smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans) (SMG8) - coding DNA reference sequence

(used for variant description)

(last modified November 29, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_018149.6 in the SMG8 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering SMG8 transcript NM_018149.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   tttactaacggaccggaaggactctagagaacgctctgcact       c.-1

          .         .         .         .         .         .       g.5102
 ATGGCTGGTCCCGTGAGCTTGCGAGACCTTCTAATGGGAGCATCAGCCTGGATGGGCTCT       c.60
 M  A  G  P  V  S  L  R  D  L  L  M  G  A  S  A  W  M  G  S         p.20

          .         .         .         .         .         .       g.5162
 GAAAGTCCCGGAGGGTCCCCTACTGAGGGCGGAGGGAGCGCGGCTGGCGGACCGGAGCCT       c.120
 E  S  P  G  G  S  P  T  E  G  G  G  S  A  A  G  G  P  E  P         p.40

          .         .         .         .         .         .       g.5222
 CCATGGCGGGAGGATGAGATCTGCGTTGTGGGAATCTTCGGCAAGACGGCTCTACGCCTG       c.180
 P  W  R  E  D  E  I  C  V  V  G  I  F  G  K  T  A  L  R  L         p.60

          .         .         .         .         .         .       g.5282
 AATTCCGAGAAGTTCTCTCTTGTGAATACGGTGTGCGACCGACAGGTCTTTCCTCTCTTT       c.240
 N  S  E  K  F  S  L  V  N  T  V  C  D  R  Q  V  F  P  L  F         p.80

          .         .         .         .         .         .       g.5342
 CGCCACCAAGATCCTGGGGATCCAGGACCTGGAATCAGAACTGAGGCTGGCGCCGTGGGT       c.300
 R  H  Q  D  P  G  D  P  G  P  G  I  R  T  E  A  G  A  V  G         p.100

          .         .         .         .         .         .       g.5402
 GAGGCCGGTGGAGCCGAGGACCCTGGGGCTGCAGCCGGGGGTTCAGTTCGGGGAAGTGGA       c.360
 E  A  G  G  A  E  D  P  G  A  A  A  G  G  S  V  R  G  S  G         p.120

          .         .         .         .         .         .       g.5462
 GCTGTCGCGGAAGGTAACCGAACTGAGGCAGGCTCCCAGGACTACAGCCTTCTGCAGGCC       c.420
 A  V  A  E  G  N  R  T  E  A  G  S  Q  D  Y  S  L  L  Q  A         p.140

          .         .         .         .         .         .       g.5522
 TACTACAGTCAGGAAAGCAAAGTTCTGTATCTTCTCCTCACCTCCATCTGTGACAATTCA       c.480
 Y  Y  S  Q  E  S  K  V  L  Y  L  L  L  T  S  I  C  D  N  S         p.160

          .         .         .         .         .         .       g.5582
 CAGCTTCTCCGGGCTTGTCGGGCTCTTCAGAGCGGGGAAGCTGGAGGTGGACTCTCTTTA       c.540
 Q  L  L  R  A  C  R  A  L  Q  S  G  E  A  G  G  G  L  S  L         p.180

          .         .         .         .         .         .       g.5642
 CCTCATGCAGAAGCACACGAGTTCTGGAAGCATCAAGAGAAGCTGCAGTGCCTCAGTCTC       c.600
 P  H  A  E  A  H  E  F  W  K  H  Q  E  K  L  Q  C  L  S  L         p.200

          .         .         .         .         .         .       g.5702
 CTTTACCTATTCTCTGTCTGTCATATCTTGCTTCTGGTCCATCCCACTTGTTCCTTTGAT       c.660
 L  Y  L  F  S  V  C  H  I  L  L  L  V  H  P  T  C  S  F  D         p.220

          .         .         .         .         .         .       g.5762
 ATCACTTATGATCGAGTATTCAGAGCCCTGGATGGGCTGAGACAGAAGGTCCTGCCGCTC       c.720
 I  T  Y  D  R  V  F  R  A  L  D  G  L  R  Q  K  V  L  P  L         p.240

          .         .         .         .         .         .       g.5822
 CTTAAAACAGCCATTAAGGATTGTCCAGTTGGCAAAGACTGGAAGCTAAACTGCCGACCT       c.780
 L  K  T  A  I  K  D  C  P  V  G  K  D  W  K  L  N  C  R  P         p.260

          .         .         .         .         .         .       g.5882
 TGCCCACCTAGACTCCTTTTCCTCTTTCAACTCAATGGAGCCCTCAAGGTAGAACCTCCT       c.840
 C  P  P  R  L  L  F  L  F  Q  L  N  G  A  L  K  V  E  P  P         p.280

          .         .         .         .         .         .       g.5942
 CGGAACCAAGACCCAGCTCATCCAGACAAGCCCAAGAAACATTCTCCCAAAAGGAGGCTG       c.900
 R  N  Q  D  P  A  H  P  D  K  P  K  K  H  S  P  K  R  R  L         p.300

          .         .         .         .         .         .       g.6002
 CAGCATGCCCTGGAGGACCAGATCTATAGAATCTTCCGGAAGAGTCGTGTCTTGACTAAT       c.960
 Q  H  A  L  E  D  Q  I  Y  R  I  F  R  K  S  R  V  L  T  N         p.320

          .         .         .         .         .         .       g.6062
 CAGAGCATCAACTGCCTCTTTACTGTGCCTGCCAACCAAGCTTTCGTGTACATAGTACCG       c.1020
 Q  S  I  N  C  L  F  T  V  P  A  N  Q  A  F  V  Y  I  V  P         p.340

          .         .         .         .         .         .       g.6122
 GGAAGCCAGGAGGAGGACCCAGTAGGTATGTTGCTGGACCAACTTAGGAGTCATTGTACT       c.1080
 G  S  Q  E  E  D  P  V  G  M  L  L  D  Q  L  R  S  H  C  T         p.360

          .         .         .         .         .         .       g.6182
 GTGAAGGACCCGGAATCTTTGCTGGTGCCTGCACCCCTTTCTGGGCCTAGGCGATACCAG       c.1140
 V  K  D  P  E  S  L  L  V  P  A  P  L  S  G  P  R  R  Y  Q         p.380

          .         .         .         .         .         .       g.6242
 GTGATGAGGCAGCACAGCCGACAACAACTTTCCTTTCACATTGACAGCAGCAGTTCCAGT       c.1200
 V  M  R  Q  H  S  R  Q  Q  L  S  F  H  I  D  S  S  S  S  S         p.400

          .         .         .         .         .         .       g.6302
 TCTTCAGGCCAGCTAGTGGATTTCACTCTTCGGGAATTCCTATGGCAGCATGTGGAGCTA       c.1260
 S  S  G  Q  L  V  D  F  T  L  R  E  F  L  W  Q  H  V  E  L         p.420

          .         .         .         .         .         .       g.6362
 GTTCTAAGCAAGAAAGGTTTCGATGACAGTGTGGGCAGGAACCCACAGCCTTCCCATTTT       c.1320
 V  L  S  K  K  G  F  D  D  S  V  G  R  N  P  Q  P  S  H  F         p.440

          .         .         .         .         .         .       g.6422
 GAACTTCCTACTTATCAGAAGTGGATCTCAGCAGCTTCAAAACTGTATGAGGTGGCTATT       c.1380
 E  L  P  T  Y  Q  K  W  I  S  A  A  S  K  L  Y  E  V  A  I         p.460

          .         .         .         .         .         .       g.6482
 GATGGGAAAGAAGAGGACTTGGGGTCACCCACTGGAGAGCTAACATCTAAGATTTTAAGC       c.1440
 D  G  K  E  E  D  L  G  S  P  T  G  E  L  T  S  K  I  L  S         p.480

          .         .         .         .         .         .       g.6542
 AGTATTAAAGTCTTGGAAGGATTTTTGGATATTGACACAAAATTCTCAGAAAACCGATGC       c.1500
 S  I  K  V  L  E  G  F  L  D  I  D  T  K  F  S  E  N  R  C         p.500

          .         .         .         .         .         .       g.6602
 CAAAAAGCTTTACCCATGGCCCACAGTGCCTACCAGTCAAATTTGCCTCATAATTACACA       c.1560
 Q  K  A  L  P  M  A  H  S  A  Y  Q  S  N  L  P  H  N  Y  T         p.520

          .         .         .         .         .         .       g.6662
 ATGACTGTCCATAAGAATCAGCTTGCCCAGGCTCTTCGAGTGTACAGTCAACATGCTAGA       c.1620
 M  T  V  H  K  N  Q  L  A  Q  A  L  R  V  Y  S  Q  H  A  R         p.540

          .         .         .         .         .         .       g.6722
 GGTCCAGCATTTCACAAATACGCCATGCAGTTACATGAGGACTGCTACAAATTTTGGAGC       c.1680
 G  P  A  F  H  K  Y  A  M  Q  L  H  E  D  C  Y  K  F  W  S         p.560

          .         .         .         .         .         .       g.6782
 AATGGCCATCAGCTCTGTGAGGAGAGGAGTTTAACTGATCAACACTGTGTGCACAAATTT       c.1740
 N  G  H  Q  L  C  E  E  R  S  L  T  D  Q  H  C  V  H  K  F         p.580

          .          | 02        .         .         .         .    g.7372
 CACTCATTACCTAAATCAG | GAGAAAAACCAGAGGCTGATAGAAATCCGCCTGTGCTATAT    c.1800
 H  S  L  P  K  S  G |   E  K  P  E  A  D  R  N  P  P  V  L  Y      p.600

          .         .         .         .         .         .       g.7432
 CACAATAGCCGAGCTCGATCTACTGGTGCTTGCAACTGTGGAAGGAAACAAGCACCTCGA       c.1860
 H  N  S  R  A  R  S  T  G  A  C  N  C  G  R  K  Q  A  P  R         p.620

          .         .         .         .      | 03  .         .    g.7734
 GATGATCCCTTTGATATCAAAGCAGCCAATTATGACTTCTATCAG | CTTCTGGAAGAAAAG    c.1920
 D  D  P  F  D  I  K  A  A  N  Y  D  F  Y  Q   | L  L  E  E  K      p.640

          .         .         .         .         .         .       g.7794
 TGTTGTGGAAAATTGGATCATATCAATTTCCCAGTATTTGAACCAAGTACTCCAGATCCT       c.1980
 C  C  G  K  L  D  H  I  N  F  P  V  F  E  P  S  T  P  D  P         p.660

          .         .         .         .         .         .       g.7854
 GCTCCTGCTAAAAATGAATCCTCTCCTGCTCCTCCAGATTCGGATGCTGATAAACTTAAA       c.2040
 A  P  A  K  N  E  S  S  P  A  P  P  D  S  D  A  D  K  L  K         p.680

          .         .         .         .         .         .       g.7914
 GAAAAAGAACCTCAAACCCAAGGAGAGAGCACGAGCCTGAGTTTAGCTTTGAGTTTGGGC       c.2100
 E  K  E  P  Q  T  Q  G  E  S  T  S  L  S  L  A  L  S  L  G         p.700

          .         .         .         .         .         .       g.7974
 CAATCCACAGATAGCTTAGGTACCTATCCAGCTGATCCACAAGCAGGAGGAGATAATCCA       c.2160
 Q  S  T  D  S  L  G  T  Y  P  A  D  P  Q  A  G  G  D  N  P         p.720

          .         .         .         .         .         .       g.8034
 GAAGTTCATGGTCAAGTAGAAGTGAAAACTGAGAAGAGGCCAAACTTCGTTGATCGACAG       c.2220
 E  V  H  G  Q  V  E  V  K  T  E  K  R  P  N  F  V  D  R  Q         p.740

          .         .         .         .         .         .       g.8094
 GCATCCACAGTTGAGTATCTCCCAGGCATGCTACATTCAAATTGCCCTAAAGGTCTCCTA       c.2280
 A  S  T  V  E  Y  L  P  G  M  L  H  S  N  C  P  K  G  L  L         p.760

          .         .         .         .         .         .       g.8154
 CCCAAATTCTCCAGCTGGTCTTTGGTTAAACTAGGCCCTGCTAAGTCTTATAACTTTCAT       c.2340
 P  K  F  S  S  W  S  L  V  K  L  G  P  A  K  S  Y  N  F  H         p.780

          .         .         .         .         .         .       g.8214
 ACAGGTTTGGACCAACAGGGCTTTATTCCAGGAACAAATTATCTTATGCCTTGGGACATT       c.2400
 T  G  L  D  Q  Q  G  F  I  P  G  T  N  Y  L  M  P  W  D  I         p.800

          .         .         .         .         .         .       g.8274
 GTCATCAGGACTAGAGCTGAAGATGAAGGAGACTTAGACACAAACTCTTGGCCTGCTCCA       c.2460
 V  I  R  T  R  A  E  D  E  G  D  L  D  T  N  S  W  P  A  P         p.820

          .         .         .         .         .         .       g.8334
 AATAAAGCTATTCCTGGAAAGAGAAGTGCGGTTGTAATGGGAAGAGGAAGACGGCGAGAT       c.2520
 N  K  A  I  P  G  K  R  S  A  V  V  M  G  R  G  R  R  R  D         p.840

          .         .         .         .         .         .       g.8394
 GACATAGCTCGAGCTTTTGTGGGCTTTGAATATGAAGACTCTCGAGGTCGGAGATTCATG       c.2580
 D  I  A  R  A  F  V  G  F  E  Y  E  D  S  R  G  R  R  F  M         p.860

          .         .         .         .         .         .       g.8454
 TGCTCTGGGCCTGACAAAGTAATGAAAGTAATGGGAAGTGGGCCAAAGGAATCAGCTTTA       c.2640
 C  S  G  P  D  K  V  M  K  V  M  G  S  G  P  K  E  S  A  L         p.880

          .         .         .         .         .         .       g.8514
 AAAGCCCTAAATAGTGACATGCCCTTATATATTCTGTCATCCTCTCAAGGTAGAGGGCTG       c.2700
 K  A  L  N  S  D  M  P  L  Y  I  L  S  S  S  Q  G  R  G  L         p.900

          .         .         .         .         .         .       g.8574
 AAACCTCATTATGCTCAACTTATGAGGCTTTTTGTTGTGGTTCCTGATGCTCCTTTGCAG       c.2760
 K  P  H  Y  A  Q  L  M  R  L  F  V  V  V  P  D  A  P  L  Q         p.920

          .         | 04         .         .         .         .    g.9837
 ATAATACTAATGCCTCAG | GTTCAGCCAGGCCCACCACCATGTCCGGTATTCTACCCAGAA    c.2820
 I  I  L  M  P  Q   | V  Q  P  G  P  P  P  C  P  V  F  Y  P  E      p.940

          .         .         .         .         .         .       g.9897
 AAACAAGAAATCACCCTTCCACCTGATGGCCTTTGGGTTTTGAGATTTCCTTATGCATAT       c.2880
 K  Q  E  I  T  L  P  P  D  G  L  W  V  L  R  F  P  Y  A  Y         p.960

          .         .         .         .         .         .       g.9957
 GTGACTGAGAGAGGACCTTGTTTCCCCCCTAAGGAAAATGTGCAGTTAATGAGCTACAAG       c.2940
 V  T  E  R  G  P  C  F  P  P  K  E  N  V  Q  L  M  S  Y  K         p.980

          .         .         .                                     g.9993
 GTGCTCCGTGGGGTTCTTAAGGCAGTAACACAATAA                               c.2976
 V  L  R  G  V  L  K  A  V  T  Q  X                                 p.991

          .         .         .         .         .         .       g.10053
 gtgttttccagccagttcaatcctatacttgagctggtttttgtttttggtatttgtggc       c.*60

          .         .         .         .         .         .       g.10113
 tgtgtttttggtatgtgtttactgtgttttcccaaatccaaaatgtgttttggttacagg       c.*120

          .         .         .         .         .         .       g.10173
 agttcagtatttggaaactaatttgttctactttttcattatattgttgatatttattgt       c.*180

          .         .         .         .         .         .       g.10233
 aaacgtgactacaactttctaataaagattggttgttctagaaaagaatataaaatacat       c.*240

                                                                    g.10241
 ggatgata                                                           c.*248

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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