SprT-like N-terminal domain (SPRTN) - coding DNA reference sequence

(used for variant description)

(last modified May 29, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_032018.5 in the SPRTN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering SPRTN transcript NM_032018.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5028
                                 tgcgcagcaatgccatcggttaaagcgc       c.-421

 .         .         .         .         .         .                g.5088
 atgcgcaagatgagctattgcggaagtgaggggagggagaggccgagagaaatttcggta       c.-361

 .         .         .         .         .         .                g.5148
 ctgcgcatgaaccgagcgtgacgttgaggtttgaaataaccggcaaagagtaaaggctga       c.-301

 .         .         .         .         .         .                g.5208
 aactagcttcctgaaagcttcgtagggcccgagccctgtgagcccaggttctgcgcccac       c.-241

 .         .         .         .         .         .                g.5268
 taggaggtgtcatgctgactgctttttttaaagccctagaatcttggcttcggcgtttgg       c.-181

 .         .         .         .         .         .                g.5328
 ggtaagctccgttctcgttctcaagcgcgtttccgcgaactctcgcgggattgacgggcc       c.-121

 .         .         .         .         .         .                g.5388
 gtctcgagagccggcatctcctaggagctagtcctggtcctcggctaggcggcttggggt       c.-61

 .         .         .         .         .         .                g.5448
 cgcggcgtaactggggagccagcctgacgccggcggaccccgcctgtgatcctggcaacg       c.-1

          .         .         .         .         .         .       g.5508
 ATGGATGATGACTTGATGTTGGCACTGCGGCTTCAGGAGGAGTGGAACTTGCAGGAGGCG       c.60
 M  D  D  D  L  M  L  A  L  R  L  Q  E  E  W  N  L  Q  E  A         p.20

          .         .         .         .         .         .       g.5568
 GAGCGCGATCATGCCCAGGAGTCCCTGTCGCTAGTGGACGCGTCGTGGGAGTTGGTGGAC       c.120
 E  R  D  H  A  Q  E  S  L  S  L  V  D  A  S  W  E  L  V  D         p.40

          .         .         .         .         .         .       g.5628
 CCCACACCGGACTTGCAGGCACTGTTTGTTCAGTTTAACGACCAATTCTTCTGGGGCCAG       c.180
 P  T  P  D  L  Q  A  L  F  V  Q  F  N  D  Q  F  F  W  G  Q         p.60

          .         .         .         .  | 02      .         .    g.6852
 CTGGAGGCCGTCGAGGTGAAGTGGAGCGTGCGAATGACCCT | GTGTGCTGGGATATGCAGC    c.240
 L  E  A  V  E  V  K  W  S  V  R  M  T  L  |  C  A  G  I  C  S      p.80

          .         .         .         .         .         .       g.6912
 TATGAAGGGAAGGGTGGAATGTGTTCCATCCGTCTCAGCGAACCCCTTTTGAAGTTGAGG       c.300
 Y  E  G  K  G  G  M  C  S  I  R  L  S  E  P  L  L  K  L  R         p.100

          .         .  | 03      .         .         .         .    g.14900
 CCAAGAAAGGATCTTGTAGAG | ACCCTCCTGCATGAAATGATACATGCCTATTTATTTGTC    c.360
 P  R  K  D  L  V  E   | T  L  L  H  E  M  I  H  A  Y  L  F  V      p.120

          .         .         .         .         .         .       g.14960
 ACTAATAACGACAAAGACCGAGAAGGGCATGGTCCAGAATTTTGTAAACATATGCATCGC       c.420
 T  N  N  D  K  D  R  E  G  H  G  P  E  F  C  K  H  M  H  R         p.140

          .         .         . | 04       .         .         .    g.18398
 ATCAACAGCCTGACTGGAGCCAATATAACG | GTATACCATACTTTTCACGATGAGGTGGAT    c.480
 I  N  S  L  T  G  A  N  I  T   | V  Y  H  T  F  H  D  E  V  D      p.160

          .         .         .         .         .         .       g.18458
 GAGTATCGGCGACACTGGTGGCGCTGCAATGGGCCGTGCCAGCACAGGCCACCGTATTAC       c.540
 E  Y  R  R  H  W  W  R  C  N  G  P  C  Q  H  R  P  P  Y  Y         p.180

          .         .         .         .         .         .       g.18518
 GGCTATGTCAAACGAGCTACTAACAGGGAACCCTCTGCTCATGACTATTGGTGGGCTGAG       c.600
 G  Y  V  K  R  A  T  N  R  E  P  S  A  H  D  Y  W  W  A  E         p.200

          .         .         .         .         .         .       g.18578
 CACCAGAAAACCTGTGGAGGCACTTACATAAAAATCAAGGAACCAGAGAATTACTCAAAA       c.660
 H  Q  K  T  C  G  G  T  Y  I  K  I  K  E  P  E  N  Y  S  K         p.220

          .         .         .         .         .         | 05    g.19676
 AAAGGCAAAGGAAAGGCAAAACTAGGAAAGGAACCAGTATTGGCCGCAGAGAATAAAG | AT    c.720
 K  G  K  G  K  A  K  L  G  K  E  P  V  L  A  A  E  N  K  D |       p.240

          .         .         .         .         .         .       g.19736
 AAACCCAACAGAGGTGAGGCCCAGCTAGTAATCCCTTTTAGTGGGAAAGGATATGTTCTA       c.780
 K  P  N  R  G  E  A  Q  L  V  I  P  F  S  G  K  G  Y  V  L         p.260

          .         .         .         .         .         .       g.19796
 GGAGAAACAAGCAATTTACCTTCACCTGGGAAACTGATCACTTCACATGCCATTAATAAA       c.840
 G  E  T  S  N  L  P  S  P  G  K  L  I  T  S  H  A  I  N  K         p.280

          .         .         .         .         .         .       g.19856
 ACCCAAGATCTTTTAAATCAAAACCATTCAGCAAATGCTGTAAGACCTAATTCTAAAATC       c.900
 T  Q  D  L  L  N  Q  N  H  S  A  N  A  V  R  P  N  S  K  I         p.300

          .         .         .         .         .         .       g.19916
 AAGGTGAAATTTGAACAGAATGGTTCAAGTAAAAATTCTCATCTGGTCTCCCCTGCTGTT       c.960
 K  V  K  F  E  Q  N  G  S  S  K  N  S  H  L  V  S  P  A  V         p.320

          .         .         .         .         .         .       g.19976
 AGTAACAGTCACCAAAATGTTCTAAGCAACTACTTTCCTAGAGTATCATTTGCCAACCAA       c.1020
 S  N  S  H  Q  N  V  L  S  N  Y  F  P  R  V  S  F  A  N  Q         p.340

          .         .         .         .         .         .       g.20036
 AAGGCTTTCAGAGGTGTGAATGGATCTCCAAGGATAAGTGTAACAGTTGGCAACATCCCT       c.1080
 K  A  F  R  G  V  N  G  S  P  R  I  S  V  T  V  G  N  I  P         p.360

          .         .         .         .         .         .       g.20096
 AAAAACTCAGTCTCTTCTAGTTCTCAGAGAAGGGTTTCATCTTCTAAGATATCCCTAAGA       c.1140
 K  N  S  V  S  S  S  S  Q  R  R  V  S  S  S  K  I  S  L  R         p.380

          .         .         .         .         .         .       g.20156
 AATTCTTCAAAAGTAACGGAATCAGCATCTGTGATGCCATCCCAGGATGTGAGTGGGTCT       c.1200
 N  S  S  K  V  T  E  S  A  S  V  M  P  S  Q  D  V  S  G  S         p.400

          .         .         .         .         .         .       g.20216
 GAAGATACATTCCCAAATAAACGACCTAGGCTAGAAGATAAGACTGTTTTTGACAATTTT       c.1260
 E  D  T  F  P  N  K  R  P  R  L  E  D  K  T  V  F  D  N  F         p.420

          .         .         .         .         .         .       g.20276
 TTTATCAAGAAAGAGCAAATAAAAAGCAGTGGTAATGATCCAAAGTATAGTACAACCACA       c.1320
 F  I  K  K  E  Q  I  K  S  S  G  N  D  P  K  Y  S  T  T  T         p.440

          .         .         .         .         .         .       g.20336
 GCTCAGAATTCCAGCAGTTCATCCAGTCAGAGCAAAATGGTTAATTGCCCAGTTTGTCAG       c.1380
 A  Q  N  S  S  S  S  S  S  Q  S  K  M  V  N  C  P  V  C  Q         p.460

          .         .         .         .         .         .       g.20396
 AATGAAGTTCTGGAGTCTCAGATTAATGAGCACTTGGACTGGTGCCTTGAAGGTGACAGC       c.1440
 N  E  V  L  E  S  Q  I  N  E  H  L  D  W  C  L  E  G  D  S         p.480

          .         .         .                                     g.20426
 ATCAAAGTCAAAAGCGAAGAAAGTCTTTGA                                     c.1470
 I  K  V  K  S  E  E  S  L  X                                       p.489

          .         .         .         .         .         .       g.20486
 aaaaggtttcaaagtctcaagtaccacctgtattatctcactaatgtgctatgtcagcca       c.*60

          .         .         .         .         .         .       g.20546
 gtcaggaagttctggttaatactaagatttgtaggttataatctagttcacataaccaat       c.*120

          .         .         .         .         .         .       g.20606
 agaaagtgtcctattttatatatacgcatataagattgtaattttaagatgttttgtgtc       c.*180

          .         .         .         .         .         .       g.20666
 tcagggtgctacattcactcttgccttaggtatactgtaacccaggttctgcctgtcgtg       c.*240

          .         .         .         .         .         .       g.20726
 tataagttttagatacttttgttctttcttgctcttaaggattttaaaaacctgttaatc       c.*300

          .         .         .         .         .         .       g.20786
 tttttatttgtatactttcctaaaaatattcatatggggaatcctgtcaggtgtttggtt       c.*360

          .         .         .         .         .         .       g.20846
 atattgactatttattaatagtattagaactcattccctgaactgatgtaaatcttcata       c.*420

          .         .         .         .         .         .       g.20906
 gtgtcagacatactgaccaaaaccacaatctagactacaaagtatattgttttagagtac       c.*480

          .         .         .         .         .         .       g.20966
 tcaaattgtattatttattaatttttttgtttgcaaaatcttaacaggaactgtattttc       c.*540

          .         .         .         .         .         .       g.21026
 tatattttaaagaattttatttgtcccacttttactaaacagtggcagcagattttaagt       c.*600

          .         .         .         .         .         .       g.21086
 taaagaatatggaatatagtaaaataagtaaatttcttttggaatatttttagtaacaaa       c.*660

          .         .         .         .         .         .       g.21146
 tagccactataattctgtaggccaaattttatattgagtttagctgttttctcaaaattt       c.*720

          .         .         .         .         .         .       g.21206
 agcagagtggttaaaattctgtgctgataagtaactgatacatataacataaacataaca       c.*780

          .         .         .         .         .         .       g.21266
 aagttgcctagttgatgtaacagtggaaagttatctggaaatagtattttgaactttaag       c.*840

          .         .         .         .         .         .       g.21326
 ccaagtttaaaacattataataaaaggaataccatttgtgcattttaagtaatctttttt       c.*900

          .         .         .         .         .         .       g.21386
 aaaaaaaatattttccatgttatagggaaaggacaaagagacttttatcagtttgctttt       c.*960

          .         .         .         .         .         .       g.21446
 tgtcttgtggctgtacatgctgttggcatagccctaacacagttgttcacaagttttctt       c.*1020

          .         .         .         .         .         .       g.21506
 ttttcttgttgcaattttccttcactttgttgtaatacaggtgcacaaatcttaagtgca       c.*1080

          .         .         .         .         .         .       g.21566
 cagctgggtaaacttttacagtgttcacctgtgtaactaccacccggatcaagttagaga       c.*1140

          .         .         .         .         .         .       g.21626
 acacttccattgccacagaaggcttcctataggtgtctgttcccagttgatacccatgac       c.*1200

          .         .         .         .         .         .       g.21686
 cctcaccacctccagaggtccccactgttttcaccccatcgtcgcagattattttttaat       c.*1260

          .         .         .         .         .         .       g.21746
 tttataatgtagtatctttgttcctatgtatagcaggagttcattttcattgctcttgca       c.*1320

          .         .         .         .         .         .       g.21806
 tttgtatgaatatactagaatttattcatccattctaatgttaatggacatttgaattat       c.*1380

          .         .         .         .         .         .       g.21866
 ttccagtttggggctgttaagcataatgctgctaagaacattcttatcttttctgttggg       c.*1440

          .         .         .         .         .         .       g.21926
 tatatatacaggaatggaattgctgagtcacggggtatatttctgtttagctttagtaaa       c.*1500

          .         .         .         .         .         .       g.21986
 ttctgccagtttacactcctaccagcaatgtatgagagttttagttgttcaccattcata       c.*1560

          .         .         .         .         .         .       g.22046
 acactgttagcagcccttttcgttttagactggttggctgttcacaaattttgatattcc       c.*1620

          .         .         .         .                           g.22088
 ttaaagcattaaaacattttaataaatacttataaataggta                         c.*1662

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SprT-like N-terminal domain protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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