SMAD family member 3 (SMAD3) - coding DNA reference sequence

(used for variant description)

(last modified December 10, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_005902.3 in the SMAD3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011990.1, covering SMAD3 transcript NM_005902.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   gcggccgccgcctccgccccgcgttcggggccttcccgaccctgcactgctgccgtcc       c.-241

 .         .         .         .         .         .                g.5118
 gcccgcccggccgctcttctcttcgccgtgggagccgctccgggcgcagggccgcgcgcc       c.-181

 .         .         .         .         .         .                g.5178
 gagccccgcaggctgcagcgccgcggcccggcccggcgccccggcaacttcgccgagagt       c.-121

 .         .         .         .         .         .                g.5238
 tgaggcgaagtttgggcgaccgcggcaggccccggccgagctcccctctgcgcccccggc       c.-61

 .         .         .         .         .         .                g.5298
 gtcccgtcgagcccagccccgccgggggcgctcctcgccgcccgcgcgccctccccagcc       c.-1

          .         .         .         .         .         .       g.5358
 ATGTCGTCCATCCTGCCTTTCACTCCCCCGATCGTGAAGCGCCTGCTGGGCTGGAAGAAG       c.60
 M  S  S  I  L  P  F  T  P  P  I  V  K  R  L  L  G  W  K  K         p.20

          .         .         .         .         .         .       g.5418
 GGCGAGCAGAACGGGCAGGAGGAGAAATGGTGCGAGAAGGCGGTCAAGAGCCTGGTCAAG       c.120
 G  E  Q  N  G  Q  E  E  K  W  C  E  K  A  V  K  S  L  V  K         p.40

          .         .         .         .         .         .       g.5478
 AAACTCAAGAAGACGGGGCAGCTGGACGAGCTGGAGAAGGCCATCACCACGCAGAACGTC       c.180
 K  L  K  K  T  G  Q  L  D  E  L  E  K  A  I  T  T  Q  N  V         p.60

          .         .       | 02 .         .         .         .    g.104072
 AACACCAAGTGCATCACCATCCCCAG | GTCCCTGGATGGCCGGTTGCAGGTGTCCCATCGG    c.240
 N  T  K  C  I  T  I  P  R  |  S  L  D  G  R  L  Q  V  S  H  R      p.80

          .         .         .         .         .         .       g.104132
 AAGGGGCTCCCTCATGTCATCTACTGCCGCCTGTGGCGATGGCCAGACCTGCACAGCCAC       c.300
 K  G  L  P  H  V  I  Y  C  R  L  W  R  W  P  D  L  H  S  H         p.100

          .         .         .         .         .         .       g.104192
 CACGAGCTACGGGCCATGGAGCTGTGTGAGTTCGCCTTCAATATGAAGAAGGACGAGGTC       c.360
 H  E  L  R  A  M  E  L  C  E  F  A  F  N  M  K  K  D  E  V         p.120

          .         .         .         . | 03       .         .    g.104416
 TGCGTGAATCCCTACCACTACCAGAGAGTAGAGACACCAG | TTCTACCTCCTGTGTTGGTG    c.420
 C  V  N  P  Y  H  Y  Q  R  V  E  T  P  V |   L  P  P  V  L  V      p.140

          .         .         .         .         .         .       g.104476
 CCACGCCACACAGAGATCCCGGCCGAGTTCCCCCCACTGGACGACTACAGCCATTCCATC       c.480
 P  R  H  T  E  I  P  A  E  F  P  P  L  D  D  Y  S  H  S  I         p.160

          .         .         .         .         .   | 04     .    g.105930
 CCCGAAAACACTAACTTCCCCGCAGGCATCGAGCCCCAGAGCAATATTCCAG | AGACCCCA    c.540
 P  E  N  T  N  F  P  A  G  I  E  P  Q  S  N  I  P  E |   T  P      p.180

          .         .         .         .         .         .       g.105990
 CCCCCTGGCTACCTGAGTGAAGATGGAGAAACCAGTGACCACCAGATGAACCACAGCATG       c.600
 P  P  G  Y  L  S  E  D  G  E  T  S  D  H  Q  M  N  H  S  M         p.200

         | 05.         .         .         .         .         | 06 g.120386
 GACGCAG | GTTCTCCAAACCTATCCCCGAATCCGATGTCCCCAGCACATAATAACTTGG | AC c.660
 D  A  G |   S  P  N  L  S  P  N  P  M  S  P  A  H  N  N  L  D |    p.220

          .         .         .         .         .         .       g.120446
 CTGCAGCCAGTTACCTACTGCGAGCCGGCCTTCTGGTGCTCCATCTCCTACTACGAGCTG       c.720
 L  Q  P  V  T  Y  C  E  P  A  F  W  C  S  I  S  Y  Y  E  L         p.240

          .         .         .         .         .         .       g.120506
 AACCAGCGCGTCGGGGAGACATTCCACGCCTCGCAGCCATCCATGACTGTGGATGGCTTC       c.780
 N  Q  R  V  G  E  T  F  H  A  S  Q  P  S  M  T  V  D  G  F         p.260

          .         .         .         .         .         .       g.120566
 ACCGACCCCTCCAATTCGGAGCGCTTCTGCCTAGGGCTGCTCTCCAATGTCAACAGGAAT       c.840
 T  D  P  S  N  S  E  R  F  C  L  G  L  L  S  N  V  N  R  N         p.280

          .         .         .  | 07      .         .         .    g.123899
 GCAGCAGTGGAGCTGACACGGAGACACATCG | GAAGAGGCGTGCGGCTCTACTACATCGGA    c.900
 A  A  V  E  L  T  R  R  H  I  G |   R  G  V  R  L  Y  Y  I  G      p.300

          .         .         .         .         .         .       g.123959
 GGGGAGGTCTTCGCAGAGTGCCTCAGTGACAGCGCTATTTTTGTCCAGTCTCCCAACTGT       c.960
 G  E  V  F  A  E  C  L  S  D  S  A  I  F  V  Q  S  P  N  C         p.320

          .         .         .         .          | 08        .    g.126519
 AACCAGCGCTATGGCTGGCACCCGGCCACCGTCTGCAAGATCCCACCAG | GATGCAACCTG    c.1020
 N  Q  R  Y  G  W  H  P  A  T  V  C  K  I  P  P  G |   C  N  L      p.340

          .         .         .         .         .         .       g.126579
 AAGATCTTCAACAACCAGGAGTTCGCTGCCCTCCTGGCCCAGTCGGTCAACCAGGGCTTT       c.1080
 K  I  F  N  N  Q  E  F  A  A  L  L  A  Q  S  V  N  Q  G  F         p.360

          .         .         .         .         .         .       g.126639
 GAGGCTGTCTACCAGTTGACCCGAATGTGCACCATCCGCATGAGCTTCGTCAAAGGCTGG       c.1140
 E  A  V  Y  Q  L  T  R  M  C  T  I  R  M  S  F  V  K  G  W         p.380

          .     | 09   .         .         .         .         .    g.129602
 GGAGCGGAGTACAG | GAGACAGACTGTGACCAGTACCCCCTGCTGGATTGAGCTGCACCTG    c.1200
 G  A  E  Y  R  |  R  Q  T  V  T  S  T  P  C  W  I  E  L  H  L      p.400

          .         .         .         .         .         .       g.129662
 AATGGGCCTTTGCAGTGGCTTGACAAGGTCCTCACCCAGATGGGCTCCCCAAGCATCCGC       c.1260
 N  G  P  L  Q  W  L  D  K  V  L  T  Q  M  G  S  P  S  I  R         p.420

          .                                                         g.129680
 TGTTCCAGTGTGTCTTAG                                                 c.1278
 C  S  S  V  S  X                                                   p.425

          .         .         .         .         .         .       g.129740
 agacatcaagtatggtaggggagggcaggcttggggaaaatggccatgcaggaggtggag       c.*60

          .         .         .         .         .         .       g.129800
 aaaattggaactctactcaacccattgttgtcaaggaagaagaaatctttctccctcaac       c.*120

          .         .         .         .         .         .       g.129860
 tgaaggggtgcacccacctgttttctgaaacacacgagcaaacccagaggtggatgttat       c.*180

          .         .         .         .         .         .       g.129920
 gaacagctgtgtctgccaaacacatttaccctttggccccactttgaagggcaagaaatg       c.*240

          .         .         .         .         .         .       g.129980
 gcgtctgctctggtggcttaagtgagcagaacaggtagtattacaccaccggccccctcc       c.*300

          .         .         .         .         .         .       g.130040
 ccccagactctttttttgagtgacagctttctgggatgtcacagtccaaccagaaacacc       c.*360

          .         .         .         .         .         .       g.130100
 cctctgtctaggactgcagtgtggagttcaccttggaagggcgttctaggtaggaagagc       c.*420

          .         .         .         .         .         .       g.130160
 ccgcagggccatgcagacctcatgcccagctctctgacgcttgtgacagtgcctcttcca       c.*480

          .         .         .         .         .         .       g.130220
 gtgaacattcccagcccagccccgccccgccccgccccaccactccagcagaccttgccc       c.*540

          .         .         .         .         .         .       g.130280
 cttgtgagctggatagacttgggatggggagggagggagttttgtctgtctccctcccct       c.*600

          .         .         .         .         .         .       g.130340
 ctcagaacatactgattgggaggtgcgtgttcagcagaacctgcacacaggacagcggga       c.*660

          .         .         .         .         .         .       g.130400
 aaaatcgatgagcgccacctctttaaaaactcacttacgtttgtcctttttcactttgaa       c.*720

          .         .         .         .         .         .       g.130460
 aagttggaaggatctgctgaggcccagtgcatatgcaatgtatagtgtctattatcacat       c.*780

          .         .         .         .         .         .       g.130520
 taatctcaaagagattcgaatgacggtaagtgttctcatgaagcaggaggcccttgtcgt       c.*840

          .         .         .         .         .         .       g.130580
 gggatggcatttggtctcaggcagcaccacactgggtgcgtctccagtcatctgtaagag       c.*900

          .         .         .         .         .         .       g.130640
 cttgctccagattctgatgcatacggctatattggtttatgtagtcagttgcattcatta       c.*960

          .         .         .         .         .         .       g.130700
 aatcaactttatcatatgctcttttaaatgtttggtttatatattttctttaaaaatcct       c.*1020

          .         .         .         .         .         .       g.130760
 gggctggcacattgactgggaaacctgagtgagacccagcaactgcttctctcccttctc       c.*1080

          .         .         .         .         .         .       g.130820
 tctcctgaggtgaagcttttccaggttttgttgaagagatacctgccagcacttctgcaa       c.*1140

          .         .         .         .         .         .       g.130880
 gctgaaatttacagaagcaaattcaccagaagggaaacatctcaggccaacataggcaaa       c.*1200

          .         .         .         .         .         .       g.130940
 tgaaaagggctattaaaatatttttacacctttgaaaattgcaggcttggtacaaagagg       c.*1260

          .         .         .         .         .         .       g.131000
 tctgtcatcttccccctgggatataagatgatctagctcccggtagaggatcaccggtga       c.*1320

          .         .         .         .         .         .       g.131060
 caactatagcagttgtattgtgtaacaagtactgctcccagcagcaattagggagaaaac       c.*1380

          .         .         .         .         .         .       g.131120
 tagtctaaattatttcaactggaaaaaagaaaaaagagtcctcttcttttcccagccttt       c.*1440

          .         .         .         .         .         .       g.131180
 tgcagaacacagtagacagaactgccaccttcaattggtactttattctttgctgctgtt       c.*1500

          .         .         .         .         .         .       g.131240
 tttgtataaaatgacctatcccacgtttttgcatgaatttatagcaggaaaaatcaaggg       c.*1560

          .         .         .         .         .         .       g.131300
 atttcctatggaagtcctgctttattccaggtgaagggaaggaagtgtatatacttttgg       c.*1620

          .         .         .         .         .         .       g.131360
 caagtcatacagctcaaatgtgatgagatttctgatgttagagggagatggagaggcttc       c.*1680

          .         .         .         .         .         .       g.131420
 ctgatgcctcatctgcagggtcctgtgcctctgaagttctagccatgaggtttccaggta       c.*1740

          .         .         .         .         .         .       g.131480
 ggacagctgctccccaagcctcctgaggacacaggaagagacggaaggagcaccttgaca       c.*1800

          .         .         .         .         .         .       g.131540
 gacttgtgtgagtcttctcgaaggagggttgactcagaacccagagacaatacaaaaccc       c.*1860

          .         .         .         .         .         .       g.131600
 ctcacttcctctgagagggccaaatgctgtgagtctgaagtatgtgcctggtgtgaaatg       c.*1920

          .         .         .         .         .         .       g.131660
 atctatggcctgtttcttacacaggaagccccctgaacctcctgtacatgtgttcatgtt       c.*1980

          .         .         .         .         .         .       g.131720
 cccagccagctctgagacccaggaaccaaatattccattttggcttctgctagagcagtc       c.*2040

          .         .         .         .         .         .       g.131780
 atggttcctctcctaaaagccatgggcagcagtttccgagggcctgcatgatccacctgc       c.*2100

          .         .         .         .         .         .       g.131840
 tgcacgatcctatgagggcttcctgtggcacacagccctctgggtgcttgggaactagct       c.*2160

          .         .         .         .         .         .       g.131900
 tcaggcacagcctgattctggtgatccagtgatctatggaagtcgtgtcttactccaggt       c.*2220

          .         .         .         .         .         .       g.131960
 gaagggggaaaaaaaaagcctatactttggcaggttatgaactttgaatgtgatgaaatg       c.*2280

          .         .         .         .         .         .       g.132020
 acacgtttggctgcatttggatggtgtcttagaaccctcattgctcagacctgaaggcta       c.*2340

          .         .         .         .         .         .       g.132080
 cttctaggagcatgaagtttgagttttgtgtttttccaaaggatacttccttggcccttt       c.*2400

          .         .         .         .         .         .       g.132140
 ttctttattgactagaccaccagaggaggatgtgtgggattgtaggcaaacccacctgtg       c.*2460

          .         .         .         .         .         .       g.132200
 gcatcactgaaaataaatttgatcatacctaagaggttaggaaatggtgccattcccacc       c.*2520

          .         .         .         .         .         .       g.132260
 ttagagtgctacataggtgctttgggcgtatgtaacattagtgtccttccttgaagccac       c.*2580

          .         .         .         .         .         .       g.132320
 aagctagttttcttagttttaaaatcctgttgtatgaatggcatttgtatattaaaacac       c.*2640

          .         .         .         .         .         .       g.132380
 ttttttaaaggacagttgaaaagggcaagaggaaaccagggcagttctagaggagtgctg       c.*2700

          .         .         .         .         .         .       g.132440
 gtgactggatagcagttttaagtggcgttcacctagtcaacacgaccgcgtgtgttgccc       c.*2760

          .         .         .         .         .         .       g.132500
 ctgccctgggctccccgccatgacatcttcaccttgcagcttgtgctgagactgacccaa       c.*2820

          .         .         .         .         .         .       g.132560
 gtgcagctagcactgggacacagatccttgtcttcagcaccttccaaggagccaactttt       c.*2880

          .         .         .         .         .         .       g.132620
 attccctttcctctctcccctccccacctcgcttcttcccaatttagtaacttagatgct       c.*2940

          .         .         .         .         .         .       g.132680
 tccagcacatacgtaggtagctaccccagccggtttggattacaggcctgtgctggaaca       c.*3000

          .         .         .         .         .         .       g.132740
 tcatctcagttggccaccttcctggcaggctgtagacctgacattttgagacaagcctag       c.*3060

          .         .         .         .         .         .       g.132800
 agtcaggagcagggactttgactcttaggaagagcacacatgagggcaaggctgctggca       c.*3120

          .         .         .         .         .         .       g.132860
 gacgtctccattgtccttatgttgtctgtgttgtatttttttttttttattgaccatggt       c.*3180

          .         .         .         .         .         .       g.132920
 gattatttttttaaaccatcgttaatatactgaagtgagctatagcacatatcatgtgct       c.*3240

          .         .         .         .         .         .       g.132980
 tagtttgtttatttttctccatctccccttggcttcctagagtttggacatattccaggc       c.*3300

          .         .         .         .         .         .       g.133040
 taaatgcttttactcaagactacagaaaggtttgaagtagtgtgtgcatggcatgcacgt       c.*3360

          .         .         .         .         .         .       g.133100
 atgtaagtaatctggggaagaagcaaagatctgtttcattcttagcctcaggcctcatga       c.*3420

          .         .         .         .         .         .       g.133160
 gggtctccacagggccggagctcaggttacaccactccttcgtccttacaggagatgtag       c.*3480

          .         .         .         .         .         .       g.133220
 ggagaagaatctgcaggctgcttgtaggactgttcaccaagggggataccagcagcaaga       c.*3540

          .         .         .         .         .         .       g.133280
 gagtgcacccgtttagccctggaccctgtttcttactgtgtgacttggctagagttggga       c.*3600

          .         .         .         .         .         .       g.133340
 gttcccccaaaataaacgtgtccccattttaccagaaccaaacctcaacacagcgaagct       c.*3660

          .         .         .         .         .         .       g.133400
 gtactgtctttgtgtggcaaagatgttcccttgtaggcccctttcaggtaaccgtcttca       c.*3720

          .         .         .         .         .         .       g.133460
 caatgtattttcatcacagtttaaggagcatcagccgcttctcaagtgggtagggaaagc       c.*3780

          .         .         .         .         .         .       g.133520
 agaaaaacgtacgcaagaggacatggatccaaaatgatgatgaagcatctcccatgggga       c.*3840

          .         .         .         .         .         .       g.133580
 ggtgatggtggggagatgatgggctaaacaggcaacttttcaaaaacacagctatcatag       c.*3900

          .         .         .         .         .         .       g.133640
 aaaagaaacttgcctcatgtaaactggattgagaaattctcagtgattctgcaatggatt       c.*3960

          .         .         .         .         .         .       g.133700
 tttttttaatgcagaagtaatgtatactctagtattctggtgtttttatatttatgtaat       c.*4020

          .         .         .         .         .         .       g.133760
 aatttcttaaaaccattcagacagataactatttaattttttttaagaaagttggaaagg       c.*4080

          .         .         .         .         .         .       g.133820
 tctctcctcccaaggacagtggctggaagagttggggcacagccagttctgaatgttggt       c.*4140

          .         .         .         .         .         .       g.133880
 ggagggtgtagtggctttttggctcagcatccagaaacaccaaaccaggctggctaaaca       c.*4200

          .         .         .         .         .         .       g.133940
 agtggccgcgtgtaaaaacagacagctctgagtcaaatctgggcccttccacaagggtcc       c.*4260

          .         .         .         .         .         .       g.134000
 tctgaaccaagccccactcccttgctaggggtgaaagcattacagagagatggagccatc       c.*4320

          .         .         .         .         .         .       g.134060
 tatccaagaagccttcactcaccttcactgctgctgttgcaactcggctgttctggactc       c.*4380

          .         .         .         .         .         .       g.134120
 tgatgtgtgtggagggatggggaatagaacattgactgtgttgattaccttcactattcg       c.*4440

          .         .         .         .         .         .       g.134180
 gccagcctgaccttttaataactttgtaaaaagcatgtatgtatttatagtgttttagat       c.*4500

          .         .         .         .         .         .       g.134240
 ttttctaacttttatatcttaaaagcagagcacctgtttaagcattgtacccctattgtt       c.*4560

          .         .         .         .         .         .       g.134300
 aaagatttgtgtcctctcattccctctcttcctcttgtaagtgcccttctaataaacttt       c.*4620

          .         .         .                                     g.134336
 tcatggaaaagctcctgtgccaggagctcagtctga                               c.*4656

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SMAD family member 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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