solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (SLC6A5) - coding DNA reference sequence

(used for variant description)

(last modified May 23, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_004211.3 in the SLC6A5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013086.1, covering SLC6A5 transcript NM_004211.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            cacgccaaacacgcagccccctcccgctggagt       c.-241

 .         .         .         .         .         .                g.5093
 gacaactggccagcatactctaggctgttgtccctttaaaacttgaatccaagggggtaa       c.-181

 .         .         .         .         .         .                g.5153
 tgatttatcaaacttgtattatcaagaaaatgtcaaaccaagggcaccttgctttgcact       c.-121

 .         .         .         .         .         .                g.5213
 gacgcaaacccggcctttcccaaggagatatagaaagcgcctctcctgcctgagccaaac       c.-61

 .         .         .         .         .         .                g.5273
 ccagtcttgtcaatagcgggtttcaccctccaccagttcagtctgttgcctgtgtcagac       c.-1

     | 02    .         .         .         .         .         .    g.6786
 ATG | GATTGCAGTGCTCCCAAGGAAATGAATAAACTGCCAGCCAACAGCCCGGAGGCGGCG    c.60
 M   | D  C  S  A  P  K  E  M  N  K  L  P  A  N  S  P  E  A  A      p.20

          .         .         .         .         .         .       g.6846
 GCGGCGCAGGGCCACCCGGATGGCCCATGCGCTCCCAGGACGAGCCCGGAGCAGGAGCTT       c.120
 A  A  Q  G  H  P  D  G  P  C  A  P  R  T  S  P  E  Q  E  L         p.40

          .         .         .         .         .         .       g.6906
 CCCGCGGCTGCCGCCCCGCCGCCGCCACGTGTGCCCAGGTCCGCTTCCACCGGCGCCCAA       c.180
 P  A  A  A  A  P  P  P  P  R  V  P  R  S  A  S  T  G  A  Q         p.60

          .         .         .         .         .         .       g.6966
 ACTTTCCAGTCAGCGGACGCGCGAGCCTGCGAGGCTGAGCGGCCAGGAGTGGGGTCTTGC       c.240
 T  F  Q  S  A  D  A  R  A  C  E  A  E  R  P  G  V  G  S  C         p.80

          .         .         .         .         .         .       g.7026
 AAACTCAGTAGCCCGCGGGCGCAGGCGGCCTCTGCAGCTCTGCGGGACTTGAGAGAGGCG       c.300
 K  L  S  S  P  R  A  Q  A  A  S  A  A  L  R  D  L  R  E  A         p.100

          .         .         .         .         .         .       g.7086
 CAAGGCGCGCAGGCCTCGCCCCCTCCCGGGAGCTCCGGGCCCGGCAACGCGCTGCACTGT       c.360
 Q  G  A  Q  A  S  P  P  P  G  S  S  G  P  G  N  A  L  H  C         p.120

          .         .         .         .         .         .       g.7146
 AAGATCCCTTTTCTGCGAGGCCCGGAGGGGGATGCGAACGTGAGTGTGGGCAAGGGCACC       c.420
 K  I  P  F  L  R  G  P  E  G  D  A  N  V  S  V  G  K  G  T         p.140

          .         .         .         .         .         .       g.7206
 CTGGAGCGGAACAATACCCCTGTTGTGGGCTGGGTGAACATGAGCCAGAGCACCGTGGTG       c.480
 L  E  R  N  N  T  P  V  V  G  W  V  N  M  S  Q  S  T  V  V         p.160

          .         .         .         .         .         .       g.7266
 CTGGCCACGGATGGAATCACGTCCGTGCTCCCGGGCAGCGTGGCCACCGTTGCCACCCAG       c.540
 L  A  T  D  G  I  T  S  V  L  P  G  S  V  A  T  V  A  T  Q         p.180

  | 03       .         .         .         .         .         .    g.9946
  | GAGGACGAGCAAGGGGATGAGAATAAGGCCCGAGGGAACTGGTCCAGCAAACTGGACTTC    c.600
  | E  D  E  Q  G  D  E  N  K  A  R  G  N  W  S  S  K  L  D  F      p.200

          .         .         .         .         .         .       g.10006
 ATCCTGTCCATGGTGGGGTACGCAGTGGGGCTGGGCAATGTCTGGAGGTTTCCCTACCTG       c.660
 I  L  S  M  V  G  Y  A  V  G  L  G  N  V  W  R  F  P  Y  L         p.220

          .          | 04        .         .         .         .    g.12648
 GCCTTCCAGAACGGGGGAG | GTGCTTTCCTCATCCCTTACCTGATGATGCTGGCTCTGGCT    c.720
 A  F  Q  N  G  G  G |   A  F  L  I  P  Y  L  M  M  L  A  L  A      p.240

          .         .         .         .         .         .       g.12708
 GGATTACCCATCTTCTTCTTGGAGGTGTCGCTGGGCCAGTTTGCCAGCCAGGGACCAGTG       c.780
 G  L  P  I  F  F  L  E  V  S  L  G  Q  F  A  S  Q  G  P  V         p.260

          .         .         .  | 05      .         .         .    g.13108
 TCTGTGTGGAAGGCCATCCCAGCTCTACAAG | GCTGTGGCATCGCGATGCTGATCATCTCT    c.840
 S  V  W  K  A  I  P  A  L  Q  G |   C  G  I  A  M  L  I  I  S      p.280

          .         .         .         .         .         .       g.13168
 GTCCTAATAGCCATATACTACAATGTGATTATTTGCTATACACTTTTCTACCTGTTTGCC       c.900
 V  L  I  A  I  Y  Y  N  V  I  I  C  Y  T  L  F  Y  L  F  A         p.300

          .         .         .         .         .         .       g.13228
 TCCTTTGTGTCTGTACTACCCTGGGGCTCCTGCAACAACCCTTGGAATACGCCAGAATGC       c.960
 S  F  V  S  V  L  P  W  G  S  C  N  N  P  W  N  T  P  E  C         p.320

          .         .      | 06  .         .         .         .    g.20314
 AAAGATAAAACCAAACTTTTATTAG | ATTCCTGTGTTATCAGTGACCATCCCAAAATACAG    c.1020
 K  D  K  T  K  L  L  L  D |   S  C  V  I  S  D  H  P  K  I  Q      p.340

          .         .         .         .         .         .       g.20374
 ATCAAGAACTCGACTTTCTGCATGACCGCTTATCCCAACGTGACAATGGTTAATTTCACC       c.1080
 I  K  N  S  T  F  C  M  T  A  Y  P  N  V  T  M  V  N  F  T         p.360

          .         .         .         .        | 07.         .    g.23365
 AGCCAGGCCAATAAGACATTTGTCAGTGGAAGTGAAGAGTACTTCAA | GTACTTTGTGCTG    c.1140
 S  Q  A  N  K  T  F  V  S  G  S  E  E  Y  F  K  |  Y  F  V  L      p.380

          .         .         .         .         .         .       g.23425
 AAGATTTCTGCAGGGATTGAATATCCTGGCGAGATCAGGTGGCCACTAGCTCTCTGCCTC       c.1200
 K  I  S  A  G  I  E  Y  P  G  E  I  R  W  P  L  A  L  C  L         p.400

          .         .         .         .         .         .       g.23485
 TTCCTGGCTTGGGTCATTGTGTATGCATCATTGGCTAAAGGAATCAAGACTTCAGGAAAA       c.1260
 F  L  A  W  V  I  V  Y  A  S  L  A  K  G  I  K  T  S  G  K         p.420

  | 08       .         .         .         .         .         .    g.32368
  | GTGGTGTACTTCACGGCCACGTTCCCGTATGTCGTACTCGTGATCCTCCTCATCCGAGGA    c.1320
  | V  V  Y  F  T  A  T  F  P  Y  V  V  L  V  I  L  L  I  R  G      p.440

          .         .         .         .         .         .       g.32428
 GTCACCCTGCCTGGAGCTGGAGCTGGGATCTGGTACTTCATCACACCCAAGTGGGAGAAA       c.1380
 V  T  L  P  G  A  G  A  G  I  W  Y  F  I  T  P  K  W  E  K         p.460

          .      | 09  .         .         .         .         .    g.33625
 CTCACGGATGCCACG | GTGTGGAAAGATGCTGCCACTCAGATTTTCTTCTCTTTATCTGCT    c.1440
 L  T  D  A  T   | V  W  K  D  A  A  T  Q  I  F  F  S  L  S  A      p.480

          .         .         .         .         .          | 10    g.36292
 GCATGGGGAGGCCTGATCACTCTCTCTTCTTACAACAAATTCCACAACAACTGCTACAG | G    c.1500
 A  W  G  G  L  I  T  L  S  S  Y  N  K  F  H  N  N  C  Y  R  |      p.500

          .         .         .         .         .         .       g.36352
 GACACTCTAATTGTCACCTGCACCAACAGTGCCACAAGCATCTTTGCCGGCTTCGTCATC       c.1560
 D  T  L  I  V  T  C  T  N  S  A  T  S  I  F  A  G  F  V  I         p.520

          .         .         .         .         .         .       g.36412
 TTCTCCGTTATCGGCTTCATGGCCAATGAACGCAAAGTCAACATTGAGAATGTGGCAGAC       c.1620
 F  S  V  I  G  F  M  A  N  E  R  K  V  N  I  E  N  V  A  D         p.540

      | 11   .         .         .         .         .         .    g.41963
 CAAG | GGCCAGGCATTGCATTTGTGGTTTACCCGGAAGCCTTAACCAGGCTGCCTCTCTCT    c.1680
 Q  G |   P  G  I  A  F  V  V  Y  P  E  A  L  T  R  L  P  L  S      p.560

          .         .         .         .         .        | 12.    g.42775
 CCGTTCTGGGCCATCATCTTTTTCCTGATGCTCCTCACTCTTGGACTTGACACTATG | TTT    c.1740
 P  F  W  A  I  I  F  F  L  M  L  L  T  L  G  L  D  T  M   | F      p.580

          .         .         .         .         .         .       g.42835
 GCCACCATCGAGACCATAGTGACCTCCATCTCAGACGAGTTTCCCAAGTACCTACGCACA       c.1800
 A  T  I  E  T  I  V  T  S  I  S  D  E  F  P  K  Y  L  R  T         p.600

          .         .         .         .         .         .       g.42895
 CACAAGCCAGTGTTTACTCTGGGCTGCTGCATTTGTTTCTTCATCATGGGTTTTCCAATG       c.1860
 H  K  P  V  F  T  L  G  C  C  I  C  F  F  I  M  G  F  P  M         p.620

           | 13        .         .         .         .         .    g.44110
 ATCACTCAG | GGTGGAATTTACATGTTTCAGCTTGTGGACACCTATGCTGCCTCCTATGCC    c.1920
 I  T  Q   | G  G  I  Y  M  F  Q  L  V  D  T  Y  A  A  S  Y  A      p.640

          .         .         .         .          | 14        .    g.52445
 CTTGTCATCATTGCCATTTTTGAGCTCGTGGGGATCTCTTATGTGTATG | GCTTGCAAAGA    c.1980
 L  V  I  I  A  I  F  E  L  V  G  I  S  Y  V  Y  G |   L  Q  R      p.660

          .         .         .         .         .         .       g.52505
 TTCTGTGAAGATATAGAGATGATGATTGGATTCCAGCCTAACATCTTCTGGAAAGTCTGC       c.2040
 F  C  E  D  I  E  M  M  I  G  F  Q  P  N  I  F  W  K  V  C         p.680

          .         .         . | 15       .         .         .    g.57919
 TGGGCATTTGTAACCCCAACCATTTTAACC | TTTATCCTTTGCTTCAGCTTTTACCAGTGG    c.2100
 W  A  F  V  T  P  T  I  L  T   | F  I  L  C  F  S  F  Y  Q  W      p.700

          .         .         .         .         .         .       g.57979
 GAGCCCATGACCTATGGCTCTTACCGCTATCCTAACTGGTCCATGGTGCTCGGATGGCTA       c.2160
 E  P  M  T  Y  G  S  Y  R  Y  P  N  W  S  M  V  L  G  W  L         p.720

          .         .         .         .         .         .       g.58039
 ATGCTCGCCTGTTCCGTCATCTGGATCCCAATTATGTTTGTGATAAAAATGCATCTGGCC       c.2220
 M  L  A  C  S  V  I  W  I  P  I  M  F  V  I  K  M  H  L  A         p.740

          .         | 16         .         .         .         .    g.60355
 CCTGGAAGATTTATTGAG | AGGCTGAAGTTGGTGTGCTCGCCACAGCCGGACTGGGGCCCA    c.2280
 P  G  R  F  I  E   | R  L  K  L  V  C  S  P  Q  P  D  W  G  P      p.760

          .         .         .         .         .         .       g.60415
 TTCTTAGCTCAACACCGCGGGGAGCGTTACAAGAACATGATCGACCCCTTGGGAACCTCT       c.2340
 F  L  A  Q  H  R  G  E  R  Y  K  N  M  I  D  P  L  G  T  S         p.780

          .         .         .         .         .                 g.60469
 TCCTTGGGACTCAAACTGCCAGTGAAGGATTTGGAACTGGGCACTCAGTGCTAG             c.2394
 S  L  G  L  K  L  P  V  K  D  L  E  L  G  T  Q  C  X               p.797

          .         .         .         .         .         .       g.60529
 tccagtggtgtgggatggtccagacttgatcctgtttttcctctctgcctcctcctaatg       c.*60

          .         .         .         .         .         .       g.60589
 ttttccatagctctcctcccatttttcttcatctttcttcctacatcttggttcacatcc       c.*120

          .         .         .         .         .         .       g.60649
 acgcatgagagtgattatgtagaaaagtaggcatagtgtcgcatgctgcagtaaagagct       c.*180

          .                                                         g.60665
 acatagaccacctgaa                                                   c.*196

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 6 (neurotransmitter transporter, glycine), member 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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