sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (SMPD4) - coding DNA reference sequence

(used for variant description)

(last modified December 19, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_017951.4 in the SMPD4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering SMPD4 transcript NM_017951.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.6029
                         ctaaggaccactccctcccccgcactcctgcctcgc       c.-121

 .         .         .         .         .         .                g.6089
 catttctcttccccgcccggccggccttcgctttgcgcacgcgccttttgaggtaacggc       c.-61

 .         .         .         .         .         .                g.6149
 ccaaagaggtggaagcgcttttcccgcccggccgcggggcgtggctctgcgcgcagcttg       c.-1

          .         .         .         .         .         .       g.6209
 ATGACGACTTTCGGCGCCGTGGCGGAATGGCGGCTTCCATCTCTGAGGCGAGCGACGCTA       c.60
 M  T  T  F  G  A  V  A  E  W  R  L  P  S  L  R  R  A  T  L         p.20

          .   | 02     .         .         .         .         .    g.11161
 TGGATCCCACAG | TGGTTTGCTAAGAAGGCCATTTTCAACTCTCCACTGGAGGCTGCTATG    c.120
 W  I  P  Q   | W  F  A  K  K  A  I  F  N  S  P  L  E  A  A  M      p.40

          .         .         .       | 03 .         .         .    g.12774
 GCGTTCCCTCACCTGCAGCAGCCCAGCTTTCTACTG | GCTAGCCTGAAAGCTGACTCTATA    c.180
 A  F  P  H  L  Q  Q  P  S  F  L  L   | A  S  L  K  A  D  S  I      p.60

          .         .         .         .         .         .       g.12834
 AATAAGCCCTTTGCACAGCAGTGCCAAGACTTGGTTAAAGTCATTGAGGACTTTCCAGCA       c.240
 N  K  P  F  A  Q  Q  C  Q  D  L  V  K  V  I  E  D  F  P  A         p.80

     | 04    .         .         .         .         .         .    g.14151
 AAG | GAGCTGCACACCATCTTCCCATGGCTGGTAGAAAGCATTTTTGGCAGCCTAGATGGT    c.300
 K   | E  L  H  T  I  F  P  W  L  V  E  S  I  F  G  S  L  D  G      p.100

          .         .         .         .         .         .       g.14211
 GTCCTCGTTGGCTGGAACCTCCGCTGCTTACAGGGGCGCGTGAATCCTGTGGAGTACAGC       c.360
 V  L  V  G  W  N  L  R  C  L  Q  G  R  V  N  P  V  E  Y  S         p.120

          .         .       | 05 .         .         .         .    g.14430
 ATCGTGATGGAATTTCTCGACCCTGG | TGGCCCAATGATGAAGTTGGTTTATAAGCTTCAA    c.420
 I  V  M  E  F  L  D  P  G  |  G  P  M  M  K  L  V  Y  K  L  Q      p.140

          .         .         .         .   | 06     .         .    g.14873
 GCTGAAGACTATAAGTTCGACTTTCCTGTCTCCTACTTGCCT | GGTCCTGTGAAGGCGTCC    c.480
 A  E  D  Y  K  F  D  F  P  V  S  Y  L  P   | G  P  V  K  A  S      p.160

          .         .         .         .         .         .       g.14933
 ATCCAGGAGTGCATCCTCCCTGACAGTCCTCTGTACCACAACAAGGTCCAGTTCACCCCT       c.540
 I  Q  E  C  I  L  P  D  S  P  L  Y  H  N  K  V  Q  F  T  P         p.180

          .         .         .  | 07      .         .         .    g.15102
 ACTGGGGGCCTTGGTCTGAACTTGGCCCTGA | ATCCGTTCGAGTATTACATATTCTTCTTT    c.600
 T  G  G  L  G  L  N  L  A  L  N |   P  F  E  Y  Y  I  F  F  F      p.200

          .         .     | 08   .         .         .         .    g.15286
 GCCTTGAGCCTCATCACTCAGAAG | CCACTTCCTGTGTCCCTCCACGTCCGTACTTCAGAC    c.660
 A  L  S  L  I  T  Q  K   | P  L  P  V  S  L  H  V  R  T  S  D      p.220

          .         .         .         .         .         .       g.15346
 TGTGCCTATTTCATCCTGGTGGACAGGTACCTGTCATGGTTCCTGCCCACCGAAGGCAGT       c.720
 C  A  Y  F  I  L  V  D  R  Y  L  S  W  F  L  P  T  E  G  S         p.240

          .         .         .         .         .       | 09 .    g.20164
 GTGCCCCCACCACTCTCCTCCAGCCCAGGGGGGACCAGCCCCTCACCACCTCCCAG | GACA    c.780
 V  P  P  P  L  S  S  S  P  G  G  T  S  P  S  P  P  P  R  |  T      p.260

          .         .         .         .         .         .       g.20224
 CCAGCCATACCCTTTGCTTCCTATGGCCTCCACCACACTAGCCTCCTAAAGCGACACATC       c.840
 P  A  I  P  F  A  S  Y  G  L  H  H  T  S  L  L  K  R  H  I         p.280

          .         .         .         .         .         .       g.20284
 TCTCATCAGACGTCTGTGAATGCAGACCCCGCCTCCCACGAGATCTGGAGGTCAGAAACT       c.900
 S  H  Q  T  S  V  N  A  D  P  A  S  H  E  I  W  R  S  E  T         p.300

           | 10        .         .         .         .         .    g.23356
 CTGCTCCAG | GTTTTTGTTGAAATGTGGCTTCATCACTATTCCTTGGAGATGTATCAAAAA    c.960
 L  L  Q   | V  F  V  E  M  W  L  H  H  Y  S  L  E  M  Y  Q  K      p.320

          .         .  | 11      .         .         .         .    g.26517
 ATGCAGTCCCCTCATGCCAAG | CTGGAGGTTCTGCACTACCGACTCAGTGTCTCCAGCGCC    c.1020
 M  Q  S  P  H  A  K   | L  E  V  L  H  Y  R  L  S  V  S  S  A      p.340

          .         .         .         .         | 12         .    g.30366
 CTCTACAGCCCCGCCCAACCCAGCCTCCAGGCCCTCCACGCCTACCAA | GAGTCGTTCACG    c.1080
 L  Y  S  P  A  Q  P  S  L  Q  A  L  H  A  Y  Q   | E  S  F  T      p.360

          .         .         .         .         .         .       g.30426
 CCTACTGAGGAGCATGTGTTGGTGGTGCGCCTGCTGCTGAAGCACCTGCACGCCTTTGCC       c.1140
 P  T  E  E  H  V  L  V  V  R  L  L  L  K  H  L  H  A  F  A         p.380

          .         .         .         .         .         .       g.30486
 AACAGCCTGAAGCCAGAGCAGGCCTCACCCTCCGCCCACTCCCACGCCACCAGCCCCCTG       c.1200
 N  S  L  K  P  E  Q  A  S  P  S  A  H  S  H  A  T  S  P  L         p.400

          .     | 13   .         .         .         .         .    g.31121
 GAGGAGTTCAAACG | GGCTGCTGTCCCGAGGTTCGTCCAGCAGAAACTCTACCTCTTCTTG    c.1260
 E  E  F  K  R  |  A  A  V  P  R  F  V  Q  Q  K  L  Y  L  F  L      p.420

          .         .         .         .      | 14  .         .    g.31630
 CAGCATTGCTTTGGCCACTGGCCCCTGGACGCATCGTTCAGAGCT | GTCCTGGAGATGTGG    c.1320
 Q  H  C  F  G  H  W  P  L  D  A  S  F  R  A   | V  L  E  M  W      p.440

          .         .         .         .         .         .       g.31690
 CTGAGCTACCTGCAGCCGTGGCGGTACGCGCCTGACAAGCAGGCTCCGGGCAGCGACTCC       c.1380
 L  S  Y  L  Q  P  W  R  Y  A  P  D  K  Q  A  P  G  S  D  S         p.460

          .         .       | 15 .         .         .         .    g.32525
 CAGCCCCGGTGTGTGTCGGAGAAATG | GGCACCCTTTGTCCAGGAGAACCTGCTGATGTAC    c.1440
 Q  P  R  C  V  S  E  K  W  |  A  P  F  V  Q  E  N  L  L  M  Y      p.480

          .         .         .         .         .         .       g.32585
 ACCAAGTTGTTTGTGGGCTTTCTGAACCGCGCGCTCCGCACAGACCTGGTCAGCCCCAAG       c.1500
 T  K  L  F  V  G  F  L  N  R  A  L  R  T  D  L  V  S  P  K         p.500

          .         .         .         .         .         .       g.32645
 CACGCGCTCATGGTGTTCCGAGTGGCCAAAGTCTTTGCCCAGCCCAACCTGGCTGAGATG       c.1560
 H  A  L  M  V  F  R  V  A  K  V  F  A  Q  P  N  L  A  E  M         p.520

          . | 16       .         .         .         .         .    g.33318
 ATTCAGAAAG | GTGAGCAGCTATTCCTGGAGCCAGAGCTGGTCATCCCCCACCGCCAGCAC    c.1620
 I  Q  K  G |   E  Q  L  F  L  E  P  E  L  V  I  P  H  R  Q  H      p.540

          .         .         .         .         .         .       g.33378
 CGACTCTTCACGGCCCCCACATTCACTGGGAGCTTCCTGTCACCCTGGCCACCAGCGGTC       c.1680
 R  L  F  T  A  P  T  F  T  G  S  F  L  S  P  W  P  P  A  V         p.560

          .         .         .         .         .         .       g.33438
 ACTGATGCCTCCTTCAAGGTGAAGAGCCACGTCTACAGCCTGGAGGGCCAGGACTGCAAG       c.1740
 T  D  A  S  F  K  V  K  S  H  V  Y  S  L  E  G  Q  D  C  K         p.580

          .         .         .       | 17 .         .         .    g.33839
 TACACCCCGATGTTTGGGCCCGAGGCCCGCACCCTG | GTCCTGCGCCTCGCTCAGCTCATC    c.1800
 Y  T  P  M  F  G  P  E  A  R  T  L   | V  L  R  L  A  Q  L  I      p.600

          .         .         .         .         .         .       g.33899
 ACACAGGCCAAACACACAGCCAAGTCCATCTCCGACCAGTGTGCGGAGAGCCCGGCTGGC       c.1860
 T  Q  A  K  H  T  A  K  S  I  S  D  Q  C  A  E  S  P  A  G         p.620

          .         .         .         .         .         .       g.33959
 CACTCCTTCCTCTCATGGCTGGGCTTTAGCTCCATGGACACCAATGGCTCCTACACAGCC       c.1920
 H  S  F  L  S  W  L  G  F  S  S  M  D  T  N  G  S  Y  T  A         p.640

          .         .         .         .         .         .       g.34019
 AACGACCTGGACGAGATGGGGCAAGACAGTGTCCGGAAGACAGATGAATACCTGGAGAAG       c.1980
 N  D  L  D  E  M  G  Q  D  S  V  R  K  T  D  E  Y  L  E  K         p.660

          .         .         . | 18       .         .         .    g.34330
 GCCCTGGAGTACCTGCGCCAGATATTCCGG | CTCAGCGAAGCGCAGCTCAGGCAGTTCACA    c.2040
 A  L  E  Y  L  R  Q  I  F  R   | L  S  E  A  Q  L  R  Q  F  T      p.680

          .         .         .         .         .         .       g.34390
 CTCGCCTTGGGCACCACCCAGGATGAGAATGGAAAAAAGCAACTCCCCGACTGCATCGTG       c.2100
 L  A  L  G  T  T  Q  D  E  N  G  K  K  Q  L  P  D  C  I  V         p.700

          .         .         .         .   | 19     .         .    g.34597
 GGTGAGGACGGACTCATCCTTACGCCCCTGGGGCGGTACCAG | ATCATCAATGGGCTGCGA    c.2160
 G  E  D  G  L  I  L  T  P  L  G  R  Y  Q   | I  I  N  G  L  R      p.720

          .         .         .         .         .         .       g.34657
 AGGTTTGAAATTGAGTACCAGGGGGACCCGGAGCTGCAGCCCATCCGGAGCTATGAGATC       c.2220
 R  F  E  I  E  Y  Q  G  D  P  E  L  Q  P  I  R  S  Y  E  I         p.740

          .         .         .         .         .  | 20      .    g.34875
 GCCAGCTTGGTCCGCACACTCTTTAGGCTGTCGTCTGCCATCAACCACAGA | TTTGCAGGA    c.2280
 A  S  L  V  R  T  L  F  R  L  S  S  A  I  N  H  R   | F  A  G      p.760

          .         .         .         .         .         .       g.34935
 CAGATGGCGGCTCTGTGTTCCCGGGATGACTTCCTCGGCAGCTTCTGTCGCTACCACCTC       c.2340
 Q  M  A  A  L  C  S  R  D  D  F  L  G  S  F  C  R  Y  H  L         p.780

          .         .         .         .         .         .       g.34995
 ACAGAACCTGGGCTGGCCAGCAGGCACCTGCTGAGCCCTGTGGGGCGGAGGCAGGTGGCC       c.2400
 T  E  P  G  L  A  S  R  H  L  L  S  P  V  G  R  R  Q  V  A         p.800

          .         .         .         .         .         .       g.35055
 GGCCACACCCGCGGCCCCAGGCTCAGCCTGCGCTTCCTGGGCAGTTACCGGACGCTGGTC       c.2460
 G  H  T  R  G  P  R  L  S  L  R  F  L  G  S  Y  R  T  L  V         p.820

          .         .         .         .         .         .       g.35115
 TCGCTGCTGCTGGCCTTCTTCGTGGCCTCTCTGTTCTGCGTCGGGCCCCTCCCATGCACG       c.2520
 S  L  L  L  A  F  F  V  A  S  L  F  C  V  G  P  L  P  C  T         p.840

          .         .         .         .         .         .       g.35175
 CTGCTGCTCACCCTGGGCTATGTCCTCTACGCCTCTGCCATGACACTGCTGACCGAGCGG       c.2580
 L  L  L  T  L  G  Y  V  L  Y  A  S  A  M  T  L  L  T  E  R         p.860

          .         .                                               g.35196
 GGGAAGCTGCACCAGCCCTGA                                              c.2601
 G  K  L  H  Q  P  X                                                p.866

          .         .         .         .         .         .       g.35256
 aggtgtcagctgccttcagagcaggctggagggatttgccacacagccccacccttgggc       c.*60

          .         .         .         .         .         .       g.35316
 tgagaggacctgggaagcccctccaggagggaacacggtcatcctcgggcttctggagcg       c.*120

          .         .         .         .         .         .       g.35376
 gggttcctgcagccgcagaggcatctggaggaaacgcaaccaagaaaggaaggcaggtgg       c.*180

          .         .         .         .         .         .       g.35436
 gccccagcaaaggagtagctgccagggctcaacagctacgctctgtgacagcgcagagct       c.*240

          .         .         .         .         .         .       g.35496
 cagcggcggcctttccctccctccgccaaggactcacggccaagccagctctcggggcct       c.*300

          .         .         .         .         .         .       g.35556
 tttttccactgcccatttggctactctgctgcaccaagcttgggagccagcctgccaaca       c.*360

          .         .         .         .         .         .       g.35616
 gccacctgggcctggcctccccactggctggccttgaggttggcagagtgggttgtggcg       c.*420

          .         .         .         .         .         .       g.35676
 cttcctctctctgtgtgggaccaggacagtggcttaagtctccactccaggaaagaatca       c.*480

          .         .         .         .         .         .       g.35736
 aagtttctagagttgtgagaaaaccagagagtggctgtcctgattcttcactgtgagggg       c.*540

          .         .         .         .         .         .       g.35796
 cgttcttcatgttctcccagctgttccaagactgggccgtagaattccatgtttcaggag       c.*600

          .         .         .         .         .         .       g.35856
 cctaagaccctcccagagcccaggggcttcaccgcagaccccaagccattgagcacatca       c.*660

          .         .         .         .         .         .       g.35916
 cccaaagcagtggccaacatcgcggacccctgtgccttgtcacagatgggtgctggtcct       c.*720

          .         .         .         .         .         .       g.35976
 caggcgttggggacactgctgggtcgatggggtcggattctgccagtttctgctctgcag       c.*780

          .         .         .         .         .         .       g.36036
 ccaaagatggtcagaagcattgtcacttcagtaacatcaagtgctcaaagacatggcaac       c.*840

          .         .         .         .         .         .       g.36096
 cgttcagtggtacttaagtattcaaaatatacaactacagattctctgacagaaaccagc       c.*900

          .         .         .         .         .         .       g.36156
 acggggtcttcaccttcattcaccccacaggcgacatgcgagggagaacagcatctcagt       c.*960

          .         .         .         .         .         .       g.36216
 ggtgatttccaaaccaagcctttgttttcggtgtggggttttgggggtttgctttaatgt       c.*1020

          .         .         .         .         .         .       g.36276
 ttttgaaattgtaaatgttgggctttgtattttgatgtaaactgagcataatggcatttt       c.*1080

          .         .         .         .         .         .       g.36336
 agggcctgtgaccaaaaatgaagcttgtaacgaccatggatctgaataaacatgtccttg       c.*1140

          .         .                                               g.36359
 cttctgagtcttctggcacctgg                                            c.*1163

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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