sterol regulatory element binding transcription factor 1 (SREBF1) - coding DNA reference sequence

(used for variant description)

(last modified June 8, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004176.4 in the SREBF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029029.1, covering SREBF1 transcript NM_004176.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               agcagagctgcggc       c.-181

 .         .         .         .         .         .                g.5074
 cgggggaacccagtttccgaggaacttttcgccggcgccgggccgcctctgaggccaggg       c.-121

 .         .         .         .         .         .                g.5134
 caggacacgaacgcgcggagcggcggcggcgactgagagccggggccgcggcggcgctcc       c.-61

 .         .         .         .         .         .                g.5194
 ctaggaagggccgtacgaggcggcgggcccggcgggcctcccggaggaggcggctgcgcc       c.-1

          .         .         .         .         .         .       g.5254
 ATGGACGAGCCACCCTTCAGCGAGGCGGCTTTGGAGCAGGCGCTGGGCGAGCCGTGCGAT       c.60
 M  D  E  P  P  F  S  E  A  A  L  E  Q  A  L  G  E  P  C  D         p.20

          .         .         .  | 02      .         .         .    g.21519
 CTGGACGCGGCGCTGCTGACCGACATCGAAG | ACATGCTTCAGCTTATCAACAACCAAGAC    c.120
 L  D  A  A  L  L  T  D  I  E  D |   M  L  Q  L  I  N  N  Q  D      p.40

          .         .         .         .         .         .       g.21579
 AGTGACTTCCCTGGCCTATTTGACCCACCCTATGCTGGGAGTGGGGCAGGGGGCACAGAC       c.180
 S  D  F  P  G  L  F  D  P  P  Y  A  G  S  G  A  G  G  T  D         p.60

          .         .         .         .         .         .       g.21639
 CCTGCCAGCCCCGATACCAGCTCCCCAGGCAGCTTGTCTCCACCTCCTGCCACATTGAGC       c.240
 P  A  S  P  D  T  S  S  P  G  S  L  S  P  P  P  A  T  L  S         p.80

          .         .         .         .         .         .       g.21699
 TCCTCTCTTGAAGCCTTCCTGAGCGGGCCGCAGGCAGCGCCCTCACCCCTGTCCCCTCCC       c.300
 S  S  L  E  A  F  L  S  G  P  Q  A  A  P  S  P  L  S  P  P         p.100

          .         .         .         .         .         .       g.21759
 CAGCCTGCACCCACTCCATTGAAGATGTACCCGTCCATGCCCGCTTTCTCCCCTGGGCCT       c.360
 Q  P  A  P  T  P  L  K  M  Y  P  S  M  P  A  F  S  P  G  P         p.120

          .         .         .         .         .         .       g.21819
 GGTATCAAGGAAGAGTCAGTGCCACTGAGCATCCTGCAGACCCCCACCCCACAGCCCCTG       c.420
 G  I  K  E  E  S  V  P  L  S  I  L  Q  T  P  T  P  Q  P  L         p.140

          .         .         .         .         .         .       g.21879
 CCAGGGGCCCTCCTGCCACAGAGCTTCCCAGCCCCAGCCCCACCGCAGTTCAGCTCCACC       c.480
 P  G  A  L  L  P  Q  S  F  P  A  P  A  P  P  Q  F  S  S  T         p.160

          .         .         .         .    | 03    .         .    g.22303
 CCTGTGTTAGGCTACCCCAGCCCTCCGGGAGGCTTCTCTACAG | GAAGCCCTCCCGGGAAC    c.540
 P  V  L  G  Y  P  S  P  P  G  G  F  S  T  G |   S  P  P  G  N      p.180

          .         .         .         .         .         .       g.22363
 ACCCAGCAGCCGCTGCCTGGCCTGCCACTGGCTTCCCCGCCAGGGGTCCCGCCCGTCTCC       c.600
 T  Q  Q  P  L  P  G  L  P  L  A  S  P  P  G  V  P  P  V  S         p.200

          .         .         .         .         .         .       g.22423
 TTGCACACCCAGGTCCAGAGTGTGGTCCCCCAGCAGCTACTGACAGTCACAGCTGCCCCC       c.660
 L  H  T  Q  V  Q  S  V  V  P  Q  Q  L  L  T  V  T  A  A  P         p.220

          .         .         .         .         .  | 04      .    g.22566
 ACGGCAGCCCCTGTAACGACCACTGTGACCTCGCAGATCCAGCAGGTCCCG | GTCCTGCTG    c.720
 T  A  A  P  V  T  T  T  V  T  S  Q  I  Q  Q  V  P   | V  L  L      p.240

          .         .         .         .         .         .       g.22626
 CAGCCCCACTTCATCAAGGCAGACTCGCTGCTTCTGACAGCCATGAAGACAGACGGAGCC       c.780
 Q  P  H  F  I  K  A  D  S  L  L  L  T  A  M  K  T  D  G  A         p.260

          .         .         .         .         .         .       g.22686
 ACTGTGAAGGCGGCAGGTCTCAGTCCCCTGGTCTCTGGCACCACTGTGCAGACAGGGCCT       c.840
 T  V  K  A  A  G  L  S  P  L  V  S  G  T  T  V  Q  T  G  P         p.280

        | 05 .         .         .         .         .         .    g.22831
 TTGCCG | ACCCTGGTGAGTGGCGGAACCATCTTGGCAACAGTCCCACTGGTCGTAGATGCG    c.900
 L  P   | T  L  V  S  G  G  T  I  L  A  T  V  P  L  V  V  D  A      p.300

          .         .         .         .         .         .       g.22891
 GAGAAGCTGCCTATCAACCGGCTCGCAGCTGGCAGCAAGGCCCCGGCCTCTGCCCAGAGC       c.960
 E  K  L  P  I  N  R  L  A  A  G  S  K  A  P  A  S  A  Q  S         p.320

          .         .         .         .         .         .       g.22951
 CGTGGAGAGAAGCGCACAGCCCACAACGCCATTGAGAAGCGCTACCGCTCCTCCATCAAT       c.1020
 R  G  E  K  R  T  A  H  N  A  I  E  K  R  Y  R  S  S  I  N         p.340

          .         .         .         .         | 06         .    g.23649
 GACAAAATCATTGAGCTCAAGGATCTGGTGGTGGGCACTGAGGCAAAG | CTGAATAAATCT    c.1080
 D  K  I  I  E  L  K  D  L  V  V  G  T  E  A  K   | L  N  K  S      p.360

          .         .         .         .         .         .       g.23709
 GCTGTCTTGCGCAAGGCCATCGACTACATTCGCTTTCTGCAACACAGCAACCAGAAACTC       c.1140
 A  V  L  R  K  A  I  D  Y  I  R  F  L  Q  H  S  N  Q  K  L         p.380

          .         .         .         .    | 07    .         .    g.24112
 AAGCAGGAGAACCTAAGTCTGCGCACTGCTGTCCACAAAAGCA | AATCTCTGAAGGATCTG    c.1200
 K  Q  E  N  L  S  L  R  T  A  V  H  K  S  K |   S  L  K  D  L      p.400

          .         .         .         .         .         .       g.24172
 GTGTCGGCCTGTGGCAGTGGAGGGAACACAGACGTGCTCATGGAGGGCGTGAAGACTGAG       c.1260
 V  S  A  C  G  S  G  G  N  T  D  V  L  M  E  G  V  K  T  E         p.420

          .         .         .         .         .         .       g.24232
 GTGGAGGACACACTGACCCCACCCCCCTCGGATGCTGGCTCACCTTTCCAGAGCAGCCCC       c.1320
 V  E  D  T  L  T  P  P  P  S  D  A  G  S  P  F  Q  S  S  P         p.440

          .         .         .         .         .         .       g.24292
 TTGTCCCTTGGCAGCAGGGGCAGTGGCAGCGGTGGCAGTGGCAGTGACTCGGAGCCTGAC       c.1380
 L  S  L  G  S  R  G  S  G  S  G  G  S  G  S  D  S  E  P  D         p.460

          .         .     | 08   .         .         .         .    g.24590
 AGCCCAGTCTTTGAGGACAGCAAG | GCAAAGCCAGAGCAGCGGCCGTCTCTGCACAGCCGG    c.1440
 S  P  V  F  E  D  S  K   | A  K  P  E  Q  R  P  S  L  H  S  R      p.480

          .         .         .         .         .         .       g.24650
 GGCATGCTGGACCGCTCCCGCCTGGCCCTGTGCACGCTCGTCTTCCTCTGCCTGTCCTGC       c.1500
 G  M  L  D  R  S  R  L  A  L  C  T  L  V  F  L  C  L  S  C         p.500

          .         .         .         .         .         .       g.24710
 AACCCCTTGGCCTCCTTGCTGGGGGCCCGGGGGCTTCCCAGCCCCTCAGATACCACCAGC       c.1560
 N  P  L  A  S  L  L  G  A  R  G  L  P  S  P  S  D  T  T  S         p.520

          .         .         .         .       | 09 .         .    g.24889
 GTCTACCATAGCCCTGGGCGCAACGTGCTGGGCACCGAGAGCAGAG | ATGGCCCTGGCTGG    c.1620
 V  Y  H  S  P  G  R  N  V  L  G  T  E  S  R  D |   G  P  G  W      p.540

          .         .         .         .         .         .       g.24949
 GCCCAGTGGCTGCTGCCCCCAGTGGTCTGGCTGCTCAATGGGCTGTTGGTGCTCGTCTCC       c.1680
 A  Q  W  L  L  P  P  V  V  W  L  L  N  G  L  L  V  L  V  S         p.560

          .         .         .         .         .         .       g.25009
 TTGGTGCTTCTCTTTGTCTACGGTGAGCCAGTCACACGGCCCCACTCAGGCCCCGCCGTG       c.1740
 L  V  L  L  F  V  Y  G  E  P  V  T  R  P  H  S  G  P  A  V         p.580

          .         .         .         .      | 10  .         .    g.25308
 TACTTCTGGAGGCATCGCAAGCAGGCTGACCTGGACCTGGCCCGG | GGAGACTTTGCCCAG    c.1800
 Y  F  W  R  H  R  K  Q  A  D  L  D  L  A  R   | G  D  F  A  Q      p.600

          .         .         .         .         .         .       g.25368
 GCTGCCCAGCAGCTGTGGCTGGCCCTGCGGGCACTGGGCCGGCCCCTGCCCACCTCCCAC       c.1860
 A  A  Q  Q  L  W  L  A  L  R  A  L  G  R  P  L  P  T  S  H         p.620

          .         .         .         .         .         .       g.25428
 CTGGACCTGGCTTGTAGCCTCCTCTGGAACCTCATCCGTCACCTGCTGCAGCGTCTCTGG       c.1920
 L  D  L  A  C  S  L  L  W  N  L  I  R  H  L  L  Q  R  L  W         p.640

          .         .         .         .         .         .       g.25488
 GTGGGCCGCTGGCTGGCAGGCCGGGCAGGGGGCCTGCAGCAGGACTGTGCTCTGCGAGTG       c.1980
 V  G  R  W  L  A  G  R  A  G  G  L  Q  Q  D  C  A  L  R  V         p.660

          .         .         .         .         .         .       g.25548
 GATGCTAGCGCCAGCGCCCGAGACGCAGCCCTGGTCTACCATAAGCTGCACCAGCTGCAC       c.2040
 D  A  S  A  S  A  R  D  A  A  L  V  Y  H  K  L  H  Q  L  H         p.680

         | 11.         .         .         .         .         .    g.25691
 ACCATGG | GGAAGCACACAGGCGGGCACCTCACTGCCACCAACCTGGCGCTGAGTGCCCTG    c.2100
 T  M  G |   K  H  T  G  G  H  L  T  A  T  N  L  A  L  S  A  L      p.700

          .         .         .         .         .         .       g.25751
 AACCTGGCAGAGTGTGCAGGGGATGCCGTGTCTGTGGCGACGCTGGCCGAGATCTATGTG       c.2160
 N  L  A  E  C  A  G  D  A  V  S  V  A  T  L  A  E  I  Y  V         p.720

          .         .         .         .         .     | 12   .    g.25989
 GCGGCTGCATTGAGAGTGAAGACCAGTCTCCCACGGGCCTTGCATTTTCTGACA | CGCTTC    c.2220
 A  A  A  L  R  V  K  T  S  L  P  R  A  L  H  F  L  T   | R  F      p.740

          .         .         .         .         .         .       g.26049
 TTCCTGAGCAGTGCCCGCCAGGCCTGCCTGGCACAGAGTGGCTCAGTGCCTCCTGCCATG       c.2280
 F  L  S  S  A  R  Q  A  C  L  A  Q  S  G  S  V  P  P  A  M         p.760

          .         .         .         .         .         .       g.26109
 CAGTGGCTCTGCCACCCCGTGGGCCACCGTTTCTTCGTGGATGGGGACTGGTCCGTGCTC       c.2340
 Q  W  L  C  H  P  V  G  H  R  F  F  V  D  G  D  W  S  V  L         p.780

          .         .         .         .    | 13    .         .    g.26699
 AGTACCCCATGGGAGAGCCTGTACAGCTTGGCCGGGAACCCAG | TGGACCCCCTGGCCCAG    c.2400
 S  T  P  W  E  S  L  Y  S  L  A  G  N  P  V |   D  P  L  A  Q      p.800

          .         .         .         .         .         .       g.26759
 GTGACTCAGCTATTCCGGGAACATCTCTTAGAGCGAGCACTGAACTGTGTGACCCAGCCC       c.2460
 V  T  Q  L  F  R  E  H  L  L  E  R  A  L  N  C  V  T  Q  P         p.820

          .         .         .   | 14     .         .         .    g.27095
 AACCCCAGCCCTGGGTCAGCTGATGGGGACAA | GGAATTCTCGGATGCCCTCGGGTACCTG    c.2520
 N  P  S  P  G  S  A  D  G  D  K  |  E  F  S  D  A  L  G  Y  L      p.840

          .         .         .         .         .         .       g.27155
 CAGCTGCTGAACAGCTGTTCTGATGCTGCGGGGGCTCCTGCCTACAGCTTCTCCATCAGT       c.2580
 Q  L  L  N  S  C  S  D  A  A  G  A  P  A  Y  S  F  S  I  S         p.860

          .         .   | 15     .         .         .         .    g.27302
 TCCAGCATGGCCACCACCACCG | GCGTAGACCCGGTGGCCAAGTGGTGGGCCTCTCTGACA    c.2640
 S  S  M  A  T  T  T  G |   V  D  P  V  A  K  W  W  A  S  L  T      p.880

          .         .         .         .         .         .       g.27362
 GCTGTGGTGATCCACTGGCTGCGGCGGGATGAGGAGGCGGCTGAGCGGCTGTGCCCGCTG       c.2700
 A  V  V  I  H  W  L  R  R  D  E  E  A  A  E  R  L  C  P  L         p.900

          .         .         .      | 16  .         .         .    g.27626
 GTGGAGCACCTGCCCCGGGTGCTGCAGGAGTCTGA | GAGACCCCTGCCCAGGGCAGCTCTG    c.2760
 V  E  H  L  P  R  V  L  Q  E  S  E  |  R  P  L  P  R  A  A  L      p.920

          .         .         .         .         .         .       g.27686
 CACTCCTTCAAGGCTGCCCGGGCCCTGCTGGGCTGTGCCAAGGCAGAGTCTGGTCCAGCC       c.2820
 H  S  F  K  A  A  R  A  L  L  G  C  A  K  A  E  S  G  P  A         p.940

          .         .         .         .         .         .       g.27746
 AGCCTGACCATCTGTGAGAAGGCCAGTGGGTACCTGCAGGACAGCCTGGCTACCACACCA       c.2880
 S  L  T  I  C  E  K  A  S  G  Y  L  Q  D  S  L  A  T  T  P         p.960

          .         .  | 17      .         .         .         .    g.28281
 GCCAGCAGCTCCATTGACAAG | GCCGTGCAGCTGTTCCTGTGTGACCTGCTTCTTGTGGTG    c.2940
 A  S  S  S  I  D  K   | A  V  Q  L  F  L  C  D  L  L  L  V  V      p.980

          .         .         .         .         .         .       g.28341
 CGCACCAGCCTGTGGCGGCAGCAGCAGCCCCCGGCCCCGGCCCCAGCAGCCCAGGGCACC       c.3000
 R  T  S  L  W  R  Q  Q  Q  P  P  A  P  A  P  A  A  Q  G  T         p.1000

          .         .         .         .         .         .       g.28401
 AGCAGCAGGCCCCAGGCTTCCGCCCTTGAGCTGCGTGGCTTCCAACGGGACCTGAGCAGC       c.3060
 S  S  R  P  Q  A  S  A  L  E  L  R  G  F  Q  R  D  L  S  S         p.1020

          .         .         .         .   | 18     .         .    g.28550
 CTGAGGCGGCTGGCACAGAGCTTCCGGCCCGCCATGCGGAGG | GTGTTCCTACATGAGGCC    c.3120
 L  R  R  L  A  Q  S  F  R  P  A  M  R  R   | V  F  L  H  E  A      p.1040

          .         .         .         .         .         .       g.28610
 ACGGCCCGGCTGATGGCGGGGGCCAGCCCCACACGGACACACCAGCTCCTCGACCGCAGT       c.3180
 T  A  R  L  M  A  G  A  S  P  T  R  T  H  Q  L  L  D  R  S         p.1060

          .         .         .     | 19   .         .         .    g.29186
 CTGAGGCGGCGGGCAGGCCCCGGTGGCAAAGGAG | GCGCGGTGGCGGAGCTGGAGCCGCGG    c.3240
 L  R  R  R  A  G  P  G  G  K  G  G |   A  V  A  E  L  E  P  R      p.1080

          .         .         .         .         .         .       g.29246
 CCCACGCGGCGGGAGCACGCGGAGGCCTTGCTGCTGGCCTCCTGCTACCTGCCCCCCGGC       c.3300
 P  T  R  R  E  H  A  E  A  L  L  L  A  S  C  Y  L  P  P  G         p.1100

          .         .         .         .         .         .       g.29306
 TTCCTGTCGGCGCCCGGGCAGCGCGTGGGCATGCTGGCTGAGGCGGCGCGCACACTCGAG       c.3360
 F  L  S  A  P  G  Q  R  V  G  M  L  A  E  A  A  R  T  L  E         p.1120

          .         .         .         .         .         .       g.29366
 AAGCTTGGCGATCGCCGGCTGCTGCACGACTGTCAGCAGATGCTCATGCGCCTGGGCGGT       c.3420
 K  L  G  D  R  R  L  L  H  D  C  Q  Q  M  L  M  R  L  G  G         p.1140

          .         .                                               g.29390
 GGGACCACTGTCACTTCCAGCTAG                                           c.3444
 G  T  T  V  T  S  S  X                                             p.1147

          .         .         .         .         .         .       g.29450
 accccgtgtccccggcctcagcacccctgtctctagccactttggtcccgtgcagcttct       c.*60

          .         .         .         .         .         .       g.29510
 gtcctgcgtcgaagctttgaaggccgaaggcagtgcaagagactctggcctccacagttc       c.*120

          .         .         .         .         .         .       g.29570
 gacctgcggctgctgtgtgccttcgcggtggaaggcccgaggggcgcgatcttgacccta       c.*180

          .         .         .         .         .         .       g.29630
 agaccggcggccatgatggtgctgacctctggtggccgatcggggcactgcaggggccga       c.*240

          .         .         .         .         .         .       g.29690
 gccattttggggggcccccctccttgctctgcaggcaccttagtggcttttttcctcctg       c.*300

          .         .         .         .         .         .       g.29750
 tgtacagggaagagaggggtacatttccctgtgctgacggaagccaacttggctttcccg       c.*360

          .         .         .         .         .         .       g.29810
 gactgcaagcagggctctgccccagaggcctctctctccgtcgtgggagagagacgtgta       c.*420

          .         .         .         .         .         .       g.29870
 catagtgtaggtcagcgtgcttagcctcctgacctgaggctcctgtgctactttgccttt       c.*480

          .         .         .         .         .         .       g.29930
 tgcaaactttattttcatagattgagaagttttgtacagagaattaaaaatgaaattatt       c.*540

          .         .         .         .         .         .       g.29990
 tataatctgggttttgtgtcttcagctgatggatgtgctgactagtgagagtgcttgggc       c.*600

          .         .         .         .         .         .       g.30050
 cctcccccagcacctagggaaaggcttcccctccccctccggccacaaggtacacaactt       c.*660

          .         .         .         .         .         .       g.30110
 ttaacttagctcttcccgatgtttgtttgttagtgggaggagtggggagggctggctgta       c.*720

          .         .         .         .         .         .       g.30170
 tggcctccagcctacctgttccccctgctcccagggcacatggttgggctgtgtcaaccc       c.*780

          .         .         .         .         .         .       g.30230
 ttagggcctccatggggtcagttgtcccttctcacctcccagctctgtccccatcaggtc       c.*840

          .         .         .         .         .         .       g.30290
 cctgggtggcacgggaggatggactgacttccaggacctgttgtgtgacaggagctacag       c.*900

          .         .         .         .         .         .       g.30350
 cttgggtctccctgcaagaagtctggcacgtctcacctcccccatcccggcccctggtca       c.*960

          .         .         .         .         .         .       g.30410
 tctcacagcaaagaagcctcctccctcccgacctgccgccacactggagagggggcacag       c.*1020

          .         .         .         .         .         .       g.30470
 gggcgggggaggtttcctgttctgtgaaaggccgactccctgactccattcatgcccccc       c.*1080

          .         .         .         .         .         .       g.30530
 cccccagcccctcccttcattcccattccccaacctaaagcctggcccggctcccagctg       c.*1140

          .         .         .         .         .         .       g.30590
 aatctggtcggaatccacgggctgcagattttccaaaacaatcgttgtatctttattgac       c.*1200

          .         .         .         .         .         .       g.30650
 ttttttttttttttttttctgaatgcaatgactgttttttactcttaaggaaaataaaca       c.*1260

          .                                                         g.30663
 tcttttagaaaca                                                      c.*1273

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sterol regulatory element binding transcription factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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