signal transducing adaptor family member 1 (STAP1) - coding DNA reference sequence

(used for variant description)

(last modified March 5, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_012108.2 in the STAP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering STAP1 transcript NM_012108.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       aacagttgccttttcctctcac       c.-61

 .         .         .         .         .         .                g.5082
 agaaggaagatttcattttgtttgagacgagaaaccaaaccacacaccaaagagaggggt       c.-1

          .         .         .         .         .         .       g.5142
 ATGATGGCTAAGAAGCCCCCAAAACCAGCCCCTCGCAGGATCTTCCAGGAAAGGTTAAAG       c.60
 M  M  A  K  K  P  P  K  P  A  P  R  R  I  F  Q  E  R  L  K         p.20

          .         .         .         .         .         .       g.5202
 ATTACTGCTCTACCTTTGTACTTTGAAGGTTTTTTATTAATCAAGCGGTCAGGATACCGG       c.120
 I  T  A  L  P  L  Y  F  E  G  F  L  L  I  K  R  S  G  Y  R         p.40

  | 02       .         .         .         .         .         .    g.17416
  | GAGTATGAGCATTACTGGACAGAGTTGAGAGGAACTACTCTTTTCTTTTATACCGACAAA    c.180
  | E  Y  E  H  Y  W  T  E  L  R  G  T  T  L  F  F  Y  T  D  K      p.60

          .   | 03     .         .         .         .         .    g.21705
 AAGAGTATAATA | TATGTTGACAAATTAGACATAGTAGACCTCACATGCCTTACTGAGCAG    c.240
 K  S  I  I   | Y  V  D  K  L  D  I  V  D  L  T  C  L  T  E  Q      p.80

          .         .         .         .         .         .       g.21765
 AATTCAACTGAAAAGAACTGTGCGAAATTCACCCTTGTTTTGCCGAAAGAGGAAGTACAA       c.300
 N  S  T  E  K  N  C  A  K  F  T  L  V  L  P  K  E  E  V  Q         p.100

        | 04 .         .         .         .         .         .    g.23529
 CTGAAG | ACAGAGAACACAGAAAGTGGGGAAGAATGGAGAGGCTTCATTCTTACAGTAACA    c.360
 L  K   | T  E  N  T  E  S  G  E  E  W  R  G  F  I  L  T  V  T      p.120

     | 05    .         .         .         .         .         .    g.27634
 GAG | CTGTCAGTTCCCCAAAACGTGTCACTCCTACCTGGGCAAGTAATTAAACTGCATGAA    c.420
 E   | L  S  V  P  Q  N  V  S  L  L  P  G  Q  V  I  K  L  H  E      p.140

          .         .         .         .         .         .       g.27694
 GTCCTAGAGAGAGAAAAGAAAAGGAGGATTGAGACAGAGCAGAGTACGTCCGTGGAAAAA       c.480
 V  L  E  R  E  K  K  R  R  I  E  T  E  Q  S  T  S  V  E  K         p.160

          .         .         .         .         . | 06       .    g.29856
 GAGAAGGAACCAACTGAAGATTATGTGGATGTACTGAACCCTATGCCAGC | ATGTTTTTAT    c.540
 E  K  E  P  T  E  D  Y  V  D  V  L  N  P  M  P  A  |  C  F  Y      p.180

          .         .         .         .         .         .       g.29916
 ACAGTGTCCCGGAAAGAGGCAACTGAGATGCTCCAGAAGAACCCTTCTTTGGGAAATATG       c.600
 T  V  S  R  K  E  A  T  E  M  L  Q  K  N  P  S  L  G  N  M         p.200

          .         .         .         .         .          | 07    g.37157
 ATCCTGAGGCCTGGTAGTGACAGTAGAAACTACTCCATCACTATTCGGCAGGAGATAGA | C    c.660
 I  L  R  P  G  S  D  S  R  N  Y  S  I  T  I  R  Q  E  I  D  |      p.220

          .         .         .         .         .         .       g.37217
 ATTCCAAGAATCAAGCACTACAAAGTGATGAGCGTAGGACAAAACTACACTATTGAACTG       c.720
 I  P  R  I  K  H  Y  K  V  M  S  V  G  Q  N  Y  T  I  E  L         p.240

           | 08        .         .         .         .         .    g.39583
 GAAAAACCT | GTAACACTCCCAAACCTTTTCAGTGTCATTGATTATTTTGTGAAGGAGACT    c.780
 E  K  P   | V  T  L  P  N  L  F  S  V  I  D  Y  F  V  K  E  T      p.260

          .         .         .         .       | 09 .         .    g.52582
 CGAGGAAATTTAAGACCATTTATATGTTCAACTGATGAAAACACTG | GTCAAGAACCCAGT    c.840
 R  G  N  L  R  P  F  I  C  S  T  D  E  N  T  G |   Q  E  P  S      p.280

          .         .         .         .                           g.52630
 ATGGAAGGGAGAAGTGAAAAGTTGAAGAAAAATCCACACATTGCATGA                   c.888
 M  E  G  R  S  E  K  L  K  K  N  P  H  I  A  X                     p.295

          .         .         .         .         .         .       g.52690
 aatacaatgtgaaagctcctttgtatatcttggtaatttatattttcaaaacgaagttct       c.*60

          .         .         .         .         .         .       g.52750
 tacttttaaagagaattacctatattctcctgatactgattaccaagtcattcacctgaa       c.*120

          .         .         .         .         .         .       g.52810
 caccagaattagaattaaacattgtaccatacaatttcattatcttatcagaatgaaacc       c.*180

          .         .         .         .         .         .       g.52870
 aattcacagggaaactagagactacggctgtggtggtaacctgcagatatacacattccc       c.*240

          .         .         .         .         .         .       g.52930
 atgcactgacataagttgaaaacacatagtactttctagatggaatttttttctttaggc       c.*300

          .         .         .         .         .         .       g.52990
 ctcaatgaaatacatttcccctatataattccaacagcagtttctctagttctaaatttt       c.*360

          .         .         .         .         .         .       g.53050
 accaattcccaaaaaacctaagttttgctgaaatctgatttgaccaatttatcaaatatg       c.*420

          .         .         .         .         .         .       g.53110
 tcattttaattacctagctggaagttagagacatgaaatgtactagaggagcccttttcc       c.*480

          .         .         .         .         .         .       g.53170
 aatggaaatattatataccacattttttgttaatggaaataaatgtcttcattcccatgt       c.*540

                                                                    g.53171
 t                                                                  c.*541

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Signal transducing adaptor family member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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