solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (SLC6A3) - coding DNA reference sequence

(used for variant description)

(last modified July 6, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001044.4 in the SLC6A3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015885.1, covering SLC6A3 transcript NM_001044.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       cgctgc       c.-121

 .         .         .         .         .         .                g.5066
 ggagcgggaggggaggcttcgcggaacgctctcggcgccaggactcgcgtgcaaagccca       c.-61

 .         .     | 02   .         .         .         .             g.7231
 ggcccgggcggccag | accaagagggaagaagcacagaattcctcaactcccagtgtgccc    c.-1

          .         .         .         .         .         .       g.7291
 ATGAGTAAGAGCAAATGCTCCGTGGGACTCATGTCTTCCGTGGTGGCCCCGGCTAAGGAG       c.60
 M  S  K  S  K  C  S  V  G  L  M  S  S  V  V  A  P  A  K  E         p.20

          .         .         .         .         .         .       g.7351
 CCCAATGCCGTGGGCCCGAAGGAGGTGGAGCTCATCCTTGTCAAGGAGCAGAACGGAGTG       c.120
 P  N  A  V  G  P  K  E  V  E  L  I  L  V  K  E  Q  N  G  V         p.40

          .         .         .         .         .         .       g.7411
 CAGCTCACCAGCTCCACCCTCACCAACCCGCGGCAGAGCCCCGTGGAGGCCCAGGATCGG       c.180
 Q  L  T  S  S  T  L  T  N  P  R  Q  S  P  V  E  A  Q  D  R         p.60

          .         .         .         .         .         .       g.7471
 GAGACCTGGGGCAAGAAGATCGACTTTCTCCTGTCCGTCATTGGCTTTGCTGTGGACCTG       c.240
 E  T  W  G  K  K  I  D  F  L  L  S  V  I  G  F  A  V  D  L         p.80

          .         .         .         .       | 03 .         .    g.8952
 GCCAACGTCTGGCGGTTCCCCTACCTGTGCTACAAAAATGGTGGCG | GTGCCTTCCTGGTC    c.300
 A  N  V  W  R  F  P  Y  L  C  Y  K  N  G  G  G |   A  F  L  V      p.100

          .         .         .         .         .         .       g.9012
 CCCTACCTGCTCTTCATGGTCATTGCTGGGATGCCACTTTTCTACATGGAGCTGGCCCTC       c.360
 P  Y  L  L  F  M  V  I  A  G  M  P  L  F  Y  M  E  L  A  L         p.120

          .         .         .         .         .         | 04    g.17732
 GGCCAGTTCAACAGGGAAGGGGCCGCTGGTGTCTGGAAGATCTGCCCCATACTGAAAG | GT    c.420
 G  Q  F  N  R  E  G  A  A  G  V  W  K  I  C  P  I  L  K  G |       p.140

          .         .         .         .         .         .       g.17792
 GTGGGCTTCACGGTCATCCTCATCTCACTGTATGTCGGCTTCTTCTACAACGTCATCATC       c.480
 V  G  F  T  V  I  L  I  S  L  Y  V  G  F  F  Y  N  V  I  I         p.160

          .         .         .         .         .         .       g.17852
 GCCTGGGCGCTGCACTATCTCTTCTCCTCCTTCACCACGGAGCTCCCCTGGATCCACTGC       c.540
 A  W  A  L  H  Y  L  F  S  S  F  T  T  E  L  P  W  I  H  C         p.180

          .         .         .         .         .         .       g.17912
 AACAACTCCTGGAACAGCCCCAACTGCTCGGATGCCCATCCTGGTGACTCCAGTGGAGAC       c.600
 N  N  S  W  N  S  P  N  C  S  D  A  H  P  G  D  S  S  G  D         p.200

          .         .         .         .         .    | 05    .    g.28421
 AGCTCGGGCCTCAACGACACTTTTGGGACCACACCTGCTGCCGAGTACTTTGA | ACGTGGC    c.660
 S  S  G  L  N  D  T  F  G  T  T  P  A  A  E  Y  F  E  |  R  G      p.220

          .         .         .         .         .         .       g.28481
 GTGCTGCACCTCCACCAGAGCCATGGCATCGACGACCTGGGGCCTCCGCGGTGGCAGCTC       c.720
 V  L  H  L  H  Q  S  H  G  I  D  D  L  G  P  P  R  W  Q  L         p.240

          .         .         .         .         .         .       g.28541
 ACAGCCTGCCTGGTGCTGGTCATCGTGCTGCTCTACTTCAGCCTCTGGAAGGGCGTGAAG       c.780
 T  A  C  L  V  L  V  I  V  L  L  Y  F  S  L  W  K  G  V  K         p.260

          .   | 06     .         .         .         .         .    g.29773
 ACCTCAGGGAAG | GTGGTATGGATCACAGCCACCATGCCATACGTGGTCCTCACTGCCCTG    c.840
 T  S  G  K   | V  V  W  I  T  A  T  M  P  Y  V  V  L  T  A  L      p.280

          .         .         .         .         .         .       g.29833
 CTCCTGCGTGGGGTCACCCTCCCTGGAGCCATAGACGGCATCAGAGCATACCTGAGCGTT       c.900
 L  L  R  G  V  T  L  P  G  A  I  D  G  I  R  A  Y  L  S  V         p.300

          .         .        | 07.         .         .         .    g.34260
 GACTTCTACCGGCTCTGCGAGGCGTCT | GTTTGGATTGACGCGGCCACCCAGGTGTGCTTC    c.960
 D  F  Y  R  L  C  E  A  S   | V  W  I  D  A  A  T  Q  V  C  F      p.320

          .         .         .         .         .         .       g.34320
 TCCCTGGGCGTGGGGTTCGGGGTGCTGATCGCCTTCTCCAGCTACAACAAGTTCACCAAC       c.1020
 S  L  G  V  G  F  G  V  L  I  A  F  S  S  Y  N  K  F  T  N         p.340

          .  | 08      .         .         .         .         .    g.35662
 AACTGCTACAG | GGACGCGATTGTCACCACCTCCATCAACTCCCTGACGAGCTTCTCCTCC    c.1080
 N  C  Y  R  |  D  A  I  V  T  T  S  I  N  S  L  T  S  F  S  S      p.360

          .         .         .         .         .         .       g.35722
 GGCTTCGTCGTCTTCTCCTTCCTGGGGTACATGGCACAGAAGCACAGTGTGCCCATCGGG       c.1140
 G  F  V  V  F  S  F  L  G  Y  M  A  Q  K  H  S  V  P  I  G         p.380

          .       | 09 .         .         .         .         .    g.39117
 GACGTGGCCAAGGACG | GGCCAGGGCTGATCTTCATCATCTACCCGGAAGCCATCGCCACG    c.1200
 D  V  A  K  D  G |   P  G  L  I  F  I  I  Y  P  E  A  I  A  T      p.400

          .         .         .         .         .         .       g.39177
 CTCCCTCTGTCCTCAGCCTGGGCCGTGGTCTTCTTCATCATGCTGCTCACCCTGGGTATC       c.1260
 L  P  L  S  S  A  W  A  V  V  F  F  I  M  L  L  T  L  G  I         p.420

           | 10        .         .         .         .         .    g.40630
 GACAGCGCC | ATGGGTGGTATGGAGTCAGTGATCACCGGGCTCATCGATGAGTTCCAGCTG    c.1320
 D  S  A   | M  G  G  M  E  S  V  I  T  G  L  I  D  E  F  Q  L      p.440

          .         .         .         .         .         .       g.40690
 CTGCACAGACACCGTGAGCTCTTCACGCTCTTCATCGTCCTGGCGACCTTCCTCCTGTCC       c.1380
 L  H  R  H  R  E  L  F  T  L  F  I  V  L  A  T  F  L  L  S         p.460

          .         | 11         .         .         .         .    g.41345
 CTGTTCTGCGTCACCAAC | GGTGGCATCTACGTCTTCACGCTCCTGGACCATTTTGCAGCC    c.1440
 L  F  C  V  T  N   | G  G  I  Y  V  F  T  L  L  D  H  F  A  A      p.480

          .         .         .         .         .         | 12    g.44142
 GGCACGTCCATCCTCTTTGGAGTGCTCATCGAAGCCATCGGAGTGGCCTGGTTCTATG | GT    c.1500
 G  T  S  I  L  F  G  V  L  I  E  A  I  G  V  A  W  F  Y  G |       p.500

          .         .         .         .         .         .       g.44202
 GTTGGGCAGTTCAGCGACGACATCCAGCAGATGACCGGGCAGCGGCCCAGCCTGTACTGG       c.1560
 V  G  Q  F  S  D  D  I  Q  Q  M  T  G  Q  R  P  S  L  Y  W         p.520

          .         .         .          | 13        .         .    g.47360
 CGGCTGTGCTGGAAGCTGGTCAGCCCCTGCTTTCTCCTG | TTCGTGGTCGTGGTCAGCATT    c.1620
 R  L  C  W  K  L  V  S  P  C  F  L  L   | F  V  V  V  V  S  I      p.540

          .         .         .         .         .         .       g.47420
 GTGACCTTCAGACCCCCCCACTACGGAGCCTACATCTTCCCCGACTGGGCCAACGCGCTG       c.1680
 V  T  F  R  P  P  H  Y  G  A  Y  I  F  P  D  W  A  N  A  L         p.560

          .         .         .         .         .         .       g.47480
 GGCTGGGTCATCGCCACATCCTCCATGGCCATGGTGCCCATCTATGCGGCCTACAAGTTC       c.1740
 G  W  V  I  A  T  S  S  M  A  M  V  P  I  Y  A  A  Y  K  F         p.580

          .         .        | 14.         .         .         .    g.49475
 TGCAGCCTGCCTGGGTCCTTTCGAGAG | AAACTGGCCTACGCCATTGCACCCGAGAAGGAC    c.1800
 C  S  L  P  G  S  F  R  E   | K  L  A  Y  A  I  A  P  E  K  D      p.600

          .         .         .          | 15        .         .    g.55691
 CGTGAGCTGGTGGACAGAGGGGAGGTGCGCCAGTTCACG | CTCCGCCACTGGCTCAAGGTG    c.1860
 R  E  L  V  D  R  G  E  V  R  Q  F  T   | L  R  H  W  L  K  V      p.620

                                                                    g.55694
 TAG                                                                c.1863
 X                                                                  p.620

          .         .         .         .         .         .       g.55754
 agggagcagagacgaagaccccaggaagtcatcctgcaatgggagagacacgaacaaacc       c.*60

          .         .         .         .         .         .       g.55814
 aaggaaatctaagtttcgagagaaaggagggcaacttctactcttcaacctctactgaaa       c.*120

          .         .         .         .         .         .       g.55874
 acacaaacaacaaagcagaagactcctctcttctgactgtttacacctttccgtgccggg       c.*180

          .         .         .         .         .         .       g.55934
 agcgcacctcgccgtgtcttgtgttgctgtaataacgacgtagatctgtgcagcgaggtc       c.*240

          .         .         .         .         .         .       g.55994
 caccccgttgttgtccctgcagggcagaaaaacgtctaacttcatgctgtctgtgtgagg       c.*300

          .         .         .         .         .         .       g.56054
 ctccctccctccctgctccctgctcccggctctgaggctgccccaggggcactgtgttct       c.*360

          .         .         .         .         .         .       g.56114
 caggcggggatcacgatccttgtagacgcacctgctgagaatccccgtgctcacagtagc       c.*420

          .         .         .         .         .         .       g.56174
 ttcctagaccatttactttgcccatattaaaaagccaagtgtcctgcttggtttagctgt       c.*480

          .         .         .         .         .         .       g.56234
 gcagaaggtgaaatggaggaaaccacaaattcatgcaaagtcctttcccgatgcgtggct       c.*540

          .         .         .         .         .         .       g.56294
 cccagcagaggccgtaaattgagcgttcagttgacacattgcacacacagtctgttcaga       c.*600

          .         .         .         .         .         .       g.56354
 ggcattggaggatgggggtcctggtatgtctcaccaggaaattctgtttatgttcttgca       c.*660

          .         .         .         .         .         .       g.56414
 gcagagagaaataaaactccttgaaaccagctcaggctactgccactcaggcagcctgtg       c.*720

          .         .         .         .         .         .       g.56474
 ggtccttgcggtgtagggaacggcctgagaggagcgtgtcctatccccggacgcatgcag       c.*780

          .         .         .         .         .         .       g.56534
 ggcccccacaggagcgtgtcctatccccggacgcatgcagggcccccacaggagcatgtc       c.*840

          .         .         .         .         .         .       g.56594
 ctatccctggacgcatgcagggcccccacaggagcgtgtactaccccagaacgcatgcag       c.*900

          .         .         .         .         .         .       g.56654
 ggcccccacaggagcgtgtactaccccaggacgcatgcagggcccccactggagcgtgta       c.*960

          .         .         .         .         .         .       g.56714
 ctaccccaggacgcatgcagggcccccacaggagcgtgtcctatccccggaccggacgca       c.*1020

          .         .         .         .         .         .       g.56774
 tgcagggcccccacaggagcgtgtactaccccaggacgcatgcagggcccccacaggagc       c.*1080

          .         .         .         .         .         .       g.56834
 gtgtactaccccaggatgcatgcagggcccccacaggagcgtgtactaccccaggacgca       c.*1140

          .         .         .         .         .         .       g.56894
 tgcagggcccccatgcaggcagcctgcagaccacactctgcctggccttgagccgtgacc       c.*1200

          .         .         .         .         .         .       g.56954
 tccaggaagggaccccactggaattttatttctctcaggtgcgtgccacatcaataacaa       c.*1260

          .         .         .         .         .         .       g.57014
 cagtttttatgtttgcgaatggctttttaaaatcatatttacctgtgaatcaaaacaaat       c.*1320

          .         .         .         .         .         .       g.57074
 tcaagaatgcagtatccgcgagcctgcttgctgatattgcagtttttgtttacaagaata       c.*1380

          .         .         .         .         .         .       g.57134
 attagcaatactgagtgaaggatgttggccaaaagctgctttccatggcacactgccctc       c.*1440

          .         .         .         .         .         .       g.57194
 tgccactgacaggaaagtggatgccatagtttgaattcatgcctcaagtcggtgggcctg       c.*1500

          .         .         .         .         .         .       g.57254
 cctacgtgctgcccgagggcaggggccgtgcagggccagtcatggctgtcccctgcaagt       c.*1560

          .         .         .         .         .         .       g.57314
 ggacgtgggctccagggactggagtgtaatgctcggtgggagccgtcagcctgtgaactg       c.*1620

          .         .         .         .         .         .       g.57374
 ccaggcagctgcagttagcacagaggatggcttccccattgccttctggggagggacaca       c.*1680

          .         .         .         .         .         .       g.57434
 gaggacggcttccccatcgccttctggccgctgcagtcagcacagagagcggcttcccca       c.*1740

          .         .         .         .         .         .       g.57494
 ttgccttctggggagggacacagaggacagcttccccatcgccttctggctgctgcagtc       c.*1800

          .         .         .         .         .         .       g.57554
 agcacagagagcggcttccccatcgccttctggggaggggctccgtgtagcaacccaggt       c.*1860

          .         .         .         .         .         .       g.57614
 gttgtccgtgtctgttgaccaatctctattcagcatcgtgtgggtccctaagcacaataa       c.*1920

          .         .                                               g.57639
 aagacatccacaatggaaaaactgc                                          c.*1945

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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