solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 (SLC25A19) - coding DNA reference sequence

(used for variant description)

(last modified January 9, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_021734.4 in the SLC25A19 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008274.1, covering SLC25A19 transcript NM_021734.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5028
                                 agtttcgtccgagctcagtagagttttg       c.-181

 .         .         .         .         .         .                g.5088
 ctgttaagactgcgcgaggagctagagagagcggagagcgctgagccgggccgcacccgc       c.-121

 .        | 02.         .         .         .         .             g.6040
 cgagccgt | gaaaaaagtacatctcctggaagggatgctttttagctgagctctggtggat    c.-61

 .         .         .  | 03      .         .         .             g.7685
 gagaggagctagccttgaaaaa | cttgatactgatggacattgtgtgggccagaggcaggg    c.-1

          .         .         .         .         .         .       g.7745
 ATGGTTGGCTATGACCCCAAACCAGATGGCAGGAATAACACCAAGTTCCAGGTGGCAGTG       c.60
 M  V  G  Y  D  P  K  P  D  G  R  N  N  T  K  F  Q  V  A  V         p.20

          .         .         .         .         .         .       g.7805
 GCTGGGTCTGTGTCTGGACTTGTTACTCGGGCGCTGATCAGTCCCTTCGACGTCATCAAG       c.120
 A  G  S  V  S  G  L  V  T  R  A  L  I  S  P  F  D  V  I  K         p.40

          .   | 04     .         .         .         .         .    g.8038
 ATCCGTTTCCAG | CTTCAGCATGAGCGCCTGTCTCGCAGTGACCCCAGCGCAAAGTACCAT    c.180
 I  R  F  Q   | L  Q  H  E  R  L  S  R  S  D  P  S  A  K  Y  H      p.60

          .         .         .         .         .         .       g.8098
 GGCATCCTCCAGGCCTCTAGGCAGATTCTGCAGGAGGAGGGTCCGACAGCTTTCTGGAAA       c.240
 G  I  L  Q  A  S  R  Q  I  L  Q  E  E  G  P  T  A  F  W  K         p.80

          .         .         .         .         | 05         .    g.10868
 GGACACGTCCCAGCTCAGATTCTCTCCATAGGCTATGGAGCTGTCCAA | TTCTTGTCATTT    c.300
 G  H  V  P  A  Q  I  L  S  I  G  Y  G  A  V  Q   | F  L  S  F      p.100

          .         .         .         .         .         .       g.10928
 GAAATGCTGACGGAGCTGGTCCACAGAGGCAGCGTGTATGACGCCCGGGAATTCTCAGTG       c.360
 E  M  L  T  E  L  V  H  R  G  S  V  Y  D  A  R  E  F  S  V         p.120

          .         .         .         .         .         .       g.10988
 CACTTTGTATGTGGTGGCCTGGCTGCCTGTATGGCCACCCTCACTGTGCACCCCGTGGAT       c.420
 H  F  V  C  G  G  L  A  A  C  M  A  T  L  T  V  H  P  V  D         p.140

          .         .         .          | 06        .         .    g.16135
 GTTCTGCGCACCCGCTTTGCAGCTCAGGGTGAGCCCAAG | GTCTATAATACGCTGCGCCAC    c.480
 V  L  R  T  R  F  A  A  Q  G  E  P  K   | V  Y  N  T  L  R  H      p.160

          .         .         .         .         .         .       g.16195
 GCCGTGGGGACCATGTATAGGAGCGAAGGCCCCCAGGTTTTCTACAAAGGCTTGGCTCCC       c.540
 A  V  G  T  M  Y  R  S  E  G  P  Q  V  F  Y  K  G  L  A  P         p.180

          .         .         .         .         .         .       g.16255
 ACCTTGATCGCCATCTTCCCCTACGCCGGGCTGCAGTTCTCTTGCTACAGCTCCTTGAAG       c.600
 T  L  I  A  I  F  P  Y  A  G  L  Q  F  S  C  Y  S  S  L  K         p.200

          .         .         .         .    | 07    .         .    g.16983
 CACCTGTACAAGTGGGCCATACCAGCCGAAGGAAAGAAAAATG | AGAACCTCCAAAACCTG    c.660
 H  L  Y  K  W  A  I  P  A  E  G  K  K  N  E |   N  L  Q  N  L      p.220

          .         .         .         .         .         .       g.17043
 CTTTGTGGCAGTGGAGCTGGTGTCATCAGCAAGACCCTGACATATCCGCTGGACCTCTTC       c.720
 L  C  G  S  G  A  G  V  I  S  K  T  L  T  Y  P  L  D  L  F         p.240

          .         .         .         .         .     | 08   .    g.20816
 AAGAAGCGGCTACAGGTTGGAGGGTTTGAGCATGCCAGAGCTGCCTTTGGCCAG | GTACGG    c.780
 K  K  R  L  Q  V  G  G  F  E  H  A  R  A  A  F  G  Q   | V  R      p.260

          .         .         .         .         .         .       g.20876
 AGATACAAGGGCCTCATGGACTGTGCCAAGCAGGTGCTGCAAAAGGAAGGCGCCCTGGGC       c.840
 R  Y  K  G  L  M  D  C  A  K  Q  V  L  Q  K  E  G  A  L  G         p.280

          .         .         .         .         .         .       g.20936
 TTCTTCAAGGGCCTGTCCCCCAGCTTGCTGAAGGCTGCCCTCTCCACAGGCTTCATGTTC       c.900
 F  F  K  G  L  S  P  S  L  L  K  A  A  L  S  T  G  F  M  F         p.300

          .         .         .         .         .         .       g.20996
 TTCTCGTATGAATTCTTCTGTAATGTCTTCCACTGCATGAACAGGACAGCCAGCCAGCGC       c.960
 F  S  Y  E  F  F  C  N  V  F  H  C  M  N  R  T  A  S  Q  R         p.320

                                                                    g.20999
 TGA                                                                c.963
 X                                                                  p.320

          .         .         .         .         .         .       g.21059
 gtgcaggaaggaccccaggtcttccctggaggcagcctcctgaaggaaggaagattcagt       c.*60

          .         .         .         .         .         .       g.21119
 ctccactgagaggtgccgtctggcccttccctgcaggccagctgccccaagcggggtagc       c.*120

          .         .         .         .         .         .       g.21179
 agccttgaacccacccagctgggacaccaccagaaggtccagggctctccccatgagaga       c.*180

          .         .         .         .         .         .       g.21239
 atcagagggaatgcaggacgtggtctatggtgagccaacgacacagtgagaaggagcagg       c.*240

          .         .         .         .         .         .       g.21299
 aagttgctgtttctcctctgaccagcccacactccaaaggaaacagacgccatcctacac       c.*300

          .         .         .         .         .         .       g.21359
 ctatcagccctgcctgccaggagaacagaacacactcctggtctggatggggctgctgct       c.*360

          .         .         .         .         .         .       g.21419
 tgagtgcagagggctgcggtaggccctttgcaggagtcaggtccctacacttggcctgtt       c.*420

          .         .         .         .         .                 g.21470
 tttccaacctatttaatagacattaaagctaaacacacattccttatctta                c.*471

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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