serine/arginine-rich splicing factor 1 (SRSF1) - coding DNA reference sequence

(used for variant description)

(last modified May 30, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_006924.4 in the SRSF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering SRSF1 transcript NM_006924.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                gttgcgctcccgcgcgtgcgtgttgggat       c.-181

 .         .         .         .         .         .                g.5089
 cgaatcgctgtttccttccgcttctcttcctctgtctcccccccatatccgtgcgccgag       c.-121

 .         .         .         .         .         .                g.5149
 ctgataaaggcgccattttggaggggccgcgggagacgtggtgccgctgcgggctcgctc       c.-61

 .         .         .         .         .         .                g.5209
 tgccgtgcgctaggcttggtgggaaggcctgttctcgagtccgcgcttttcgtcaccgcc       c.-1

          .         .         .         .         .         .       g.5269
 ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTG       c.60
 M  S  G  G  G  V  I  R  G  P  A  G  N  N  D  C  R  I  Y  V         p.20

          .         .         .         .         .         .       g.5329
 GGTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGC       c.120
 G  N  L  P  P  D  I  R  T  K  D  I  E  D  V  F  Y  K  Y  G         p.40

          .         .         .         .         .         .       g.5389
 GCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG       c.180
 A  I  R  D  I  D  L  K  N  R  R  G  G  P  P  F  A  F  V  E         p.60

          .     | 02   .         .         .         .         .    g.5865
 TTCGAGGACCCGCG | AGACGCGGAAGACGCGGTGTATGGTCGCGACGGCTATGATTACGAT    c.240
 F  E  D  P  R  |  D  A  E  D  A  V  Y  G  R  D  G  Y  D  Y  D      p.80

          .         .         .         .         .         .       g.5925
 GGGTACCGTCTGCGGGTGGAGTTTCCTCGAAGCGGCCGTGGAACAGGCCGAGGCGGCGGC       c.300
 G  Y  R  L  R  V  E  F  P  R  S  G  R  G  T  G  R  G  G  G         p.100

          .         .         .         .         .         .       g.5985
 GGGGGTGGAGGTGGCGGAGCTCCCCGAGGTCGCTATGGCCCCCCATCCAGGCGGTCTGAA       c.360
 G  G  G  G  G  G  A  P  R  G  R  Y  G  P  P  S  R  R  S  E         p.120

          .          | 03        .         .         .         .    g.6414
 AACAGAGTGGTTGTCTCTG | GACTGCCTCCAAGTGGAAGTTGGCAGGATTTAAAGGATCAC    c.420
 N  R  V  V  V  S  G |   L  P  P  S  G  S  W  Q  D  L  K  D  H      p.140

          .         .         .         .         .         .       g.6474
 ATGCGTGAAGCAGGTGATGTATGTTATGCTGATGTTTACCGAGATGGCACTGGTGTCGTG       c.480
 M  R  E  A  G  D  V  C  Y  A  D  V  Y  R  D  G  T  G  V  V         p.160

          .         .         .         .         .         .       g.6534
 GAGTTTGTACGGAAAGAAGATATGACCTATGCAGTTCGAAAACTGGATAACACTAAGTTT       c.540
 E  F  V  R  K  E  D  M  T  Y  A  V  R  K  L  D  N  T  K  F         p.180

          .   | 04     .         .         .         .         .    g.6794
 AGATCTCATGAG | GGAGAAACTGCCTACATCCGGGTTAAAGTTGATGGGCCCAGAAGTCCA    c.600
 R  S  H  E   | G  E  T  A  Y  I  R  V  K  V  D  G  P  R  S  P      p.200

          .         .         .         .         .         .       g.6854
 AGTTATGGAAGATCTCGATCTCGAAGCCGTAGTCGTAGCAGAAGCCGTAGCAGAAGCAAC       c.660
 S  Y  G  R  S  R  S  R  S  R  S  R  S  R  S  R  S  R  S  N         p.220

          .         .         .         .         .         .       g.6914
 AGCAGGAGTCGCAGTTACTCCCCAAGGAGAAGCAGAGGATCACCACGCTATTCTCCCCGT       c.720
 S  R  S  R  S  Y  S  P  R  R  S  R  G  S  P  R  Y  S  P  R         p.240

          .         .                                               g.6941
 CATAGCAGATCTCGCTCTCGTACATAA                                        c.747
 H  S  R  S  R  S  R  T  X                                          p.248

          .         .         .         .         .         .       g.7001
 gatgattggtgacactttttgtagaacccatgttgtatacagttttcctttattcagtac       c.*60

          .         .         .         .         .         .       g.7061
 aatcttttcattttttaattcaaactgttttgttcagaatgggctaaagtgttgaattgc       c.*120

          .         .         .         .         .         .       g.7121
 attcttgtaatatccccttgctcctaacatctacattcccttcgtgtctttgataaattg       c.*180

          .         .         .         .         .         .       g.7181
 tattttaagtgatgtcatagacaggattgtttaaatttagttaactccatactcttcaga       c.*240

          .         .         .         .         .         .       g.7241
 ctgtgatattgtgtaaatgtctatctgccctggtttgtgtgaactgggatgttgggggtg       c.*300

          .         .         .         .         .         .       g.7301
 tttgtggttatcttacctggggaagttcttatgtttatcttgcttttcatgtgtctttct       c.*360

          .         .         .         .         .         .       g.7361
 gtagacatatctgaagagatggattaagaatgctttggattaaggattgtggagcacatt       c.*420

          .         .         .         .         .         .       g.7421
 tcaatcattttaggattgtcaaaaggaggattgaggaggatcagatcaataatggaggca       c.*480

          .         .         .         .         .         .       g.7481
 atggtatgactccaagtgctattgtcacagatgaaattggcagtattgaccttatactaa       c.*540

          .         .         .         .         .         .       g.7541
 aaggcaggggttaaaaatgattatatacattttccttaaaacacttgcaaacattttatt       c.*600

          .         .         .         .         .         .       g.7601
 cagttgtctttagctacaattgctttgctttttaaaccttggcaattgtggcaaaattat       c.*660

          .         .         .         .         .         .       g.7661
 attgcccattttgtagcaacttattttgctcccttccccccatttttgttttaataggga       c.*720

          .         .         .         .         .         .       g.7721
 ctaatgtgggaagaactggctaatttgtcacagtgcttagttacaactgttaatgtgtga       c.*780

          .         .         .         .         .         .       g.7781
 cctgctgttggtgtacatgtgggtacagggtgtttttaaatccaacaagatagagtataa       c.*840

          .         .         .         .         .         .       g.7841
 tatcaatactgctaaatctgcatgtcctctgtgtgactgatagagcgttgctatttcatt       c.*900

          .         .         .         .         .         .       g.7901
 tttttaagacaaaatgaaagcaaaatatagagttccaatgtattggtgtagataatctag       c.*960

          .         .         .         .         .         .       g.7961
 ttgggaatacttttaagtctcaccttcccctttaaactaatattcataattggttcatat       c.*1020

          .         .         .         .         .         .       g.8021
 gtttaaaagactttaatttacaaattaaattgcaaatgggagcattagatttagttttag       c.*1080

          .         .         .         .         .         .       g.8081
 acttaggtgggtagcaatgccagtaaacttaaattacgtaacttcttgcaaccacgaaac       c.*1140

          .         .         .         .         .         .       g.8141
 ctgtaatacgctgtacagtaacaagtgttggcattatcagttgaactgtaaatacaaaat       c.*1200

          .         .         .         .         .         .       g.8201
 gcttcttccaattagtctctatgatgattaagtttctaaaatttatctgaacaccattca       c.*1260

          .         .         .         .         .         .       g.8261
 gaaacttgttttggggaatttgatagttattgatgtgcatctgttaaactgatgacagac       c.*1320

          .         .         .         .         .         .       g.8321
 ataactcatcattccccagaaaccttttttgattacagtatctaacattttgcctcctct       c.*1380

          .         .         .         .         .         .       g.8381
 tttttggttttgctggttataaaggtttggattggagagggctcactggatcccaatcct       c.*1440

          .         .         .         .         .         .       g.8441
 tggagctggatcattggattcaaatcataatgtggataggatagggaggatgaattacca       c.*1500

          .         .         .         .         .         .       g.8501
 ggattcatggagcgggatcagattaccaggaacataggagtggattcctgccccaaccaa       c.*1560

          .         .         .         .         .         .       g.8561
 accgcattcgtgtggatttttttattcaacttaattggctattccaaagatttttttttt       c.*1620

          .         .         .         .         .         .       g.8621
 cctatttttgacgattggagcccttaagatgcacgatggaattgtgttttgcgttttttg       c.*1680

          .         .         .         .         .         .       g.8681
 gtaaaaggagcaaagcgaggacctggagataaacgctggagcaatctccttggaaggatt       c.*1740

          .         .         .         .         .         .       g.8741
 cagcacgagtagatggtaaacatttaaaggggaaagggggggtttgtttaaaatagtaaa       c.*1800

          .         .         .         .         .         .       g.8801
 tcagtaagtcacttctaaatttaaagaaaacaaaattggagttgaagaataagtaggttt       c.*1860

          .         .         .         .         .         .       g.8861
 ccaattggctattgccgttttctttgaaaaaataaacattttttaaaaaactatgcatgg       c.*1920

          .         .         .         .         .         .       g.8921
 ttgtcctttttcctcttcatgtaagattctaactgggtctatcagttaatctttaaattg       c.*1980

          .         .         .         .         .         .       g.8981
 ttaagtaagataagattttgactcttgtgttaatgtgttagcaaattaaaagttcttaaa       c.*2040

          .         .         .         .         .         .       g.9041
 aggcaatctaatggtattagccatcttttattgttaattgtaaaagtcttcaggggaaag       c.*2100

          .         .         .         .         .         .       g.9101
 caaaaggggagaataaggcatttgtgtatgtaacttggtaaatgacggtgggggatggat       c.*2160

          .         .         .         .         .         .       g.9161
 ctagcatctgaaagataagcttctctactttgttataaagtggttaaaaaactatagatg       c.*2220

          .         .         .         .         .         .       g.9221
 ctgcttattttctggtggtcatagacaacataggcttttgtgcaaaattggttgatggct       c.*2280

          .         .         .         .         .         .       g.9281
 actaatgttcacttggagatagcttttgatattctcaatgaaactcatctcaaaaaaagg       c.*2340

          .         .         .         .         .         .       g.9341
 taagtattaaatgttaacatcagcacagatgtattagaactgttttttgtttttgagaca       c.*2400

          .         .         .         .         .         .       g.9401
 gagtctcgctctgttctccagactggagggcagtggtgtgatctaggctcactgcaacct       c.*2460

          .         .         .         .         .         .       g.9461
 ccacccctggatttgagtgattctcgtgcctcagtctcccaagtagctgagactacaagt       c.*2520

          .         .         .         .         .         .       g.9521
 gtgtgccacccttgcccggctaattttgtatttttagtagagatgtggtttctctgtgtt       c.*2580

          .         .         .         .         .         .       g.9581
 acccaggctggtcccaaaactcctggcctcaagtgatctgcctgccttggcctcccaaag       c.*2640

          .         .         .         .         .         .       g.9641
 tgttaggattacaggtgtgagccaccatgctcagcctgtagaacttttaacccaagtctc       c.*2700

          .         .         .         .         .         .       g.9701
 atttcttttttgaaagggaagagtgcacaagattaactgcttctttggatgaatcattgt       c.*2760

          .         .         .         .         .         .       g.9761
 taataaaaagctgggcatttagaattttgccttataagcccttctccaaccataagatta       c.*2820

          .         .         .         .         .         .       g.9821
 ttttgtaccaaaaactttggtgttctctaccaaagcagttaaaaacttttagcctgctac       c.*2880

          .         .         .         .         .         .       g.9881
 ttcttgtatttgtctactgacagccccttggtactatttaggttgggggaggggacctaa       c.*2940

          .         .         .         .         .         .       g.9941
 aataaatagactttaacatttcccttgggtgctaatcatagttggaagttgaatttaagg       c.*3000

          .         .         .         .         .         .       g.10001
 tgattatttgggtgacaattaaaaacctaaggaaaaccagaaatcttggtagtggaagaa       c.*3060

          .         .         .         .         .         .       g.10061
 atgtgtaaggtcaccccaatcggtagattttaatgaacgttgtggaatgttgggaagagg       c.*3120

          .         .         .         .         .         .       g.10121
 ggatgttaagttgaatgcagaatttcactaagtacttagtgtaagtttaaggatgtagct       c.*3180

          .         .         .         .         .         .       g.10181
 ctttttatctaagaattcaatgtaatggccaaaaggcagatttactgtttaaaaatttga       c.*3240

          .         .         .         .         .         .       g.10241
 ataattttacatgacattcttgaaattctaagaagttttatgtgtagaacattttaaaaa       c.*3300

          .         .         .         .         .         .       g.10301
 ttcatcagattattaaagggaaaataaatgattaatgataattttggaaggttaatgtga       c.*3360

          .         .         .         .         .         .       g.10361
 gctagacttaagtaaactttggttcatttgtgttcattgaatgttttggaaatgaccaaa       c.*3420

          .         .         .         .         .         .       g.10421
 aaatgtaaatggccttcactcaagtttgagtgtttaaagttgaaagatgtgctctactaa       c.*3480

          .         .         .         .         .         .       g.10481
 aagttatagtaattctaacctcacattgaaatgagacagtattccttgttatacaggctg       c.*3540

          .         .         .         .         .         .       g.10541
 aatttgaagattagagaggatctaatgtttacttaggtaaaggggcataggttttgtagt       c.*3600

          .         .         .         .         .         .       g.10601
 taagatgaccagacagctaaaagctgtgatgggaagtatggactgctcctatttatagtc       c.*3660

          .         .         .         .         .         .       g.10661
 tcagaaaatggacctttaggtctctatccgtattggcaattattagaagaaagttacacc       c.*3720

          .         .         .         .         .         .       g.10721
 cttttgaaactacaaaagctgtcttggaatttccccctcttctccctatttatgtcccct       c.*3780

          .         .         .         .         .         .       g.10781
 tagaatattttagggagcctataattattttctaaccaaggaaaaacttaagtctcttta       c.*3840

          .         .         .         .         .         .       g.10841
 agaagcaattacttttcataacatcagattgaataacccaccttgctgttcagcccacat       c.*3900

          .         .         .         .         .         .       g.10901
 cctactggaaacaaaaggtaagaaacccattttctggttcttgattgtttgggtctgaat       c.*3960

          .         .         .         .         .         .       g.10961
 tttgtttttaaaactaagctaagtttaatgttttttaaaatgctgtttggaatatgaata       c.*4020

          .         .         .         .         .         .       g.11021
 gattccccgtaaaatgatttttcctaagttttatgctttagtaaatattcagtgctcacg       c.*4080

          .         .         .         .         .         .       g.11081
 tctgtgcatcatagtgcttgcgtttaatatgatttattgtagaatctcaacttttcttgg       c.*4140

          .         .         .         .         .         .       g.11141
 tgtttgttgtctttgaaacattgtcttggtcattagggctggtgttttcacatttctgtg       c.*4200

          .         .         .         .         .         .       g.11201
 gtcaaggtggatttcttatgtgtgcctttttgcttactttgtatatgaattttgtaattt       c.*4260

          .         .         .         .         .         .       g.11261
 aaattgcaagtaagttatatatatgtatttaccataaatagtattaaaagatgagaaact       c.*4320

          .         .         .         .         .         .       g.11321
 gttagactgaagttctgttgtaacataaccattatttccatcacagtatgaagactgcaa       c.*4380

          .         .         .         .         .         .       g.11381
 acgcagaaaacagattacagtctcttatccattttttgaaatccaaaaactacgaaaaca       c.*4440

          .         .         .         .                           g.11428
 aaagattttctgttgttgagctaattaaatgtgaaccctgaccagaa                    c.*4487

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Serine/arginine-rich splicing factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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