solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 (SLC3A1) - coding DNA reference sequence

(used for variant description)

(last modified September 23, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_000341.3 in the SLC3A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering SLC3A1 transcript NM_000341.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           aagaccaagcattcagca       c.-61

 .         .         .         .         .         .                g.5078
 agccactcttccacctcccttactgcaggaaggcactccgaagacataagtcggtgagac       c.-1

          .         .         .         .         .         .       g.5138
 ATGGCTGAAGATAAAAGCAAGAGAGACTCCATCGAGATGAGTATGAAGGGATGCCAGACA       c.60
 M  A  E  D  K  S  K  R  D  S  I  E  M  S  M  K  G  C  Q  T         p.20

          .         .         .         .         .         .       g.5198
 AACAACGGGTTTGTCCATAATGAAGACATTCTGGAGCAGACCCCGGATCCAGGAAGCTCA       c.120
 N  N  G  F  V  H  N  E  D  I  L  E  Q  T  P  D  P  G  S  S         p.40

          .         .         .         .         .         .       g.5258
 ACAGACAACCTGAAGCACAGCACCAGGGGCATCCTTGGCTCCCAGGAGCCCGACTTCAAG       c.180
 T  D  N  L  K  H  S  T  R  G  I  L  G  S  Q  E  P  D  F  K         p.60

          .         .         .         .         .         .       g.5318
 GGCGTCCAGCCCTATGCGGGGATGCCCAAGGAGGTGCTGTTCCAGTTCTCTGGCCAGGCC       c.240
 G  V  Q  P  Y  A  G  M  P  K  E  V  L  F  Q  F  S  G  Q  A         p.80

          .         .         .         .         .         .       g.5378
 CGCTACCGCATACCTCGGGAGATCCTCTTCTGGCTCACAGTGGCTTCTGTGCTGGTGCTC       c.300
 R  Y  R  I  P  R  E  I  L  F  W  L  T  V  A  S  V  L  V  L         p.100

          .         .         .         .         .         .       g.5438
 ATCGCGGCCACCATAGCCATCATTGCCCTCTCTCCAAAGTGCCTAGACTGGTGGCAGGAG       c.360
 I  A  A  T  I  A  I  I  A  L  S  P  K  C  L  D  W  W  Q  E         p.120

          .         .         .         .         .         .       g.5498
 GGGCCCATGTACCAGATCTACCCAAGGTCTTTCAAGGACAGTAACAAGGATGGGAACGGA       c.420
 G  P  M  Y  Q  I  Y  P  R  S  F  K  D  S  N  K  D  G  N  G         p.140

          . | 02       .         .         .         .         .    g.10308
 GATCTGAAAG | GTATTCAAGATAAACTGGACTACATCACAGCTTTAAATATAAAAACTGTT    c.480
 D  L  K  G |   I  Q  D  K  L  D  Y  I  T  A  L  N  I  K  T  V      p.160

          .         .         .         .         .         .       g.10368
 TGGATTACTTCATTTTATAAATCGTCCCTTAAAGATTTCAGATATGGTGTTGAAGATTTC       c.540
 W  I  T  S  F  Y  K  S  S  L  K  D  F  R  Y  G  V  E  D  F         p.180

          .         .         .         .         .         .       g.10428
 CGGGAAGTTGATCCCATTTTTGGAACGATGGAAGATTTTGAGAATCTGGTTGCAGCCATA       c.600
 R  E  V  D  P  I  F  G  T  M  E  D  F  E  N  L  V  A  A  I         p.200

          . | 03       .         .         .         .         .    g.10979
 CATGATAAAG | GTTTAAAATTAATCATCGATTTCATACCAAACCACACGAGTGATAAACAT    c.660
 H  D  K  G |   L  K  L  I  I  D  F  I  P  N  H  T  S  D  K  H      p.220

          .         .         .         .         .         .       g.11039
 ATTTGGTTTCAATTGAGTCGGACACGGACAGGAAAATATACTGATTATTATATCTGGCAT       c.720
 I  W  F  Q  L  S  R  T  R  T  G  K  Y  T  D  Y  Y  I  W  H         p.240

          .         .         .         .      | 04  .         .    g.15589
 GACTGTACCCATGAAAATGGCAAAACCATTCCACCCAACAACTGG | TTAAGTGTGTATGGA    c.780
 D  C  T  H  E  N  G  K  T  I  P  P  N  N  W   | L  S  V  Y  G      p.260

          .         .         .         .         .         .       g.15649
 AACTCCAGTTGGCACTTTGACGAAGTGCGAAACCAATGTTATTTTCATCAGTTTATGAAA       c.840
 N  S  S  W  H  F  D  E  V  R  N  Q  C  Y  F  H  Q  F  M  K         p.280

          .         .         .         .         .  | 05      .    g.29522
 GAGCAACCTGATTTAAATTTCCGCAATCCTGATGTTCAAGAAGAAATAAAA | GAAATTTTA    c.900
 E  Q  P  D  L  N  F  R  N  P  D  V  Q  E  E  I  K   | E  I  L      p.300

          .         .         .         .         .         .       g.29582
 CGGTTCTGGCTCACAAAGGGTGTTGATGGTTTTAGTTTGGATGCTGTTAAATTCCTCCTA       c.960
 R  F  W  L  T  K  G  V  D  G  F  S  L  D  A  V  K  F  L  L         p.320

          .         .         .         .         .  | 06      .    g.30554
 GAAGCAAAGCACCTGAGAGATGAGATCCAAGTAAATAAGACCCAAATCCCG | GACACGGTC    c.1020
 E  A  K  H  L  R  D  E  I  Q  V  N  K  T  Q  I  P   | D  T  V      p.340

          .         .         .         .         .         .       g.30614
 ACACAATACTCGGAGCTGTACCATGACTTCACCACCACGCAGGTGGGAATGCACGACATT       c.1080
 T  Q  Y  S  E  L  Y  H  D  F  T  T  T  Q  V  G  M  H  D  I         p.360

          .         .         .         .         .       | 07 .    g.33689
 GTCCGCAGCTTCCGGCAGACCATGGACCAATACAGCACGGAGCCCGGCAGATACAG | GTTC    c.1140
 V  R  S  F  R  Q  T  M  D  Q  Y  S  T  E  P  G  R  Y  R  |  F      p.380

          .         .         .         .         .         .       g.33749
 ATGGGGACTGAAGCCTATGCAGAGAGTATTGACAGGACCGTGATGTACTATGGATTGCCA       c.1200
 M  G  T  E  A  Y  A  E  S  I  D  R  T  V  M  Y  Y  G  L  P         p.400

          .         .         .         .         .         .       g.33809
 TTTATCCAAGAAGCTGATTTTCCCTTCAACAATTACCTCAGCATGCTAGACACTGTTTCT       c.1260
 F  I  Q  E  A  D  F  P  F  N  N  Y  L  S  M  L  D  T  V  S         p.420

          .         .         .         .         .         .       g.33869
 GGGAACAGCGTGTATGAGGTTATCACATCCTGGATGGAAAACATGCCAGAAGGAAAATGG       c.1320
 G  N  S  V  Y  E  V  I  T  S  W  M  E  N  M  P  E  G  K  W         p.440

          .   | 08     .         .         .         .         .    g.42176
 CCTAACTGGATG | ATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAG    c.1380
 P  N  W  M   | I  G  G  P  D  S  S  R  L  T  S  R  L  G  N  Q      p.460

          .         .         .         .         .         .       g.42236
 TATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTAT       c.1440
 Y  V  N  V  M  N  M  L  L  F  T  L  P  G  T  P  I  T  Y  Y         p.480

          .         .         .         .         .         .       g.42296
 GGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATT       c.1500
 G  E  E  I  G  M  G  N  I  V  A  A  N  L  N  E  S  Y  D  I         p.500

  | 09       .         .         .         .         .         .    g.43437
  | AATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCT    c.1560
  | N  T  L  R  S  K  S  P  M  Q  W  D  N  S  S  N  A  G  F  S      p.520

          .         .         .         .         .        | 10.    g.49744
 GAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGAT | GTC    c.1620
 E  A  S  N  T  W  L  P  T  N  S  D  Y  H  T  V  N  V  D   | V      p.540

          .         .         .         .         .         .       g.49804
 CAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCC       c.1680
 Q  K  T  Q  P  R  S  A  L  K  L  Y  Q  D  L  S  L  L  H  A         p.560

          .         .         .         .         .         .       g.49864
 AATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTATGTT       c.1740
 N  E  L  L  L  N  R  G  W  F  C  H  L  R  N  D  S  H  Y  V         p.580

          .         .         .         .         .         .       g.49924
 GTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGA       c.1800
 V  Y  T  R  E  L  D  G  I  D  R  I  F  I  V  V  L  N  F  G         p.600

          .         .         .         .         .         .       g.49984
 GAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATA       c.1860
 E  S  T  L  L  N  L  H  N  M  I  S  G  L  P  A  K  M  R  I         p.620

          .         .         .         .         .         .       g.50044
 AGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTG       c.1920
 R  L  S  T  N  S  A  D  K  G  S  K  V  D  T  S  G  I  F  L         p.640

          .         .         .         .         .         .       g.50104
 GACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACA       c.1980
 D  K  G  E  G  L  I  F  E  H  N  T  K  N  L  L  H  R  Q  T         p.660

          .         .         .         .         .         .       g.50164
 GCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATA       c.2040
 A  F  R  D  R  C  F  V  S  N  R  A  C  Y  S  S  V  L  N  I         p.680

          .                                                         g.50182
 CTGTATACCTCGTGTTAG                                                 c.2058
 L  Y  T  S  C  X                                                   p.685

          .         .         .         .         .         .       g.50242
 gcacctttatgaagagatgaagacactggcatttcagtgggattgtaagcatttgtaata       c.*60

          .         .         .         .         .         .       g.50302
 gcttcatgtacagcatgctgcttggtgaacaatcattaattcttcgatatttctgtagct       c.*120

          .         .         .         .         .         .       g.50362
 tgaatgtaactgctttaagaaaggttctcaaatgttttgaaaaaaataaaatgtttaaaa       c.*180

                                                                    g.50367
 gtaaa                                                              c.*185

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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