sprouty-related, EVH1 domain containing 2 (SPRED2) - coding DNA reference sequence

(used for variant description)

(last modified October 9, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_181784.2 in the SPRED2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering SPRED2 transcript NM_181784.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      atccaatatggagtaaatcggtggagtcgagagatggggctcggacggggcgccc       c.-481

 .         .         .         .         .         .                g.5115
 tgcaccgcctcccaggcgcacctcccccggccgccgaccgctccccggaaccgtgattgg       c.-421

 .         .         .         .         .         .                g.5175
 cccggccccccgggggcgaccccggactgagcccccccacccgcggccggcgctctcctc       c.-361

 .         .         .         .         .         .                g.5235
 ctcctcgcagcagtccctgccgctccgaggcgcgcttgtttttctcctgctctcccccac       c.-301

 .         .         .         .         .         .                g.5295
 cgccgtccccttcccaaatctcgccccctctgcccgctcccgagcccccggagcctccgc       c.-241

 .         .         .         .         .         .                g.5355
 ccgcctctccccacggcgctgcggcgttcactccccgcgcagcctgcctttgcacccctt       c.-181

 .         .         .         .         .         .                g.5415
 cccccaaaccctatcccgcgccctgcttccccttctgctgcggcgccctcttcatctcta       c.-121

 .         .         .         .         .         .                g.5475
 gccgccccccctccccaaatcaggcgatctccggagatgtgaagaaggggggcgagcgga       c.-61

 .         .         .         .         .         .                g.5535
 caggaagatgaagggagcaaagctgcccgccgcgggacaggcgtctaggtgaacaagaaa       c.-1

          .         .       | 02 .         .         .         .    g.92660
 ATGACCGAAGAAACACACCCAGACGA | TGACAGCTATATTGTGCGTGTCAAGGCTGTGGTT    c.60
 M  T  E  E  T  H  P  D  D  |  D  S  Y  I  V  R  V  K  A  V  V      p.20

          .         .         .         .         .         .       g.92720
 ATGACCAGAGATGACTCCAGCGGGGGATGGTTCCCACAGGAAGGAGGCGGGATCAGTCGC       c.120
 M  T  R  D  D  S  S  G  G  W  F  P  Q  E  G  G  G  I  S  R         p.40

          .         .         .         .         .         .       g.92780
 GTCGGGGTCTGTAAGGTCATGCACCCCGAAGGCAATGGACGAAGCGGCTTTCTCATCCAT       c.180
 V  G  V  C  K  V  M  H  P  E  G  N  G  R  S  G  F  L  I  H         p.60

          .         .     | 03   .         .         .         .    g.102785
 GGTGAACGACAGAAAGACAAACTG | GTGGTATTGGAATGCTATGTAAGAAAGGACTTGGTC    c.240
 G  E  R  Q  K  D  K  L   | V  V  L  E  C  Y  V  R  K  D  L  V      p.80

          .         .         .         .         .         .       g.102845
 TACACCAAAGCCAATCCAACGTTTCATCACTGGAAGGTCGATAATAGGAAGTTTGGACTT       c.300
 Y  T  K  A  N  P  T  F  H  H  W  K  V  D  N  R  K  F  G  L         p.100

          .         .         .         .         .         .       g.102905
 ACTTTCCAAAGCCCTGCTGATGCCCGAGCCTTTGACAGGGGAGTAAGGAAAGCAATCGAA       c.360
 T  F  Q  S  P  A  D  A  R  A  F  D  R  G  V  R  K  A  I  E         p.120

          .    | 04    .         .         .         .         .    g.105518
 GACCTTATAGAAG | GTTCAACAACGTCATCTTCCACCATCCATAATGAAGCTGAGCTTGGC    c.420
 D  L  I  E  G |   S  T  T  S  S  S  T  I  H  N  E  A  E  L  G      p.140

          .         | 05         .         .         .         .    g.120681
 GATGATGACGTTTTTACA | ACAGCTACAGACAGTTCTTCTAATTCCTCTCAGAAGAGAGAG    c.480
 D  D  D  V  F  T   | T  A  T  D  S  S  S  N  S  S  Q  K  R  E      p.160

          .         .         .         .         .         .       g.120741
 CAACCTACTCGGACAATCTCCTCTCCCACATCCTGTGAGCACCGGAGGATTTATACCCTG       c.540
 Q  P  T  R  T  I  S  S  P  T  S  C  E  H  R  R  I  Y  T  L         p.180

          .         .         .         .         | 06         .    g.123365
 GGCCACCTCCACGACTCATACCCCACAGACCACTATCACCTCGATCAG | CCGATGCCAAGG    c.600
 G  H  L  H  D  S  Y  P  T  D  H  Y  H  L  D  Q   | P  M  P  R      p.200

          .         .         .         .         .         .       g.123425
 CCCTACCGCCAGGTGAGCTTCCCGGACGACGACGAGGAGATCGTGCGCATCAACCCCCGG       c.660
 P  Y  R  Q  V  S  F  P  D  D  D  E  E  I  V  R  I  N  P  R         p.220

          .         .         .         .         .         .       g.123485
 GAGAAGATCTGGATGACGGGGTACGAGGATTACCGGCACGCACCCGTCAGGGGCAAGTAC       c.720
 E  K  I  W  M  T  G  Y  E  D  Y  R  H  A  P  V  R  G  K  Y         p.240

          .         .         .         .         .         .       g.123545
 CCGGACCCCTCGGAGGACGCGGACTCCTCCTACGTGCGCTTCGCCAAGGGCGAGGTCCCC       c.780
 P  D  P  S  E  D  A  D  S  S  Y  V  R  F  A  K  G  E  V  P         p.260

          .         .         .         .         .         .       g.123605
 AAGCATGACTACAACTACCCCTACGTGGACTCCTCAGACTTTGGCCTAGGCGAGGACCCC       c.840
 K  H  D  Y  N  Y  P  Y  V  D  S  S  D  F  G  L  G  E  D  P         p.280

          .         .         .         .         .         .       g.123665
 AAAGGCCGCGGGGGCAGCGTGATCAAGACGCAGCCCTCCCGGGGCAAGTCGCGGCGGCGG       c.900
 K  G  R  G  G  S  V  I  K  T  Q  P  S  R  G  K  S  R  R  R         p.300

          .         .         .         .         .         .       g.123725
 AAGGAGGACGGAGAGCGCTCGCGGTGCGTGTACTGCAGGGACATGTTCAACCACGAGGAG       c.960
 K  E  D  G  E  R  S  R  C  V  Y  C  R  D  M  F  N  H  E  E         p.320

          .         .         .         .         .         .       g.123785
 AACCGCCGGGGCCACTGCCAGGACGCGCCCGACTCCGTGAGAACTTGCATCCGCCGGGTG       c.1020
 N  R  R  G  H  C  Q  D  A  P  D  S  V  R  T  C  I  R  R  V         p.340

          .         .         .         .         .         .       g.123845
 AGCTGCATGTGGTGCGCGGACAGCATGCTCTATCACTGTATGTCGGACCCCGAGGGAGAC       c.1080
 S  C  M  W  C  A  D  S  M  L  Y  H  C  M  S  D  P  E  G  D         p.360

          .         .         .         .         .         .       g.123905
 TATACAGACCCTTGCTCGTGCGATACTAGCGACGAGAAGTTTTGCCTCCGGTGGATGGCT       c.1140
 Y  T  D  P  C  S  C  D  T  S  D  E  K  F  C  L  R  W  M  A         p.380

          .         .         .         .         .         .       g.123965
 CTTATTGCCTTGTCTTTCCTGGCCCCCTGTATGTGCTGTTACCTGCCCCTTCGGGCCTGC       c.1200
 L  I  A  L  S  F  L  A  P  C  M  C  C  Y  L  P  L  R  A  C         p.400

          .         .         .         .         .                 g.124022
 TACCACTGCGGAGTGATGTGCAGGTGCTGTGGCGGGAAGCACAAAGCGGCCGCGTGA          c.1257
 Y  H  C  G  V  M  C  R  C  C  G  G  K  H  K  A  A  A  X            p.418

          .         .         .         .         .         .       g.124082
 ctcagtttccctcccttctccctccatccgcagccacaggggaactcgtctcttacatac       c.*60

          .         .         .         .         .         .       g.124142
 tctcatcttctcccccgctcccttccactccaaggagcgaggagggcaagcggcctccca       c.*120

          .         .         .         .         .         .       g.124202
 gctccctggtacctcgaggcaccattccagccagggacgctgccgggtagactctccact       c.*180

          .         .         .         .         .         .       g.124262
 ccccctgccgcccacactgcagcagccacatccatacacacacgctcgcacagtgttctg       c.*240

          .         .         .         .         .         .       g.124322
 aggaaggaaccttcgccacagactcctgtactattaacaatctgtaaccaagctaactgt       c.*300

          .         .         .         .         .         .       g.124382
 ctcatccatgtgttgatttcctgtttcctcctcccccgcctcttccagttcaaaggagtc       c.*360

          .         .         .         .         .         .       g.124442
 tgcaattggaactgctgattttcggtgggttttgtagttgatttttccaagagcgtcgaa       c.*420

          .         .         .         .         .         .       g.124502
 gactctctttctcttggttcaccttgcctgtcgctagcaagcatctggttcagcggaaat       c.*480

          .         .         .         .         .         .       g.124562
 gggatgtgagaatgatgaaacccgacagaagtatctcagcctgcagtcagttattatgta       c.*540

          .         .         .         .         .         .       g.124622
 taggaggtgagctagttaacaaacttgtaccacaaaacaatatcgctttaacttttctaa       c.*600

          .         .         .         .         .         .       g.124682
 agccaaatttcccatgtaagctgcagtttctatctttagcccatcatcattttctgcccc       c.*660

          .         .         .         .         .         .       g.124742
 cccaaaatctgttgaaatgattcactgatgcaaaacattcacccgtaatagactgagaat       c.*720

          .         .         .         .         .         .       g.124802
 tgagccttaacttcagattaacttgtgagaatcaggaaaattccttcaactgcattgcat       c.*780

          .         .         .         .         .         .       g.124862
 cctcttggaccagggctagaatggggatttcaggtttctatgagcctccccattacccct       c.*840

          .         .         .         .         .         .       g.124922
 aaagtagaacattttttaaattgtgttgccaccacttctaaaaatttagcaatattagaa       c.*900

          .         .         .         .         .         .       g.124982
 taggatactagtgaagtaagaaattttgcttgttgttttgcaaaccaaatagtttcctca       c.*960

          .         .         .         .         .         .       g.125042
 aacacaaatcagtgttcccacgaacaagttccagttgagaaacactaaggttatggtgaa       c.*1020

          .         .         .         .         .         .       g.125102
 taaaaccatagggagcttcttccccccaacccctggctattttatattaatggggagagg       c.*1080

          .         .         .         .         .         .       g.125162
 ggatttttaaatgtcataaatttgaagagtggtgggttgcattttcttcatgggtttatg       c.*1140

          .         .         .         .         .         .       g.125222
 ttttcgtttcattttggactcaatttcacatcaccaaattcctcatttatacttggggaa       c.*1200

          .         .         .         .         .         .       g.125282
 aaaacaaggccatatgtaaaaacccttccaatgcctaagtgtctttctcctgcaactcca       c.*1260

          .         .         .         .         .         .       g.125342
 aacccagactcgccactttgggtgcacaggtggttaggtcagccaactggttctgcctgt       c.*1320

          .         .         .         .         .         .       g.125402
 cgccttgccacggaggaggcttctaattagctggaaaagagtatttttctaatacgttgc       c.*1380

          .         .         .         .         .         .       g.125462
 aaggattagccaaatcttcttattgaagaaagaagaaaagtgaagagtggttacctatac       c.*1440

          .         .         .         .         .         .       g.125522
 ctagcatagtacaatcagaacctcgtggagaccaccggggacaggcttgcggacgccggc       c.*1500

          .         .         .         .         .         .       g.125582
 tgttcttcccgccacgatctttctgtggtagcggccagcagaagacatggcctgctcccc       c.*1560

          .         .         .         .         .         .       g.125642
 actccctttccccactccttctttattgcacacaggacaccagtcttcaaggaaagggac       c.*1620

          .         .         .         .         .         .       g.125702
 ttttttccagtctgccaatcatattgggaaagtgctagctgtgctcaccttcatggggct       c.*1680

          .         .         .         .         .         .       g.125762
 gtttccagctcgtccacaagctcatcgattttctttagtagattaccggtgtaaataccc       c.*1740

          .         .         .         .         .         .       g.125822
 agtgtgcttatgagtcagttagtagacgtcttcattcattggagtaactggtttaggctt       c.*1800

          .         .         .         .         .         .       g.125882
 tccagtttggaaaaggagcagagagctgtccatctggattgatggaagaaaagagaacct       c.*1860

          .         .         .         .         .         .       g.125942
 catccatgcctggagaacatctagaaaaccttcagccagcctccagtgctgtcgagagac       c.*1920

          .         .         .         .         .         .       g.126002
 caccttcccccgacccggaggcacttccttggggtctttctctagggtctcttctctaca       c.*1980

          .         .         .         .         .         .       g.126062
 aagcacaacactaatgttcgtttccttagacctcagttcaagtgcccctatttatttcaa       c.*2040

          .         .         .         .         .         .       g.126122
 taagaacgcacatatcccagctgttttttgtttgtcacctctatttagttgttacctgtt       c.*2100

          .         .         .         .         .         .       g.126182
 tctctcttctttcaccccttgtccttttccacccttttaagagttacgctagcagatctt       c.*2160

          .         .         .         .         .         .       g.126242
 actccacgtatactttttggtttgtgaaggcatcggttaagggcacaaagacagccatgg       c.*2220

          .         .         .         .         .         .       g.126302
 ggacatttatgtaaatacgtctctaattgccacactgcagctgaacagtgtgtagtattt       c.*2280

          .         .         .         .         .         .       g.126362
 tcccagtcagctttgccatactgacgtcaatcatttgagagaaattattcagattttatt       c.*2340

          .         .         .         .         .         .       g.126422
 tttgtatctgtggtaacaaaacattaaccaaaagattttctgtccagaagcctccccgac       c.*2400

          .         .         .         .         .         .       g.126482
 cccccaagctatttgctcacattaacaaattaaagtgcctgaagcataattcattcttta       c.*2460

          .         .         .         .         .         .       g.126542
 cctgtatactaaaaaccctgttgtattgatttttttataataagcctttttacctctgtg       c.*2520

          .         .         .         .         .         .       g.126602
 taaaaaatatatatacaagtgtatgatgtacattttagttcttaacttttttttatggtt       c.*2580

          .         .         .         .         .         .       g.126662
 tctaatatgtatgaccaatgtagccattgctttaaaatgtaccgtgtaaatataaacaca       c.*2640

          .                                                         g.126672
 tcctatcaga                                                         c.*2650

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sprouty-related, EVH1 domain containing 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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