sprouty homolog 4 (Drosophila) (SPRY4) - coding DNA reference sequence

(used for variant description)

(last modified February 8, 2020)
This file was created to facilitate the description of sequence variants on transcript NM_030964.3 in the SPRY4 gene based on a coding DNA reference sequence following the HGVS recommendations.
The sequence was taken from NG_034148.1, covering SPRY4 transcript NM_030964.3.
Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            a       c.-241

 .         .         .         .         .         .                g.5061
 ttcataaaaaagccattttcccaggcagtggttgcaacatcgccgcggaggtagcgagct       c.-181

 .         .         .         .         .         .                g.5121
 gagctgacagcgcggagctggcgctgtggagcgcagggagccttgccggttcctccgacc       c.-121

 .         .         .         .         .         .                g.5181
 ggcgtctgcgagtacagcggcggctaacctgccccggcttcaggatttacacagacgtgg       c.-61

 .         .         .         . | 02       .         .             g.10290
 ggcgatgcttgtgaccctgcagctcctcaaa | ccagcctgtattgagcggtttgcagcctg    c.-1

          .         .   | 03     .         .         .         .    g.14938
 ATGCTCAGCCCCCTCCCCACAG | GGCCCCTAGAAGCCTGTTTCTCCGTACAGTCCAGGACC    c.60
 M  L  S  P  L  P  T  G |   P  L  E  A  C  F  S  V  Q  S  R  T      p.20

          .         .         .         .         .         .       g.14998
 TCCAGCCCCATGGAGCCCCCGATCCCACAGAGCGCCCCCTTGACTCCCAACTCAGTCATG       c.120
 S  S  P  M  E  P  P  I  P  Q  S  A  P  L  T  P  N  S  V  M         p.40

          .         .         .         .         .         .       g.15058
 GTCCAGCCCCTTCTTGACAGCCGGATGTCCCACAGCCGGCTCCAGCACCCACTCACCATC       c.180
 V  Q  P  L  L  D  S  R  M  S  H  S  R  L  Q  H  P  L  T  I         p.60

          .         .         .         .         .         .       g.15118
 CTACCCATTGACCAGGTGAAGACCAGCCATGTGGAGAATGACTACATAGACAACCCTAGC       c.240
 L  P  I  D  Q  V  K  T  S  H  V  E  N  D  Y  I  D  N  P  S         p.80

          .         .         .         .         .         .       g.15178
 CTGGCCCTGACCACCGGCCCAAAGCGGACCCGGGGCGGGGCCCCAGAGCTGGCCCCGACG       c.300
 L  A  L  T  T  G  P  K  R  T  R  G  G  A  P  E  L  A  P  T         p.100

          .         .         .         .         .         .       g.15238
 CCCGCCCGCTGTGACCAGGATGTCACCCACCATTGGATCTCCTTCAGCGGGCGCCCCAGC       c.360
 P  A  R  C  D  Q  D  V  T  H  H  W  I  S  F  S  G  R  P  S         p.120

          .         .         .         .         .         .       g.15298
 TCTGTGAGCAGCAGCAGCAGCACATCCTCTGACCAACGGCTCTTAGACCACATGGCACCA       c.420
 S  V  S  S  S  S  S  T  S  S  D  Q  R  L  L  D  H  M  A  P         p.140

          .         .         .         .         .         .       g.15358
 CCACCCGTGGCTGACCAGGCCTCACCAAGGGCTGTGCGCATCCAGCCCAAGGTGGTCCAC       c.480
 P  P  V  A  D  Q  A  S  P  R  A  V  R  I  Q  P  K  V  V  H         p.160

          .         .         .         .         .         .       g.15418
 TGCCAGCCGCTGGACCTCAAGGGCCCGGCGGTCCCACCCGAGCTGGACAAGCACTTCTTG       c.540
 C  Q  P  L  D  L  K  G  P  A  V  P  P  E  L  D  K  H  F  L         p.180

          .         .         .         .         .         .       g.15478
 CTGTGCGAGGCCTGTGGGAAGTGTAAATGCAAGGAGTGTGCATCCCCCCGGACGTTGCCT       c.600
 L  C  E  A  C  G  K  C  K  C  K  E  C  A  S  P  R  T  L  P         p.200

          .         .         .         .         .         .       g.15538
 TCCTGCTGGGTCTGCAACCAGGAGTGCCTGTGCTCAGCCCAGACTCTGGTCAACTATGGC       c.660
 S  C  W  V  C  N  Q  E  C  L  C  S  A  Q  T  L  V  N  Y  G         p.220

          .         .         .         .         .         .       g.15598
 ACGTGCATGTGTTTGGTGCAGGGCATCTTCTACCACTGCACGAATGAGGACGATGAGGGC       c.720
 T  C  M  C  L  V  Q  G  I  F  Y  H  C  T  N  E  D  D  E  G         p.240

          .         .         .         .         .         .       g.15658
 TCCTGCGCTGACCACCCCTGCTCCTGCTCCCGCTCCAACTGCTGCGCCCGCTGGTCCTTC       c.780
 S  C  A  D  H  P  C  S  C  S  R  S  N  C  C  A  R  W  S  F         p.260

          .         .         .         .         .         .       g.15718
 ATGGGTGCTCTCTCCGTGGTGCTGCCCTGCCTGCTCTGCTACCTGCCTGCCACCGGCTGC       c.840
 M  G  A  L  S  V  V  L  P  C  L  L  C  Y  L  P  A  T  G  C         p.280

          .         .         .         .         .         .       g.15778
 GTGAAGCTGGCCCAGCGTGGCTACGACCGTCTGCGCCGCCCTGGTTGCCGCTGCAAGCAC       c.900
 V  K  L  A  Q  R  G  Y  D  R  L  R  R  P  G  C  R  C  K  H         p.300

          .         .         .         .         .         .       g.15838
 ACGAACAGCGTCATCTGCAAAGCAGCCAGCGGGGATGCCAAGACCAGCAGGCCCGACAAG       c.960
 T  N  S  V  I  C  K  A  A  S  G  D  A  K  T  S  R  P  D  K         p.320

                                                                    g.15847
 CCTTTCTGA                                                          c.969
 P  F  X                                                            p.322

          .         .         .         .         .         .       g.15907
 cagtttgtgtcgaagccccagtgctctgcctggaaacctggttctcttctgacatctaag       c.*60

          .         .         .         .         .         .       g.15967
 aagactgcagcaaggtcagaggttttagcctcctgaggctgaccttgctagtctgcccac       c.*120

          .         .         .         .         .         .       g.16027
 tccctacccccagcttcggaaaatacagagaccaccaccacgtaccctgtattccccaag       c.*180

          .         .         .         .         .         .       g.16087
 gtgatgaagaagcactttggggctttttttcagggtcctgaaactttgtgtcaaacagac       c.*240

          .         .         .         .         .         .       g.16147
 aatgcaggggcagggtgtggtttggggggaaatttttctttttcagaagacagaacacag       c.*300

          .         .         .         .         .         .       g.16207
 atgtggacacatatccggaaactgcagctgcttgaatgccttcccagcccctccttctcc       c.*360

          .         .         .         .         .         .       g.16267
 ctccctccctccgcccccccccccttcctcttttccattgtctttggctctcacaggagc       c.*420

          .         .         .         .         .         .       g.16327
 tagctgcctgggaggaattgttaactgagtaccagggtacctttaaagaagacccttgga       c.*480

          .         .         .         .         .         .       g.16387
 gtcttctataccttcttctccttccccatctcactccaccccactttgtccctgatgtct       c.*540

          .         .         .         .         .         .       g.16447
 tggggaaggtgtagaacaccctagcagttcctattgtatatacttgggagccactgagaa       c.*600

          .         .         .         .         .         .       g.16507
 cagaggacggccagtgagtccaagcctcgttcctccttctgcctccccggagccacagga       c.*660

          .         .         .         .         .         .       g.16567
 tggatttaggagccactgctcagtgcacttctcccttccaactgcatcaactaactctcg       c.*720

          .         .         .         .         .         .       g.16627
 ggggtgttctgctcaccacaccgtccttcggttcttactgagtcacagactcgcctgccc       c.*780

          .         .         .         .         .         .       g.16687
 actacgtgtcctgggttctctctactcagatcccttccagaaactttatatgggtagagg       c.*840

          .         .         .         .         .         .       g.16747
 aagccagggcggcaaatgcgagaccaaatatcattttgccaatgagtctgaggctgtggt       c.*900

          .         .         .         .         .         .       g.16807
 ctctggatccagtcattatgtttttatagaataattaaaccggatgctaacggtgtttta       c.*960

          .         .         .         .         .         .       g.16867
 aaaaataataataaaacaacttgtttccttttggccacccccaggaagggctgatttcaa       c.*1020

          .         .         .         .         .         .       g.16927
 aatctgggggcgagcaacctcaaggaacacaatttccctccctatcaacaagaggatttt       c.*1080

          .         .         .         .         .         .       g.16987
 aacagcaaagaagagaggcagcacctcccattggcagaatgaccgctgagccaggctggg       c.*1140

          .         .         .         .         .         .       g.17047
 tttgggtttcttctcttctgattctgctgctcactgtcatagccttttgtgtatagtgat       c.*1200

          .         .         .         .         .         .       g.17107
 gtgtctgtatctttaatgtaaatagagagatgatgaaaaaagagtctattttagtgttag       c.*1260

          .         .         .         .         .         .       g.17167
 gaagccccagcaggggagtcggaagagcttggaagagctggggagagggtaggggaaagg       c.*1320

          .         .         .         .         .         .       g.17227
 tttttccaggggccactgggtttgagccctgcttctgtgcacagccacaccaccctctcc       c.*1380

          .         .         .         .         .         .       g.17287
 cgacagccctcaaagacgtagcaactctttctctcaaggtgctaaaggactcagaaggtg       c.*1440

          .         .         .         .         .         .       g.17347
 cagcacgtccagtgggtaggtacttgttgcatgcaaaagctgtagtgtatctggtccttc       c.*1500

          .         .         .         .         .         .       g.17407
 ctccccagcttttgtgtggggttcttgctttgtgtggtattttgttttcccctctaatga       c.*1560

          .         .         .         .         .         .       g.17467
 gagggcatggcctgagtcagaagagctaccccaggtgaaactggaagtgcatgaggcaga       c.*1620

          .         .         .         .         .         .       g.17527
 gcgtccgtagcatttccagtttgttctgtataggaacagaggtgcctccgggaaggaggc       c.*1680

          .         .         .         .         .         .       g.17587
 agcgaggtaggtagctatgataggcacctaatgcttctcaaggacttattttttccttct       c.*1740

          .         .         .         .         .         .       g.17647
 tgaagactagtagtaacatcttatgatttagagtaagttgattgtaaccataggtattta       c.*1800

          .         .         .         .         .         .       g.17707
 ttgattggaggaagggagggtcatattattttcggctttatttatgtaacatttgctagc       c.*1860

          .         .         .         .         .         .       g.17767
 ttgtaaaaggcgaatgtgaaatattgcatctgcattttccaaggctgattcgtgtagcta       c.*1920

          .         .         .         .         .         .       g.17827
 cccttgccacagttgtgacggatgtatggatgttcttgaacatttcagaaggagtggtag       c.*1980

          .         .         .         .         .         .       g.17887
 aaaaaaacacacattcagccaaccacttatatgaattgaatgtatcagaagtgtactgaa       c.*2040

          .         .         .         .         .         .       g.17947
 gggactggagatggttttcctcagatgagggggccccaaaattgatagtgcacatctgca       c.*2100

          .         .         .         .         .         .       g.18007
 cgctttctgcgaggcctcagaacttcccagggcccctccctcaaattgtctccatgggaa       c.*2160

          .         .         .         .         .         .       g.18067
 acttgacccagtggcaagttgcactttggtgatcttggtggtctacacacccgttctgtg       c.*2220

          .         .         .         .         .         .       g.18127
 gagagtcgatttacataagctgtgtatacacacacacacacacacacacacacccctacc       c.*2280

          .         .         .         .         .         .       g.18187
 ccacactgactgtctaccgacaaagaccctatttcctggcaaacggcctcctgaaccctg       c.*2340

          .         .         .         .         .         .       g.18247
 actttttgtgtacatacttgtaaacacggatttttctgggttttggtttgctttttcctt       c.*2400

          .         .         .         .         .         .       g.18307
 ttttccccctgcccctgttctagcttgttcttcttggtttgctttcaacctgcttgatgg       c.*2460

          .         .         .         .         .         .       g.18367
 atgtctgcagagtgctctctaagagtccacctcagtgcctcgtgtgctcagtggtcatgg       c.*2520

          .         .         .         .         .         .       g.18427
 gaaaggagcgaaggaaccatccttggttctcccagcttggttgtgtagcaatccctcagc       c.*2580

          .         .         .         .         .         .       g.18487
 attgtttttctcagcttcttggcaaaaattaaaacaacaacaacaacaacaacaacaaca       c.*2640

          .         .         .         .         .         .       g.18547
 acaaacagaaggataaactggcttgcctgtggaccctccccggctctggggccagtcgag       c.*2700

          .         .         .         .         .         .       g.18607
 agccactgagggacccagcactcagagacacaacacacatgtgtagctgcttctggctga       c.*2760

          .         .         .         .         .         .       g.18667
 gtgtgtttcctgtcaccaatggcctgtttggctggacgatgcctcggcttgacctttttt       c.*2820

          .         .         .         .         .         .       g.18727
 gaaaagtgctggttagttcccgcccctggtaaacctggggtaggtgggggttctgtctta       c.*2880

          .         .         .         .         .         .       g.18787
 actcgaggggcacctgggatccaggacgcttctagggggctctggctgcccgtgttaatg       c.*2940

          .         .         .         .         .         .       g.18847
 aaggacagcgcttccgcgagcaccctgggaactgggtcttgggtagcaaagccctcccag       c.*3000

          .         .         .         .         .         .       g.18907
 agaaaagattgggcacaactaaggctttcctgagcaggaagggggtgaagaccaatccct       c.*3060

          .         .         .         .         .         .       g.18967
 tcctttggtcctttggtacgcaccccctcagagctgagatggaagacatggctagttctt       c.*3120

          .         .         .         .         .         .       g.19027
 ttcagccttgtggagcctgtcagtcgccatcatacctcgagtgaggcccagctagataat       c.*3180

          .         .         .         .         .         .       g.19087
 gacttgtccaagatggcacacgtggaaagttgatctgcaccagaacccggatgactgtca       c.*3240

          .         .         .         .         .         .       g.19147
 ccttgaagcatcctgttctccttctgtgctgtcccaggaagtgtctggcgggcgtgggca       c.*3300

          .         .         .         .         .         .       g.19207
 gcacagctctacactgtacgattcactagggcatcctgcgagcctcactagccttctggt       c.*3360

          .         .         .         .         .         .       g.19267
 tcatgcctttgacaagcatttttgtgccccctctgcttactgtgacagtcgatgatgaat       c.*3420

          .         .         .         .         .         .       g.19327
 cttgcgttgccattttctgctgtgggtaactgcgtgcagtgtcttgccttgctttctctt       c.*3480

          .         .         .         .         .         .       g.19387
 cttactgtcccacagcttggtttcatgttacaaacagaaaagctcgaggctcccaccccg       c.*3540

          .         .         .         .         .         .       g.19447
 ccacatcccaacttcatttccccctcactgtagcccatttccaccccaccacaaagttgc       c.*3600

          .         .         .         .         .         .       g.19507
 cacaggttttctttgtatagaatatttattttgaagctctattttaatagtatttatttt       c.*3660

          .         .         .         .         .         .       g.19567
 agaaagtctactattgtaagagttcttctgtttgtgaagaaaaaaacaagttaaaaactg       c.*3720

          .         .         .         .         .         .       g.19627
 aatgtactgatttagaaaatatatataaatatatattgttaaatatacacgggactgccg       c.*3780

                                                                    g.19629
 tt                                                                 c.*3782

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Sprouty homolog 4 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.