sorbitol dehydrogenase (SORD) - coding DNA reference sequence

(used for variant description)

(last modified May 10, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_003104.5 in the SORD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering SORD transcript NM_003104.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 ctccacgctagcgccgcccaggctggcacaaaggaggaagcctagtcccgcccctgcgtg       c.-121

 .         .         .         .         .         .                g.5120
 cggcgcttctcccaggccccaccttccatccagtgccctggaccctcggctgggtagcgc       c.-61

 .         .         .         .         .         .                g.5180
 caccagagcgaccaaacgtcccgcgccttccaggccgcactccagagccaaaagagctcc       c.-1

          .         .         .         .         .         .       g.5240
 ATGGCGGCGGCGGCCAAGCCCAACAACCTTTCCCTGGTGGTGCACGGACCGGGGGACTTG       c.60
 M  A  A  A  A  K  P  N  N  L  S  L  V  V  H  G  P  G  D  L         p.20

        | 02 .         .         .         . | 03       .         . g.25173
 CGCCTG | GAGAACTATCCTATCCCTGAACCAGGCCCAAATG | AGGTCTTGCTGAGGATGCAT c.120
 R  L   | E  N  Y  P  I  P  E  P  G  P  N  E |   V  L  L  R  M  H   p.40

          .         .         .         .         .         .       g.25233
 TCTGTTGGAATCTGTGGCTCAGATGTCCACTACTGGGAGTATGGTCGAATTGGGAATTTT       c.180
 S  V  G  I  C  G  S  D  V  H  Y  W  E  Y  G  R  I  G  N  F         p.60

          .         .         .         .         .         .       g.25293
 ATTGTGAAAAAGCCCATGGTGCTGGGACATGAAGCTTCGGGAACAGTCGAAAAAGTGGGA       c.240
 I  V  K  K  P  M  V  L  G  H  E  A  S  G  T  V  E  K  V  G         p.80

          .         .      | 04  .         .         .         .    g.42998
 TCATCGGTAAAGCACCTAAAACCAG | GTGATCGTGTTGCCATCGAGCCTGGTGCTCCCCGA    c.300
 S  S  V  K  H  L  K  P  G |   D  R  V  A  I  E  P  G  A  P  R      p.100

          .         .         .         .         .         .       g.43058
 GAAAATGATGAATTCTGCAAGATGGGCCGATACAATCTGTCACCTTCCATCTTCTTCTGT       c.360
 E  N  D  E  F  C  K  M  G  R  Y  N  L  S  P  S  I  F  F  C         p.120

          .         .         .         .         .         .       g.43118
 GCCACGCCCCCCGATGACGGGAACCTCTGCCGGTTCTATAAGCACAATGCAGCCTTTTGT       c.420
 A  T  P  P  D  D  G  N  L  C  R  F  Y  K  H  N  A  A  F  C         p.140

       | 05  .         .         .         .         .         .    g.47222
 TACAA | GCTTCCTGACAATGTCACCTTTGAGGAAGGCGCCCTGATCGAGCCACTTTCTGTG    c.480
 Y  K  |  L  P  D  N  V  T  F  E  E  G  A  L  I  E  P  L  S  V      p.160

          .         .         .         .         .         .       g.47282
 GGGATCCATGCCTGCAGGAGAGGCGGAGTTACCCTGGGACACAAGGTCCTTGTGTGTGGA       c.540
 G  I  H  A  C  R  R  G  G  V  T  L  G  H  K  V  L  V  C  G         p.180

      | 06   .         .         .         .         .         .    g.50133
 GCTG | GGCCAATCGGGATGGTCACTTTGCTCGTGGCCAAAGCAATGGGAGCAGCTCAAGTA    c.600
 A  G |   P  I  G  M  V  T  L  L  V  A  K  A  M  G  A  A  Q  V      p.200

          . | 07       .         .         .         .         .    g.50823
 GTGGTGACTG | ATCTGTCTGCTACCCGATTGTCCAAAGCCAAGGAGATTGGGGCTGATTTA    c.660
 V  V  T  D |   L  S  A  T  R  L  S  K  A  K  E  I  G  A  D  L      p.220

          .         .         .         .         .         .       g.50883
 GTCCTCCAGATCTCCAAGGAGAGCCCTCAGGAAATCGCCAGGAAAGTAGAAGGTCAGCTG       c.720
 V  L  Q  I  S  K  E  S  P  Q  E  I  A  R  K  V  E  G  Q  L         p.240

          .         .         .         .         .         .       g.50943
 GGGTGCAAGCCGGAAGTCACCATCGAGTGCACGGGGGCAGAGGCCTCCATCCAGGCGGGC       c.780
 G  C  K  P  E  V  T  I  E  C  T  G  A  E  A  S  I  Q  A  G         p.260

        | 08 .         .         .         .         .         .    g.54267
 ATCTAC | GCCACTCGCTCTGGTGGGAACCTCGTGCTTGTGGGGCTGGGCTCTGAGATGACC    c.840
 I  Y   | A  T  R  S  G  G  N  L  V  L  V  G  L  G  S  E  M  T      p.280

          .         .         .         .         .         .       g.54327
 ACCGTACCCCTACTGCATGCAGCCATCCGGGAGGTGGATATCAAGGGCGTGTTTCGATAC       c.900
 T  V  P  L  L  H  A  A  I  R  E  V  D  I  K  G  V  F  R  Y         p.300

          | 09         .         .         .         .         .    g.55313
 TGCAACAC | GTGGCCAGTGGCGATTTCGATGCTTGCGTCCAAGTCTGTGAATGTAAAACCC    c.960
 C  N  T  |  W  P  V  A  I  S  M  L  A  S  K  S  V  N  V  K  P      p.320

          .         .         .         .         .         .       g.55373
 CTCGTCACCCATAGGTTTCCTCTGGAGAAAGCTCTGGAGGCCTTTGAAACATTTAAAAAG       c.1020
 L  V  T  H  R  F  P  L  E  K  A  L  E  A  F  E  T  F  K  K         p.340

          .         .         .         .         .                 g.55427
 GGATTGGGGTTGAAAATCATGCTCAAGTGTGACCCCAGTGACCAGAATCCCTGA             c.1074
 G  L  G  L  K  I  M  L  K  C  D  P  S  D  Q  N  P  X               p.357

          .         .         .         .         .         .       g.55487
 tgttaatgggctctgccctcatccccacagtcttgggatctcagggcacaatggctggac       c.*60

          .         .         .         .         .         .       g.55547
 atgggtgggctctgatgcagaactttctcttttgaatgttaagaataactaatacaattc       c.*120

          .         .         .         .         .         .       g.55607
 attgtgaacagaagtccttaagcagaggaattggtgtgccttaaagatacaatctgggat       c.*180

          .         .         .         .         .         .       g.55667
 agtttgggggaacttgtagccagaatgccctgttcatgctgagcaaagttcagcaagtag       c.*240

          .         .         .         .         .         .       g.55727
 agcagagtttggcaggcaggtgccaggaactccccttcttcctggagtgccttcattgag       c.*300

          .         .         .         .         .         .       g.55787
 gaaggaaatctggcccttgggtttcctggttccactgctactgacccagaggggaatgag       c.*360

          .         .         .         .         .         .       g.55847
 ggctgagttatgaaaagataacttcatgaagacttaactggcccagaagctgattttcat       c.*420

          .         .         .         .         .         .       g.55907
 gaaaatctgccactcagggtctgggatgaaggcttgtcagcacttccagtttagaacgca       c.*480

          .         .         .         .         .         .       g.55967
 atgtttctagagacatattggctgtttgttttgatgataaaaggagaataagaaaaggca       c.*540

          .         .         .         .         .         .       g.56027
 tcactttcctggatccaggataatttttaaaccaatcaaatgaaaaaaacaaacaaacaa       c.*600

          .         .         .         .         .         .       g.56087
 aaaaggaaatgtcatgtgaggttaaaccagtttgcattcccctaatgtggaaaaagtaag       c.*660

          .         .         .         .         .         .       g.56147
 aggactactcagcactgtttgaagattgcctcttctacagcttctgagaattgtgttatt       c.*720

          .         .         .         .         .         .       g.56207
 tcacttgccaagtgaaggaccccctccccaacatgccccagcccacccctaagcatggtc       c.*780

          .         .         .         .         .         .       g.56267
 ccttgtcaccaggcaaccaggaaactgctacttgtggacctcaccagagaccaggagggt       c.*840

          .         .         .         .         .         .       g.56327
 ttggttagctcacaggacttcccccaccccagaagattagcatcccatactagactcata       c.*900

          .         .         .         .         .         .       g.56387
 ctcaactcaactaggctcatactcaattgatggttattagacaattccatttctttctgg       c.*960

          .         .         .         .         .         .       g.56447
 ttattataaacagaaaatctttcctcttctcattaccagtaaaggctcttggtatctttc       c.*1020

          .         .         .         .         .         .       g.56507
 tgttggaatgatttctatgaacttgtcttattttaatggtgggttttttttctggtaaga       c.*1080

          .         .         .         .         .         .       g.56567
 tttagacctaaatcgcatcatgccaacttgtgactttgagactattcatcaagaatgagg       c.*1140

          .         .         .         .         .         .       g.56627
 atatagtagccatgacatagcttgagctatagcctttaattccttactttggctatgggt       c.*1200

          .         .         .         .         .         .       g.56687
 ggagggtgagtttgaagaggttctgattttcttgtaacctgggaaagccatgaccttgtg       c.*1260

          .         .         .         .         .         .       g.56747
 cccgattctttcagattgctttgggtaataaatattggtggtggtatctgactcatgctg       c.*1320

          .         .         .         .         .         .       g.56807
 ctgtttatggtcctgtttagtggggaatggactcaggttacccatttcccagagggaagg       c.*1380

          .         .         .         .         .         .       g.56867
 atcccaggatttttgaaggttacatattttctgtaccaaatataatttcattgacatgaa       c.*1440

          .         .         .         .         .         .       g.56927
 ttatctctaatcctcatgacaagccacatacacaatcattttgtagataaagaagatata       c.*1500

          .         .         .         .         .                 g.56986
 aatgccagaggagaccttaagattgtcttacaacacaacccttcagttaacgagagagg        c.*1559

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sorbitol dehydrogenase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 23
©2004-2020 Leiden University Medical Center