sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1) - coding DNA reference sequence

(used for variant description)

(last modified December 24, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000543.4 in the SMPD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011780.1, covering SMPD1 transcript NM_000543.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        agctg       c.-181

 .         .         .         .         .         .                g.5065
 tcagagatcagaggaagaggaaggggcggagctgctttgcggccggccgcggagcagtca       c.-121

 .         .         .         .         .         .                g.5125
 gccgactacagagaagggtaatcgggtgtccccggcgccgcccggggccctgagggctgg       c.-61

 .         .         .         .         .         .                g.5185
 ctagggtccaggccgggggggacgggacagacgaaccagccccgtgtaggaagcgcgaca       c.-1

          .         .         .         .         .         .       g.5245
 ATGCCCCGCTACGGAGCGTCACTCCGCCAGAGCTGCCCCAGGTCCGGCCGGGAGCAGGGA       c.60
 M  P  R  Y  G  A  S  L  R  Q  S  C  P  R  S  G  R  E  Q  G         p.20

          .         .         .         .         .         .       g.5305
 CAAGACGGGACCGCCGGAGCCCCCGGACTCCTTTGGATGGGCCTGGTGCTGGCGCTGGCG       c.120
 Q  D  G  T  A  G  A  P  G  L  L  W  M  G  L  V  L  A  L  A         p.40

          .         .         .         .         .         .       g.5365
 CTGGCGCTGGCGCTGGCGCTGGCTCTGTCTGACTCTCGGGTTCTCTGGGCTCCGGCAGAG       c.180
 L  A  L  A  L  A  L  A  L  S  D  S  R  V  L  W  A  P  A  E         p.60

          .         .         .         .         .         .       g.5425
 GCTCACCCTCTTTCTCCCCAAGGCCATCCTGCCAGGTTACATCGCATAGTGCCCCGGCTC       c.240
 A  H  P  L  S  P  Q  G  H  P  A  R  L  H  R  I  V  P  R  L         p.80

          .         .         .         .         .         .       g.5485
 CGAGATGTCTTTGGGTGGGGGAACCTCACCTGCCCAATCTGCAAAGGTCTATTCACCGCC       c.300
 R  D  V  F  G  W  G  N  L  T  C  P  I  C  K  G  L  F  T  A         p.100

          .         | 02         .         .         .         .    g.6012
 ATCAACCTCGGGCTGAAG | AAGGAACCCAATGTGGCTCGCGTGGGCTCCGTGGCCATCAAG    c.360
 I  N  L  G  L  K   | K  E  P  N  V  A  R  V  G  S  V  A  I  K      p.120

          .         .         .         .         .         .       g.6072
 CTGTGCAATCTGCTGAAGATAGCACCACCTGCCGTGTGCCAATCCATTGTCCACCTCTTT       c.420
 L  C  N  L  L  K  I  A  P  P  A  V  C  Q  S  I  V  H  L  F         p.140

          .         .         .         .         .         .       g.6132
 GAGGATGACATGGTGGAGGTGTGGAGACGCTCAGTGCTGAGCCCATCTGAGGCCTGTGGC       c.480
 E  D  D  M  V  E  V  W  R  R  S  V  L  S  P  S  E  A  C  G         p.160

          .         .         .         .         .         .       g.6192
 CTGCTCCTGGGCTCCACCTGTGGGCACTGGGACATTTTCTCATCTTGGAACATCTCTTTG       c.540
 L  L  L  G  S  T  C  G  H  W  D  I  F  S  S  W  N  I  S  L         p.180

          .         .         .         .         .         .       g.6252
 CCTACTGTGCCGAAGCCGCCCCCCAAACCCCCTAGCCCCCCAGCCCCAGGTGCCCCTGTC       c.600
 P  T  V  P  K  P  P  P  K  P  P  S  P  P  A  P  G  A  P  V         p.200

          .         .         .         .         .         .       g.6312
 AGCCGCATCCTCTTCCTCACTGACCTGCACTGGGATCATGACTACCTGGAGGGCACGGAC       c.660
 S  R  I  L  F  L  T  D  L  H  W  D  H  D  Y  L  E  G  T  D         p.220

          .         .         .         .         .         .       g.6372
 CCTGACTGTGCAGACCCACTGTGCTGCCGCCGGGGTTCTGGCCTGCCGCCCGCATCCCGG       c.720
 P  D  C  A  D  P  L  C  C  R  R  G  S  G  L  P  P  A  S  R         p.240

          .         .         .         .         .         .       g.6432
 CCAGGTGCCGGATACTGGGGCGAATACAGCAAGTGTGACCTGCCCCTGAGGACCCTGGAG       c.780
 P  G  A  G  Y  W  G  E  Y  S  K  C  D  L  P  L  R  T  L  E         p.260

          .         .         .         .         .         .       g.6492
 AGCCTGTTGAGTGGGCTGGGCCCAGCCGGCCCTTTTGATATGGTGTACTGGACAGGAGAC       c.840
 S  L  L  S  G  L  G  P  A  G  P  F  D  M  V  Y  W  T  G  D         p.280

          .         .         .         .         .         .       g.6552
 ATCCCCGCACATGATGTCTGGCACCAGACTCGTCAGGACCAACTGCGGGCCCTGACCACC       c.900
 I  P  A  H  D  V  W  H  Q  T  R  Q  D  Q  L  R  A  L  T  T         p.300

          .         .         .         .         .         .       g.6612
 GTCACAGCACTTGTGAGGAAGTTCCTGGGGCCAGTGCCAGTGTACCCTGCTGTGGGTAAC       c.960
 V  T  A  L  V  R  K  F  L  G  P  V  P  V  Y  P  A  V  G  N         p.320

          .         .         .         .         .         .       g.6672
 CATGAAAGCACACCTGTCAATAGCTTCCCTCCCCCCTTCATTGAGGGCAACCACTCCTCC       c.1020
 H  E  S  T  P  V  N  S  F  P  P  P  F  I  E  G  N  H  S  S         p.340

          .         .         .         .         .         .       g.6732
 CGCTGGCTCTATGAAGCGATGGCCAAGGCTTGGGAGCCCTGGCTGCCTGCCGAAGCCCTG       c.1080
 R  W  L  Y  E  A  M  A  K  A  W  E  P  W  L  P  A  E  A  L         p.360

          .  | 03      .         .         .         .         .    g.7851
 CGCACCCTCAG | AATTGGGGGGTTCTATGCTCTTTCCCCATACCCCGGTCTCCGCCTCATC    c.1140
 R  T  L  R  |  I  G  G  F  Y  A  L  S  P  Y  P  G  L  R  L  I      p.380

          .         .         .         .         .         .       g.7911
 TCTCTCAATATGAATTTTTGTTCCCGTGAGAACTTCTGGCTCTTGATCAACTCCACGGAT       c.1200
 S  L  N  M  N  F  C  S  R  E  N  F  W  L  L  I  N  S  T  D         p.400

          .         .         .         .         .         .       g.7971
 CCCGCAGGACAGCTCCAGTGGCTGGTGGGGGAGCTTCAGGCTGCTGAGGATCGAGGAGAC       c.1260
 P  A  G  Q  L  Q  W  L  V  G  E  L  Q  A  A  E  D  R  G  D         p.420

     | 04    .         .         .         .         .         .    g.8260
 AAA | GTGCATATAATTGGCCACATTCCCCCAGGGCACTGTCTGAAGAGCTGGAGCTGGAAT    c.1320
 K   | V  H  I  I  G  H  I  P  P  G  H  C  L  K  S  W  S  W  N      p.440

          .         . | 05       .         .         .         .    g.8522
 TATTACCGAATTGTAGCCAG | GTATGAGAACACCCTGGCTGCTCAGTTCTTTGGCCACACT    c.1380
 Y  Y  R  I  V  A  R  |  Y  E  N  T  L  A  A  Q  F  F  G  H  T      p.460

          .         .         .         .         .         .       g.8582
 CATGTGGATGAATTTGAGGTCTTCTATGATGAAGAGACTCTGAGCCGGCCGCTGGCTGTA       c.1440
 H  V  D  E  F  E  V  F  Y  D  E  E  T  L  S  R  P  L  A  V         p.480

          .         .         .         .       | 06 .         .    g.8798
 GCCTTCCTGGCACCCAGTGCAACTACCTACATCGGCCTTAATCCTG | GTTACCGTGTGTAC    c.1500
 A  F  L  A  P  S  A  T  T  Y  I  G  L  N  P  G |   Y  R  V  Y      p.500

          .         .         .         .         .         .       g.8858
 CAAATAGATGGAAACTACTCCGGGAGCTCTCACGTGGTCCTGGACCATGAGACCTACATC       c.1560
 Q  I  D  G  N  Y  S  G  S  S  H  V  V  L  D  H  E  T  Y  I         p.520

          .         .         .         .         .         .       g.8918
 CTGAATCTGACCCAGGCAAACATACCGGGAGCCATACCGCACTGGCAGCTTCTCTACAGG       c.1620
 L  N  L  T  Q  A  N  I  P  G  A  I  P  H  W  Q  L  L  Y  R         p.540

          .         .         .         .         .         .       g.8978
 GCTCGAGAAACCTATGGGCTGCCCAACACACTGCCTACCGCCTGGCACAACCTGGTATAT       c.1680
 A  R  E  T  Y  G  L  P  N  T  L  P  T  A  W  H  N  L  V  Y         p.560

          .         .         .         .         .         .       g.9038
 CGCATGCGGGGCGACATGCAACTTTTCCAGACCTTCTGGTTTCTCTACCATAAGGGCCAC       c.1740
 R  M  R  G  D  M  Q  L  F  Q  T  F  W  F  L  Y  H  K  G  H         p.580

          .         .         .         .         .         .       g.9098
 CCACCCTCGGAGCCCTGTGGCACGCCCTGCCGTCTGGCTACTCTTTGTGCCCAGCTCTCT       c.1800
 P  P  S  E  P  C  G  T  P  C  R  L  A  T  L  C  A  Q  L  S         p.600

          .         .         .         .         .         .       g.9158
 GCCCGTGCTGACAGCCCTGCTCTGTGCCGCCACCTGATGCCAGATGGGAGCCTCCCAGAG       c.1860
 A  R  A  D  S  P  A  L  C  R  H  L  M  P  D  G  S  L  P  E         p.620

          .         .         .                                     g.9194
 GCCCAGAGCCTGTGGCCAAGGCCACTGTTTTGCTAG                               c.1896
 A  Q  S  L  W  P  R  P  L  F  C  X                                 p.631

          .         .         .         .         .         .       g.9254
 ggccccagggcccacatttgggaaagttcttgatgtaggaaagggtgaaaaagcccaaat       c.*60

          .         .         .         .         .         .       g.9314
 gctgctgtggttcaaccaggcaagatcatccggtgaaagaaccagtccctgggccccaag       c.*120

          .         .         .         .         .         .       g.9374
 gatgccggggaaacaggaccttctcctttcctggagctggtttagctggatatgggaggg       c.*180

          .         .         .         .         .         .       g.9434
 ggtttggctgcctgtgcccaggagctagactgccttgaggctgctgtcctttcacagcca       c.*240

          .         .         .         .         .         .       g.9494
 tggagtagaggcctaagttgacactgccctgggcagacaagacaggagctgtcgccccag       c.*300

          .         .         .         .         .         .       g.9554
 gcctgtgctgcccagccaggaaccctgtactgctgctgcgacctgatgctgccagtctgt       c.*360

          .         .         .                                     g.9585
 taaaataaagataagagacttggactccaga                                    c.*391

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sphingomyelin phosphodiesterase 1, acid lysosomal protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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