactccctagaagcagatgttgccacgcttcctatatagcctgtgagc       c.*2160

          .         .                                               g.37820
 taattaaaccccttttcttacaaacta                                        c.*2187

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 19, member 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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