ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (ST3GAL3) - coding DNA reference sequence

(used for variant description)

(last modified March 17, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_174963.3 in the ST3GAL3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028196.1, covering ST3GAL3 transcript NM_174963.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  gccgctgcgtc       c.-181

 .         .         .         .         .         .                g.5071
 cccactatggcggcgcccatgcagcccagcgcgttgtgggctcccgccggggtcccccgc       c.-121

 .         .         .         .         .         .                g.5131
 ggctgtcgccgccgcctacgccgctgcctccgccttcctgccccgcgtcgggccgggcgc       c.-61

 .         .         .          | 02        .         .             g.33730
 cacctcccccctgcctccctctccgctgtg | gtcatttaggaaatcgtaaatcatgtgaag    c.-1

          .         .         .         .         .         .       g.33790
 ATGGGACTCTTGGTATTTGTGCGCAATCTGCTGCTAGCCCTCTGCCTCTTTCTGGTACTG       c.60
 M  G  L  L  V  F  V  R  N  L  L  L  A  L  C  L  F  L  V  L         p.20

          .         .         .         .         .         .       g.33850
 GGATTTTTGTATTATTCTGCGTGGAAGCTACACTTACTCCAGTGGGAGGAGGACTCCAGT       c.120
 G  F  L  Y  Y  S  A  W  K  L  H  L  L  Q  W  E  E  D  S  S         p.40

          .         .         .         .    | 03    .         .    g.89586
 AAGTATAGTCACTCTAGCTCACCCCAGGAGAAGCCTGTTGCAG | ATTCAGTGGTTCTTTCC    c.180
 K  Y  S  H  S  S  S  P  Q  E  K  P  V  A  D |   S  V  V  L  S      p.60

          .         .         .  | 04      .         .         .    g.112388
 TTTGACTCCGCTGGACAAACACTAGGCTCAG | AGTATGATCGGTTGGGCTTCCTCCTGAAT    c.240
 F  D  S  A  G  Q  T  L  G  S  E |   Y  D  R  L  G  F  L  L  N      p.80

          .     | 05   .         .         .         .         .    g.122245
 CTGGACTCTAAACT | CTCACCGAGGACTCTCTGCACGGTGGTTTTTGGCCTTGACTGCATA    c.300
 L  D  S  K  L  |  S  P  R  T  L  C  T  V  V  F  G  L  D  C  I      p.100

          .         .         .         .         .         .       g.122305
 TTGGAATCACCTGGAGAGCCTAAAAAATTACTGATGCCTGCATCCCACCCTCTAGAGATT       c.360
 L  E  S  P  G  E  P  K  K  L  L  M  P  A  S  H  P  L  E  I         p.120

          .         .         .         .         .       | 06 .    g.135691
 TTGAAGTCACTGAGCGAGGACACAGCCTTTGCATTAGGATTTTTAAAGCTGCCCAG | GCCT    c.420
 L  K  S  L  S  E  D  T  A  F  A  L  G  F  L  K  L  P  R  |  P      p.140

          .         .         .         .         .         .       g.135751
 GCTGAATTAGCCACCAAGTACGCAAACTTTTCAGAGGGAGCTTGCAAGCCTGGCTATGCT       c.480
 A  E  L  A  T  K  Y  A  N  F  S  E  G  A  C  K  P  G  Y  A         p.160

          .         .          | 07        .         .         .    g.191882
 TCAGCCTTGATGACGGCCATCTTCCCCCG | GTTCTCCAAGCCAGCACCCATGTTCCTGGAT    c.540
 S  A  L  M  T  A  I  F  P  R  |  F  S  K  P  A  P  M  F  L  D      p.180

          .         .         .         .         .         .       g.191942
 GACTCCTTTCGCAAGTGGGCTAGAATCCGGGAGTTCGTGCCGCCTTTTGGGATCAAAGGT       c.600
 D  S  F  R  K  W  A  R  I  R  E  F  V  P  P  F  G  I  K  G         p.200

      | 08   .         .         .         .         .         .    g.195759
 CAAG | ACAATCTGATCAAAGCCATCTTGTCAGTCACCAAAGAGTACCGCCTGACCCCTGCC    c.660
 Q  D |   N  L  I  K  A  I  L  S  V  T  K  E  Y  R  L  T  P  A      p.220

          | 09         .         .         .         .         .    g.196688
 TTGGACAG | CCTCCGCTGCCGCCGCTGCATCATCGTGGGCAATGGAGGCGTTCTTGCCAAC    c.720
 L  D  S  |  L  R  C  R  R  C  I  I  V  G  N  G  G  V  L  A  N      p.240

          .         .         .         .     | 10   .         .    g.197025
 AAGTCTCTGGGGTCACGAATTGACGACTATGACATTGTGGTGAG | ACTGAATTCAGCACCA    c.780
 K  S  L  G  S  R  I  D  D  Y  D  I  V  V  R  |  L  N  S  A  P      p.260

          .         .         .         .         .         .       g.197085
 GTGAAAGGCTTTGAGAAGGACGTGGGCAGCAAAACGACACTGCGCATCACCTACCCCGAG       c.840
 V  K  G  F  E  K  D  V  G  S  K  T  T  L  R  I  T  Y  P  E         p.280

          .         .         .         .         .         .       g.197145
 GGCGCCATGCAGCGGCCTGAGCAGTACGAGCGCGATTCTCTCTTTGTCCTCGCCGGCTTC       c.900
 G  A  M  Q  R  P  E  Q  Y  E  R  D  S  L  F  V  L  A  G  F         p.300

          .         .         .         .         .  | 11      .    g.217881
 AAGTGGCAGGACTTTAAGTGGTTGAAATACATCGTCTACAAGGAGAGAGTG | AGTGCATCG    c.960
 K  W  Q  D  F  K  W  L  K  Y  I  V  Y  K  E  R  V   | S  A  S      p.320

          .         .         .         .         .         .       g.217941
 GATGGCTTCTGGAAATCTGTGGCCACTCGAGTGCCCAAGGAGCCCCCTGAGATTCGAATC       c.1020
 D  G  F  W  K  S  V  A  T  R  V  P  K  E  P  P  E  I  R  I         p.340

          .         .         .         .         .         .       g.218001
 CTCAACCCATATTTCATCCAGGAGGCCGCCTTCACCCTCATTGGCCTGCCCTTCAACAAT       c.1080
 L  N  P  Y  F  I  Q  E  A  A  F  T  L  I  G  L  P  F  N  N         p.360

          .         | 12         .         .         .         .    g.218292
 GGCCTCATGGGCCGGGGG | AACATCCCTACCCTTGGCAGTGTGGCAGTGACCATGGCACTA    c.1140
 G  L  M  G  R  G   | N  I  P  T  L  G  S  V  A  V  T  M  A  L      p.380

          .         .         .         .         .         .       g.218352
 CACGGCTGTGACGAGGTGGCAGTCGCAGGATTTGGCTATGACATGAGCACACCCAACGCA       c.1200
 H  G  C  D  E  V  A  V  A  G  F  G  Y  D  M  S  T  P  N  A         p.400

          .         .         .         .      | 13  .         .    g.227615
 CCCCTGCACTACTATGAGACCGTTCGCATGGCAGCCATCAAAGAG | TCCTGGACGCACAAT    c.1260
 P  L  H  Y  Y  E  T  V  R  M  A  A  I  K  E   | S  W  T  H  N      p.420

          .         .         .         .         .         .       g.227675
 ATCCAGCGAGAGAAAGAGTTTCTGCGGAAGCTGGTGAAAGCTCGCGTCATCACTGATCTA       c.1320
 I  Q  R  E  K  E  F  L  R  K  L  V  K  A  R  V  I  T  D  L         p.440

          .                                                         g.227690
 AGCAGTGGCATCTGA                                                    c.1335
 S  S  G  I  X                                                      p.444

          .         .         .         .         .         .       g.227750
 gtgggcccagcacatggccatagaggcccaggcaccaccaggagcagcagccagcaccac       c.*60

          .         .         .         .         .         .       g.227810
 ctacacaggagtcttcagacccagagaaggacggtgccaagggccccaggggcagcaagg       c.*120

          .         .         .         .         .         .       g.227870
 ccttggtggagcagccagagctgtgcctgctcagcagccagtctcagagaccagcactca       c.*180

          .         .         .         .         .         .       g.227930
 gcctcattcagcatgggtccttgatgccagagggccagcaggctcctggctgtgcccagc       c.*240

          .         .         .         .         .         .       g.227990
 aggcccagcatgcaggtggtgggacactgggcagcaaggctgctgccggaatcacttctc       c.*300

          .         .         .         .         .         .       g.228050
 caatcagtgtttggtgtattatcattttgtgaatttgggtaggggggagggtagggataa       c.*360

          .         .         .         .         .         .       g.228110
 tttatttttaaataaggttggagatgtcaagttgggttcacttgccatgcaggaagaggc       c.*420

          .         .         .         .         .         .       g.228170
 ccactagagggcccatcaggcagtgttacctgttagctccctgtggggcaggagtgccag       c.*480

          .         .         .         .         .         .       g.228230
 gaccagcctgtaccttgctgtggggctacaggatggtgggcaggatctcaagccagcccc       c.*540

          .         .         .         .         .         .       g.228290
 ctccagctcatgacactgtttggcctttcttggggagaaggcggggtattcccactcacc       c.*600

          .         .         .         .         .         .       g.228350
 agccctagctgtcccatggggaaaccctggagccatcccttcggagccaacaagaccgcc       c.*660

          .         .         .         .         .         .       g.228410
 ccagggctatagcagaaagaactttaaagctcaggagggtgacgcccagctccgcctgct       c.*720

          .         .         .         .         .         .       g.228470
 gggaagagctcccctccacagctgcagctgatccataggactaccgcaggcccggactca       c.*780

          .         .         .         .         .         .       g.228530
 ccaacttgccacatgttctaggtttcagcaacaagactgccaggtggttgggttctgcct       c.*840

          .         .         .         .         .         .       g.228590
 ttagcctggaccaaagggaagtgaggcccaaggagcttacccaagctgtggcagccgtcc       c.*900

          .         .         .         .                           g.228634
 caggccacccccatggaagcaataaagctcttccctgagcctgg                       c.*944

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ST3 beta-galactoside alpha-2,3-sialyltransferase 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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