solute carrier family 6 (neurotransmitter transporter, GABA), member 1 (SLC6A1) - coding DNA reference sequence

(used for variant description)

(last modified October 21, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_003042.3 in the SLC6A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_053003.1, covering SLC6A1 transcript NM_003042.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          gcgaccctccgcccgccctcggaagaccgagacagcggagaggttgcgggt       c.-361

 .         .         .         .         .         .                g.5111
 gagctgcgctgagcccaggagccgaggagtcgggagcgcagtagcgctgagcccgagccc       c.-301

 .         .         .         .         .         .                g.5171
 gagcggccccgcgtcccgagcgcatcggagcggccgagccgcccggatgcagcgcctgtc       c.-241

 .         .         .     | 02   .         .         .             g.27973
 ccgggcagcgcagccccggccgcag | gatctcacccagggtggcagaaggaggccttctgg    c.-181

 .         .         .       | 03 .         .         .             g.29358
 agctgacccacccccgacgaccatcag | ggtgaggcaactccaaggtcctactctctttct    c.-121

 .         .         .         .         .         .                g.29418
 gtgcctgttacccaccccgtcctcctagggtgcccttgagccgcaaaactgctgtccacg       c.-61

 .         .         .         .         .         .                g.29478
 tggaccgggggtgacatcgcacgtccatctgccaggacccctgcgtccaaattccgagac       c.-1

          .         .         .         .         .         .       g.29538
 ATGGCGACCAACGGCAGCAAGGTGGCCGACGGGCAGATCTCCACCGAGGTCAGCGAGGCC       c.60
 M  A  T  N  G  S  K  V  A  D  G  Q  I  S  T  E  V  S  E  A         p.20

          .         .         .         .         .         .       g.29598
 CCTGTGGCCAATGACAAGCCCAAAACCTTGGTGGTCAAGGTGCAGAAGAAGGCGGCAGAC       c.120
 P  V  A  N  D  K  P  K  T  L  V  V  K  V  Q  K  K  A  A  D         p.40

          .         .         .         .         .         .       g.29658
 CTCCCCGACCGGGACACGTGGAAGGGCCGCTTCGACTTCCTCATGTCCTGTGTGGGCTAT       c.180
 L  P  D  R  D  T  W  K  G  R  F  D  F  L  M  S  C  V  G  Y         p.60

          .         .         .         .         .         | 04    g.30111
 GCCATCGGCCTGGGCAACGTCTGGAGGTTCCCCTATCTCTGCGGGAAAAATGGTGGGG | GA    c.240
 A  I  G  L  G  N  V  W  R  F  P  Y  L  C  G  K  N  G  G  G |       p.80

          .         .         .         .         .         .       g.30171
 GCCTTCCTGATCCCCTATTTCCTGACACTCATCTTTGCGGGGGTCCCACTCTTCCTGCTG       c.300
 A  F  L  I  P  Y  F  L  T  L  I  F  A  G  V  P  L  F  L  L         p.100

          .         .         .         .         .         .       g.30231
 GAGTGCTCCCTGGGCCAGTACACCTCCATCGGGGGGCTAGGGGTATGGAAGCTGGCTCCT       c.360
 E  C  S  L  G  Q  Y  T  S  I  G  G  L  G  V  W  K  L  A  P         p.120

          . | 05       .         .         .         .         .    g.30914
 ATGTTCAAGG | GCGTGGGCCTTGCGGCTGCTGTGCTATCATTCTGGCTGAACATCTACTAC    c.420
 M  F  K  G |   V  G  L  A  A  A  V  L  S  F  W  L  N  I  Y  Y      p.140

          .         .         .         .         .  | 06      .    g.32488
 ATCGTCATCATCTCCTGGGCCATTTACTACCTGTACAACTCCTTCACCACG | ACACTGCCG    c.480
 I  V  I  I  S  W  A  I  Y  Y  L  Y  N  S  F  T  T   | T  L  P      p.160

          .         .         .         .         .         .       g.32548
 TGGAAACAGTGCGACAACCCCTGGAACACAGACCGCTGCTTCTCCAACTACAGCATGGTC       c.540
 W  K  Q  C  D  N  P  W  N  T  D  R  C  F  S  N  Y  S  M  V         p.180

          .         .         .         .  | 07      .         .    g.34621
 AACACTACCAACATGACCAGCGCTGTGGTGGAGTTCTGGGA | GCGCAACATGCATCAGATG    c.600
 N  T  T  N  M  T  S  A  V  V  E  F  W  E  |  R  N  M  H  Q  M      p.200

          .         .         .         .         .         .       g.34681
 ACGGACGGGCTGGATAAGCCAGGTCAGATCCGCTGGCCACTGGCCATCACGCTGGCCATC       c.660
 T  D  G  L  D  K  P  G  Q  I  R  W  P  L  A  I  T  L  A  I         p.220

          .         .         .         .         .     | 08   .    g.37721
 GCCTGGATCCTTGTGTATTTCTGTATCTGGAAGGGTGTTGGCTGGACTGGAAAG | GTGGTC    c.720
 A  W  I  L  V  Y  F  C  I  W  K  G  V  G  W  T  G  K   | V  V      p.240

          .         .         .         .         .         .       g.37781
 TACTTTTCAGCCACATACCCCTACATCATGCTGATCATCCTGTTCTTCCGTGGAGTGACG       c.780
 Y  F  S  A  T  Y  P  Y  I  M  L  I  I  L  F  F  R  G  V  T         p.260

          .         .         .         .         .         .       g.37841
 CTGCCCGGGGCCAAGGAGGGCATCCTCTTCTACATCACACCCAACTTCCGCAAGCTGTCT       c.840
 L  P  G  A  K  E  G  I  L  F  Y  I  T  P  N  F  R  K  L  S         p.280

           | 09        .         .         .         .         .    g.38090
 GACTCCGAG | GTGTGGCTGGATGCGGCAACCCAGATCTTCTTCTCATACGGGCTGGGCCTG    c.900
 D  S  E   | V  W  L  D  A  A  T  Q  I  F  F  S  Y  G  L  G  L      p.300

          .         .         .         .         .    | 10    .    g.38508
 GGGTCCCTGATCGCTCTCGGGAGCTACAACTCTTTCCACAACAATGTCTACAG | GGACTCC    c.960
 G  S  L  I  A  L  G  S  Y  N  S  F  H  N  N  V  Y  R  |  D  S      p.320

          .         .         .         .         .         .       g.38568
 ATCATCGTCTGCTGCATCAATTCGTGCACCAGCATGTTCGCAGGATTCGTCATCTTCTCC       c.1020
 I  I  V  C  C  I  N  S  C  T  S  M  F  A  G  F  V  I  F  S         p.340

          .         .         .         .         .         | 11    g.41003
 ATCGTGGGCTTCATGGCCCATGTCACCAAGAGGTCCATTGCTGATGTGGCGGCCTCAG | GC    c.1080
 I  V  G  F  M  A  H  V  T  K  R  S  I  A  D  V  A  A  S  G |       p.360

          .         .         .         .         .         .       g.41063
 CCCGGGCTGGCGTTCCTGGCATACCCAGAGGCGGTGACCCAGCTGCCTATCTCCCCACTC       c.1140
 P  G  L  A  F  L  A  Y  P  E  A  V  T  Q  L  P  I  S  P  L         p.380

          .         .         .         .         .  | 12      .    g.41496
 TGGGCCATCCTCTTCTTCTCCATGCTGTTGATGCTGGGCATTGACAGCCAG | TTCTGCACT    c.1200
 W  A  I  L  F  F  S  M  L  L  M  L  G  I  D  S  Q   | F  C  T      p.400

          .         .         .         .         .         .       g.41556
 GTGGAGGGCTTCATCACAGCCCTGGTGGATGAGTACCCCAGGCTCCTCCGCAACCGCAGA       c.1260
 V  E  G  F  I  T  A  L  V  D  E  Y  P  R  L  L  R  N  R  R         p.420

          .         .         .         .         .         .       g.41616
 GAGCTCTTCATTGCTGCTGTCTGCATCATCTCCTACCTGATCGGTCTCTCTAACATCACT       c.1320
 E  L  F  I  A  A  V  C  I  I  S  Y  L  I  G  L  S  N  I  T         p.440

     | 13    .         .         .         .         .         .    g.43500
 CAG | GGGGGTATTTATGTCTTCAAACTCTTTGACTACTACTCTGCCAGTGGCATGAGCCTG    c.1380
 Q   | G  G  I  Y  V  F  K  L  F  D  Y  Y  S  A  S  G  M  S  L      p.460

          .         .         .         .       | 14 .         .    g.45919
 CTGTTCCTCGTGTTCTTTGAATGTGTCTCTATTTCCTGGTTTTACG | GTGTCAACCGATTC    c.1440
 L  F  L  V  F  F  E  C  V  S  I  S  W  F  Y  G |   V  N  R  F      p.480

          .         .         .         .         .         .       g.45979
 TATGACAATATCCAAGAGATGGTTGGATCCAGGCCCTGCATCTGGTGGAAACTCTGCTGG       c.1500
 Y  D  N  I  Q  E  M  V  G  S  R  P  C  I  W  W  K  L  C  W         p.500

          .         .        | 15.         .         .         .    g.46830
 TCTTTCTTCACACCAATCATTGTGGCG | GGCGTGTTCATTTTCAGTGCTGTGCAGATGACG    c.1560
 S  F  F  T  P  I  I  V  A   | G  V  F  I  F  S  A  V  Q  M  T      p.520

          .         .         .         .         .         .       g.46890
 CCACTCACCATGGGAAACTATGTTTTCCCCAAGTGGGGCCAGGGTGTGGGCTGGCTGATG       c.1620
 P  L  T  M  G  N  Y  V  F  P  K  W  G  Q  G  V  G  W  L  M         p.540

          .         .         .         .         .         .       g.46950
 GCTCTGTCTTCCATGGTCCTCATCCCCGGGTACATGGCCTACATGTTCCTCACCTTAAAG       c.1680
 A  L  S  S  M  V  L  I  P  G  Y  M  A  Y  M  F  L  T  L  K         p.560

          .      | 16  .         .         .         .         .    g.49173
 GGCTCCCTGAAGCAG | CGCATCCAAGTCATGGTCCAGCCCAGCGAAGACATCGTTCGCCCA    c.1740
 G  S  L  K  Q   | R  I  Q  V  M  V  Q  P  S  E  D  I  V  R  P      p.580

          .         .         .         .         .         .       g.49233
 GAGAATGGTCCTGAGCAGCCCCAGGCGGGCAGCTCCACCAGCAAGGAGGCCTACATCTAG       c.1800
 E  N  G  P  E  Q  P  Q  A  G  S  S  T  S  K  E  A  Y  I  X         p.599

          .         .         .         .         .         .       g.49293
 ggtgggggccactcaccgacccgacactctcaccccccgacctggctgagtgcgaccacc       c.*60

          .         .         .         .         .         .       g.49353
 acttgatgtctgaggataccttccatctcaacctacctcgagtggcgagtccagacacca       c.*120

          .         .         .         .         .         .       g.49413
 tcaccacgcagagaggggaggtgggaggacagttagacccctgggtgggccctgccgtgg       c.*180

          .         .         .         .         .         .       g.49473
 gcaaggatacccggtggcttctggcacctggcgggctggtgacctttttaatccaggccc       c.*240

          .         .         .         .         .         .       g.49533
 catcagcatcccacgatcggccttggtaaccgccgcggtagatcatttttatcccgccag       c.*300

          .         .         .         .         .         .       g.49593
 ggagtgtgatgcaggaagaccacatgcgctcctggcttttaaacctgttcctgactgttc       c.*360

          .         .         .         .         .         .       g.49653
 tcttactgccgaaacccttgactgttatctcggactttgcaggagttcctttccctccga       c.*420

          .         .         .         .         .         .       g.49713
 acgctgctccatgcacaggaaaagggcattttgtacaatggggacttcccgggaacgctt       c.*480

          .         .         .         .         .         .       g.49773
 gctcttaagtaccagaagccggcggagctctggctttcgtgtttttggttttctccttcc       c.*540

          .         .         .         .         .         .       g.49833
 caaggcagctggattgaaaaaacaaaacaaaacaaaaaaacccaggggcgtcagtcgata       c.*600

          .         .         .         .         .         .       g.49893
 ttcccagggccgcttctcctgcagtctgtggagcgtccttgtccccgccgccggaatgaa       c.*660

          .         .         .         .         .         .       g.49953
 tgagcattctgcagcccgatgtccctgtcccctcctcgccgggccattctgattggacct       c.*720

          .         .         .         .         .         .       g.50013
 ggcccagtgcaatctgtccagacaagccctgcttgctggaaaactgccacaagcacaatt       c.*780

          .         .         .         .         .         .       g.50073
 gatctctttttatcgccattccaggggcctcaggtcctactggggaaacttcctataccg       c.*840

          .         .         .         .         .         .       g.50133
 gagctccagtttctcttaagctgcccaatttcacagagtacaaaatagttgtaggggaaa       c.*900

          .         .         .         .         .         .       g.50193
 tcaaggtgaaggatctgtccgacagtcaagacggatccacagtaatctttcggtctcctt       c.*960

          .         .         .         .         .         .       g.50253
 aaactaccaccctcgctgccacccaccccaagctgctgccgcctcaccttccttgaaatt       c.*1020

          .         .         .         .         .         .       g.50313
 tctcagcgggagtctcctcactgccactaaaatccacccagcccactaactgaggagcta       c.*1080

          .         .         .         .         .         .       g.50373
 gtgttaatccagagaaccccccgcaatgtgcttccgagattcagactgcttcattgggaa       c.*1140

          .         .         .         .         .         .       g.50433
 gtatgatttgttcctttctggaattgggctccgtggtggcggcggcacttcaagcaaaga       c.*1200

          .         .         .         .         .         .       g.50493
 cagtttcttgcaagctccagtagctccgcgtgtctcatttgccaggaagatgggttccca       c.*1260

          .         .         .         .         .         .       g.50553
 cgtagcaaatcgtacattgtgccctgtagctccttagctagttagctcacaagccgtgtt       c.*1320

          .         .         .         .         .         .       g.50613
 ttatgactaatccttaataactatggtaaataactgtgactgtggggtttttaatctctt       c.*1380

          .         .         .         .         .         .       g.50673
 gtcattctcatccaaaagtgaccagcataccagttcttgcaataagatattaccctcaga       c.*1440

          .         .         .         .         .         .       g.50733
 atattaagcacattattgtagagaaaaaaaaatatgtgtacacatatgaacgcacaacat       c.*1500

          .         .         .         .         .         .       g.50793
 gcacattcatcctcacatgtggcacgtaaggtctcatttgatattgtgtaggaaatctga       c.*1560

          .         .         .         .         .         .       g.50853
 agccttttcctgaggtcatctgtaaaatagtctcattgccaaggcatccccagtgccagc       c.*1620

          .         .         .         .         .         .       g.50913
 tggtgaatccatgatcaaaatgcatacgtattgttaaatgataaggtttagaatgacagg       c.*1680

          .         .         .         .         .         .       g.50973
 aacccatcactgtgtctcatggtcccacttccccatctgtgtgtgaattcctttagacta       c.*1740

          .         .         .         .         .         .       g.51033
 agggcaggaagacttccagctttctctttgttcttcaatgtgaaactgagaccaagtctc       c.*1800

          .         .         .         .         .         .       g.51093
 tctaagacaaatgcagtgtatttaatgtttgtaagcaattctaagtgagatgtttggcaa       c.*1860

          .         .         .         .         .         .       g.51153
 gaaatcccctaactgatttccatccaaacctaccttatagagcacaatattaagtgttgt       c.*1920

          .         .         .         .         .         .       g.51213
 acaattactgtgagaactgtgaatatgtgtaacttttttttagtatttgcccggggggaa       c.*1980

          .         .         .         .         .         .       g.51273
 aaagatattgtattatcatatatgcttttttgcaataaggatttattctcagaacaccaa       c.*2040

          .         .         .         .         .         .       g.51333
 gtaaatctatctctatataaaaaatatatgtaatatatacatattcaaagtatatacaga       c.*2100

          .         .         .         .         .         .       g.51393
 gcctgttttaaaaaatacagtattatttagtaaaattatctgttctatggaccaaatgta       c.*2160

          .         .         .         .         .         .       g.51453
 aaatatttataaatgaagatgcattttaaatgtctataaatggtgtcataactagagcac       c.*2220

          .         .         .         .         .         .       g.51513
 gggcgttatgtaagtttctaagaatttagaggataaataataaaggttctatgatataca       c.*2280

                                                                    g.51516
 aca                                                                c.*2283

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 6 (neurotransmitter transporter, GABA), member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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