sequestosome 1 (SQSTM1) - coding DNA reference sequence

(used for variant description)

(last modified March 25, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001142298.1 in the SQSTM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011342.1, covering SQSTM1 transcript NM_001142298.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 gcgtcggcttccggccgccttccgcggccaccgccgggcccgctcccgccgccgacgccc       c.-301

 .         .         .         .         .         .                g.5120
 aggtgcgccaggtgcgggccgggcgggggtcgcgctcacctttctggccgctgagtgccg       c.-241

 .         .         .         .         .         .                g.5180
 cgtaccaggacagcgagaggaaggcgcacaggcagaagagcagcagcgtcaggaaggtgc       c.-181

 .         .         .    | 02    .         .         .             g.10222
 cattgcggagcctcatctcctcgg | tgtctgcgagattaatctctcatggccgctgcacaa    c.-121

 .         .         .         .         .         .                g.10282
 gaacctggcttttagctgaactaaggagaaagtcctacaacagtttggcgtgcaacatgg       c.-61

 .         .   | 03     .         .         .         .             g.21617
 ggcttgagaaagg | atgaggacggggacttggttgccttttccagtgacgaggaattgaca    c.-1

          .         .         .         .          | 04        .    g.22481
 ATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAG | AGAAAAAAGAG    c.60
 M  A  M  S  Y  V  K  D  D  I  F  R  I  Y  I  K  E |   K  K  E      p.20

          .         .         .         .         .         .       g.22541
 TGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAACATGGTGCACCCC       c.120
 C  R  R  D  H  R  P  P  C  A  Q  E  A  P  R  N  M  V  H  P         p.40

          .         .         .         .         .         .       g.22601
 AATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTC       c.180
 N  V  I  C  D  G  C  N  G  P  V  V  G  T  R  Y  K  C  S  V         p.60

          .         .         .         .         .         .       g.22661
 TGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACC       c.240
 C  P  D  Y  D  L  C  S  V  C  E  G  K  G  L  H  R  G  H  T         p.80

          .         .         .          | 05        .         .    g.22815
 AAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAG | GGCTTCTCGCACAGCCGCTGG    c.300
 K  L  A  F  P  S  P  F  G  H  L  S  E   | G  F  S  H  S  R  W      p.100

          .         .         .         .         .         .       g.22875
 CTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGA       c.360
 L  R  K  V  K  H  G  H  F  G  W  P  G  W  E  M  G  P  P  G         p.120

          .         .         .         .         .         .       g.22935
 AACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCA       c.420
 N  W  S  P  R  P  P  R  A  G  E  A  R  P  G  P  T  A  E  S         p.140

   | 06      .         .         .         .         .         .    g.23817
 G | CTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGGGGAGAGTGTG    c.480
 A |   S  G  P  S  E  D  P  S  V  N  F  L  K  N  V  G  E  S  V      p.160

          .         .   | 07     .         .         .         .    g.31682
 GCAGCTGCCCTTAGCCCTCTGG | GCATTGAAGTTGATATCGATGTGGAGCACGGAGGGAAA    c.540
 A  A  A  L  S  P  L  G |   I  E  V  D  I  D  V  E  H  G  G  K      p.180

          .         .         .         .         .         .       g.31742
 AGAAGCCGCCTGACCCCCGTCTCTCCAGAGAGTTCCAGCACAGAGGAGAAGAGCAGCTCA       c.600
 R  S  R  L  T  P  V  S  P  E  S  S  S  T  E  E  K  S  S  S         p.200

          .         .         .         .         .         .       g.31802
 CAGCCAAGCAGCTGCTGCTCTGACCCCAGCAAGCCGGGTGGGAATGTTGAGGGCGCCACG       c.660
 Q  P  S  S  C  C  S  D  P  S  K  P  G  G  N  V  E  G  A  T         p.220

          .         .         .         .         .        | 08.    g.32202
 CAGTCTCTGGCGGAGCAGATGAGGAAGATCGCCTTGGAGTCCGAGGGGCGCCCTGAG | GAA    c.720
 Q  S  L  A  E  Q  M  R  K  I  A  L  E  S  E  G  R  P  E   | E      p.240

          .         .         .         .         .         .       g.32262
 CAGATGGAGTCGGATAACTGTTCAGGAGGAGATGATGACTGGACCCATCTGTCTTCAAAA       c.780
 Q  M  E  S  D  N  C  S  G  G  D  D  D  W  T  H  L  S  S  K         p.260

          .         .         .         .         .         .       g.32322
 GAAGTGGACCCGTCTACAGGTGAACTCCAGTCCCTACAGATGCCAGAATCCGAAGGGCCA       c.840
 E  V  D  P  S  T  G  E  L  Q  S  L  Q  M  P  E  S  E  G  P         p.280

          .         .         .         .         .         .       g.32382
 AGCTCTCTGGACCCCTCCCAGGAGGGACCCACAGGGCTGAAGGAAGCTGCCTTGTACCCA       c.900
 S  S  L  D  P  S  Q  E  G  P  T  G  L  K  E  A  A  L  Y  P         p.300

          .    | 09    .         .         .         .         .    g.35095
 CATCTCCCGCCAG | AGGCTGACCCGCGGCTGATTGAGTCCCTCTCCCAGATGCTGTCCATG    c.960
 H  L  P  P  E |   A  D  P  R  L  I  E  S  L  S  Q  M  L  S  M      p.320

          .         .         .         .         .         .       g.35155
 GGCTTCTCTGATGAAGGCGGCTGGCTCACCAGGCTCCTGCAGACCAAGAACTATGACATC       c.1020
 G  F  S  D  E  G  G  W  L  T  R  L  L  Q  T  K  N  Y  D  I         p.340

          .         .         .         .         .                 g.35206
 GGAGCGGCTCTGGACACCATCCAGTATTCAAAGCATCCCCCGCCGTTGTGA                c.1071
 G  A  A  L  D  T  I  Q  Y  S  K  H  P  P  P  L  X                  p.356

          .         .         .         .         .         .       g.35266
 ccacttttgcccacctcttctgcgtgcccctcttctgtctcatagttgtgttaagcttgc       c.*60

          .         .         .         .         .         .       g.35326
 gtagaattgcaggtctctgtacgggccagtttctctgccttcttccaggatcaggggtta       c.*120

          .         .         .         .         .         .       g.35386
 gggtgcaagaagccatttagggcagcaaaacaagtgacatgaagggagggtccctgtgtg       c.*180

          .         .         .         .         .         .       g.35446
 tgtgtgtgctgatgtttcctgggtgccctggctccttgcagcagggctgggcctgcgaga       c.*240

          .         .         .         .         .         .       g.35506
 cccaaggctcactgcagcgcgctcctgacccctccctgcaggggctacgttagcagccca       c.*300

          .         .         .         .         .         .       g.35566
 gcacatagcttgcctaatggctttcactttctcttttgttttaaatgactcataggtccc       c.*360

          .         .         .         .         .         .       g.35626
 tgacatttagttgattattttctgctacagacctggtacactctgattttagataaagta       c.*420

          .         .         .         .         .         .       g.35686
 agcctaggtgttgtcagcaggcaggctggggaggccagtgttgtgggcttcctgctggga       c.*480

          .         .         .         .         .         .       g.35746
 ctgagaaggctcacgaagggcatccgcaatgttggtttcactgagagctgcctcctggtc       c.*540

          .         .         .         .         .         .       g.35806
 tcttcaccactgtagttctctcatttccaaaccatcagctgcttttaaaataagatctct       c.*600

          .         .         .         .         .         .       g.35866
 ttgtagccatcctgttaaatttgtaaacaatctaattaaatggcatcagcactttaacca       c.*660

          .         .         .         .         .         .       g.35926
 atgacgtttgcatagagagaaatgattgacagtaagtttattgttaatggttcttacaga       c.*720

          .         .         .         .         .         .       g.35986
 gtatctttaaaagtgccttaggggaaccctgtccctcctaacaagtgtatctcgattaat       c.*780

          .         .         .         .         .         .       g.36046
 aacctgccagtcccagatcacacatcatcatcgaagtcttccccagttataaagaggtca       c.*840

          .         .         .         .         .         .       g.36106
 catagtcgtgtgggtcgaggattctgtgcctccaggaccaggggcccaccctctgcccag       c.*900

          .         .         .         .         .         .       g.36166
 ggagtccttgcgtcccatgaggtcttcccgcaaggcctctcagacccagatgtgacgggg       c.*960

          .         .         .         .         .         .       g.36226
 tgtgtggcccgaggaagctggacagcggcagtgggcctgctgaggccttctcttgaggcc       c.*1020

          .         .         .         .         .         .       g.36286
 tgtgctctgggggtcccttgcttagcctgtgctggaccagctggcctggggtccctctga       c.*1080

          .         .         .         .         .         .       g.36346
 agagaccttggctgctcactgtccacatgtgaactttttctaggtggcaggacaaattgc       c.*1140

          .         .         .         .         .         .       g.36406
 gcccatttagaggatgtggctgtaacctgctggatgggactccatagctccttcccagga       c.*1200

          .         .         .         .         .         .       g.36466
 cccctcagctccccggcactgcagtctgcagagttctcctggaggcaggggctgctgcct       c.*1260

          .         .         .         .         .         .       g.36526
 tgtttcaccttccatgtcaggccagcctgtccctgaaagagaagatggccatgccctcca       c.*1320

          .         .         .         .         .         .       g.36586
 tgtgtaagaacaatgccagggcccaggaggaccgcctgccctgcctgggccttggctggg       c.*1380

          .         .         .         .         .         .       g.36646
 cctctggttctgacactttctgctggaagctgtcaggctgggacaggctttgattttgag       c.*1440

          .         .         .         .                           g.36691
 ggttagcaagacaaagcaaataaatgccttccacctcaccgcaaa                      c.*1485

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sequestosome 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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