solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (SLC25A10) - coding DNA reference sequence

(used for variant description)

(last modified February 4, 2023)

This file was created to facilitate the description of sequence variants on transcript NM_012140.4 in the SLC25A10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering SLC25A10 transcript NM_012140.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5011
                                                  aatcgcagggg       c.-181

 .         .         .         .         .         .                g.5071
 gcgtggcctagcggtcccgcccccggggcgcgcgcgcgcattggctgtgcggggtgcggg       c.-121

 .         .         .         .         .         .                g.5131
 cgcgcgggcggcgctttgaaccgggcgcggggcgcggggcgcggggcgctgcggccggta       c.-61

 .         .         .         .         .         .                g.5191
 cacgccggggtagggccggggtcgggttgtggtcgggccgggattgggctctcctgggcc       c.-1

          .         .         .         .         .         .       g.5251
 ATGGCAGCCGAGGCGCGCGTGTCGCGCTGGTACTTCGGGGGGCTGGCCTCCTGCGGGGCC       c.60
 M  A  A  E  A  R  V  S  R  W  Y  F  G  G  L  A  S  C  G  A         p.20

          .         .         .    | 02    .         .         .    g.7744
 GCCTGCTGCACGCACCCGCTGGACCTGCTCAAG | GTGCATCTGCAGACGCAGCAGGAGGTG    c.120
 A  C  C  T  H  P  L  D  L  L  K   | V  H  L  Q  T  Q  Q  E  V      p.40

          .         .         .         .         .         .       g.7804
 AAGCTGCGCATGACGGGCATGGCGCTGCGGGTGGTGCGTACCGACGGCATCCTGGCACTC       c.180
 K  L  R  M  T  G  M  A  L  R  V  V  R  T  D  G  I  L  A  L         p.60

          .         .         .    | 03    .         .         .    g.8269
 TACAGCGGCCTGAGCGCCTCGCTGTGCAGACAG | ATGACCTACTCCCTGACTCGGTTCGCC    c.240
 Y  S  G  L  S  A  S  L  C  R  Q   | M  T  Y  S  L  T  R  F  A      p.80

          .         .         .         .         .         .       g.8329
 ATCTACGAGACTGTGCGGGACCGTGTGGCCAAGGGCAGCCAGGGGCCTCTCCCCTTCCAC       c.300
 I  Y  E  T  V  R  D  R  V  A  K  G  S  Q  G  P  L  P  F  H         p.100

          .         .         | 04         .         .         .    g.8489
 GAGAAGGTGTTGCTGGGCTCCGTCAGCG | GTTTAGCTGGAGGCTTCGTGGGGACGCCCGCA    c.360
 E  K  V  L  L  G  S  V  S  G |   L  A  G  G  F  V  G  T  P  A      p.120

          .        | 05.         .         .         .          | 06 g.9577
 GACTTGGTCAACGTCAG | GATGCAGAACGACGTGAAGCTGCCCCAGGGTCAGCGGCGCAA | C c.420
 D  L  V  N  V  R  |  M  Q  N  D  V  K  L  P  Q  G  Q  R  R  N  |   p.140

          .         .         .         .    | 07    .         .    g.9783
 TACGCCCATGCGCTGGATGGCCTGTACCGCGTAGCTCGTGAAG | AGGGTCTCAGGAGACTG    c.480
 Y  A  H  A  L  D  G  L  Y  R  V  A  R  E  E |   G  L  R  R  L      p.160

          .         .         .         .         .     | 08   .    g.10169
 TTCTCGGGTGCAACCATGGCATCCAGCCGAGGGGCCTTAGTCACTGTGGGCCAG | CTGTCC    c.540
 F  S  G  A  T  M  A  S  S  R  G  A  L  V  T  V  G  Q   | L  S      p.180

          .         .         .         .         .         .       g.10229
 TGCTACGACCAGGCCAAGCAGCTGGTCCTTAGCACCGGGTACCTCTCTGACAACATCTTC       c.600
 C  Y  D  Q  A  K  Q  L  V  L  S  T  G  Y  L  S  D  N  I  F         p.200

          .         .        | 09.         .         .         .    g.10581
 ACTCACTTTGTCGCCAGCTTTATTGCA | GGTGGATGTGCCACGTTCCTGTGCCAGCCCCTG    c.660
 T  H  F  V  A  S  F  I  A   | G  G  C  A  T  F  L  C  Q  P  L      p.220

          .         .         .         .      | 10  .         .    g.12610
 GATGTGCTGAAGACTCGCCTGATGAACTCCAAGGGGGAGTATCAG | GGCGTTTTCCACTGC    c.720
 D  V  L  K  T  R  L  M  N  S  K  G  E  Y  Q   | G  V  F  H  C      p.240

          .         .         .         .   | 11     .         .    g.12758
 GCCGTGGAGACAGCGAAGCTCGGGCCTCTGGCCTTTTACAAG | GGCCTCGTCCCAGCTGGC    c.780
 A  V  E  T  A  K  L  G  P  L  A  F  Y  K   | G  L  V  P  A  G      p.260

          .         .         .         .         .         .       g.12818
 ATCCGCCTCATCCCCCACACCGTGCTCACTTTTGTGTTTCTGGAACAGCTACGCAAAAAC       c.840
 I  R  L  I  P  H  T  V  L  T  F  V  F  L  E  Q  L  R  K  N         p.280

          .         .                                               g.12842
 TTTGGCATCAAAGTGCCATCCTGA                                           c.864
 F  G  I  K  V  P  S  X                                             p.287

          .         .         .         .         .         .       g.12902
 ccagccgtgggaatggctgggctgccaggccagacacgctaggttcttccaaagagtccc       c.*60

          .         .         .         .         .         .       g.12962
 aagcccagcacctgctcctggggccacgacctccctggccgtggccacccgtcctccgca       c.*120

          .         .         .         .         .         .       g.13022
 gcaggcccctgctgtccccccacctgctggctgagctcctcctggcctcgtcccctctca       c.*180

          .         .         .         .         .         .       g.13082
 gctgtagctgcaccacccccgctctggctaccaggctctcccggctgggcactgcgtggc       c.*240

          .         .         .         .         .         .       g.13142
 cttgcccctctcccgctggcagctcctcaggggaacaggggctaccagaggctgatttct       c.*300

          .         .         .         .         .         .       g.13202
 cccctctcctgggccaggggaggggtattatccctgcctcctgcccccgatgcccaaagc       c.*360

          .         .         .         .         .         .       g.13262
 agcatcttccagcactttccatcgaggacttgggtggcagagtgtgggtgcagcctggct       c.*420

          .         .         .         .         .         .       g.13322
 gttgctcacccaagtgctagctctgcacttcgtgtctgctgagagcaaccagaccttcca       c.*480

          .         .         .         .         .         .       g.13382
 tgtcctcgggcagctgcaactccccgcgagaccccgcagctgggtgggatgaacaagcaa       c.*540

          .         .         .         .         .         .       g.13442
 cgcagaccacaagcgagtgcctgggagggagtggcccagggtggttctggagccattgtg       c.*600

          .         .         .         .         .         .       g.13502
 ggtgagggtcgagggccaccgaggtcccgcgcaccgctgcctgccctgcagtggctttaa       c.*660

          .         .         .         .         .         .       g.13562
 cagttagttttgccaaagcctctccactcaccagcaggcggtctctgtcttcagggattg       c.*720

          .         .         .         .         .         .       g.13622
 tgcctgcgtccctcgggcacctgggcccccccgcttggctccctgggggaatggcccagg       c.*780

          .         .         .         .         .         .       g.13682
 cgggccgcggttcctccttagggccttctccccgacaaggagtccgacggggcggatgct       c.*840

          .         .         .         .         .         .       g.13742
 gcatcctctgcctccctggtcgctgggcttcaccccacctgggaagggcagtgtgctctg       c.*900

          .         .         .                                     g.13781
 tgggggctgcaatcaataaatgccgggagctgccacatc                            c.*939

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.