solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (SLC6A8) - coding DNA reference sequence

(used for variant description)

(last modified November 16, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_005629.3 in the SLC6A8 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012016.1, covering SLC6A8 transcript NM_005629.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       gccgggccccgccgccgcccgcgcgcccccgggccccc       c.-241

 .         .         .         .         .         .                g.5098
 gacacacatgagattcttcaggctcactttcaagtgcttcgtggactgcttctgactgcg       c.-181

 .         .         .         .         .         .                g.5158
 ccgcccgcgccccgcaccccgccgcccgcccgccgccccgtcccccggcccggccgcccc       c.-121

 .         .         .         .         .         .                g.5218
 ccggcccccggccggcccgcgccctcggggccctccccggtgccgccggtgccccccgcc       c.-61

 .         .         .         .         .         .                g.5278
 tgaccgccgccccccgtgaggcgccgcgaccccggcccggccgtgcggcccgccgaggcc       c.-1

          .         .         .         .         .         .       g.5338
 ATGGCGAAGAAGAGCGCCGAGAACGGCATCTATAGCGTGTCCGGCGACGAGAAGAAGGGC       c.60
 M  A  K  K  S  A  E  N  G  I  Y  S  V  S  G  D  E  K  K  G         p.20

          .         .         .         .         .         .       g.5398
 CCCCTCATCGCGCCCGGGCCCGACGGGGCCCCGGCCAAGGGCGACGGCCCCGTGGGCCTG       c.120
 P  L  I  A  P  G  P  D  G  A  P  A  K  G  D  G  P  V  G  L         p.40

          .         .         .         .         .         .       g.5458
 GGGACACCCGGCGGCCGCCTGGCCGTGCCGCCGCGCGAGACCTGGACGCGCCAGATGGAC       c.180
 G  T  P  G  G  R  L  A  V  P  P  R  E  T  W  T  R  Q  M  D         p.60

          .         .         .         .         .         .       g.5518
 TTCATCATGTCGTGCGTGGGCTTCGCCGTGGGCTTGGGCAACGTGTGGCGCTTCCCCTAC       c.240
 F  I  M  S  C  V  G  F  A  V  G  L  G  N  V  W  R  F  P  Y         p.80

          .         .   | 02     .         .         .         .    g.7116
 CTGTGCTACAAGAACGGCGGAG | GTGTGTTCCTTATTCCCTACGTCCTGATCGCCCTGGTT    c.300
 L  C  Y  K  N  G  G  G |   V  F  L  I  P  Y  V  L  I  A  L  V      p.100

          .         .         .         .         .         .       g.7176
 GGAGGAATCCCCATTTTCTTCTTAGAGATCTCGCTGGGCCAGTTCATGAAGGCCGGCAGC       c.360
 G  G  I  P  I  F  F  L  E  I  S  L  G  Q  F  M  K  A  G  S         p.120

          .         .         .     | 03   .         .         .    g.8033
 ATCAATGTCTGGAACATCTGTCCCCTGTTCAAAG | GCCTGGGCTACGCCTCCATGGTGATC    c.420
 I  N  V  W  N  I  C  P  L  F  K  G |   L  G  Y  A  S  M  V  I      p.140

          .         .         .         .         .         .       g.8093
 GTCTTCTACTGCAACACCTACTACATCATGGTGCTGGCCTGGGGCTTCTATTACCTGGTC       c.480
 V  F  Y  C  N  T  Y  Y  I  M  V  L  A  W  G  F  Y  Y  L  V         p.160

          .         .         .         .         .         .       g.8153
 AAGTCCTTTACCACCACGCTGCCCTGGGCCACATGTGGCCACACCTGGAACACTCCCGAC       c.540
 K  S  F  T  T  T  L  P  W  A  T  C  G  H  T  W  N  T  P  D         p.180

          .         .         .         .         .         .       g.8213
 TGCGTGGAGATCTTCCGCCATGAAGACTGTGCCAATGCCAGCCTGGCCAACCTCACCTGT       c.600
 C  V  E  I  F  R  H  E  D  C  A  N  A  S  L  A  N  L  T  C         p.200

          .         .         .         .     | 04   .         .    g.8694
 GACCAGCTTGCTGACCGCCGGTCCCCTGTCATCGAGTTCTGGGA | GAACAAAGTCTTGAGG    c.660
 D  Q  L  A  D  R  R  S  P  V  I  E  F  W  E  |  N  K  V  L  R      p.220

          .         .         .         .         .         .       g.8754
 CTGTCTGGGGGACTGGAGGTGCCAGGGGCCCTCAACTGGGAGGTGACCCTTTGTCTGCTG       c.720
 L  S  G  G  L  E  V  P  G  A  L  N  W  E  V  T  L  C  L  L         p.240

          .         .         .         .         .        | 05.    g.9747
 GCCTGCTGGGTGCTGGTCTACTTCTGTGTCTGGAAGGGGGTCAAATCCACGGGAAAG | ATC    c.780
 A  C  W  V  L  V  Y  F  C  V  W  K  G  V  K  S  T  G  K   | I      p.260

          .         .         .         .         .         .       g.9807
 GTGTACTTCACTGCTACATTCCCCTACGTGGTCCTGGTCGTGCTGCTGGTGCGTGGAGTG       c.840
 V  Y  F  T  A  T  F  P  Y  V  V  L  V  V  L  L  V  R  G  V         p.280

          .         .         .         .         .         .       g.9867
 CTGCTGCCTGGCGCCCTGGATGGCATCATTTACTATCTCAAGCCTGACTGGTCAAAGCTG       c.900
 L  L  P  G  A  L  D  G  I  I  Y  Y  L  K  P  D  W  S  K  L         p.300

          .   | 06     .         .         .         .         .    g.10014
 GGGTCCCCTCAG | GTGTGGATAGATGCGGGGACCCAGATTTTCTTTTCTTACGCCATTGGC    c.960
 G  S  P  Q   | V  W  I  D  A  G  T  Q  I  F  F  S  Y  A  I  G      p.320

          .         .         .         .         .       | 07 .    g.10169
 CTGGGGGCCCTCACAGCCCTGGGCAGCTACAACCGCTTCAACAACAACTGCTACAA | GGAC    c.1020
 L  G  A  L  T  A  L  G  S  Y  N  R  F  N  N  N  C  Y  K  |  D      p.340

          .         .         .         .         .         .       g.10229
 GCCATCATCCTGGCTCTCATCAACAGTGGGACCAGCTTCTTTGCTGGCTTCGTGGTCTTC       c.1080
 A  I  I  L  A  L  I  N  S  G  T  S  F  F  A  G  F  V  V  F         p.360

          .         .         .         .         .         .       g.10289
 TCCATCCTGGGCTTCATGGCTGCAGAGCAGGGCGTGCACATCTCCAAGGTGGCAGAGTCA       c.1140
 S  I  L  G  F  M  A  A  E  Q  G  V  H  I  S  K  V  A  E  S         p.380

   | 08      .         .         .         .         .         .    g.10667
 G | GGCCGGGCCTGGCCTTCATCGCCTACCCGCGGGCTGTCACGCTGATGCCAGTGGCCCCA    c.1200
 G |   P  G  L  A  F  I  A  Y  P  R  A  V  T  L  M  P  V  A  P      p.400

          .         .         .         .         .     | 09   .    g.10839
 CTCTGGGCTGCCCTGTTCTTCTTCATGCTGTTGCTGCTTGGTCTCGACAGCCAG | TTTGTA    c.1260
 L  W  A  A  L  F  F  F  M  L  L  L  L  G  L  D  S  Q   | F  V      p.420

          .         .         .         .         .         .       g.10899
 GGTGTGGAGGGCTTCATCACCGGCCTCCTCGACCTCCTCCCGGCCTCCTACTACTTCCGT       c.1320
 G  V  E  G  F  I  T  G  L  L  D  L  L  P  A  S  Y  Y  F  R         p.440

          .         .         .         .         .         .       g.10959
 TTCCAAAGGGAGATCTCTGTGGCCCTCTGTTGTGCCCTCTGCTTTGTCATCGATCTCTCC       c.1380
 F  Q  R  E  I  S  V  A  L  C  C  A  L  C  F  V  I  D  L  S         p.460

          .   | 10     .         .         .         .         .    g.11095
 ATGGTGACTGAT | GGCGGGATGTACGTCTTCCAGCTGTTTGACTACTACTCGGCCAGCGGC    c.1440
 M  V  T  D   | G  G  M  Y  V  F  Q  L  F  D  Y  Y  S  A  S  G      p.480

          .         .         .         .         .      | 11  .    g.11241
 ACCACCCTGCTCTGGCAGGCCTTTTGGGAGTGCGTGGTGGTGGCCTGGGTGTACG | GAGCT    c.1500
 T  T  L  L  W  Q  A  F  W  E  C  V  V  V  A  W  V  Y  G |   A      p.500

          .         .         .         .         .         .       g.11301
 GACCGCTTCATGGACGACATTGCCTGTATGATCGGGTACCGACCTTGCCCCTGGATGAAA       c.1560
 D  R  F  M  D  D  I  A  C  M  I  G  Y  R  P  C  P  W  M  K         p.520

          .         .         .       | 12 .         .         .    g.11446
 TGGTGCTGGTCCTTCTTCACCCCGCTGGTCTGCATG | GGCATCTTCATCTTCAACGTTGTG    c.1620
 W  C  W  S  F  F  T  P  L  V  C  M   | G  I  F  I  F  N  V  V      p.540

          .         .         .         .         .         .       g.11506
 TACTACGAGCCGCTGGTCTACAACAACACCTACGTGTACCCGTGGTGGGGTGAGGCCATG       c.1680
 Y  Y  E  P  L  V  Y  N  N  T  Y  V  Y  P  W  W  G  E  A  M         p.560

          .         .         .         .         .         .       g.11566
 GGCTGGGCCTTCGCCCTGTCCTCCATGCTGTGCGTGCCGCTGCACCTCCTGGGCTGCCTC       c.1740
 G  W  A  F  A  L  S  S  M  L  C  V  P  L  H  L  L  G  C  L         p.580

          .         .        | 13.         .         .         .    g.11810
 CTCAGGGCCAAGGGCACCATGGCTGAG | CGCTGGCAGCACCTGACCCAGCCCATCTGGGGC    c.1800
 L  R  A  K  G  T  M  A  E   | R  W  Q  H  L  T  Q  P  I  W  G      p.600

          .         .         .         .         .         .       g.11870
 CTCCACCACTTGGAGTACCGAGCTCAGGACGCAGATGTCAGGGGCCTGACCACCCTGACC       c.1860
 L  H  H  L  E  Y  R  A  Q  D  A  D  V  R  G  L  T  T  L  T         p.620

          .         .         .         .                           g.11918
 CCAGTGTCCGAGAGCAGCAAGGTCGTCGTGGTGGAGAGTGTCATGTGA                   c.1908
 P  V  S  E  S  S  K  V  V  V  V  E  S  V  M  X                     p.635

          .         .         .         .         .         .       g.11978
 caactcagctcacatcaccagctcacctctggtagccatagcagcccctgcttcagcccc       c.*60

          .         .         .         .         .         .       g.12038
 accgcacccctccagggggcctgcctttccctgacacttttggggtctgcctgggggagg       c.*120

          .         .         .         .         .         .       g.12098
 aggggagaaagcaccatgagtgctcactaaaacaactttttccatttttaataaaacgcc       c.*180

          .         .         .         .         .         .       g.12158
 aaaaatatcacaacccaccaaaaatagatgcctctccccctccagccctagccgagctgg       c.*240

          .         .         .         .         .         .       g.12218
 tcctaggccccgcctagtgccccacccccacccacagtgctgcactcctcctgcccctgc       c.*300

          .         .         .         .         .         .       g.12278
 cacgcccaccccctgcccacctctccaggctctgctctgcagcacacccgtgggtgaccc       c.*360

          .         .         .         .         .         .       g.12338
 ctcaccccagaagcagcagtggcagcttgggaaatgtgaggaagggaaggagggagagac       c.*420

          .         .         .         .         .         .       g.12398
 gggagggaggagagagaggagaagggaggcaggggaggggcagcagaaccaaggcaaata       c.*480

          .         .         .         .         .         .       g.12458
 tttcagctgggctatacccctctccccatccctgttatagaagcttagagagccagccag       c.*540

          .         .         .         .         .         .       g.12518
 caatggaaccttctggttcctgcgccaatcgccaccagtatcaattgtgtgagcttgggt       c.*600

          .         .         .         .         .         .       g.12578
 gcgagtgcacgcgtgcgtgagtacggagagtatatatagatctctatctcttagcaaagg       c.*660

          .         .         .         .         .         .       g.12638
 tgaatgccagatgtaaatggcgcctctgggcaaaggaggcttgtattttgcacattttat       c.*720

          .         .         .         .         .         .       g.12698
 aaaaacttgagagaatgagatttctgcttgtatatttctaaaaagaggaaggagcccaaa       c.*780

          .         .         .         .         .         .       g.12758
 ccatcctctccttaccactcccatccctgtgagccctaccttacccctctgcccctagcc       c.*840

          .         .         .         .         .         .       g.12818
 aaggagtgtgaatttatagatctaactttcataggcaaaacaaaagcttcgagctgttgc       c.*900

          .         .         .         .         .         .       g.12878
 gtgtgtgagtctgttgtgtggatgtgcgtgtgtggtccccagccccagactggattggaa       c.*960

          .         .         .         .         .         .       g.12938
 aagtgcatggtgggggcctcggggctgtccccacgctgtccctttgccacaagtctgtgg       c.*1020

          .         .         .         .         .         .       g.12998
 ggcaagaggctgcaatattccgtcctgggtgtctgggctgctaacctggcctgctcaggc       c.*1080

          .         .         .         .         .         .       g.13058
 ttcccaccctgtgcggggcacacccccaggaagggaccctggacacggctcccacgtcca       c.*1140

          .         .         .         .         .         .       g.13118
 ggcttaaggtggatgcacttcccgcacctccagtcttctgtgtagcagctttaacccacg       c.*1200

          .         .         .         .         .         .       g.13178
 tttgtctgtcacgtccagtcccgagacggctgagtgaccccaagaaaggcttccccgaca       c.*1260

          .         .         .         .         .         .       g.13238
 cccagacagaggctgcagggctggggctgggtgagggtggcgggcctgcggggacattct       c.*1320

          .         .         .         .         .                 g.13297
 actgtgctaaaaagccactgcagacatagcaataaaaacatgtcattttccaaagcagg        c.*1379

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier family 6 (neurotransmitter transporter, creatine), member 8 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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