SRY (sex determining region Y)-box 10 (SOX10) - coding DNA reference sequence

(used for variant description)

(last modified October 17, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_006941.3 in the SOX10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007948.1, covering SOX10 transcript NM_006941.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       gtccggccagggtggttggtggtaaggattcaggctcc       c.-241

 .         .         .         .         .         .                g.5098
 gtcctaacgaggccgtggcctgaggctcagggccccccgcccctccctcccagcccacca       c.-181

 .         .         .         .         .         .                g.5158
 gcgtcacctcccagccccgagctggaccgcacaccttgggacacggttttccacttccta       c.-121

 .         .         .         .      | 02  .         .             g.5688
 aggacgagccccagactggaggagaggtccgaggag | gtgggcgttggactctttgcgagg    c.-61

 .         .         .         .         .         .                g.5748
 accccggcggctggcccgggggaggcggccgaggcggcggcggcggcggccgggggcgac       c.-1

          .         .         .         .         .         .       g.5808
 ATGGCGGAGGAGCAGGACCTATCGGAGGTGGAGCTGAGCCCCGTGGGCTCGGAGGAGCCC       c.60
 M  A  E  E  Q  D  L  S  E  V  E  L  S  P  V  G  S  E  E  P         p.20

          .         .         .         .         .         .       g.5868
 CGCTGCCTGTCCCCGGGGAGCGCGCCCTCGCTAGGGCCCGACGGCGGCGGCGGCGGATCG       c.120
 R  C  L  S  P  G  S  A  P  S  L  G  P  D  G  G  G  G  G  S         p.40

          .         .         .         .         .         .       g.5928
 GGCCTGCGAGCCAGCCCGGGGCCAGGCGAGCTGGGCAAGGTCAAGAAGGAGCAGCAGGAC       c.180
 G  L  R  A  S  P  G  P  G  E  L  G  K  V  K  K  E  Q  Q  D         p.60

          .         .         .         .         .         .       g.5988
 GGCGAGGCGGACGATGACAAGTTCCCCGTGTGCATCCGCGAGGCCGTCAGCCAGGTGCTC       c.240
 G  E  A  D  D  D  K  F  P  V  C  I  R  E  A  V  S  Q  V  L         p.80

          .         .         .         .         .         .       g.6048
 AGCGGCTACGACTGGACGCTGGTGCCCATGCCCGTGCGCGTCAACGGCGCCAGCAAAAGC       c.300
 S  G  Y  D  W  T  L  V  P  M  P  V  R  V  N  G  A  S  K  S         p.100

          .         .         .         .         .         .       g.6108
 AAGCCGCACGTCAAGCGGCCCATGAACGCCTTCATGGTGTGGGCTCAGGCAGCGCGCAGG       c.360
 K  P  H  V  K  R  P  M  N  A  F  M  V  W  A  Q  A  A  R  R         p.120

          .         .         .         .         .         .       g.6168
 AAGCTCGCGGACCAGTACCCGCACCTGCACAACGCTGAGCTCAGCAAGACGCTGGGCAAG       c.420
 K  L  A  D  Q  Y  P  H  L  H  N  A  E  L  S  K  T  L  G  K         p.140

          | 03         .         .         .         .         .    g.11449
 CTCTGGAG | GCTGCTGAACGAAAGTGACAAGCGCCCCTTCATCGAGGAGGCTGAGCGGCTC    c.480
 L  W  R  |  L  L  N  E  S  D  K  R  P  F  I  E  E  A  E  R  L      p.160

          .         .         .         .         .         .       g.11509
 CGTATGCAGCACAAGAAAGACCACCCGGACTACAAGTACCAGCCCAGGCGGCGGAAGAAC       c.540
 R  M  Q  H  K  K  D  H  P  D  Y  K  Y  Q  P  R  R  R  K  N         p.180

          .         .         .         .         .         .       g.11569
 GGGAAGGCCGCCCAGGGCGAGGCGGAGTGCCCCGGTGGGGAGGCCGAGCAAGGTGGGACC       c.600
 G  K  A  A  Q  G  E  A  E  C  P  G  G  E  A  E  Q  G  G  T         p.200

          .         .         .         .         .         .       g.11629
 GCCGCCATCCAGGCCCACTACAAGAGCGCCCACTTGGACCACCGGCACCCAGGAGAGGGC       c.660
 A  A  I  Q  A  H  Y  K  S  A  H  L  D  H  R  H  P  G  E  G         p.220

          .         .         .        | 04.         .         .    g.15357
 TCCCCCATGTCAGATGGGAACCCCGAGCACCCCTCAG | GCCAGAGCCATGGCCCACCCACC    c.720
 S  P  M  S  D  G  N  P  E  H  P  S  G |   Q  S  H  G  P  P  T      p.240

          .         .         .         .         .         .       g.15417
 CCTCCAACCACCCCGAAGACAGAGCTGCAGTCGGGCAAGGCAGACCCGAAGCGGGACGGG       c.780
 P  P  T  T  P  K  T  E  L  Q  S  G  K  A  D  P  K  R  D  G         p.260

          .         .         .         .         .         .       g.15477
 CGCTCCATGGGGGAGGGCGGGAAGCCTCACATCGACTTCGGCAACGTGGACATTGGTGAG       c.840
 R  S  M  G  E  G  G  K  P  H  I  D  F  G  N  V  D  I  G  E         p.280

          .         .         .         .         .         .       g.15537
 ATCAGCCACGAGGTAATGTCCAACATGGAGACCTTTGATGTGGCTGAGTTGGACCAGTAC       c.900
 I  S  H  E  V  M  S  N  M  E  T  F  D  V  A  E  L  D  Q  Y         p.300

          .         .         .         .         .         .       g.15597
 CTGCCGCCCAATGGGCACCCAGGCCATGTGAGCAGCTACTCAGCAGCCGGCTATGGGCTG       c.960
 L  P  P  N  G  H  P  G  H  V  S  S  Y  S  A  A  G  Y  G  L         p.320

          .         .         .         .         .         .       g.15657
 GGCAGTGCCCTGGCCGTGGCCAGTGGACACTCCGCCTGGATCTCCAAGCCACCAGGCGTG       c.1020
 G  S  A  L  A  V  A  S  G  H  S  A  W  I  S  K  P  P  G  V         p.340

          .         .         .         .         .         .       g.15717
 GCTCTGCCCACGGTCTCACCACCTGGTGTGGATGCCAAAGCCCAGGTGAAGACAGAGACC       c.1080
 A  L  P  T  V  S  P  P  G  V  D  A  K  A  Q  V  K  T  E  T         p.360

          .         .         .         .         .         .       g.15777
 GCGGGGCCCCAGGGGCCCCCACACTACACCGACCAGCCATCCACCTCACAGATCGCCTAC       c.1140
 A  G  P  Q  G  P  P  H  Y  T  D  Q  P  S  T  S  Q  I  A  Y         p.380

          .         .         .         .         .         .       g.15837
 ACCTCCCTCAGCCTGCCCCACTATGGCTCAGCCTTCCCCTCCATCTCCCGCCCCCAGTTT       c.1200
 T  S  L  S  L  P  H  Y  G  S  A  F  P  S  I  S  R  P  Q  F         p.400

          .         .         .         .         .         .       g.15897
 GACTACTCTGACCATCAGCCCTCAGGACCCTATTATGGCCACTCGGGCCAGGCCTCTGGC       c.1260
 D  Y  S  D  H  Q  P  S  G  P  Y  Y  G  H  S  G  Q  A  S  G         p.420

          .         .         .         .         .         .       g.15957
 CTCTACTCGGCCTTCTCCTATATGGGGCCCTCGCAGCGGCCCCTCTACACGGCCATCTCT       c.1320
 L  Y  S  A  F  S  Y  M  G  P  S  Q  R  P  L  Y  T  A  I  S         p.440

          .         .         .         .         .         .       g.16017
 GACCCCAGCCCCTCAGGGCCCCAGTCCCACAGCCCCACACACTGGGAGCAGCCAGTATAT       c.1380
 D  P  S  P  S  G  P  Q  S  H  S  P  T  H  W  E  Q  P  V  Y         p.460

          .         .                                               g.16038
 ACGACACTGTCCCGGCCCTAA                                              c.1401
 T  T  L  S  R  P  X                                                p.466

          .         .         .         .         .         .       g.16098
 agggggccctgtcgccaccaccccccgcccagcccctgcccccagcctgtgtgccctgtt       c.*60

          .         .         .         .         .         .       g.16158
 ccttgcccacctcaggcctggtggtggcagtggaggaggctgaggaggctgaagaggctg       c.*120

          .         .         .         .         .         .       g.16218
 acaggtcggggggctttctgtctggctcactgccctgatgacccacccgccccatccagg       c.*180

          .         .         .         .         .         .       g.16278
 ctccagcagcaaagccccaggagaacaggctggacagaggagaaggaggttgactgttgc       c.*240

          .         .         .         .         .         .       g.16338
 acccacactgaaagatgaggggctgcaccttcccccaggaatgaccctctatcccaggac       c.*300

          .         .         .         .         .         .       g.16398
 ctgagaagggcctgctcaccctcctcggggaggggaagcaccagggttggtggcatcgga       c.*360

          .         .         .         .         .         .       g.16458
 ggccttaccactcctatgactcctgttttctctctcacagatagtgagggtctgacatgc       c.*420

          .         .         .         .         .         .       g.16518
 ccatgccacctatgccacagtgcctaagggctaggccacccagagactgtgcccggagct       c.*480

          .         .         .         .         .         .       g.16578
 ggccgtgtctcccactcaggggctgagagtagctttgaggagcctcattggggagtgggg       c.*540

          .         .         .         .         .         .       g.16638
 ggttcgagggacttagtggagttctcatcccttcaatgccccctccctttctgaaggcag       c.*600

          .         .         .         .         .         .       g.16698
 gaaggagttggcacagaggccccctgatccaattctgtgccaataacctcattctttgtc       c.*660

          .         .         .         .         .         .       g.16758
 tgagaaacagcccccagtcctcctccactacaacctccatgaccttgagacgcatcccag       c.*720

          .         .         .         .         .         .       g.16818
 gaggtgacgaggcaggggctccaggaaaggaatcagagacaattcacagagcctccctcc       c.*780

          .         .         .         .         .         .       g.16878
 ctgggctccttgccagctccctcttcccttactaggctctatggcccctgctcagtcagc       c.*840

          .         .         .         .         .         .       g.16938
 cccactccctgggcttcccagagagtgacagctgctcaggccctaacccttggctccagg       c.*900

          .         .         .         .         .         .       g.16998
 agacacagggcccagcacccaggttgctgtcggcaggctgaagacactagaatcctgacc       c.*960

          .         .         .         .         .         .       g.17058
 tgtacattctgcccttgcctcttaccccttgcctcccagtggtatttgaataaagtatgt       c.*1020

          .         .         .         .         .         .       g.17118
 agctatatctgcccctattttcctgttctgcagccccccaaatccacatgtaactcatta       c.*1080

          .         .         .         .         .         .       g.17178
 ctgtctcctgttatttatctcagtagtcccctctcctagccactctagcccctattaact       c.*1140

          .         .         .         .                           g.17221
 ctgcattaagcattccacataataaaattaaaggttccggtta                        c.*1183

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SRY (sex determining region Y)-box 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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