solute carrier organic anion transporter family, member 1B1 (SLCO1B1) - coding DNA reference sequence

(used for variant description)

(last modified November 30, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_006446.4 in the SLCO1B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011745.1, covering SLCO1B1 transcript NM_006446.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .         | 02    g.15321
                 aaagggtggacttgttgcagttgctgtaggattctaaatccag | g    c.-61

 .         .         .         .         .         .                g.15381
 tgattgtttcaaactgagcatcaacaacaaaaacatttgtatgatatctatatttcaatc       c.-1

          .         .         .         .         .         .       g.15441
 ATGGACCAAAATCAACATTTGAATAAAACAGCAGAGGCACAACCTTCAGAGAATAAGAAA       c.60
 M  D  Q  N  Q  H  L  N  K  T  A  E  A  Q  P  S  E  N  K  K         p.20

          .         .     | 03   .         .         .         .    g.46492
 ACAAGATACTGCAATGGATTGAAG | ATGTTCTTGGCAGCTCTGTCACTCAGCTTTATTGCT    c.120
 T  R  Y  C  N  G  L  K   | M  F  L  A  A  L  S  L  S  F  I  A      p.40

          .         .         .         .         .         .       g.46552
 AAGACACTAGGTGCAATTATTATGAAAAGTTCCATCATTCATATAGAACGGAGATTTGAG       c.180
 K  T  L  G  A  I  I  M  K  S  S  I  I  H  I  E  R  R  F  E         p.60

          .         .         .         .       | 04 .         .    g.48397
 ATATCCTCTTCTCTTGTTGGTTTTATTGACGGAAGCTTTGAAATTG | GAAATTTGCTTGTG    c.240
 I  S  S  S  L  V  G  F  I  D  G  S  F  E  I  G |   N  L  L  V      p.80

          .         .         .         .         .         .       g.48457
 ATTGTATTTGTGAGTTACTTTGGATCCAAACTACATAGACCAAAGTTAATTGGAATCGGT       c.300
 I  V  F  V  S  Y  F  G  S  K  L  H  R  P  K  L  I  G  I  G         p.100

          .         .         .         .         .          | 05    g.50583
 TGTTTCATTATGGGAATTGGAGGTGTTTTGACTGCTTTGCCACATTTCTTCATGGGATA | T    c.360
 C  F  I  M  G  I  G  G  V  L  T  A  L  P  H  F  F  M  G  Y  |      p.120

          .         .         .         .         .         .       g.50643
 TACAGGTATTCTAAAGAAACTAATATCAATTCATCAGAAAATTCAACATCGACCTTATCC       c.420
 Y  R  Y  S  K  E  T  N  I  N  S  S  E  N  S  T  S  T  L  S         p.140

          .         .         .         .         .         .       g.50703
 ACTTGTTTAATTAATCAAATTTTATCACTCAATAGAGCATCACCTGAGATAGTGGGAAAA       c.480
 T  C  L  I  N  Q  I  L  S  L  N  R  A  S  P  E  I  V  G  K         p.160

   | 06      .         .         .         .         .         .    g.52441
 G | GTTGTTTAAAGGAATCTGGGTCATACATGTGGATATATGTGTTCATGGGTAATATGCTT    c.540
 G |   C  L  K  E  S  G  S  Y  M  W  I  Y  V  F  M  G  N  M  L      p.180

          .         .         .         .         .         .       g.52501
 CGTGGAATAGGGGAGACTCCCATAGTACCATTGGGGCTTTCTTACATTGATGATTTCGCT       c.600
 R  G  I  G  E  T  P  I  V  P  L  G  L  S  Y  I  D  D  F  A         p.200

          .         .         | 07         .         .         .    g.52760
 AAAGAAGGACATTCTTCTTTGTATTTAG | GTATATTGAATGCAATAGCAATGATTGGTCCA    c.660
 K  E  G  H  S  S  L  Y  L  G |   I  L  N  A  I  A  M  I  G  P      p.220

          .         .         .         .         .         .       g.52820
 ATCATTGGCTTTACCCTGGGATCTCTGTTTTCTAAAATGTACGTGGATATTGGATATGTA       c.720
 I  I  G  F  T  L  G  S  L  F  S  K  M  Y  V  D  I  G  Y  V         p.240

         | 08.         .         .         .         .         .    g.70805
 GATCTAA | GCACTATCAGGATAACTCCTACTGATTCTCGATGGGTTGGAGCTTGGTGGCTT    c.780
 D  L  S |   T  I  R  I  T  P  T  D  S  R  W  V  G  A  W  W  L      p.260

          .         .         .         .         .         .       g.70865
 AATTTCCTTGTGTCTGGACTATTCTCCATTATTTCTTCCATACCATTCTTTTTCTTGCCC       c.840
 N  F  L  V  S  G  L  F  S  I  I  S  S  I  P  F  F  F  L  P         p.280

          .         .         .         .         .         .       g.70925
 CAAACTCCAAATAAACCACAAAAAGAAAGAAAAGCTTCACTGTCTTTGCATGTGCTGGAA       c.900
 Q  T  P  N  K  P  Q  K  E  R  K  A  S  L  S  L  H  V  L  E         p.300

          .         .         .         .         .         .       g.70985
 ACAAATGATGAAAAGGATCAAACAGCTAATTTGACCAATCAAGGAAAAAATATTACCAAA       c.960
 T  N  D  E  K  D  Q  T  A  N  L  T  N  Q  G  K  N  I  T  K         p.320

          . | 09       .         .         .         .         .    g.74364
 AATGTGACTG | GTTTTTTCCAGTCTTTTAAAAGCATCCTTACTAATCCCCTGTATGTTATG    c.1020
 N  V  T  G |   F  F  Q  S  F  K  S  I  L  T  N  P  L  Y  V  M      p.340

          .         .         .         .         .         .       g.74424
 TTTGTGCTTTTGACGTTGTTACAAGTAAGCAGCTATATTGGTGCTTTTACTTATGTCTTC       c.1080
 F  V  L  L  T  L  L  Q  V  S  S  Y  I  G  A  F  T  Y  V  F         p.360

          .         .         .         .         .      | 10  .    g.76302
 AAATACGTAGAGCAACAGTATGGTCAGCCTTCATCTAAGGCTAACATCTTATTGG | GAGTC    c.1140
 K  Y  V  E  Q  Q  Y  G  Q  P  S  S  K  A  N  I  L  L  G |   V      p.380

          .         .         .         .         .         .       g.76362
 ATAACCATACCTATTTTTGCAAGTGGAATGTTTTTAGGAGGATATATCATTAAAAAATTC       c.1200
 I  T  I  P  I  F  A  S  G  M  F  L  G  G  Y  I  I  K  K  F         p.400

          .         .         .         .         .         .       g.76422
 AAACTGAACACCGTTGGAATTGCCAAATTCTCATGTTTTACTGCTGTGATGTCATTGTCC       c.1260
 K  L  N  T  V  G  I  A  K  F  S  C  F  T  A  V  M  S  L  S         p.420

          .         .         .         .         .         .       g.76482
 TTTTACCTATTATATTTTTTCATACTCTGTGAAAACAAATCAGTTGCCGGACTAACCATG       c.1320
 F  Y  L  L  Y  F  F  I  L  C  E  N  K  S  V  A  G  L  T  M         p.440

          .  | 11      .         .         .         .         .    g.79723
 ACCTATGATGG | AAATAATCCAGTGACATCTCATAGAGATGTACCACTTTCTTATTGCAAC    c.1380
 T  Y  D  G  |  N  N  P  V  T  S  H  R  D  V  P  L  S  Y  C  N      p.460

          .         .         .         .         .         .       g.79783
 TCAGACTGCAATTGTGATGAAAGTCAATGGGAACCAGTCTGTGGAAACAATGGAATAACT       c.1440
 S  D  C  N  C  D  E  S  Q  W  E  P  V  C  G  N  N  G  I  T         p.480

          .         .         .         .         .        | 12.    g.90928
 TACATCTCACCCTGTCTAGCAGGTTGCAAATCTTCAAGTGGCAATAAAAAGCCTATA | GTG    c.1500
 Y  I  S  P  C  L  A  G  C  K  S  S  S  G  N  K  K  P  I   | V      p.500

          .         .         .         .         .         .       g.90988
 TTTTACAACTGCAGTTGTTTGGAAGTAACTGGTCTCCAGAACAGAAATTACTCAGCCCAT       c.1560
 F  Y  N  C  S  C  L  E  V  T  G  L  Q  N  R  N  Y  S  A  H         p.520

          .         .         .         .         .         .       g.91048
 TTGGGTGAATGCCCAAGAGATGATGCTTGTACAAGGAAATTTTACTTTTTTGTTGCAATA       c.1620
 L  G  E  C  P  R  D  D  A  C  T  R  K  F  Y  F  F  V  A  I         p.540

          .         .         .         .         .         .       g.91108
 CAAGTCTTGAATTTATTTTTCTCTGCACTTGGAGGCACCTCACATGTCATGCTGATTGTT       c.1680
 Q  V  L  N  L  F  F  S  A  L  G  G  T  S  H  V  M  L  I  V         p.560

    | 13     .         .         .         .         .         .    g.96164
 AA | AATTGTTCAACCTGAATTGAAATCACTTGCACTGGGTTTCCACTCAATGGTTATACGA    c.1740
 K  |  I  V  Q  P  E  L  K  S  L  A  L  G  F  H  S  M  V  I  R      p.580

         | 14.         .         .         .         .         .    g.98581
 GCACTAG | GAGGAATTCTAGCTCCAATATATTTTGGGGCTCTGATTGATACAACGTGTATA    c.1800
 A  L  G |   G  I  L  A  P  I  Y  F  G  A  L  I  D  T  T  C  I      p.600

          .         .         .         .         .         .       g.98641
 AAGTGGTCCACCAACAACTGTGGCACACGTGGGTCATGTAGGACATATAATTCCACATCA       c.1860
 K  W  S  T  N  N  C  G  T  R  G  S  C  R  T  Y  N  S  T  S         p.620

       | 15  .         .         .         .         .         .    g.112840
 TTTTC | AAGGGTCTACTTGGGCTTGTCTTCAATGTTAAGAGTCTCATCACTTGTTTTATAT    c.1920
 F  S  |  R  V  Y  L  G  L  S  S  M  L  R  V  S  S  L  V  L  Y      p.640

          .         .         .         .         .         .       g.112900
 ATTATATTAATTTATGCCATGAAGAAAAAATATCAAGAGAAAGATATCAATGCATCAGAA       c.1980
 I  I  L  I  Y  A  M  K  K  K  Y  Q  E  K  D  I  N  A  S  E         p.660

          .         .         .         .         .         .       g.112960
 AATGGAAGTGTCATGGATGAAGCAAACTTAGAATCCTTAAATAAAAATAAACATTTTGTC       c.2040
 N  G  S  V  M  D  E  A  N  L  E  S  L  N  K  N  K  H  F  V         p.680

          .         .         .                                     g.112996
 CCTTCTGCTGGGGCAGATAGTGAAACACATTGTTAA                               c.2076
 P  S  A  G  A  D  S  E  T  H  C  X                                 p.691

          .         .         .         .         .         .       g.113056
 ggggagaaaaaaagccacttctgcttctgtgtttccaaacagcattgcattgattcagta       c.*60

          .         .         .         .         .         .       g.113116
 agatgttatttttgaggagttcctggtcctttcactaagaatttccacatcttttatggt       c.*120

          .         .         .         .         .         .       g.113176
 ggaagtataaataagcctatgaacttataataaaacaaactgtaggtagaaaaaatgaga       c.*180

          .         .         .         .         .         .       g.113236
 gtactcattgttacattatagctacatatttgtggttaaggttagactatatgatccata       c.*240

          .         .         .         .         .         .       g.113296
 caaattaaagtgagagacatggttactgtgtaataaaagaaaaaatacttgttcaggtaa       c.*300

          .         .         .         .         .         .       g.113356
 ttctaattcttaataaaacaaatgagtatcatacaggtagaggttaaaaaggaggagcta       c.*360

          .         .         .         .         .         .       g.113416
 gattcatatcctaagtaaagagaaatgcctagtgtctattttattaaacaaacaaacaca       c.*420

          .         .         .         .         .         .       g.113476
 gagtttgaactataatactaaggcctgaagtctagcttggatatatgctacaataatatc       c.*480

          .         .         .         .         .         .       g.113536
 tgttactcacataaaattatatatttcacagactttatcaatgtataattaacaattatc       c.*540

          .         .         .         .         .         .       g.113596
 ttgtttaagtaaatttagaatacatttaagtattgtggaagaaataaagacattccaata       c.*600

                                                                    g.113603
 tttgcaa                                                            c.*607

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Solute carrier organic anion transporter family, member 1B1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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