SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (SMARCE1) - coding DNA reference sequence

(used for variant description)

(last modified September 3, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_003079.4 in the SMARCE1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032163.1, covering SMARCE1 transcript NM_003079.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         gctc       c.-121

 .         .         .         .         .         .                g.5064
 cggacgcgaggggcggggcgagcgcgggacaaagggaagcgaagccggagctgcgggcgc       c.-61

 .         .     | 02   .         .         .         .             g.7049
 tttttctgcccgcgg | tgtctcagattcattcttaaggaactgagaacttaatcttccaaa    c.-1

         | 03.         .         .         .         .  | 04      . g.10301
 ATGTCAA | AAAGACCATCTTATGCCCCACCTCCCACCCCAGCTCCTGCAACA | CAAATGCCC c.60
 M  S  K |   R  P  S  Y  A  P  P  P  T  P  A  P  A  T   | Q  M  P   p.20

          .         .         .         .         .         .       g.10361
 AGCACACCAGGGTTTGTGGGATACAATCCATACAGTCATCTCGCCTACAACAACTACAGG       c.120
 S  T  P  G  F  V  G  Y  N  P  Y  S  H  L  A  Y  N  N  Y  R         p.40

          .         .         .       | 05 .         .         .    g.15303
 CTGGGAGGGAACCCGGGCACCAACAGCCGGGTCACG | GCATCCTCTGGTATCACGATTCCA    c.180
 L  G  G  N  P  G  T  N  S  R  V  T   | A  S  S  G  I  T  I  P      p.60

          .         .         .         .         .        | 06.    g.16328
 AAACCCCCAAAGCCACCAGATAAGCCGCTGATGCCCTACATGAGGTACAGCAGAAAG | GTC    c.240
 K  P  P  K  P  P  D  K  P  L  M  P  Y  M  R  Y  S  R  K   | V      p.80

          .         .         .         .         .         .       g.16388
 TGGGACCAAGTAAAGGCTTCCAACCCTGACCTAAAGTTGTGGGAGATTGGCAAGATTATT       c.300
 W  D  Q  V  K  A  S  N  P  D  L  K  L  W  E  I  G  K  I  I         p.100

          .         .         .         .         .         .       g.16448
 GGTGGCATGTGGCGAGATCTCACTGATGAAGAAAAACAAGAATATTTAAACGAATACGAA       c.360
 G  G  M  W  R  D  L  T  D  E  E  K  Q  E  Y  L  N  E  Y  E         p.120

           | 07        .         .         .         .         .    g.16800
 GCAGAAAAG | ATAGAGTACAATGAATCTATGAAGGCCTATCATAATTCCCCCGCGTACCTT    c.420
 A  E  K   | I  E  Y  N  E  S  M  K  A  Y  H  N  S  P  A  Y  L      p.140

          .         .         .         .         .         .       g.16860
 GCTTACATAAATGCAAAAAGTCGTGCAGAAGCTGCTTTAGAGGAAGAAAGTCGACAGAGA       c.480
 A  Y  I  N  A  K  S  R  A  E  A  A  L  E  E  E  S  R  Q  R         p.160

          .         .         .         .         .         .       g.16920
 CAATCTCGCATGGAGAAAGGAGAACCGTACATGAGCATTCAGCCTGCTGAAGATCCAGAT       c.540
 Q  S  R  M  E  K  G  E  P  Y  M  S  I  Q  P  A  E  D  P  D         p.180

   | 08      .         .         .         .         .         .    g.20543
 G | ATTATGATGATGGCTTTTCAATGAAGCATACAGCCACCGCCCGTTTCCAGAGAAACCAC    c.600
 D |   Y  D  D  G  F  S  M  K  H  T  A  T  A  R  F  Q  R  N  H      p.200

          .         .         .         .         .         .       g.20603
 CGCCTCATCAGTGAAATTCTTAGTGAGAGTGTGGTGCCAGACGTTCGGTCAGTTGTCACA       c.660
 R  L  I  S  E  I  L  S  E  S  V  V  P  D  V  R  S  V  V  T         p.220

          .         .         .         .         .     | 09   .    g.21164
 ACAGCTAGAATGCAGGTCCTCAAACGGCAGGTCCAGTCCTTAATGGTTCATCAG | CGAAAA    c.720
 T  A  R  M  Q  V  L  K  R  Q  V  Q  S  L  M  V  H  Q   | R  K      p.240

          .         .         .         .         .         .       g.21224
 CTAGAAGCTGAACTTCTTCAAATAGAGGAACGACACCAGGAGAAGAAGAGGAAATTCCTG       c.780
 L  E  A  E  L  L  Q  I  E  E  R  H  Q  E  K  K  R  K  F  L         p.260

          .         .         .       | 10 .         .         .    g.21951
 GAAAGCACAGATTCATTTAACAATGAACTTAAAAGG | TTGTGCGGTCTGAAAGTAGAAGTG    c.840
 E  S  T  D  S  F  N  N  E  L  K  R   | L  C  G  L  K  V  E  V      p.280

          .         .         .         .         .         .       g.22011
 GATATGGAGAAAATTGCAGCTGAGATTGCACAGGCAGAGGAACAGGCCCGCAAAAGGCAG       c.900
 D  M  E  K  I  A  A  E  I  A  Q  A  E  E  Q  A  R  K  R  Q         p.300

          .         .         .         .         .         .       g.22071
 GAGGAAAGGGAGAAGGAGGCCGCAGAGCAAGCTGAGCGCAGTCAGAGCAGCATCGTTCCT       c.960
 E  E  R  E  K  E  A  A  E  Q  A  E  R  S  Q  S  S  I  V  P         p.320

          .         .         .         .         .         .       g.22131
 GAGGAAGAACAAGCAGCTAACAAAGGCGAGGAGAAGAAAGACGACGAGAACATTCCGATG       c.1020
 E  E  E  Q  A  A  N  K  G  E  E  K  K  D  D  E  N  I  P  M         p.340

         | 11.         .         .         .         .         .    g.23911
 GAGACAG | AGGAGACACACCTTGAAGAAACAACAGAGAGCCAACAGAATGGTGAAGAAGGC    c.1080
 E  T  E |   E  T  H  L  E  E  T  T  E  S  Q  Q  N  G  E  E  G      p.360

          .         .         .         .         .         .       g.23971
 ACGTCTACTCCTGAGGACAAGGAGAGTGGGCAGGAGGGGGTCGACAGTATGGCAGAGGAA       c.1140
 T  S  T  P  E  D  K  E  S  G  Q  E  G  V  D  S  M  A  E  E         p.380

          .         .         .         .         .         .       g.24031
 GGAACCAGTGATAGTAACACTGGCTCGGAGAGCAACAGTGCAACAGTGGAGGAGCCACCA       c.1200
 G  T  S  D  S  N  T  G  S  E  S  N  S  A  T  V  E  E  P  P         p.400

          .         .         .                                     g.24067
 ACAGATCCCATACCAGAAGATGAGAAAAAAGAATAA                               c.1236
 T  D  P  I  P  E  D  E  K  K  E  X                                 p.411

          .         .         .         .         .         .       g.24127
 gtgttgccttgttttgtgtgttctaaatactttttttaatgaaaaaatgttttttggttt       c.*60

          .         .         .         .         .         .       g.24187
 taatggtgttacgtggtttgtgtattaattttttttcttgtccatatcacaccaccaaag       c.*120

          .         .         .         .         .         .       g.24247
 gcttttggaccatttagcatcatgagcctaatggctcagtcagtcacctttcttaagtgt       c.*180

          .         .         .         .         .         .       g.24307
 tgtgaagatggctcttttctttggatcttgtttctagccctcaactgctgaaagcctcag       c.*240

          .         .         .         .         .         .       g.24367
 aatttagattaattgagaaaacacccacctcttttagagaattatcctttgatgctgcag       c.*300

          .         .         .         .         .         .       g.24427
 aatctactcttacaatgccttcctacagctcactggggtgcttaccaaagccatagcttt       c.*360

          .         .         .         .         .         .       g.24487
 aaaccttcccagtccccatcagtagcttcctgaaagtctcctctcttgtttacttctgca       c.*420

          .         .         .         .         .         .       g.24547
 aagggtagcttcttaaaaacgtgatcatgtatgagtatgtatttgttcacttaccctttt       c.*480

          .         .         .         .         .         .       g.24607
 ttacttttaatcaatgtcagataccaagagttgtgttaagctgagtgtagtgtgtaacta       c.*540

          .         .         .         .         .         .       g.24667
 actacacttggatcttactgatccagaaatagtccccatagttagagtagttacttatga       c.*600

          .         .         .         .         .         .       g.24727
 agtggttattaaagtgaacacagcacatatacattatctatactgctttttgttatgatt       c.*660

          .         .         .         .         .         .       g.24787
 aatactgggtatgttctggtaaatccatccttattgtatagaaaaaaaattactttttta       c.*720

          .         .         .         .         .         .       g.24847
 ccaggttttccaaagacagaatagatcacaaagctcaaggaatttaatattcttgtaatg       c.*780

          .         .         .         .         .         .       g.24907
 gactagataattcaaactgattagcccattccagaagaaaaacagctgggaattaagtta       c.*840

          .         .         .         .         .         .       g.24967
 atccacttgaaattgttttacaataatcagaacatccaaacctcaaggctcaggatccca       c.*900

          .         .         .         .         .         .       g.25027
 tagaccagagcccacctttttgataaacttagtaaagtcttggagactagaagcaagata       c.*960

          .         .         .         .         .         .       g.25087
 gtttgtgacacataagcttcccaaaaactagaatagatttttactgaatagtggtatatc       c.*1020

          .         .         .         .                           g.25132
 tgatggtatatgtttcttaaaggtccaaatgtaataaaaaaaaaa                      c.*1065

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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