solute carrier family 5 (sodium iodide symporter), member 5 (SLC5A5) - coding DNA reference sequence

(used for variant description)

(last modified September 14, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000453.2 in the SLC5A5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012930.1, covering SLC5A5 transcript NM_000453.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              gctgtcagcgctgagcacagcgcccagggagagggacagacagccgg       c.-301

 .         .         .         .         .         .                g.5107
 ctgcatgggacagcggaacccagagtgagaggggaggtggcaggacagacagacagcagg       c.-241

 .         .         .         .         .         .                g.5167
 ggcggacgcagagacagacagcggggacagggaggccgacacggacatcgacagcccata       c.-181

 .         .         .         .         .         .                g.5227
 gattcctaacccagggagccccggcccctctcgccgcttcccaccccagacggagcgggg       c.-121

 .         .         .         .         .         .                g.5287
 acaggctgccgagcatcctcccacccgccctccccgtcctgcctcctcggcccctgccag       c.-61

 .         .         .         .         .         .                g.5347
 cttcccccgcttgagcacgcagggcgtccgaggacgcgctgggcctccgcacccgccctc       c.-1

          .         .         .         .         .         .       g.5407
 ATGGAGGCCGTGGAGACCGGGGAACGGCCCACCTTCGGAGCCTGGGACTACGGGGTCTTT       c.60
 M  E  A  V  E  T  G  E  R  P  T  F  G  A  W  D  Y  G  V  F         p.20

          .         .         .         .         .         .       g.5467
 GCCCTCATGCTCCTGGTGTCCACTGGCATCGGGCTGTGGGTCGGGCTGGCTCGGGGCGGG       c.120
 A  L  M  L  L  V  S  T  G  I  G  L  W  V  G  L  A  R  G  G         p.40

          .         .         .         .         .         .       g.5527
 CAGCGCAGCGCTGAGGACTTCTTCACCGGGGGCCGGCGCCTGGCGGCCCTGCCCGTGGGC       c.180
 Q  R  S  A  E  D  F  F  T  G  G  R  R  L  A  A  L  P  V  G         p.60

          .         .         .         .         .         .       g.5587
 CTGTCGCTGTCTGCCAGCTTCATGTCGGCCGTGCAGGTGCTGGGCGTGCCGTCGGAGGCC       c.240
 L  S  L  S  A  S  F  M  S  A  V  Q  V  L  G  V  P  S  E  A         p.80

          .         .         .         .         .         .       g.5647
 TATCGCTATGGCCTCAAGTTCCTCTGGATGTGCCTGGGCCAGCTTCTGAACTCGGTCCTC       c.300
 Y  R  Y  G  L  K  F  L  W  M  C  L  G  Q  L  L  N  S  V  L         p.100

          .         .         .         .         .        | 02.    g.7168
 ACCGCCCTGCTCTTCATGCCCGTCTTCTACCGCCTGGGCCTCACCAGCACCTACGAG | TAC    c.360
 T  A  L  L  F  M  P  V  F  Y  R  L  G  L  T  S  T  Y  E   | Y      p.120

          .         .         .         .         .         .       g.7228
 CTGGAGATGCGCTTCAGCCGCGCAGTGCGGCTCTGCGGGACTTTGCAGTACATTGTAGCC       c.420
 L  E  M  R  F  S  R  A  V  R  L  C  G  T  L  Q  Y  I  V  A         p.140

     | 03    .         .         .         .         .      | 04  . g.7696
 ACG | ATGCTGTACACCGGCATCGTAATCTACGCACCGGCCCTCATCCTGAACCAAG | TGACC c.480
 T   | M  L  Y  T  G  I  V  I  Y  A  P  A  L  I  L  N  Q  V |   T   p.160

          .         .         .         .         .         .       g.7756
 GGGCTGGACATCTGGGCGTCGCTCCTGTCCACCGGAATTATCTGCACCTTCTACACGGCT       c.540
 G  L  D  I  W  A  S  L  L  S  T  G  I  I  C  T  F  Y  T  A         p.180

     | 05    .         .         .         .         .         .    g.9036
 GTG | GGCGGCATGAAGGCTGTGGTCTGGACTGATGTGTTCCAGGTCGTGGTGATGCTAAGT    c.600
 V   | G  G  M  K  A  V  V  W  T  D  V  F  Q  V  V  V  M  L  S      p.200

          .         .         .         .         .         .       g.9096
 GGCTTCTGGGTTGTCCTGGCACGCGGTGTCATGCTTGTGGGCGGGCCCCGCCAGGTGCTC       c.660
 G  F  W  V  V  L  A  R  G  V  M  L  V  G  G  P  R  Q  V  L         p.220

          .         .         .         | 06         .         .    g.10772
 ACGCTGGCCCAGAACCACTCCCGGATCAACCTCATGGA | CTTTAACCCTGACCCGAGGAGC    c.720
 T  L  A  Q  N  H  S  R  I  N  L  M  D  |  F  N  P  D  P  R  S      p.240

          .         .         .         .         .         .       g.10832
 CGCTATACATTCTGGACTTTTGTGGTGGGTGGCACGTTGGTGTGGCTCTCCATGTATGGC       c.780
 R  Y  T  F  W  T  F  V  V  G  G  T  L  V  W  L  S  M  Y  G         p.260

          .         .         .         .         .          | 07    g.10992
 GTGAACCAGGCGCAGGTGCAGCGCTACGTGGCTTGCCGCACAGAGAAGCAGGCCAAGCT | G    c.840
 V  N  Q  A  Q  V  Q  R  Y  V  A  C  R  T  E  K  Q  A  K  L  |      p.280

          .         .         .         .         .         .       g.11052
 GCCCTGCTCATCAACCAGGTCGGCCTGTTCCTGATCGTGTCCAGCGCTGCCTGCTGTGGC       c.900
 A  L  L  I  N  Q  V  G  L  F  L  I  V  S  S  A  A  C  C  G         p.300

          .         .         .         .         .         .       g.11112
 ATCGTCATGTTTGTGTTCTACACTGACTGCGACCCTCTCCTCCTGGGGCGCATCTCTGCC       c.960
 I  V  M  F  V  F  Y  T  D  C  D  P  L  L  L  G  R  I  S  A         p.320

           | 08        .         .         .         .         .    g.13943
 CCAGACCAG | TACATGCCTCTGCTGGTGCTGGACATCTTCGAAGATCTGCCTGGAGTCCCC    c.1020
 P  D  Q   | Y  M  P  L  L  V  L  D  I  F  E  D  L  P  G  V  P      p.340

          .         .         .         | 09         .         .    g.15009
 GGGCTTTTCCTGGCCTGTGCTTACAGTGGCACCCTCAG | CACAGCATCCACCAGCATCAAT    c.1080
 G  L  F  L  A  C  A  Y  S  G  T  L  S  |  T  A  S  T  S  I  N      p.360

          .         .         .         .         .         .       g.15069
 GCTATGGCTGCAGTCACTGTAGAAGACCTCATCAAACCTCGGCTGCGGAGCCTGGCACCC       c.1140
 A  M  A  A  V  T  V  E  D  L  I  K  P  R  L  R  S  L  A  P         p.380

          .         .         .  | 10      .         .         .    g.15205
 AGGAAACTCGTGATTATCTCCAAGGGGCTCT | CACTCATCTACGGATCGGCCTGTCTCACC    c.1200
 R  K  L  V  I  I  S  K  G  L  S |   L  I  Y  G  S  A  C  L  T      p.400

          .         .         .         .   | 11     .         .    g.16726
 GTGGCAGCCCTGTCCTCACTGCTCGGAGGAGGTGTCCTTCAG | GGCTCCTTCACCGTCATG    c.1260
 V  A  A  L  S  S  L  L  G  G  G  V  L  Q   | G  S  F  T  V  M      p.420

          .         .         .         .         .         .       g.16786
 GGAGTCATCAGCGGCCCCCTGCTGGGAGCCTTCATCTTGGGAATGTTCCTGCCGGCCTGC       c.1320
 G  V  I  S  G  P  L  L  G  A  F  I  L  G  M  F  L  P  A  C         p.440

           | 12        .         .         .         .         .    g.16928
 AACACACCG | GGCGTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCC    c.1380
 N  T  P   | G  V  L  A  G  L  G  A  G  L  A  L  S  L  W  V  A      p.460

          .         .         .         .         .         .       g.16988
 TTGGGCGCCACGCTGTACCCACCCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCGGCT       c.1440
 L  G  A  T  L  Y  P  P  S  E  Q  T  M  R  V  L  P  S  S  A         p.480

          .         .         .         .         .         .       g.17048
 GCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCT       c.1500
 A  R  C  V  A  L  S  V  N  A  S  G  L  L  D  P  A  L  L  P         p.500

          .         .       | 13 .         .         .         .    g.21392
 GCTAACGACTCCAGCAGGGCCCCCAG | CTCAGGAATGGACGCCAGCCGACCCGCCTTAGCT    c.1560
 A  N  D  S  S  R  A  P  S  |  S  G  M  D  A  S  R  P  A  L  A      p.520

          .         .         .         .         .         .       g.21452
 GACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGCCCTGGGCACGCTGACCACTGTG       c.1620
 D  S  F  Y  A  I  S  Y  L  Y  Y  G  A  L  G  T  L  T  T  V         p.540

          .         .         .  | 14      .         .         .    g.23942
 CTGTGCGGAGCCCTCATCAGCTGCCTGACAG | GCCCCACCAAGCGCAGCACCCTGGCCCCG    c.1680
 L  C  G  A  L  I  S  C  L  T  G |   P  T  K  R  S  T  L  A  P      p.560

          .         .         .         .         .         .       g.24002
 GGATTGTTGTGGTGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTG       c.1740
 G  L  L  W  W  D  L  A  R  Q  T  A  S  V  A  P  K  E  E  V         p.580

          .         .        | 15.         .         .         .    g.26773
 GCCATCCTGGATGACAACTTGGTCAAG | GGTCCTGAAGAACTCCCCACTGGAAACAAGAAG    c.1800
 A  I  L  D  D  N  L  V  K   | G  P  E  E  L  P  T  G  N  K  K      p.600

          .         .         .         .         .         .       g.26833
 CCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTG       c.1860
 P  P  G  F  L  P  T  N  E  D  R  L  F  F  L  G  Q  K  E  L         p.620

          .         .         .         .         .         .       g.26893
 GAGGGGGCTGGCTCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGACCAGCAGGAG       c.1920
 E  G  A  G  S  W  T  P  C  V  G  H  D  G  G  R  D  Q  Q  E         p.640

          .                                                         g.26905
 ACAAACCTCTGA                                                       c.1932
 T  N  L  X                                                         p.643

          .         .         .         .         .         .       g.26965
 ggacagggccagccgcgggactgacaccctgggatggaacctcaggatgggccaaaccca       c.*60

          .         .         .         .         .         .       g.27025
 gacaacgggcccatggccttgggctctgattggctggattgccttgtatgcaaatgagtt       c.*120

          .         .         .         .         .         .       g.27085
 caggactacaataccctaccctatggggaggccctgcctccgggaggtcattttttaaat       c.*180

          .         .         .         .         .         .       g.27145
 ccagccccttgcttcaaccgtccccagtattagacgctgcagccctgacggctcccccca       c.*240

          .         .         .         .         .         .       g.27205
 aataaggctgggtttttctctctctcttttttttttttttttttttttgagacagggtca       c.*300

          .         .         .         .         .         .       g.27265
 tgctctgtcacccaggctggagtgcagtggtgtgatctcggctcactgcaacctctgcct       c.*360

          .         .         .         .         .         .       g.27325
 cccaggctcaagtgattctcctgcctcagcctcttgagtagctgggattgtaggtgccca       c.*420

          .         .         .         .         .         .       g.27385
 ccaccatgcccagccaactttttgtatttttagtagagacagggtttcaccatgttggtc       c.*480

          .         .         .         .         .         .       g.27445
 aggctggtctcgaactcctgacctcaagtgatccacctgcctcggcctcccaaagtgctg       c.*540

          .         .         .         .         .         .       g.27505
 ggttacaggcgtaagctaccatgcccagcctaccgtttttctcaatctataatagaaagc       c.*600

          .         .         .         .         .         .       g.27565
 caccacgcccaggtaatttttgtaattttgtatttttgtagagacggggttttgccatgt       c.*660

          .         .         .         .         .         .       g.27625
 tggccaggctggtctcaaactcctgatctcaggtgatcctcctgccttggcctcccaaag       c.*720

          .         .         .         .         .         .       g.27685
 ggctgggattacaggggtgagccaccgcgccccacctctttcttattttcttcctgggat       c.*780

          .         .         .         .         .         .       g.27745
 tggggaggggatgattcagaccccacatggcctccaaccttggcccacacacctgccatg       c.*840

          .         .         .         .         .         .       g.27805
 gctcccatcatcctgagcatgctagcgtcccctcctcacctgacaatggaggctctcgaa       c.*900

          .         .         .         .         .         .       g.27865
 ttgggttgtgtccccccaaaatttatgtctacccagaacctcagaacatgagcttacttg       c.*960

          .         .         .         .         .         .       g.27925
 gaaatagggtctttgcaggtgtaactggttaaattaaaagaggtattactggaggaggat       c.*1020

          .         .         .         .         .         .       g.27985
 ggatgaatccagtgactggttcctcatatgaagtagagaagagatgcagagaaacacatg       c.*1080

          .         .         .         .         .         .       g.28045
 gggaagatgccacgtgaagacagaggcagtggttggatcaatgcatctacgagtcggaga       c.*1140

          .         .         .         .         .         .       g.28105
 acccaaggattgccagcaacaaccagaaatcaggaggggggcatgagatgcattatttct       c.*1200

          .         .         .         .         .         .       g.28165
 tagagcctttagagggaacatggccctactgacaccttgatgtcagacttctggctgcta       c.*1260

          .         .         .                                     g.28202
 gaactgtcagagaataaatttctgttgtttgatgcca                              c.*1297

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 5 (sodium iodide symporter), member 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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