sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 (SPOCK1) - coding DNA reference sequence

(used for variant description)

(last modified February 16, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_004598.3 in the SPOCK1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering SPOCK1 transcript NM_004598.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              agcacatcgctgcgggctcacaaagcggcca       c.-121

 .         .         .         .         .         .                g.5091
 gacgctcggcggcggcgtgtggcaggagcgcaggggcgcgagccggcgatcagccttccc       c.-61

 .         .         .         .         .         .                g.5151
 ggcgaccgtgccgcgggagctcgagcaactcggactaggggacccgggccggcccccaag       c.-1

  | 02       .         .         .         .         .         .    g.5831
  | ATGCCGGCGATCGCGGTGTTGGCGGCGGCCGCCGCGGCGTGGTGCTTCCTCCAAGTCGAG    c.60
  | M  P  A  I  A  V  L  A  A  A  A  A  A  W  C  F  L  Q  V  E      p.20

          .         .         .         .         .         .       g.5891
 AGCCGGCACCTGGACGCGCTCGCCGGAGGCGCGGGCCCCAACCACGGCAATTTCCTAGAC       c.120
 S  R  H  L  D  A  L  A  G  G  A  G  P  N  H  G  N  F  L  D         p.40

          .         .         .         .         .         .       g.5951
 AATGACCAGTGGCTGAGCACCGTCTCCCAGTACGACCGGGACAAGTACTGGAACCGCTTT       c.180
 N  D  Q  W  L  S  T  V  S  Q  Y  D  R  D  K  Y  W  N  R  F         p.60

        | 03 .         .         .         .         .   | 04     . g.363643
 CGAGAC | GATGATTATTTCAGAAACTGGAATCCCAACAAGCCCTTTGACCAAG | CCCTGGAC c.240
 R  D   | D  D  Y  F  R  N  W  N  P  N  K  P  F  D  Q  A |   L  D   p.80

          .         .         .         .         .         .       g.363703
 CCATCCAAGGACCCCTGCCTGAAGGTAAAATGCAGCCCTCACAAAGTGTGTGTGACCCAG       c.300
 P  S  K  D  P  C  L  K  V  K  C  S  P  H  K  V  C  V  T  Q         p.100

          .         .         .         .        | 05.         .    g.391781
 GACTACCAGACCGCCCTGTGTGTCAGCCGCAAGCACCTGCTCCCCAG | GCAAAAGAAGGGG    c.360
 D  Y  Q  T  A  L  C  V  S  R  K  H  L  L  P  R  |  Q  K  K  G      p.120

          .         .         .         .         .         .       g.391841
 AACGTGGCCCAGAAACACTGGGTTGGACCTTCGAATTTGGTCAAGTGCAAGCCCTGTCCC       c.420
 N  V  A  Q  K  H  W  V  G  P  S  N  L  V  K  C  K  P  C  P         p.140

          .         .         .         .         .     | 06   .    g.436506
 GTGGCACAGTCAGCCATGGTCTGCGGCTCAGATGGCCACTCCTACACATCCAAG | TGCAAA    c.480
 V  A  Q  S  A  M  V  C  G  S  D  G  H  S  Y  T  S  K   | C  K      p.160

          .         .         .         .         .         .       g.436566
 TTGGAGTTCCATGCTTGTTCTACTGGCAAAAGCCTCGCCACCCTCTGTGATGGGCCCTGT       c.540
 L  E  F  H  A  C  S  T  G  K  S  L  A  T  L  C  D  G  P  C         p.180

          .         .         .         .          | 07        .    g.511740
 CCCTGTCTCCCAGAGCCTGAGCCACCAAAGCACAAGGCAGAAAGGAGTG | CCTGCACAGAC    c.600
 P  C  L  P  E  P  E  P  P  K  H  K  A  E  R  S  A |   C  T  D      p.200

          .         .         .         .         .         .       g.511800
 AAGGAGTTGCGGAACCTTGCCTCCCGGCTGAAGGATTGGTTTGGAGCTCTCCACGAGGAT       c.660
 K  E  L  R  N  L  A  S  R  L  K  D  W  F  G  A  L  H  E  D         p.220

          .         .         .         .       | 08 .         .    g.515700
 GCGAACAGAGTCATCAAGCCCACCAGCTCCAACACAGCCCAAGGCA | GGTTTGACACTAGC    c.720
 A  N  R  V  I  K  P  T  S  S  N  T  A  Q  G  R |   F  D  T  S      p.240

          .         .         .         .         .         .       g.515760
 ATCCTGCCCATCTGCAAGGACTCCCTGGGCTGGATGTTCAACAAGTTGGACATGAACTAT       c.780
 I  L  P  I  C  K  D  S  L  G  W  M  F  N  K  L  D  M  N  Y         p.260

          .         .         .         .         .         .       g.515820
 GACCTCCTGCTTGACCCTTCAGAGATCAATGCCATCTACCTGGATAAGTACGAGCCCTGT       c.840
 D  L  L  L  D  P  S  E  I  N  A  I  Y  L  D  K  Y  E  P  C         p.280

          .         .         .         .         .         .       g.515880
 ATCAAGCCTCTTTTCAACTCGTGTGACTCCTTCAAGGATGGCAAGCTTTCTAACAATGAG       c.900
 I  K  P  L  F  N  S  C  D  S  F  K  D  G  K  L  S  N  N  E         p.300

          .         .         | 09         .         .         .    g.519159
 TGGTGCTACTGCTTCCAGAAGCCTGGAG | GTCTCCCTTGCCAGAATGAAATGAACAGAATT    c.960
 W  C  Y  C  F  Q  K  P  G  G |   L  P  C  Q  N  E  M  N  R  I      p.320

          .         .         .  | 10      .         .         .    g.524889
 CAGAAGCTGAGTAAGGGGAAAAGCCTGTTGG | GGGCCTTCATACCTCGGTGTAATGAGGAG    c.1020
 Q  K  L  S  K  G  K  S  L  L  G |   A  F  I  P  R  C  N  E  E      p.340

          .         .         .         .         .         .       g.524949
 GGCTATTACAAAGCCACACAGTGCCACGGCAGCACGGGGCAGTGCTGGTGTGTGGACAAA       c.1080
 G  Y  Y  K  A  T  Q  C  H  G  S  T  G  Q  C  W  C  V  D  K         p.360

          .         .         .         .          | 11        .    g.525496
 TATGGGAATGAGTTGGCTGGCTCCAGGAAACAGGGTGCTGTGAGCTGTG | AAGAGGAGCAG    c.1140
 Y  G  N  E  L  A  G  S  R  K  Q  G  A  V  S  C  E |   E  E  Q      p.380

          .         .         .         .         .         .       g.525556
 GAAACCTCAGGGGATTTTGGCAGTGGTGGGTCCGTGGTCCTGCTGGATGACCTAGAATAT       c.1200
 E  T  S  G  D  F  G  S  G  G  S  V  V  L  L  D  D  L  E  Y         p.400

          .         .         .         .         .         .       g.525616
 GAACGGGAGCTGGGACCAAAGGACAAAGAGGGGAAGCTGAGGGTGCACACCCGAGCCGTG       c.1260
 E  R  E  L  G  P  K  D  K  E  G  K  L  R  V  H  T  R  A  V         p.420

          .         .         .         .         .         .       g.525676
 ACAGAGGATGATGAGGATGAGGATGATGACAAAGAGGATGAGGTCGGGTACATATGGTAG       c.1320
 T  E  D  D  E  D  E  D  D  D  K  E  D  E  V  G  Y  I  W  X         p.439

          .         .         .         .         .         .       g.525736
 tgcccacaagaaagaggacacaagttttgcacaaaattgcaagtcacttcctattcctgc       c.*60

          .         .         .         .         .         .       g.525796
 atttgtatctaagactccaaggcaccaaggtctcttctccattgttgctctctatacccg       c.*120

          .         .         .         .         .         .       g.525856
 acctaaggtttggaagacaactgcttgttcccagaggattctgattttgcatatgtttgt       c.*180

          .         .         .         .         .         .       g.525916
 atgggagaaagggtgttgtgttttttttttgttgttgtttattttttggatagggaagtc       c.*240

          .         .         .         .         .         .       g.525976
 attggcttaattagagcctccttcctttctgtgagatttttccaacaagcatgtgattta       c.*300

          .         .         .         .         .         .       g.526036
 cgtggaattctgacagtgcagggagccccaaccctcttaaatgtcaaagaccctttttga       c.*360

          .         .         .         .         .         .       g.526096
 ttacccacactggtggttattacagcatggttcccagccttacagtgtctaagtgcttct       c.*420

          .         .         .         .         .         .       g.526156
 cttgtgtcctgtagatgttgtgaaaaagaaaaaaacaaaaaatacaccacactgtacttt       c.*480

          .         .         .         .         .         .       g.526216
 ttccccctgcccccgttactgccggtgattattattaaaaattagtttttttcacatcat       c.*540

          .         .         .         .         .         .       g.526276
 tatatctggcttcctataaacaacagccttaattcagtcaagactccctttggggaattc       c.*600

          .         .         .         .         .         .       g.526336
 attttattaaaaattggtgtctggatacttccctgtacatgcataaatatgcatgcatgt       c.*660

          .         .         .         .         .         .       g.526396
 acagaaagactgtatgtgtgtgccttgcacacacacccatacctctcagaaaaagtgttt       c.*720

          .         .         .         .         .         .       g.526456
 gggtatcttaaaaactcgaaaaacaatgataaatttctcagcttgtccagacctggaaca       c.*780

          .         .         .         .         .         .       g.526516
 aaatttctggaataagaaatttgtattaaagtccttttttgcactaacagttggctcttg       c.*840

          .         .         .         .         .         .       g.526576
 tagcctgcaggctgaggaagtctcttctctgtgcatcagcagagttactgaaagcctctg       c.*900

          .         .         .         .         .         .       g.526636
 attgagaaaaaacctccgtctgcctaaatcacttttctcgcagaagccatgcgactccca       c.*960

          .         .         .         .         .         .       g.526696
 cacgacacgggcagcttcacaagccatctctttcatttctgcttgaagccccttggctgc       c.*1020

          .         .         .         .         .         .       g.526756
 agcaatcctgtctgccataggtttcttccttccttacctactcaagggctttttctaagg       c.*1080

          .         .         .         .         .         .       g.526816
 catgcacacatatctcctgttctctgagagtaccatggtgttccttaaaagaagaaaatt       c.*1140

          .         .         .         .         .         .       g.526876
 tctaattctgaactcaatgttttgcttttactccctttctactgacaaatcatgataagg       c.*1200

          .         .         .         .         .         .       g.526936
 gcacaaaagctgtacagatttttttttttaaccactcaatcccaaatggaggcctacaaa       c.*1260

          .         .         .         .         .         .       g.526996
 gaacatcgtaataacacatggaagcaaaccctgggtttttaagagcaaattctgtccccc       c.*1320

          .         .         .         .         .         .       g.527056
 cctcactcccccaagtgacaagatactaatgaagaaagttcttcaccatagtgtttgttt       c.*1380

          .         .         .         .         .         .       g.527116
 taactaaactcattggagtctagttccaaatttggtagggtcatcatctctacattcctt       c.*1440

          .         .         .         .         .         .       g.527176
 aggatttctctccctatcaagctggcccagatacaagtaccaaacagtagtctctgaagt       c.*1500

          .         .         .         .         .         .       g.527236
 tcccccatttccttcagtaccagtctataagctactgtccgccactgattttcatttatc       c.*1560

          .         .         .         .         .         .       g.527296
 agggtgtcctaatcagaatcagccacccaagcaagcctctctggcccacatatctatctc       c.*1620

          .         .         .         .         .         .       g.527356
 ttgccttcccccatgaacttcagcctgtccacacaaaagccacataaactcaagcaagaa       c.*1680

          .         .         .         .         .         .       g.527416
 atatgttcagccaaaacatgattatagtggcagctgaccaatcccccatcccaaattgac       c.*1740

          .         .         .         .         .         .       g.527476
 catttagatgtaccaactcaccttaaattagcatgttccaatccagtcggcattgcctga       c.*1800

          .         .         .         .         .         .       g.527536
 atacagtagcatcatacctatagttggtcttagataagaaatgaactacttgatatagca       c.*1860

          .         .         .         .         .         .       g.527596
 aagtcctttggcttcgtaaataaccctgaggttttgtacttactttccccataggaagac       c.*1920

          .         .         .         .         .         .       g.527656
 agaccataggcaaactctgttttgggatctcaactccatcacctttgtttcaatattttt       c.*1980

          .         .         .         .         .         .       g.527716
 tttctctcttgaacaaaactgagataatttagaaaacaggtgcttaattgcaataaaatt       c.*2040

          .         .         .         .         .         .       g.527776
 actatgaagtatattaaaaatcacgacattgtaaaatctcactttagatcatcaaagaaa       c.*2100

          .         .         .         .         .         .       g.527836
 accattgttactatctcctttgagcttaggaaaatgtacaagagaacaaattaaaattga       c.*2160

          .         .         .         .         .         .       g.527896
 aaaattgatttcacttagaaaaacttctaggaacagggtgaaccactgattttaatttgc       c.*2220

          .         .         .         .         .         .       g.527956
 ctaattatcttatgacaagtatcaaattaagatgacacttaaagatccttagcattaact       c.*2280

          .         .         .         .         .         .       g.528016
 taatgatggagaagagtgctcaatagacagttcccagtaaggtaatgagatgccattttc       c.*2340

          .         .         .         .         .         .       g.528076
 agagacattctaagaagatattttgattcattaaaacattaaataaaaagccctcctcag       c.*2400

          .         .         .         .         .         .       g.528136
 attggaacccccaaatcgatggagccacattaataatacttttcatgcctcactttgaca       c.*2460

          .         .         .         .         .         .       g.528196
 tgacagcattcgatttttttaaagatctttaatactttccatgagtactaaagattgtaa       c.*2520

          .         .         .         .         .         .       g.528256
 tgagttaccttatccttagaagtagaatgtttgctttcttcttcttggaaatagtcctcc       c.*2580

          .         .         .         .         .         .       g.528316
 aaaaagtccacttgtaccagtgacaagaagtcacttgtatagtgaccaagtacacataaa       c.*2640

          .         .         .         .         .         .       g.528376
 atactgattataaaaatattgtaataaaccacttcctcatttgatacaggtattaagctg       c.*2700

          .         .         .         .         .         .       g.528436
 aatcctcactaattcacttttgaaaagttcttaatgaacagttttattcttattccatga       c.*2760

          .         .         .         .         .         .       g.528496
 acagctcttttaatacaatttccttggtatccaacttaaatcccagaattttgttccacc       c.*2820

          .         .         .         .         .         .       g.528556
 atggttagttatttgccatatgaatgtattcttgtttctaccaatattctaggcatgaga       c.*2880

          .         .         .         .         .         .       g.528616
 ataccttaatactgagttggagattttgtatctgtttctcctcctttacgcccattttcc       c.*2940

          .         .         .         .         .         .       g.528676
 tacccacagcagcaaatgacaacgtgtctgtccaggtctgtccccctgctcatcccagga       c.*3000

          .         .         .         .         .         .       g.528736
 tgccactcacatttttttcttcttgttaccttgaccacgctgtacagtaacatccaagag       c.*3060

          .         .         .         .         .         .       g.528796
 cccattctacagtgggtggttttggtctttttataactttttctcaaagtcactgatgtt       c.*3120

          .         .         .         .         .         .       g.528856
 tgttcctgttaaatgtatagcattgtaatgagagcccatcaaatcctgagtgtcagtttg       c.*3180

          .         .         .         .         .         .       g.528916
 ttgtccctattgtagatgaaatagtgatgtagcaaaaacctagtaaattctgaatgcttt       c.*3240

          .         .         .         .         .         .       g.528976
 tccacgtagacttatctggaatgtgaacacaactctttggttaatagtaaatgcttaact       c.*3300

          .         .         .         .         .                 g.529032
 gtagtcctgagtaggtgcatttctgtctgtctcaataaattttactttgtctgcaa           c.*3356

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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