structural maintenance of chromosomes 1B (SMC1B) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_148674.3 in the SMC1B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering SMC1B transcript NM_148674.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         cgctttttccgcgggcgcttgataacgcgggtgaggcgtggagggcggcgcc       c.-1

          .         .         .         .         .         .       g.5112
 ATGGCCCACCTGGAGCTGCTGCTTGTGGAAAATTTCAAGTCGTGGCGGGGCCGCCAGGTC       c.60
 M  A  H  L  E  L  L  L  V  E  N  F  K  S  W  R  G  R  Q  V         p.20

          .         .         .         .          | 02        .    g.9732
 ATTGGCCCCTTCCGGAGGTTCACCTGCATCATCGGCCCCAACGGCTCTG | GAAAATCTAAT    c.120
 I  G  P  F  R  R  F  T  C  I  I  G  P  N  G  S  G |   K  S  N      p.40

          .         .         .         .         .         .       g.9792
 GTAATGGATGCACTTAGTTTTGTAATGGGAGAGAAAATAGCTAATTTAAGAGTGAAAAAT       c.180
 V  M  D  A  L  S  F  V  M  G  E  K  I  A  N  L  R  V  K  N         p.60

          .         .         .         .         .         .       g.9852
 ATTCAAGAACTCATTCATGGAGCACATATTGGAAAACCTATTTCTTCTTCTGCAAGTGTA       c.240
 I  Q  E  L  I  H  G  A  H  I  G  K  P  I  S  S  S  A  S  V         p.80

          .         .         .         .         .         | 03    g.11756
 AAAATTATATATGTGGAGGAAAGTGGCGAAGAGAAAACATTTGCAAGGATTATCCGAG | GG    c.300
 K  I  I  Y  V  E  E  S  G  E  E  K  T  F  A  R  I  I  R  G |       p.100

          .         .         .         .         .         .       g.11816
 GGATGCTCAGAATTTCGCTTTAATGATAATCTTGTGAGTCGTTCTGTTTACATTGCAGAG       c.360
 G  C  S  E  F  R  F  N  D  N  L  V  S  R  S  V  Y  I  A  E         p.120

          .         .         .         .         .  | 04      .    g.11965
 TTGGAAAAGATAGGCATAATAGTCAAAGCACAAAATTGTTTGGTTTTTCAG | GGAACTGTA    c.420
 L  E  K  I  G  I  I  V  K  A  Q  N  C  L  V  F  Q   | G  T  V      p.140

          .         .         .         .         .         .       g.12025
 GAGTCAATTTCAGTGAAGAAACCCAAAGAAAGGACCCAGTTTTTTGAGGAAATCAGCACT       c.480
 E  S  I  S  V  K  K  P  K  E  R  T  Q  F  F  E  E  I  S  T         p.160

          .         .         .         .         .         .       g.12085
 TCAGGAGAGCTTATAGGAGAATATGAAGAAAAGAAAAGAAAGTTACAAAAAGCCGAAGAG       c.540
 S  G  E  L  I  G  E  Y  E  E  K  K  R  K  L  Q  K  A  E  E         p.180

          .         .         .         .         .         .       g.12145
 GATGCACAGTTTAACTTTAATAAGAAAAAAAATATAGCGGCAGAGCGCAGACAAGCAAAA       c.600
 D  A  Q  F  N  F  N  K  K  K  N  I  A  A  E  R  R  Q  A  K         p.200

          .      | 05  .         .         .         .         .    g.16094
 TTAGAGAAGGAAGAG | GCAGAACGTTACCAGAGTCTCCTTGAAGAACTGAAAATGAACAAG    c.660
 L  E  K  E  E   | A  E  R  Y  Q  S  L  L  E  E  L  K  M  N  K      p.220

          .         .         .         .         .         .       g.16154
 ATACAACTGCAGCTTTTTCAACTATACCATAATGAGAAAAAGATTCATCTCCTGAACACC       c.720
 I  Q  L  Q  L  F  Q  L  Y  H  N  E  K  K  I  H  L  L  N  T         p.240

          .         .         .         .         .         .       g.16214
 AAGTTAGAGCATGTGAATAGGGATTTGAGTGTCAAAAGAGAGTCTTTGTCTCATCATGAA       c.780
 K  L  E  H  V  N  R  D  L  S  V  K  R  E  S  L  S  H  H  E         p.260

          .         .         .         .         .         .       g.16274
 AACATAGTTAAAGCCAGGAAAAAGGAACATGGAATGCTAACTAGACAACTACAACAAACA       c.840
 N  I  V  K  A  R  K  K  E  H  G  M  L  T  R  Q  L  Q  Q  T         p.280

          .     | 06   .         .         .         .         .    g.19313
 GAAAAAGAATTAAA | ATCGGTTGAAACCCTTTTAAATCAGAAGAGGCCTCAGTACATTAAA    c.900
 E  K  E  L  K  |  S  V  E  T  L  L  N  Q  K  R  P  Q  Y  I  K      p.300

          .         .         .         .         .         .       g.19373
 GCCAAAGAAAACACTTCTCACCACCTTAAGAAATTAGATGTGGCTAAGAAATCAATAAAG       c.960
 A  K  E  N  T  S  H  H  L  K  K  L  D  V  A  K  K  S  I  K         p.320

          .         .         .         .         .         .       g.19433
 GACAGCGAAAAACAATGTTCTAAACAGGAAGATGATATAAAAGCCCTGGAGACAGAGCTG       c.1020
 D  S  E  K  Q  C  S  K  Q  E  D  D  I  K  A  L  E  T  E  L         p.340

          .         .         .         .         .         .       g.19493
 GCTGATTTAGATGCTGCATGGAGAAGTTTTGAAAAGCAGATTGAGGAAGAAATTTTACAT       c.1080
 A  D  L  D  A  A  W  R  S  F  E  K  Q  I  E  E  E  I  L  H         p.360

          .         .         .    | 07    .         .         .    g.22161
 AAAAAGCGAGACATTGAACTGGAAGCCAGTCAG | CTGGATCGTTATAAAGAACTTAAGGAA    c.1140
 K  K  R  D  I  E  L  E  A  S  Q   | L  D  R  Y  K  E  L  K  E      p.380

          .         .         .         .         .         .       g.22221
 CAAGTAAGAAAGAAAGTAGCTACAATGACTCAACAACTGGAAAAACTGCAGTGGGAACAG       c.1200
 Q  V  R  K  K  V  A  T  M  T  Q  Q  L  E  K  L  Q  W  E  Q         p.400

          .         .         .         .         .     | 08   .    g.23859
 AAGACAGATGAAGAAAGACTGGCATTTGAAAAGAGGAGGCATGGAGAAGTTCAG | GGAAAT    c.1260
 K  T  D  E  E  R  L  A  F  E  K  R  R  H  G  E  V  Q   | G  N      p.420

          .         .         .         .         .         .       g.23919
 CTAAAACAAATAAAAGAACAAATAGAAGATCATAAAAAACGAATAGAGAAGTTAGAGGAG       c.1320
 L  K  Q  I  K  E  Q  I  E  D  H  K  K  R  I  E  K  L  E  E         p.440

          .        | 09.         .         .         .         .    g.24822
 TATACAAAGACATGCAT | GGATTGCTTGAAAGAGAAAAAACAGCAAGAGGAAACCCTAGTG    c.1380
 Y  T  K  T  C  M  |  D  C  L  K  E  K  K  Q  Q  E  E  T  L  V      p.460

          .         .         .         .         .         .       g.24882
 GATGAAATTGAAAAAACAAAATCAAGAATGTCTGAATTTAATGAAGAATTGAATCTTATT       c.1440
 D  E  I  E  K  T  K  S  R  M  S  E  F  N  E  E  L  N  L  I         p.480

          .         .         .         .         .         .       g.24942
 AGAAGTGAATTGCAGAATGCTGGGATTGATACCCATGAGGGAAAACGTCAGCAAAAGAGA       c.1500
 R  S  E  L  Q  N  A  G  I  D  T  H  E  G  K  R  Q  Q  K  R         p.500

          .         .         .         .      | 10  .         .    g.28738
 GCAGAGGTTCTGGAACACCTTAAAAGACTGTACCCAGATTCTGTG | TTTGGAAGACTATTT    c.1560
 A  E  V  L  E  H  L  K  R  L  Y  P  D  S  V   | F  G  R  L  F      p.520

          .         .         .         .         .         .       g.28798
 GACCTGTGTCATCCTATTCATAAGAAATACCAGCTGGCTGTTACTAAGGTTTTTGGCCGG       c.1620
 D  L  C  H  P  I  H  K  K  Y  Q  L  A  V  T  K  V  F  G  R         p.540

          .         .         .         .         .         .       g.28858
 TTCATCACTGCCATTGTTGTAGCCTCTGAAAAGGTAGCAAAAGATTGTATTCGATTTCTG       c.1680
 F  I  T  A  I  V  V  A  S  E  K  V  A  K  D  C  I  R  F  L         p.560

          .         .         .         .         .  | 11      .    g.31583
 AAGGAGGAAAGAGCTGAACCTGAGACATTCCTCGCTCTAGATTACCTTGAT | ATCAAGCCA    c.1740
 K  E  E  R  A  E  P  E  T  F  L  A  L  D  Y  L  D   | I  K  P      p.580

          .         .         .         .         .         .       g.31643
 ATCAATGAAAGACTAAGGGAGCTTAAAGGCTGTAAAATGGTGATTGATGTCATAAAGACT       c.1800
 I  N  E  R  L  R  E  L  K  G  C  K  M  V  I  D  V  I  K  T         p.600

          .         .         .         .         .         .       g.31703
 CAGTTTCCTCAGCTGAAGAAAGTGATTCAGTTTGTGTGTGGAAATGGTCTTGTTTGTGAG       c.1860
 Q  F  P  Q  L  K  K  V  I  Q  F  V  C  G  N  G  L  V  C  E         p.620

          .         .         .         .         .  | 12      .    g.35016
 ACTATGGAAGAAGCAAGGCATATTGCACTCAGTGGACCTGAAAGACAGAAA | ACAGTAGCT    c.1920
 T  M  E  E  A  R  H  I  A  L  S  G  P  E  R  Q  K   | T  V  A      p.640

          .         .         .         .         .         .       g.35076
 CTTGATGGAACATTATTTTTAAAATCTGGAGTGATCTCTGGAGGGTCAAGTGACTTAAAA       c.1980
 L  D  G  T  L  F  L  K  S  G  V  I  S  G  G  S  S  D  L  K         p.660

          .         .         .         .         .         .       g.35136
 TACAAGGCTAGATGCTGGGATGAGAAAGAGTTAAAGAATCTAAGAGACAGACGAAGCCAG       c.2040
 Y  K  A  R  C  W  D  E  K  E  L  K  N  L  R  D  R  R  S  Q         p.680

          .         | 13         .         .         .         .    g.46370
 AAAATCCAAGAGCTAAAG | GGTTTAATGAAGACACTCCGCAAAGAAACAGATTTGAAACAA    c.2100
 K  I  Q  E  L  K   | G  L  M  K  T  L  R  K  E  T  D  L  K  Q      p.700

          .         .         .         .         .         .       g.46430
 ATACAGACCCTGATACAGGGAACTCAAACACGACTCAAATATTCACAAAATGAACTAGAG       c.2160
 I  Q  T  L  I  Q  G  T  Q  T  R  L  K  Y  S  Q  N  E  L  E         p.720

          .         .         .       | 14 .         .         .    g.47057
 ATGATTAAGAAGAAGCACCTTGTTGCTTTTTACCAG | GAACAATCTCAGTTACAAAGTGAA    c.2220
 M  I  K  K  K  H  L  V  A  F  Y  Q   | E  Q  S  Q  L  Q  S  E      p.740

          .         .         .         .         .         .       g.47117
 CTACTAAATATTGAGTCTCAATGTATTATGTTGAGTGAAGGAATCAAGGAACGACAACGA       c.2280
 L  L  N  I  E  S  Q  C  I  M  L  S  E  G  I  K  E  R  Q  R         p.760

          .         .         .    | 15    .         .         .    g.48587
 AGAATTAAAGAATTTCAAGAAAAGATAGATAAG | GTAGAAGACGATATCTTCCAACACTTC    c.2340
 R  I  K  E  F  Q  E  K  I  D  K   | V  E  D  D  I  F  Q  H  F      p.780

          .         .         .         .         .         .       g.48647
 TGTGAAGAAATTGGCGTGGAAAATATTCGTGAATTTGAGAACAAACATGTTAAACGGCAA       c.2400
 C  E  E  I  G  V  E  N  I  R  E  F  E  N  K  H  V  K  R  Q         p.800

          .         . | 16       .         .         .         .    g.55634
 CAAGAAATTGATCAAAAAAG | ATTAGAATTTGAAAAACAAAAAACTCGGCTTAATGTTCAA    c.2460
 Q  E  I  D  Q  K  R  |  L  E  F  E  K  Q  K  T  R  L  N  V  Q      p.820

          .         .         .         .         .         .       g.55694
 CTTGAGTATAGTCGCAGTCACCTTAAGAAGAAACTGAATAAGATCAACACATTAAAAGAA       c.2520
 L  E  Y  S  R  S  H  L  K  K  K  L  N  K  I  N  T  L  K  E         p.840

          .         .         .         .   | 17     .         .    g.56654
 ACTATCCAGAAAGGTAGTGAAGATATTGATCACCTAAAGAAG | GCTGAAGAAAACTGTCTG    c.2580
 T  I  Q  K  G  S  E  D  I  D  H  L  K  K   | A  E  E  N  C  L      p.860

          .         .         .         .         .         .       g.56714
 CAGACAGTGAATGAACTCATGGCAAAGCAGCAGCAACTTAAGGACATACGTGTCACTCAG       c.2640
 Q  T  V  N  E  L  M  A  K  Q  Q  Q  L  K  D  I  R  V  T  Q         p.880

          .         .         .         .         .         .       g.56774
 AACTCCAGTGCCGAGAAAGTTCAAACTCAAATTGAAGAGGAACGGAAGAAGTTTCTGGCT       c.2700
 N  S  S  A  E  K  V  Q  T  Q  I  E  E  E  R  K  K  F  L  A         p.900

          | 18         .         .         .         .         .    g.58714
 GTTGATAG | GGAAGTGGGGAAATTGCAAAAAGAAGTTGTAAGTATTCAAACTTCTCTGGAA    c.2760
 V  D  R  |  E  V  G  K  L  Q  K  E  V  V  S  I  Q  T  S  L  E      p.920

          .         .         .         .         .         .       g.58774
 CAGAAACGATTAGAGAAGCATAACTTGCTGCTTGATTGCAAAGTGCAAGACATTGAGATA       c.2820
 Q  K  R  L  E  K  H  N  L  L  L  D  C  K  V  Q  D  I  E  I         p.940

          .         .         .         .   | 19     .         .    g.59843
 ATCCTTTTGTCGGGGTCACTGGATGACATCATTGAAGTGGAG | ATGGGAACTGAAGCAGAA    c.2880
 I  L  L  S  G  S  L  D  D  I  I  E  V  E   | M  G  T  E  A  E      p.960

          .         .         .         .         .         .       g.59903
 AGTACCCAGGCAACAATTGATATCTATGAAAAAGAAGAAGCCTTTGAAATAGACTACAGC       c.2940
 S  T  Q  A  T  I  D  I  Y  E  K  E  E  A  F  E  I  D  Y  S         p.980

          .         .  | 20      .         .         .         .    g.63544
 TCTCTAAAAGAGGATTTGAAG | GCTCTACAGTCTGATCAAGAAATCGAGGCCCACCTTAGG    c.3000
 S  L  K  E  D  L  K   | A  L  Q  S  D  Q  E  I  E  A  H  L  R      p.1000

          .         .         .         .         .         .       g.63604
 CTCTTATTGCAGCAAGTAGCATCCCAGGAAGATATCTTACTGAAAACAGCAGCCCCAAAC       c.3060
 L  L  L  Q  Q  V  A  S  Q  E  D  I  L  L  K  T  A  A  P  N         p.1020

          .         .         .         .         .         | 21    g.64490
 CTACGAGCACTGGAGAACTTAAAGACTGTCAGAGACAAGTTTCAAGAGTCCACAGATG | CT    c.3120
 L  R  A  L  E  N  L  K  T  V  R  D  K  F  Q  E  S  T  D  A |       p.1040

          .         .         .         .         .         .       g.64550
 TTTGAGGCCAGCAGAAAGGAAGCCAGACTGTGTAGGCAAGAGTTCGAGCAAGTGAAAAAA       c.3180
 F  E  A  S  R  K  E  A  R  L  C  R  Q  E  F  E  Q  V  K  K         p.1060

          .         .         .         .         .         .       g.64610
 AGGAGATACGATCTTTTCACCCAGTGTTTTGAGCATGTCTCAATCTCAATTGATCAAATC       c.3240
 R  R  Y  D  L  F  T  Q  C  F  E  H  V  S  I  S  I  D  Q  I         p.1080

          .         .         .    | 22    .         .         .    g.66045
 TACAAGAAGCTCTGCAGAAACAACAGCGCCCAA | GCATTTCTTAGCCCAGAGAACCCTGAA    c.3300
 Y  K  K  L  C  R  N  N  S  A  Q   | A  F  L  S  P  E  N  P  E      p.1100

          .         .         .         .         .         .       g.66105
 GAACCTTACTTGGAGGGAATTAGCTATAACTGTGTGGCCCCAGGCAAACGGTTTATGCCA       c.3360
 E  P  Y  L  E  G  I  S  Y  N  C  V  A  P  G  K  R  F  M  P         p.1120

          .         .         .         .         .         .       g.66165
 ATGGACAATTTGTCAGGGGGAGAAAAGTGTGTGGCAGCCTTGGCTCTCCTGTTTGCTGTG       c.3420
 M  D  N  L  S  G  G  E  K  C  V  A  A  L  A  L  L  F  A  V         p.1140

       | 23  .         .         .         .         .         .    g.68877
 CACAG | TTTTCGTCCTGCCCCATTCTTTGTTTTAGATGAAGTGGATGCAGCCCTAGACAAT    c.3480
 H  S  |  F  R  P  A  P  F  F  V  L  D  E  V  D  A  A  L  D  N      p.1160

          .      | 24  .         .         .         .         .    g.73095
 ACTAACATAGGCAAA | GTGTCAAGTTACATCAAAGAGCAAACTCAAGACCAGTTTCAGATG    c.3540
 T  N  I  G  K   | V  S  S  Y  I  K  E  Q  T  Q  D  Q  F  Q  M      p.1180

          .         .         .         .         .         .       g.73155
 ATAGTCATCTCCCTAAAAGAAGAGTTCTATTCCAGAGCCGACGCGCTGATCGGCATCTAT       c.3600
 I  V  I  S  L  K  E  E  F  Y  S  R  A  D  A  L  I  G  I  Y         p.1200

        | 25 .         .         .         .         .         .    g.74016
 CCTGAG | TACGATGACTGCATGTTCAGCCGAGTTTTGACCCTAGATCTTTCTCAGTATCCA    c.3660
 P  E   | Y  D  D  C  M  F  S  R  V  L  T  L  D  L  S  Q  Y  P      p.1220

          .         .         .         .                           g.74064
 GACACTGAAGGCCAAGAAAGCAGCAAGAGACACGGAGAGTCCCGCTAG                   c.3708
 D  T  E  G  Q  E  S  S  K  R  H  G  E  S  R  X                     p.1235

          .         .         .         .         .         .       g.74124
 gggcagtcctgcagcagtcacctgatcactgttcagttcccactctaatactcacacagc       c.*60

          .         .         .         .         .         .       g.74184
 tcctccacaggagacttctggagcaagcaggaccagcctggtgcaccctttaagagaaac       c.*120

          .         .         .         .         .         .       g.74244
 cttagtcgttctagccaaagaggctgtggctcactttagttgagtgttcagacctcattc       c.*180

          .         .         .         .         .         .       g.74304
 tagtagggaaagttttcagtgagagctggtgtcaaatgagtttttaaaaaacaaacaaaa       c.*240

          .         .         .         .         .         .       g.74364
 ggtacaattttgtactataattctaacttctattttgaaataagctagtttggttggaaa       c.*300

          .         .         .         .         .         .       g.74424
 aattttgaattcagcttcatcttcactctgatcttgccttgcacccaagtaatcttgaag       c.*360

          .         .         .         .         .         .       g.74484
 ggaacttctcttggtttttaaacatactagttataagattgttaataaactgttgaacct       c.*420

          .         .         .         .         .         .       g.74544
 ggcttttgggaaattgtttcagagaaactatgttagtattgaaaatatcaataaaaaatg       c.*480

          .                                                         g.74557
 ttctaatttcaaa                                                      c.*493

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Structural maintenance of chromosomes 1B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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