solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 (SLC24A1) - coding DNA reference sequence

(used for variant description)

(last modified November 26, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004727.2 in the SLC24A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031968.2, covering SLC24A1 transcript NM_004727.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              cccttcacacccgaccctgccttgaattaggattccataggagagct       c.-241

 .         .         .         .         .         .                g.5107
 gggggcaggagaatggggtgttccctgctgtccagcttcagacccactctttgagatatt       c.-181

 .         .         .         .         .         .    | 02        g.7029
 ggattctgacaagtttccagagctgagaagacagccagatgtcaaggtctgaag | ggttgt    c.-121

 .         .         .         .         .         .                g.7089
 ggataccccctggctgggcttcatggagaaatcttctctgatcaccaacctgaatcccag       c.-61

 .         .         .         .         .         .                g.7149
 agtagcctccatcttaggacagaatgagaggccttctgtaaccagatataactggccagc       c.-1

          .         .         .         .         .         .       g.7209
 ATGGGGAAATTGATCAGGATGGGGCCGCAAGAGAGGTGGTTACTCCGGACAAAGCGGCTT       c.60
 M  G  K  L  I  R  M  G  P  Q  E  R  W  L  L  R  T  K  R  L         p.20

          .         .         .         .         .         .       g.7269
 CATTGGAGTCGCCTCCTCTTCTTACTGGGAATGTTGATCATCGGTTCTACTTATCAGCAC       c.120
 H  W  S  R  L  L  F  L  L  G  M  L  I  I  G  S  T  Y  Q  H         p.40

          .         .         .         .         .         .       g.7329
 CTTAGGAGACCCCGGGGCCTTTCCTCATTGTGGGCAGCAGTCTCTTCTCATCAGCCTATA       c.180
 L  R  R  P  R  G  L  S  S  L  W  A  A  V  S  S  H  Q  P  I         p.60

          .         .         .         .         .         .       g.7389
 AAACTGGCCAGTCGGGACCTCTCCAGTGAAGAGATGATGATGATGAGCAGCAGCCCTTCA       c.240
 K  L  A  S  R  D  L  S  S  E  E  M  M  M  M  S  S  S  P  S         p.80

          .         .         .         .         .         .       g.7449
 AAACCTAGCTCCGAAATGGGGGGTAAGATGCTGGTACCCCAAGCCTCAGTGGGCAGTGAT       c.300
 K  P  S  S  E  M  G  G  K  M  L  V  P  Q  A  S  V  G  S  D         p.100

          .         .         .         .         .         .       g.7509
 GAAGCAACACTGAGCATGACAGTGGAGAATATCCCCAGTATGCCTAAAAGAACAGCCAAG       c.360
 E  A  T  L  S  M  T  V  E  N  I  P  S  M  P  K  R  T  A  K         p.120

          .         .         .         .         .         .       g.7569
 ATGATCCCAACAACAACCAAGAATAATTACAGCCCAACAGCAGCAGGTACAGAAAGAAGG       c.420
 M  I  P  T  T  T  K  N  N  Y  S  P  T  A  A  G  T  E  R  R         p.140

          .         .         .         .         .         .       g.7629
 AAGGAAGACACCCCAACATCCAGTAGAACACTGACTTACTACACCTCAACTTCAAGCAGA       c.480
 K  E  D  T  P  T  S  S  R  T  L  T  Y  Y  T  S  T  S  S  R         p.160

          .         .         .         .         .         .       g.7689
 CAAATAGTAAAAAAGTATACCCCAACACCCAGGGGAGAAATGAAGAGCTACAGCCCAACT       c.540
 Q  I  V  K  K  Y  T  P  T  P  R  G  E  M  K  S  Y  S  P  T         p.180

          .         .         .         .         .         .       g.7749
 CAAGTGAGGGAAAAGGTGAAGTATACTCCTTCCCCACGTGGTAGAAGAGTAGGCACTTAC       c.600
 Q  V  R  E  K  V  K  Y  T  P  S  P  R  G  R  R  V  G  T  Y         p.200

          .         .         .         .         .         .       g.7809
 GTGCCGTCCACATTCATGACAATGGAAACAAGCCATGCGATCACCCCCAGGACAACAGTG       c.660
 V  P  S  T  F  M  T  M  E  T  S  H  A  I  T  P  R  T  T  V         p.220

          .         .         .         .         .         .       g.7869
 AAAGACAGTGACATTACAGCAACCTATAAAATACTCGAAACCAACTCTCTTAAGAGAATA       c.720
 K  D  S  D  I  T  A  T  Y  K  I  L  E  T  N  S  L  K  R  I         p.240

          .         .         .         .         .         .       g.7929
 ATGGAGGAAACCACCCCAACCACTCTCAAGGGAATGTTTGATAGCACCCCAACTTTTCTG       c.780
 M  E  E  T  T  P  T  T  L  K  G  M  F  D  S  T  P  T  F  L         p.260

          .         .         .         .         .         .       g.7989
 ACACATGAGGTAGAAGCAAACGTCTTGACTTCTCCAAGGAGCGTCATGGAAAAAAACAAC       c.840
 T  H  E  V  E  A  N  V  L  T  S  P  R  S  V  M  E  K  N  N         p.280

          .         .         .         .         .         .       g.8049
 CTGTTTCCCCCCAGAAGAGTGGAAAGTAACAGCTCAGCCCATCCCTGGGGGTTAGTGGGA       c.900
 L  F  P  P  R  R  V  E  S  N  S  S  A  H  P  W  G  L  V  G         p.300

          .         .         .         .         .         .       g.8109
 AAGAGCAACCCGAAGACTCCCCAGGGAACAGTCCTGTTGCATACCCCAGCCACCTCTGAG       c.960
 K  S  N  P  K  T  P  Q  G  T  V  L  L  H  T  P  A  T  S  E         p.320

          .         .         .         .         .         .       g.8169
 GGGCAGGTGACAATAAGCACCATGACAGGCAGCAGCCCAGCAGAAACCAAAGCCTTCACT       c.1020
 G  Q  V  T  I  S  T  M  T  G  S  S  P  A  E  T  K  A  F  T         p.340

          .         .         .         .         .         .       g.8229
 GCTGCCTGGAGTCTTAGGAATCCTTCACCCAGGACCAGTGTATCAGCCATCAAAACAGCC       c.1080
 A  A  W  S  L  R  N  P  S  P  R  T  S  V  S  A  I  K  T  A         p.360

          .         .         .         .         .         .       g.8289
 CCAGCCATAGTCTGGAGGCTGGCAAAGAAACCTTCCACAGCACCCAGCACCTCAACAACC       c.1140
 P  A  I  V  W  R  L  A  K  K  P  S  T  A  P  S  T  S  T  T         p.380

          .         .         .         .         .         .       g.8349
 CCTACGGTCAGGGCAAAGCTGACCATGCAGGTCCATCACTGTGTGGTTGTGAAGCCAACC       c.1200
 P  T  V  R  A  K  L  T  M  Q  V  H  H  C  V  V  V  K  P  T         p.400

          .         .         .         .         .         .       g.8409
 CCAGCCATGCTCACCACTCCCTCCCCAAGCCTCACAACAGCCCTGCTCCCAGAGGAGCTC       c.1260
 P  A  M  L  T  T  P  S  P  S  L  T  T  A  L  L  P  E  E  L         p.420

          .         .         .         .         .         .       g.8469
 AGTCCTAGTCCCTCAGTGCTGCCTCCCAGCTTGCCAGACCTCCACCCCAAGGGAGAGTAC       c.1320
 S  P  S  P  S  V  L  P  P  S  L  P  D  L  H  P  K  G  E  Y         p.440

          .         .         .         .         .         .       g.8529
 CCCCCAGATCTGTTCAGTGTGGAGGAGCGGCGGCAGGGCTGGGTGGTCCTGCACGTTTTT       c.1380
 P  P  D  L  F  S  V  E  E  R  R  Q  G  W  V  V  L  H  V  F         p.460

          .         .         .         .         .         .       g.8589
 GGCATGATGTATGTGTTTGTGGCCTTGGCCATTGTTTGCGACGAGTACTTCGTTCCAGCC       c.1440
 G  M  M  Y  V  F  V  A  L  A  I  V  C  D  E  Y  F  V  P  A         p.480

          .         .         .         .         .         .       g.8649
 CTGGGTGTCATCACAGACAAGCTGCAGATCTCCGAGGATGTGGCAGGCGCCACATTCATG       c.1500
 L  G  V  I  T  D  K  L  Q  I  S  E  D  V  A  G  A  T  F  M         p.500

          .         .         .         .         .         .       g.8709
 GCTGCTGGAGGCTCTGCTCCTGAGCTCTTCACCTCCCTCATCGGTGTCTTCATTTCCCAC       c.1560
 A  A  G  G  S  A  P  E  L  F  T  S  L  I  G  V  F  I  S  H         p.520

          .         .         .         .         .         .       g.8769
 AGCAACGTGGGCATTGGTACCATTGTGGGCTCTGCTGTGTTCAACATTCTCTTTGTCATT       c.1620
 S  N  V  G  I  G  T  I  V  G  S  A  V  F  N  I  L  F  V  I         p.540

          .         .         .         .         .         .       g.8829
 GGCACTTGTTCCCTCTTCTCCCGAGAGATCCTCAACCTCACCTGGTGGCCCTTATTCCGT       c.1680
 G  T  C  S  L  F  S  R  E  I  L  N  L  T  W  W  P  L  F  R         p.560

          .         .         .         .         .         .       g.8889
 GATGTCTCCTTCTACATCCTTGACCTGATAATGCTCATCCTCTTCTTCCTGGACAGCCTC       c.1740
 D  V  S  F  Y  I  L  D  L  I  M  L  I  L  F  F  L  D  S  L         p.580

          .         .         .         .         .         .       g.8949
 ATTGCCTGGTGGGAGAGCCTGCTGCTGCTGCTGGCCTATGCCTTCTATGTGTTCACCATG       c.1800
 I  A  W  W  E  S  L  L  L  L  L  A  Y  A  F  Y  V  F  T  M         p.600

          .         .         .         .         .         .       g.9009
 AAGTGGAACAAGCATATCGAGGTCTGGGTGAAGGAGCAGCTCAGCAGGAGGCCAGTGGCC       c.1860
 K  W  N  K  H  I  E  V  W  V  K  E  Q  L  S  R  R  P  V  A         p.620

          .         .         . | 03       .         .         .    g.21226
 AAGGTCATGGCCTTAGAAGACCTCAGCAAG | CCGGGCGATGGGGCCATTGCGGTGGATGAG    c.1920
 K  V  M  A  L  E  D  L  S  K   | P  G  D  G  A  I  A  V  D  E      p.640

          .         .     | 04   .         .         .         .    g.22699
 CTACAGGATAACAAGAAGCTGAAG | CTCCCGTCCTTGCTGACCCGAGGGAGCAGCTCGACC    c.1980
 L  Q  D  N  K  K  L  K   | L  P  S  L  L  T  R  G  S  S  S  T      p.660

          .         .         .         .         .         .       g.22759
 TCTCTGCACAACAGCACCATCCGCAGCACCATCTACCAGCTCATGCTCCACAGCCTGGAC       c.2040
 S  L  H  N  S  T  I  R  S  T  I  Y  Q  L  M  L  H  S  L  D         p.680

          .    | 05    .         .         .         .         .    g.27542
 CCCCTGAGGGAAG | TTCGCCTTGCCAAGGAGAAGGAGGAGGAGAGCTTGAATCAAGGGGCC    c.2100
 P  L  R  E  V |   R  L  A  K  E  K  E  E  E  S  L  N  Q  G  A      p.700

          .         .         .         . | 06       .         .    g.28700
 AGAGCCCAACCCCAGGCCAAAGCAGAAAGCAAACCAGAAG | AGGAGGAGCCAGCCAAGCTC    c.2160
 R  A  Q  P  Q  A  K  A  E  S  K  P  E  E |   E  E  P  A  K  L      p.720

          .         .         .         .         .         .       g.28760
 CCTGCGGTCACGGTCACACCAGCCCCTGTTCCAGACATCAAGGGAGATCAGAAGGAGAAT       c.2220
 P  A  V  T  V  T  P  A  P  V  P  D  I  K  G  D  Q  K  E  N         p.740

          .   | 07     .         .         .         .         .    g.33498
 CCAGGCGGTCAG | GAAGATGTGGCTGAGGCCGAGAGCACAGGTGAAATGCCAGGCGAAGAG    c.2280
 P  G  G  Q   | E  D  V  A  E  A  E  S  T  G  E  M  P  G  E  E      p.760

          .         .         .         .         .         .       g.33558
 GGCGAAACTGCTGGTGAAGGTGAAACTGAAGAGAAAAGTGGAGGTGAAACTCAACCAGAA       c.2340
 G  E  T  A  G  E  G  E  T  E  E  K  S  G  G  E  T  Q  P  E         p.780

          .         .         .         .         .         .       g.33618
 GGTGAAGGTGAAACTGAAACACAAGGAAAAGGAGAAGAATGTGAAGATGAAAATGAAGCA       c.2400
 G  E  G  E  T  E  T  Q  G  K  G  E  E  C  E  D  E  N  E  A         p.800

          .         .         .         .         .         .       g.33678
 GAAGGAAAAGGAGACAATGAAGGTGAAGATGAGGGTGAAATCCACGCAGAAGATGGTGAA       c.2460
 E  G  K  G  D  N  E  G  E  D  E  G  E  I  H  A  E  D  G  E         p.820

          .         .         .         .         .         .       g.33738
 ATGAAAGGTAATGAAGGTGAAACTGAAAGCCAGGAACTCAGTGCTGAAAATCACGGTGAA       c.2520
 M  K  G  N  E  G  E  T  E  S  Q  E  L  S  A  E  N  H  G  E         p.840

          .         .         .         .         .         .       g.33798
 GCCAAAAATGATGAGAAAGGTGTAGAAGATGGAGGGGGAAGTGATGGAGGGGATAGCGAA       c.2580
 A  K  N  D  E  K  G  V  E  D  G  G  G  S  D  G  G  D  S  E         p.860

          .         .         .         .         .         .       g.33858
 GAGGAGGAAGAGGAGGAGGAAGAGCAGGAGGAAGAGGAGGAGGAGGAAGAGCAGGAGGAA       c.2640
 E  E  E  E  E  E  E  E  Q  E  E  E  E  E  E  E  E  Q  E  E         p.880

          .         .         .         .         .         .       g.33918
 GAGGAGGAGGAGGAGGAGGAAGAGGAGGAGAAGGGAAATGAAGAGCCTCTGTCCCTGGAC       c.2700
 E  E  E  E  E  E  E  E  E  E  K  G  N  E  E  P  L  S  L  D         p.900

          .         .         .         .         .         .       g.33978
 TGGCCTGAAACCAGGCAGAAGCAGGCCATTTACCTCTTCCTTCTGCCCATCGTGTTCCCA       c.2760
 W  P  E  T  R  Q  K  Q  A  I  Y  L  F  L  L  P  I  V  F  P         p.920

          .         .         .    | 08    .         .         .    g.34765
 CTGTGGCTGACAGTCCCCGACGTCCGAAGGCAG | GAGTCTAGGAAGTTTTTTGTTTTCACC    c.2820
 L  W  L  T  V  P  D  V  R  R  Q   | E  S  R  K  F  F  V  F  T      p.940

          .         .         .         .         .         .       g.34825
 TTCCTGGGATCTATCATGTGGATAGCCATGTTCTCATACCTCATGGTGTGGTGGGCTCAC       c.2880
 F  L  G  S  I  M  W  I  A  M  F  S  Y  L  M  V  W  W  A  H         p.960

     | 09    .         .         .         .         .         .    g.35767
 CAG | GTTGGTGAAACAATAGGGATTTCTGAAGAGATCATGGGCCTGACAATCCTTGCAGCA    c.2940
 Q   | V  G  E  T  I  G  I  S  E  E  I  M  G  L  T  I  L  A  A      p.980

          .         .         .         .         .         .       g.35827
 GGCACATCAATTCCTGACCTCATCACCAGTGTGATTGTCGCTCGAAAAGGCCTGGGAGAC       c.3000
 G  T  S  I  P  D  L  I  T  S  V  I  V  A  R  K  G  L  G  D         p.1000

          .         .         .         .         . | 10       .    g.36908
 ATGGCTGTGTCAAGCTCTGTGGGCAGTAACATATTTGATATCACTGTGGG | CTTGCCTGTT    c.3060
 M  A  V  S  S  S  V  G  S  N  I  F  D  I  T  V  G  |  L  P  V      p.1020

          .         .         .         .         .         .       g.36968
 CCTTGGTTGCTTTTCTCTCTTATCAATGGATTACAGCCAGTTCCAGTCAGCAGCAATGGC       c.3120
 P  W  L  L  F  S  L  I  N  G  L  Q  P  V  P  V  S  S  N  G         p.1040

          .         .         .         .         .         .       g.37028
 TTGTTTTGTGCAATTGTTTTGCTTTTTCTCATGCTTCTGTTTGTGATCTCTTCAATTGCG       c.3180
 L  F  C  A  I  V  L  L  F  L  M  L  L  F  V  I  S  S  I  A         p.1060

          .         .         .         .         .         .       g.37088
 TCATGTAAATGGAGAATGAACAAGATCCTGGGCTTCACAATGTTCCTCCTTTACTTTGTA       c.3240
 S  C  K  W  R  M  N  K  I  L  G  F  T  M  F  L  L  Y  F  V         p.1080

          .         .         .         .         .         .       g.37148
 TTCCTGATAATCAGTGTGATGTTAGAAGATCGAATCATATCCTGTCCTGTATCTGTCTGA       c.3300
 F  L  I  I  S  V  M  L  E  D  R  I  I  S  C  P  V  S  V  X         p.1099

          .         .         .         .         .         .       g.37208
 atcagtcactcttgctcacaatgggcatggatcagaagaccatgcagaagttactgtatc       c.*60

          .         .         .         .         .         .       g.37268
 tcttgtgaccctaatgaaagaatgtatatgatcctggaaagtgaactgggtgacctagga       c.*120

          .         .         .         .         .         .       g.37328
 cctctgatatgaatgtgatctgagactaaagtttgtccttggaaacacctgcagctcatt       c.*180

          .         .         .         .         .         .       g.37388
 gtggattaagaacctcacccctggaggggtggagtttctacccctgactcatgcagacat       c.*240

          .         .         .         .         .         .       g.37448
 ctattacatggaggcagtagaaggacccctggagccagagggttttctaaatgagataac       c.*300

          .         .         .         .         .         .       g.37508
 tgggggcaaaggttgggataggcgcagcagctataagacaagctcctacgctcactgttc       c.*360

          .         .         .         .         .         .       g.37568
 cctgatcattccaaaggctgctggcccaaaagatgcagatgtggtctacatctcagcctt       c.*420

          .         .         .         .         .         .       g.37628
 cctgacctctgccccaaacacacgctgcaattttgtctcctccttttctgttcaaattgt       c.*480

          .         .         .         .         .         .       g.37688
 gaggttctatcaggtttgtaatcactgtagcttcagttattggtgagtctaaggatccaa       c.*540

          .         .         .         .         .         .       g.37748
 ggctacagaaaaaaaagaaatataacaggaattaatgatcattccacgttttgtagccca       c.*600

          .         .         .         .         .         .       g.37808
 ctgcatctggatatataccagtattttctttttttttttttttgagacagagtttggctc       c.*660

          .         .         .         .         .         .       g.37868
 ttgttgcccaggctggtgtgcaatggcgtgatctcggcacaccacaaccttcacctcccc       c.*720

          .         .         .         .         .         .       g.37928
 ggttcaagcaattctcctgcctcagcctgaagtcgtgatctgcccgcctcggcctcccaa       c.*780

          .         .         .         .         .         .       g.37988
 agtgctgggattacaggcgtcagccaccgcgcctggcctataccagtattttctagttta       c.*840

          .         .         .         .         .         .       g.38048
 aaggaggactacattaactcttattgttgtgtttctgaaaagtgaaatttaaaaagcagc       c.*900

          .         .         .         .         .         .       g.38108
 ctgaaaaataaaaatttataatttgcccttgaattggaaggaatggagattagggaagga       c.*960

          .         .         .         .         .         .       g.38168
 aaactactctagaggccatttaaaagtatgtatttattagaacatgcaaattcatgttgt       c.*1020

          .         .         .         .         .         .       g.38228
 ctccatcagtggtcaccttgagggattagacattctaatggaatgtcctggctccaccct       c.*1080

          .         .         .         .         .         .       g.38288
 ccagcatgttctcacccaacaatgacagttgagtggagtgggaagggaagtcattctaaa       c.*1140

          .         .         .         .         .         .       g.38348
 gagtccaaagtcagtagcgccacatctggtttataaagtaagagatccagtgggacaatg       c.*1200

          .         .         .         .         .         .       g.38408
 ctatttttgtatgccaacctagataggattataaagcaagactgatttcttctgtggttt       c.*1260

          .         .         .         .         .         .       g.38468
 atgaatggatcttaaggtaattacaaaagggaaattccaagaatgcataacacaatgaca       c.*1320

          .         .         .         .         .         .       g.38528
 acatggtgagaaaagtgcagtactacttccaaggtagctagtgtaaaggacacttgagtt       c.*1380

          .         .         .         .         .         .       g.38588
 tttaaaactgtggttaaatgttttatgtggaatttgatgagtttgtatattaaataccac       c.*1440

          .         .         .         .         .         .       g.38648
 tgcttgctgcttttactagaatcaagttaagggacacgttagaaatagaacagcttaata       c.*1500

          .         .         .         .         .         .       g.38708
 tcactggcttcagagcaaaatgagctcgggtgactgcagattatgatggtaaatatggct       c.*1560

          .         .         .         .         .         .       g.38768
 ttaattacaaacatgaggaatgattcactgaagatgaaaagataggacggatgtgatatg       c.*1620

          .         .         .         .         .         .       g.38828
 aaaaaaacccaaacattttggcattgaatgatggctaaggtgttccaagtattccatctt       c.*1680

          .         .         .         .         .         .       g.38888
 ttaagatgaattgcttaattaattgcctcgctaccccaggattctcattctttggaaata       c.*1740

          .         .         .         .         .         .       g.38948
 atttttattaaatttcaataaactgtgaatcccaatggtattttactttacaacatggat       c.*1800

          .         .         .         .         .         .       g.39008
 gggctcatccttatctttaggtcatttggtcagaatcctcccgagaagactgatgaagag       c.*1860

          .         .         .         .         .         .       g.39068
 tatggaatcatgttccaattctatattcttaattatccttattcctgatgctactgcatt       c.*1920

          .         .         .         .         .         .       g.39128
 gctgggtttccatagccaaggcctaagaacaggaggagaaggcaatgcttgtgggaggga       c.*1980

          .         .         .         .         .         .       g.39188
 ggtcccaataccaaaattctgggcactaacctggtgtctgcagcccgttcccgttagcct       c.*2040

          .         .         .         .         .         .       g.39248
 cggggatgtcacctcacccacagcctgggatctgacgttcttcctcagactggagtaagg       c.*2100

          .         .         .         .         .         .       g.39308
 agtgatggaccgtaaaatgctgtgtaatgataaaaggctgaaatatccactgaatgatta       c.*2160

          .         .                                               g.39329
 aaaccaactctaataatctga                                              c.*2181

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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