solute carrier family 26, member 4 (SLC26A4) - coding DNA reference sequence

(used for variant description)

(last modified September 5, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000441.1 in the SLC26A4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008489.1, covering SLC26A4 transcript NM_000441.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 ctcagccttcccggttcgggaaaggggaagaatgcaggaggggt       c.-181

 .         .         .         .         .         .                g.5104
 aggatttctttcctgataggatcggttgggaaagaccgcagcctgtgtgtgtctttccct       c.-121

 .         .         .         .         .         .                g.5164
 tcgaccaaggtgtctgttgctccgtaaataaaacgtcccactgccttctgagagcgctat       c.-61

 .         .         .         .         .         .       | 02     g.6007
 aaaggcagcggaagggtagtccgcggggcattccgggcggggcgcgagcagagacag | gtc    c.-1

          .         .         .         .         .         .       g.6067
 ATGGCAGCGCCAGGCGGCAGGTCGGAGCCGCCGCAGCTCCCCGAGTACAGCTGCAGCTAC       c.60
 M  A  A  P  G  G  R  S  E  P  P  Q  L  P  E  Y  S  C  S  Y         p.20

          .         .         .         .         .         .       g.6127
 ATGGTGTCGCGGCCGGTCTACAGCGAGCTCGCTTTCCAGCAACAGCACGAGCGGCGCCTG       c.120
 M  V  S  R  P  V  Y  S  E  L  A  F  Q  Q  Q  H  E  R  R  L         p.40

          .         .         .         .     | 03   .         .    g.7677
 CAGGAGCGCAAGACGCTGCGGGAGAGCCTGGCCAAGTGCTGCAG | TTGTTCAAGAAAGAGA    c.180
 Q  E  R  K  T  L  R  E  S  L  A  K  C  C  S  |  C  S  R  K  R      p.60

          .         .         .         .         .         .       g.7737
 GCCTTTGGTGTGCTAAAGACTCTTGTGCCCATCTTGGAGTGGCTCCCCAAATACCGAGTC       c.240
 A  F  G  V  L  K  T  L  V  P  I  L  E  W  L  P  K  Y  R  V         p.80

          .         .         .         .         .         .       g.7797
 AAGGAATGGCTGCTTAGTGACGTCATTTCGGGAGTTAGTACTGGGCTAGTGGCCACGCTG       c.300
 K  E  W  L  L  S  D  V  I  S  G  V  S  T  G  L  V  A  T  L         p.100

      | 04   .         .         .         .         .         .    g.16559
 CAAG | GGATGGCATATGCCCTACTAGCTGCAGTTCCTGTCGGATATGGTCTCTACTCTGCT    c.360
 Q  G |   M  A  Y  A  L  L  A  A  V  P  V  G  Y  G  L  Y  S  A      p.120

          .         .         .         .         .      | 05  .    g.18534
 TTTTTCCCTATCCTGACATACTTTATCTTTGGAACATCAAGACATATCTCAGTTG | GACCT    c.420
 F  F  P  I  L  T  Y  F  I  F  G  T  S  R  H  I  S  V  G |   P      p.140

          .         .         .         .         .         .       g.18594
 TTTCCAGTGGTGAGTTTAATGGTGGGATCTGTTGTTCTGAGCATGGCCCCCGACGAACAC       c.480
 F  P  V  V  S  L  M  V  G  S  V  V  L  S  M  A  P  D  E  H         p.160

          .         .         .         .         .         .       g.18654
 TTTCTCGTATCCAGCAGCAATGGAACTGTATTAAATACTACTATGATAGACACTGCAGCT       c.540
 F  L  V  S  S  S  N  G  T  V  L  N  T  T  M  I  D  T  A  A         p.180

          .         .         .         .         .         .       g.18714
 AGAGATACAGCTAGAGTCCTGATTGCCAGTGCCCTGACTCTGCTGGTTGGAATTATACAG       c.600
 R  D  T  A  R  V  L  I  A  S  A  L  T  L  L  V  G  I  I  Q         p.200

  | 06       .         .         .         .         .         .    g.19370
  | TTGATATTTGGTGGCTTGCAGATTGGATTCATAGTGAGGTACTTGGCAGATCCTTTGGTT    c.660
  | L  I  F  G  G  L  Q  I  G  F  I  V  R  Y  L  A  D  P  L  V      p.220

          .         .         .         .         .         .       g.19430
 GGTGGCTTCACAACAGCTGCTGCCTTCCAAGTGCTGGTCTCACAGCTAAAGATTGTCCTC       c.720
 G  G  F  T  T  A  A  A  F  Q  V  L  V  S  Q  L  K  I  V  L         p.240

          .         .         .         .      | 07  .         .    g.27582
 AATGTTTCAACCAAAAACTACAATGGAGTTCTCTCTATTATCTAT | ACGCTGGTTGAGATT    c.780
 N  V  S  T  K  N  Y  N  G  V  L  S  I  I  Y   | T  L  V  E  I      p.260

          .         .         .         .         .         .       g.27642
 TTTCAAAATATTGGTGATACCAATCTTGCTGATTTCACTGCTGGATTGCTCACCATTGTC       c.840
 F  Q  N  I  G  D  T  N  L  A  D  F  T  A  G  L  L  T  I  V         p.280

          .         .         .         .         .         .       g.27702
 GTCTGTATGGCAGTTAAGGAATTAAATGATCGGTTTAGACACAAAATCCCAGTCCCTATT       c.900
 V  C  M  A  V  K  E  L  N  D  R  F  R  H  K  I  P  V  P  I         p.300

          .         | 08         .         .         .         .    g.27862
 CCTATAGAAGTAATTGTG | ACGATAATTGCTACTGCCATTTCATATGGAGCCAACCTGGAA    c.960
 P  I  E  V  I  V   | T  I  I  A  T  A  I  S  Y  G  A  N  L  E      p.320

          .         .         .         .  | 09      .         .    g.33437
 AAAAATTACAATGCTGGCATTGTTAAATCCATCCCAAGGGG | GTTTTTGCCTCCTGAACTT    c.1020
 K  N  Y  N  A  G  I  V  K  S  I  P  R  G  |  F  L  P  P  E  L      p.340

          .         .         .         .         .         .       g.33497
 CCACCTGTGAGCTTGTTCTCGGAGATGCTGGCTGCATCATTTTCCATCGCTGTGGTGGCT       c.1080
 P  P  V  S  L  F  S  E  M  L  A  A  S  F  S  I  A  V  V  A         p.360

          .         .         .         .         .         .       g.33557
 TATGCTATTGCAGTGTCAGTAGGAAAAGTATATGCCACCAAGTATGATTACACCATCGAT       c.1140
 Y  A  I  A  V  S  V  G  K  V  Y  A  T  K  Y  D  Y  T  I  D         p.380

           | 10        .         .         .         .         .    g.34540
 GGGAACCAG | GAATTCATTGCCTTTGGGATCAGCAACATCTTCTCAGGATTCTTCTCTTGT    c.1200
 G  N  Q   | E  F  I  A  F  G  I  S  N  I  F  S  G  F  F  S  C      p.400

          .         .         .         .         .         .       g.34600
 TTTGTGGCCACCACTGCTCTTTCCCGCACGGCCGTCCAGGAGAGCACTGGAGGAAAGACA       c.1260
 F  V  A  T  T  A  L  S  R  T  A  V  Q  E  S  T  G  G  K  T         p.420

     | 11    .         .         .         .         .         .    g.38825
 CAG | GTTGCTGGCATCATCTCTGCTGCGATTGTGATGATCGCCATTCTTGCCCTGGGGAAG    c.1320
 Q   | V  A  G  I  I  S  A  A  I  V  M  I  A  I  L  A  L  G  K      p.440

          .         .  | 12      .         .         .         .    g.39025
 CTTCTGGAACCCTTGCAGAAG | TCGGTCTTGGCAGCTGTTGTAATTGCCAACCTGAAAGGG    c.1380
 L  L  E  P  L  Q  K   | S  V  L  A  A  V  V  I  A  N  L  K  G      p.460

          .         .         .         .         .        | 13.    g.40301
 ATGTTTATGCAGCTGTGTGACATTCCTCGTCTGTGGAGACAGAATAAGATTGATGCT | GTT    c.1440
 M  F  M  Q  L  C  D  I  P  R  L  W  R  Q  N  K  I  D  A   | V      p.480

          .         .         .         .         .         .       g.40361
 ATCTGGGTGTTTACGTGTATAGTGTCCATCATTCTGGGGCTGGATCTCGGTTTACTAGCT       c.1500
 I  W  V  F  T  C  I  V  S  I  I  L  G  L  D  L  G  L  L  A         p.500

          .         .         .         .     | 14   .         .    g.42423
 GGCCTTATATTTGGACTGTTGACTGTGGTCCTGAGAGTTCAGTT | TCCTTCTTGGAATGGC    c.1560
 G  L  I  F  G  L  L  T  V  V  L  R  V  Q  F  |  P  S  W  N  G      p.520

          .         .         .         .         .     | 15   .    g.44454
 CTTGGAAGCATCCCTAGCACAGATATCTACAAAAGTACCAAGAATTACAAAAAC | ATTGAA    c.1620
 L  G  S  I  P  S  T  D  I  Y  K  S  T  K  N  Y  K  N   | I  E      p.540

          .         .         .         .         .         .       g.44514
 GAACCTCAAGGAGTGAAGATTCTTAGATTTTCCAGTCCTATTTTCTATGGCAATGTCGAT       c.1680
 E  P  Q  G  V  K  I  L  R  F  S  S  P  I  F  Y  G  N  V  D         p.560

          .         .        | 16.         .         .         .    g.45499
 GGTTTTAAAAAATGTATCAAGTCCACA | GTTGGATTTGATGCCATTAGAGTATATAATAAG    c.1740
 G  F  K  K  C  I  K  S  T   | V  G  F  D  A  I  R  V  Y  N  K      p.580

          .         .         .         .         .         .       g.45559
 AGGCTGAAAGCGCTGAGGAAAATACAGAAACTAATAAAAAGTGGACAATTAAGAGCAACA       c.1800
 R  L  K  A  L  R  K  I  Q  K  L  I  K  S  G  Q  L  R  A  T         p.600

     | 17    .         .         .         .         .         .    g.46249
 AAG | AATGGCATCATAAGTGATGCTGTTTCAACAAATAATGCTTTTGAGCCTGATGAGGAT    c.1860
 K   | N  G  I  I  S  D  A  V  S  T  N  N  A  F  E  P  D  E  D      p.620

          .         .         .         .         .         .       g.46309
 ATTGAAGATCTGGAGGAACTTGATATCCCAACCAAGGAAATAGAGATTCAAGTGGATTGG       c.1920
 I  E  D  L  E  E  L  D  I  P  T  K  E  I  E  I  Q  V  D  W         p.640

          .         .         .         .         .         .       g.46369
 AACTCTGAGCTTCCAGTCAAAGTGAACGTTCCCAAAGTGCCAATCCATAGCCTTGTGCTT       c.1980
 N  S  E  L  P  V  K  V  N  V  P  K  V  P  I  H  S  L  V  L         p.660

          .         .         .         .         .     | 18   .    g.48702
 GACTGTGGAGCTATATCTTTCCTGGACGTTGTTGGAGTGAGATCACTGCGGGTG | ATTGTC    c.2040
 D  C  G  A  I  S  F  L  D  V  V  G  V  R  S  L  R  V   | I  V      p.680

          .         .         .         .          | 19        .    g.54430
 AAAGAATTCCAAAGAATTGATGTGAATGTGTATTTTGCATCACTTCAAG | ATTATGTGATA    c.2100
 K  E  F  Q  R  I  D  V  N  V  Y  F  A  S  L  Q  D |   Y  V  I      p.700

          .         .         .         .         .         .       g.54490
 GAAAAGCTGGAGCAATGCGGGTTCTTTGACGACAACATTAGAAAGGACACATTCTTTTTG       c.2160
 E  K  L  E  Q  C  G  F  F  D  D  N  I  R  K  D  T  F  F  L         p.720

          .         .         .         .         .         .       g.54550
 ACGGTCCATGATGCTATACTCTATCTACAGAACCAAGTGAAATCTCAAGAGGGTCAAGGT       c.2220
 T  V  H  D  A  I  L  Y  L  Q  N  Q  V  K  S  Q  E  G  Q  G         p.740

          .      | 20  .         .         .         .         .    g.56949
 TCCATTTTAGAAACG | ATCACTCTCATTCAGGATTGTAAAGATACCCTTGAATTAATAGAA    c.2280
 S  I  L  E  T   | I  T  L  I  Q  D  C  K  D  T  L  E  L  I  E      p.760

          .         .         .          | 21        .         .    g.59809
 ACAGAGCTGACGGAAGAAGAACTTGATGTCCAGGATGAG | GCTATGCGTACACTTGCATCC    c.2340
 T  E  L  T  E  E  E  L  D  V  Q  D  E   | A  M  R  T  L  A  S      p.780

                                                                    g.59812
 TGA                                                                c.2343
 X                                                                  p.780

          .         .         .         .         .         .       g.59872
 aagtgggttcgggaggtctctatgagcaaggaatacaagacaaaacttcctcaatgcatt       c.*60

          .         .         .         .         .         .       g.59932
 gactatttcttcagactcaaaacactcattcttttttctattaagccattgaaagagaag       c.*120

          .         .         .         .         .         .       g.59992
 cactaagactgcttctaggctttatttataaaataaacaccttatccctaacatgggcaa       c.*180

          .         .         .         .         .         .       g.60052
 aatggctagaattattcagacgatttggcagcgtccagggtaagctggtgttataatacg       c.*240

          .         .         .         .         .         .       g.60112
 ctgctgatctacatcacagatttgctaataatgttcacgtgggccctggcatatctctgt       c.*300

          .         .         .         .         .         .       g.60172
 tcagttagagtgagtgctgacccaacagcctctgtggtcaagcgagtcacgaatgattaa       c.*360

          .         .         .         .         .         .       g.60232
 tcataaagaaaaatcagtttttgactgacctggatatccatgagctgcactgatcaccat       c.*420

          .         .         .         .         .         .       g.60292
 gtaaggtcacatttagtaaatgctgaaataaaatgattaatgcatttatcaataaaagcc       c.*480

          .         .         .         .         .         .       g.60352
 tttgaaaatactttggataataaattggagttttaaaaatgcaaatttgcttagtatcta       c.*540

          .         .         .         .         .         .       g.60412
 ataatgaagtgttattacatatagccggaattgaggatctctttgatcctggaaatggtt       c.*600

          .         .         .         .         .         .       g.60472
 tacctaaaagctacagaaccaggccaatatattttgaaatattgatgcagacaaatgaaa       c.*660

          .         .         .         .         .         .       g.60532
 taataaagagattttcatggtttataaaaatcttttttgatatgataataatcatgatca       c.*720

          .         .         .         .         .         .       g.60592
 caactgagatcaaaaaaatatatgacagattattttgtttaaaaatgcagttttaattat       c.*780

          .         .         .         .         .         .       g.60652
 cttagtctatagaaatgatcattgcatggaggcatgtataggtatgatctgtgtaaaatc       c.*840

          .         .         .         .         .         .       g.60712
 tgacataaaaacagtgctattctgagtgaaaatttttttgatgtgcttacataaccatgg       c.*900

          .         .         .         .         .         .       g.60772
 tgattaaaatgagtttatattttttctcaaaaattttagcagtgtgtaaagtaagtaatc       c.*960

          .         .         .         .         .         .       g.60832
 tttaactgaactctgaccacttaaaaaaaaatctaaaaattgaactacctatagtagtct       c.*1020

          .         .         .         .         .         .       g.60892
 gtgtttaaagtgaatttttaaagacaaagcattctaaatgaactcaatataaaaacattc       c.*1080

          .         .         .         .         .         .       g.60952
 atttggaatgtacatactgaaaaatacaggtttttttgaccaaaagtttttatatctttt       c.*1140

          .         .         .         .         .         .       g.61012
 ctttttatttatttttttcctaagtgccaacaattttctagatattatatacaacacagg       c.*1200

          .         .         .         .         .         .       g.61072
 ctttgatcttggggacttttcccatatatttcacactggagtgaatgaagttgtacttca       c.*1260

          .         .         .         .         .         .       g.61132
 tttctagagaaaagttatacccaggtccccaattgagaatgtcttgcttgattgaaaacg       c.*1320

          .         .         .         .         .         .       g.61192
 acatcatcccttggtatactccagggattggtttcaggacccctgcatttaccaaaattt       c.*1380

          .         .         .         .         .         .       g.61252
 gtgcacactcaagtcctgcagtcacccctgcctaaagatagaatggcttctctgtttttc       c.*1440

          .         .         .         .         .         .       g.61312
 ttctgaaatacaaccagaaacaatgtgtctatttctgaaagaataggattaatgatcata       c.*1500

          .         .         .         .         .         .       g.61372
 caaatgggttaatcctgaattctggttgtaaatctggttacagcataactaggattataa       c.*1560

          .         .         .         .         .         .       g.61432
 tgctgcctcattttcacagcactacttgcttatattgacaacaaatcatctcgctaaaga       c.*1620

          .         .         .         .         .         .       g.61492
 gtgaatgtaggccaggcgcggtggctcatgcctgtaatcccagcactttgggaggccgag       c.*1680

          .         .         .         .         .         .       g.61552
 gcgggtggatcacgaggtcaggagatcgagaccatcctggctaacatggtaaaaccccgt       c.*1740

          .         .         .         .         .         .       g.61612
 ctctactaaaaatagaaaaaaagaaattagcctagcgtggtggctggcgggcgcctgtag       c.*1800

          .         .         .         .         .         .       g.61672
 tcccagctatttgggaggctaaggcaggagaatggcgtgaacccgggaggcggagcttgc       c.*1860

          .         .         .         .         .         .       g.61732
 agtgagccgaggtcgtgccactgcactccagcctgggcgacagagcaagactccgtctca       c.*1920

          .         .         .         .         .         .       g.61792
 aaaaaaaaaaaaaaaaaaaaaaaagagtgaatgtaatagtcttgcagaaaatgaatgaat       c.*1980

          .         .         .         .         .         .       g.61852
 acctttgttcaataaaggaaatatgcactgctcacttttttgaaggaaatgccaaagtta       c.*2040

          .         .         .         .         .         .       g.61912
 cgttttacaacaaggctagagtttgtaaattctgggttcatttgtgatgacataagtcag       c.*2100

          .         .         .         .         .         .       g.61972
 caaactgcgggaatactgtctcttctatgtattttgtgaatagtaagcataattttagtt       c.*2160

          .         .         .         .         .         .       g.62032
 ttgtattatcaatgaaaatttcacttgaaattaaagctgccttttgttatatttttaacc       c.*2220

          .         .         .         .         .         .       g.62092
 tataggataagattccagtattgtatatgagttttaacaaattaaaaaatcaaatcatgt       c.*2280

          .         .         .         .         .         .       g.62152
 acatttgaaaatatttgcacacatttaaaaataaatgtaaagttgtcttttaaactactc       c.*2340

          .         .                                               g.62175
 ggatgtgtcctttctgaacaaaa                                            c.*2363

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 26, member 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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