SMAD family member 6 (SMAD6) - coding DNA reference sequence

(used for variant description)

(last modified October 14, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_005585.4 in the SMAD6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012244.1, covering SMAD6 transcript NM_005585.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      cgatcgagggagctgagccgaga       c.-901

 .         .         .         .         .         .                g.5083
 gaaagagccgccgggcgctgcctcgccagacctcgctgggaccccggggccaccgggagg       c.-841

 .         .         .         .         .         .                g.5143
 cacttttgtggaggggggagggggggcgacctcggcagcctcggcgcacgaagcgtccga       c.-781

 .         .         .         .         .         .                g.5203
 gggcagcgtggggcgggctgcgacctctgcatcggtggactgcatttttaattaaggatt       c.-721

 .         .         .         .         .         .                g.5263
 cccagcagctctttgggatttttacagcttccactcatgtgttgacacccgcgtccagga       c.-661

 .         .         .         .         .         .                g.5323
 gaaactcgctccaagtgcatctagcgcctgggacctgagacggcgttggcctttcgtgca       c.-601

 .         .         .         .         .         .                g.5383
 tgcaaatccagggatttaggttttgtttgggatttccttttctttctttccttttttttt       c.-541

 .         .         .         .         .         .                g.5443
 tctttttgcagggagtaagaagggagctgggggtatcaacaagcctgcctttcggatcct       c.-481

 .         .         .         .         .         .                g.5503
 gcgggaaaagcccatgtagttaagcgctttggtttaaaaaaaaggcaaggtaaaggcagg       c.-421

 .         .         .         .         .         .                g.5563
 gctttccagacacatttaggggttcgcgcgagcgctttgtgctcatggaccagccgcaca       c.-361

 .         .         .         .         .         .                g.5623
 acttttgaaggctcgccggcccatgtggggtctttctggcggcgcgccgcctgcagcccc       c.-301

 .         .         .         .         .         .                g.5683
 cctaaagcgcgggggctggagttgttgagcagccccgccgctgtggtccatgtagccgct       c.-241

 .         .         .         .         .         .                g.5743
 ggccgcgcgcggactgcggctcggcgtgcgcgtgttcccggccgtcccgcctcggcgagc       c.-181

 .         .         .         .         .         .                g.5803
 tccctcatgttgtcgccctgcggcgccccttcgacgacaggctgtgcgcggtctgcacgg       c.-121

 .         .         .         .         .         .                g.5863
 cgctccgcggcggagcttcatgtggggctgcgacccgcgcagccggcgcctcgctgaggg       c.-61

 .         .         .         .         .         .                g.5923
 aacggacccccggtaaccggagaccgcctcccccccacccctggcgccaaaggatatcgt       c.-1

          .         .         .         .         .         .       g.5983
 ATGTTCAGGTCCAAACGCTCGGGGCTGGTGCGGCGACTTTGGCGAAGTCGTGTGGTCCCC       c.60
 M  F  R  S  K  R  S  G  L  V  R  R  L  W  R  S  R  V  V  P         p.20

          .         .         .         .         .         .       g.6043
 GACCGGGAGGAAGGCGGCAGCGGCGGCGGCGGTGGCGGCGACGAGGATGGGAGCTTGGGC       c.120
 D  R  E  E  G  G  S  G  G  G  G  G  G  D  E  D  G  S  L  G         p.40

          .         .         .         .         .         .       g.6103
 AGCCGAGCTGAGCCGGCCCCGCGGGCAAGAGAGGGCGGAGGCTGCGGCCGCTCCGAAGTC       c.180
 S  R  A  E  P  A  P  R  A  R  E  G  G  G  C  G  R  S  E  V         p.60

          .         .         .         .         .         .       g.6163
 CGCCCGGTAGCCCCGCGGCGGCCCCGGGACGCAGTGGGACAGCGAGGCGCCCAGGGCGCG       c.240
 R  P  V  A  P  R  R  P  R  D  A  V  G  Q  R  G  A  Q  G  A         p.80

          .         .         .         .         .         .       g.6223
 GGGAGGCGCCGGCGCGCAGGGGGCCCCCCGAGGCCCATGTCGGAGCCAGGGGCCGGCGCT       c.300
 G  R  R  R  R  A  G  G  P  P  R  P  M  S  E  P  G  A  G  A         p.100

          .         .         .         .         .         .       g.6283
 GGGAGCTCCCTGCTGGACGTGGCGGAGCCGGGAGGCCCGGGCTGGCTGCCCGAGAGTGAC       c.360
 G  S  S  L  L  D  V  A  E  P  G  G  P  G  W  L  P  E  S  D         p.120

          .         .         .         .         .         .       g.6343
 TGCGAGACGGTGACCTGCTGTCTCTTTTCGGAGCGGGACGCCGCCGGCGCGCCCCGGGAC       c.420
 C  E  T  V  T  C  C  L  F  S  E  R  D  A  A  G  A  P  R  D         p.140

          .         .         .         .         .         .       g.6403
 GCCAGCGACCCCCTGGCCGGGGCGGCCCTGGAGCCGGCGGGCGGCGGGCGGAGTCGCGAA       c.480
 A  S  D  P  L  A  G  A  A  L  E  P  A  G  G  G  R  S  R  E         p.160

          .         .         .         .         .         .       g.6463
 GCGCGCTCGCGGCTGCTGCTGCTGGAGCAGGAACTCAAAACCGTCACGTACTCGCTGCTG       c.540
 A  R  S  R  L  L  L  L  E  Q  E  L  K  T  V  T  Y  S  L  L         p.180

          .         .         .         .         .         .       g.6523
 AAGCGGCTCAAGGAGCGCTCGCTGGACACGCTGCTGGAGGCGGTGGAGTCCCGCGGCGGC       c.600
 K  R  L  K  E  R  S  L  D  T  L  L  E  A  V  E  S  R  G  G         p.200

          .         .         .         .         .         .       g.6583
 GTGCCGGGCGGCTGCGTGCTGGTGCCGCGCGCCGACCTCCGCCTGGGCGGCCAGCCCGCG       c.660
 V  P  G  G  C  V  L  V  P  R  A  D  L  R  L  G  G  Q  P  A         p.220

          .         .         .         .         .         .       g.6643
 CCGCCGCAGCTGCTGCTCGGCCGCCTCTTTCGCTGGCCCGACCTGCAGCACGCCGTGGAG       c.720
 P  P  Q  L  L  L  G  R  L  F  R  W  P  D  L  Q  H  A  V  E         p.240

          .         .         .         .         .         .       g.6703
 CTGAAGCCCCTGTGCGGCTGCCACAGCTTCGCCGCCGCCGCCGACGGCCCTACCGTGTGC       c.780
 L  K  P  L  C  G  C  H  S  F  A  A  A  A  D  G  P  T  V  C         p.260

          .         .         .        | 02.         .         .    g.14355
 TGCAACCCCTACCACTTCAGCCGGCTCTGCGGGCCCG | AATCTCCGCCACCTCCCTACTCT    c.840
 C  N  P  Y  H  F  S  R  L  C  G  P  E |   S  P  P  P  P  Y  S      p.280

          .         .         .     | 03   .         .         .    g.19111
 CGGCTGTCTCCTCGCGACGAGTACAAGCCACTGG | ATCTGTCCGATTCCACATTGTCTTAC    c.900
 R  L  S  P  R  D  E  Y  K  P  L  D |   L  S  D  S  T  L  S  Y      p.300

          .         .         .         .         .   | 04     .    g.83669
 ACTGAAACGGAGGCTACCAACTCCCTCATCACTGCTCCGGGTGAATTCTCAG | ACGCCAGC    c.960
 T  E  T  E  A  T  N  S  L  I  T  A  P  G  E  F  S  D |   A  S      p.320

          .         .         .         .         .         .       g.83729
 ATGTCTCCGGACGCCACCAAGCCGAGCCACTGGTGCAGCGTGGCGTACTGGGAGCACCGG       c.1020
 M  S  P  D  A  T  K  P  S  H  W  C  S  V  A  Y  W  E  H  R         p.340

          .         .         .         .         .         .       g.83789
 ACGCGCGTGGGCCGCCTCTATGCGGTGTACGACCAGGCCGTCAGCATCTTCTACGACCTA       c.1080
 T  R  V  G  R  L  Y  A  V  Y  D  Q  A  V  S  I  F  Y  D  L         p.360

          .         .         .         .         .         .       g.83849
 CCTCAGGGCAGCGGCTTCTGCCTGGGCCAGCTCAACCTGGAGCAGCGCAGCGAGTCGGTG       c.1140
 P  Q  G  S  G  F  C  L  G  Q  L  N  L  E  Q  R  S  E  S  V         p.380

          .         .         .         .         .         .       g.83909
 CGGCGAACGCGCAGCAAGATCGGCTTCGGCATCCTGCTCAGCAAGGAGCCCGACGGCGTG       c.1200
 R  R  T  R  S  K  I  G  F  G  I  L  L  S  K  E  P  D  G  V         p.400

          .         .         .         .         .         .       g.83969
 TGGGCCTACAACCGCGGCGAGCACCCCATCTTCGTCAACTCCCCGACGCTGGACGCGCCC       c.1260
 W  A  Y  N  R  G  E  H  P  I  F  V  N  S  P  T  L  D  A  P         p.420

          .         .         .         .         .         .       g.84029
 GGCGGCCGCGCCCTGGTCGTGCGCAAGGTGCCCCCCGGCTACTCCATCAAGGTGTTCGAC       c.1320
 G  G  R  A  L  V  V  R  K  V  P  P  G  Y  S  I  K  V  F  D         p.440

          .         .         .         .         .         .       g.84089
 TTCGAGCGCTCGGGCCTGCAGCACGCGCCCGAGCCCGACGCCGCCGACGGCCCCTACGAC       c.1380
 F  E  R  S  G  L  Q  H  A  P  E  P  D  A  A  D  G  P  Y  D         p.460

          .         .         .         .         .         .       g.84149
 CCCAACAGCGTCCGCATCAGCTTCGCCAAGGGCTGGGGGCCCTGCTACTCCCGGCAGTTC       c.1440
 P  N  S  V  R  I  S  F  A  K  G  W  G  P  C  Y  S  R  Q  F         p.480

          .         .         .         .         .                 g.84200
 ATCACCTCCTGCCCCTGCTGGCTGGAGATCCTCCTCAACAACCCCAGATAG                c.1491
 I  T  S  C  P  C  W  L  E  I  L  L  N  N  P  R  X                  p.496

          .         .         .         .         .         .       g.84260
 tggcggccccggcgggaggggcgggtgggaggccgcggccaccgccacctgccggcctcg       c.*60

          .         .         .         .         .         .       g.84320
 agaggggccgatgcccagagacacagcccccacggacaaaaccccccagatatcatctac       c.*120

          .         .         .         .         .         .       g.84380
 ctagatttaatataaagttttatatattatatggaaatatatattatacttgtaattatg       c.*180

          .         .         .         .         .         .       g.84440
 gagtcatttttacaatgtaattatttatgtatggtgcaatgtgtgtatatggacaaaaca       c.*240

          .         .         .         .         .         .       g.84500
 agaaagacgcactttggcttataattctttcaatacagatatattttctttctcttcctc       c.*300

          .         .         .         .         .         .       g.84560
 cttcctcttccttactttttatatatatatataaagaaaatgatacagcagagctaggtg       c.*360

          .         .         .         .         .         .       g.84620
 gaaaagcctgggtttggtgtatggtttttgagatattaatgcccagacaaaaagctaata       c.*420

          .         .         .         .                           g.84665
 ccagtcactcgataataaagtattcgcattatagttttttttaaa                      c.*465

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SMAD family member 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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