steroid sulfatase (microsomal), isozyme S (STS) - coding DNA reference sequence

(used for variant description)

(last modified October 31, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000351.4 in the STS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021472.1, covering STS transcript NM_000351.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        tccgc       c.-241

 .         .         .         .         .         .                g.5065
 ctcacattatctgcccaagcacagtgctgttggccaagcctccagcagctgacgggaccc       c.-181

 .         .         .         .         .         .                g.5125
 agctgtagtgaggttgcagtgattgagtaggattggcctgcttcaaagcagaggtttctc       c.-121

 .         .         .         .         .         .                g.5185
 atgggaatatgcttattaaactcccactggtgcagaaaccatgaacagaggatgaacaag       c.-61

 .         .         .         .         .         .                g.5245
 tgaagttgcaatctcctccatcacagctcagttccccaacaacaggatcacaagctggag       c.-1

          .  | 02      .         .         .         .         .    g.38814
 ATGCCTTTAAG | GAAGATGAAGATCCCTTTCCTCCTACTGTTCTTTCTGTGGGAAGCCGAG    c.60
 M  P  L  R  |  K  M  K  I  P  F  L  L  L  F  F  L  W  E  A  E      p.20

          .         .         .         .         .         .       g.38874
 AGCCACGCAGCATCAAGGCCGAACATCATCCTGGTGATGGCTGACGACCTCGGCATTGGA       c.120
 S  H  A  A  S  R  P  N  I  I  L  V  M  A  D  D  L  G  I  G         p.40

          .         .         .   | 03     .         .         .    g.42839
 GATCCTGGGTGCTATGGGAACAAAACTATCAG | GACTCCCAATATCGACCGGTTGGCCAGT    c.180
 D  P  G  C  Y  G  N  K  T  I  R  |  T  P  N  I  D  R  L  A  S      p.60

          .         .         .         .         .         .       g.42899
 GGGGGAGTGAAACTCACTCAGCACCTGGCAGCATCACCGCTGTGCACACCAAGCAGGGCA       c.240
 G  G  V  K  L  T  Q  H  L  A  A  S  P  L  C  T  P  S  R  A         p.80

          .         .         .     | 04   .         .         .    g.43061
 GCCTTCATGACTGGCCGGTACCCTGTCCGATCAG | GAATGGCATCTTGGTCCCGCACTGGA    c.300
 A  F  M  T  G  R  Y  P  V  R  S  G |   M  A  S  W  S  R  T  G      p.100

          .         .         .         .         .         .       g.43121
 GTTTTCCTCTTCACAGCCTCTTCGGGAGGACTTCCCACCGATGAGATTACCTTTGCTAAG       c.360
 V  F  L  F  T  A  S  S  G  G  L  P  T  D  E  I  T  F  A  K         p.120

          .         .         .        | 05.         .         .    g.44941
 CTTCTGAAGGATCAAGGTTATTCAACAGCACTGATAG | GGAAATGGCACCTTGGGATGAGC    c.420
 L  L  K  D  Q  G  Y  S  T  A  L  I  G |   K  W  H  L  G  M  S      p.140

          .         .         .         .         .         .       g.45001
 TGTCACAGCAAGACTGACTTCTGTCACCACCCTTTACATCACGGCTTCAATTATTTCTAT       c.480
 C  H  S  K  T  D  F  C  H  H  P  L  H  H  G  F  N  Y  F  Y         p.160

          .         .         .         .         .         .       g.45061
 GGGATCTCTTTGACCAATCTGAGAGACTGCAAGCCCGGAGAGGGCAGTGTCTTCACCACG       c.540
 G  I  S  L  T  N  L  R  D  C  K  P  G  E  G  S  V  F  T  T         p.180

          .         .         .         .         .         .       g.45121
 GGCTTCAAGAGGCTGGTCTTCCTCCCCCTGCAGATCGTCGGGGTCACCCTCCTTACCCTT       c.600
 G  F  K  R  L  V  F  L  P  L  Q  I  V  G  V  T  L  L  T  L         p.200

          .         .         .         .         .         .       g.45181
 GCTGCACTCAATTGTCTGGGGCTACTCCACGTGCCTCTAGGCGTTTTTTTCAGCCTTCTC       c.660
 A  A  L  N  C  L  G  L  L  H  V  P  L  G  V  F  F  S  L  L         p.220

          .         .         .         .         .         .       g.45241
 TTCCTAGCAGCCCTAATCCTGACCCTTTTCTTGGGCTTCCTTCATTACTTCCGGCCCCTG       c.720
 F  L  A  A  L  I  L  T  L  F  L  G  F  L  H  Y  F  R  P  L         p.240

          .         .         .         .         .         .       g.45301
 AACTGCTTCATGATGAGGAACTACGAGATCATTCAGCAGCCCATGTCCTATGACAATCTC       c.780
 N  C  F  M  M  R  N  Y  E  I  I  Q  Q  P  M  S  Y  D  N  L         p.260

          .         .         .         .  | 06      .         .    g.61539
 ACCCAGAGGCTAACGGTGGAGGCGGCCCAGTTCATACAGCG | GAACACTGAGACTCCGTTC    c.840
 T  Q  R  L  T  V  E  A  A  Q  F  I  Q  R  |  N  T  E  T  P  F      p.280

          .         .         .         .         .         .       g.61599
 CTGCTTGTCTTGTCCTACCTCCACGTGCACACAGCCCTGTTCTCCAGCAAAGACTTTGCT       c.900
 L  L  V  L  S  Y  L  H  V  H  T  A  L  F  S  S  K  D  F  A         p.300

          .         .         .         .         .         | 07    g.90617
 GGCAAAAGTCAACACGGAGTCTACGGGGATGCTGTTGAGGAAATGGACTGGAGTGTGG | GG    c.960
 G  K  S  Q  H  G  V  Y  G  D  A  V  E  E  M  D  W  S  V  G |       p.320

          .         .         .         .         .         .       g.90677
 CAGATCTTGAACCTTCTGGATGAGCTGAGATTGGCTAATGATACCCTCATCTACTTCACA       c.1020
 Q  I  L  N  L  L  D  E  L  R  L  A  N  D  T  L  I  Y  F  T         p.340

          .         .         .         .         .         .       g.90737
 TCGGACCAGGGAGCACATGTAGAAGAAGTGTCTTCCAAAGGAGAAATTCATGGCGGAAGT       c.1080
 S  D  Q  G  A  H  V  E  E  V  S  S  K  G  E  I  H  G  G  S         p.360

          .       | 08 .         .         .         .         .    g.110952
 AATGGGATCTATAAAG | GAGGAAAAGCAAACAACTGGGAAGGAGGTATCCGGGTTCCAGGC    c.1140
 N  G  I  Y  K  G |   G  K  A  N  N  W  E  G  G  I  R  V  P  G      p.380

          .         .         .         .         .         .       g.111012
 ATCCTTCGTTGGCCCAGGGTGATACAGGCTGGCCAGAAGATTGATGAGCCCACTAGCAAC       c.1200
 I  L  R  W  P  R  V  I  Q  A  G  Q  K  I  D  E  P  T  S  N         p.400

          .         .         .         .         .       | 09 .    g.119559
 ATGGACATATTTCCTACAGTAGCCAAGCTGGCTGGAGCTCCCTTGCCTGAGGACAG | GATC    c.1260
 M  D  I  F  P  T  V  A  K  L  A  G  A  P  L  P  E  D  R  |  I      p.420

          .         .         .         .         .         .       g.119619
 ATTGATGGACGTGATCTGATGCCCCTGCTTGAAGGAAAAAGCCAACGCTCCGATCATGAG       c.1320
 I  D  G  R  D  L  M  P  L  L  E  G  K  S  Q  R  S  D  H  E         p.440

          .         .         .         .         .         | 10    g.135459
 TTTCTCTTCCATTACTGCAACGCCTACTTAAATGCTGTGCGCTGGCACCCTCAGAACA | GC    c.1380
 F  L  F  H  Y  C  N  A  Y  L  N  A  V  R  W  H  P  Q  N  S |       p.460

          .         .         .         .         .         .       g.135519
 ACATCCATCTGGAAGGCCTTTTTCTTCACCCCCAACTTCAACCCCGTGGGTTCCAACGGA       c.1440
 T  S  I  W  K  A  F  F  F  T  P  N  F  N  P  V  G  S  N  G         p.480

          .         .         .         .         .         .       g.135579
 TGCTTTGCCACACACGTGTGCTTCTGTTTCGGGAGTTATGTCACCCATCACGACCCACCT       c.1500
 C  F  A  T  H  V  C  F  C  F  G  S  Y  V  T  H  H  D  P  P         p.500

          .         .         .         .         .         .       g.135639
 TTACTCTTTGATATTTCCAAAGATCCCAGAGAGAGAAACCCACTAACTCCAGCATCCGAG       c.1560
 L  L  F  D  I  S  K  D  P  R  E  R  N  P  L  T  P  A  S  E         p.520

          .         .         .         .         .         .       g.135699
 CCCCGGTTTTATGAAATCCTCAAAGTCATGCAGGAAGCTGCGGACAGACACACCCAGACC       c.1620
 P  R  F  Y  E  I  L  K  V  M  Q  E  A  A  D  R  H  T  Q  T         p.540

          .         .         .         .         .         .       g.135759
 CTGCCAGAGGTGCCCGATCAGTTTTCATGGAACAACTTTCTTTGGAAGCCCTGGCTTCAG       c.1680
 L  P  E  V  P  D  Q  F  S  W  N  N  F  L  W  K  P  W  L  Q         p.560

          .         .         .         .         .         .       g.135819
 CTGTGCTGTCCTTCCACCGGCCTGTCTTGCCAGTGTGATAGAGAAAAACAGGATAAGAGA       c.1740
 L  C  C  P  S  T  G  L  S  C  Q  C  D  R  E  K  Q  D  K  R         p.580

          .                                                         g.135831
 CTGAGCCGCTAG                                                       c.1752
 L  S  R  X                                                         p.583

          .         .         .         .         .         .       g.135891
 cagcgcctggggaccagacagacgcatgtggcaaagctcaccatcttcactacaaacacg       c.*60

          .         .         .         .         .         .       g.135951
 cctgagagtggcactggggaaacataactccatctacaccttggatttggactgattctc       c.*120

          .         .         .         .         .         .       g.136011
 cattttatcacctgaaggcttgggccagagctcaacagctactcaactggaggggtgagg       c.*180

          .         .         .         .         .         .       g.136071
 gggataaggtctgtagtatacagacaggaagatggtaggtttatgccttctgtggccaga       c.*240

          .         .         .         .         .         .       g.136131
 gtcttggactcatggaaatagaatgaatagaggggcattcacaaggcacaccagtgcaag       c.*300

          .         .         .         .         .         .       g.136191
 cagatgacaaaaaggtgcagaaggcaatcttaaaacagaaaggtgcaggaggtaccttaa       c.*360

          .         .         .         .         .         .       g.136251
 ctcacccctcagcaaatacctatgtcaacagtataagttaccatttactctataatctgc       c.*420

          .         .         .         .         .         .       g.136311
 agtgatgcaataaccagcataataaaaaggcaatcacataaaaaagagtttagtcgtcta       c.*480

          .         .         .         .         .         .       g.136371
 aacataagtaactttaaggtgaatgaaagatcttctttaggaataatagatgatggtaag       c.*540

          .         .         .         .         .         .       g.136431
 ttccactttggttattggaaggcaagtcattattactggtattagttaaaacacatatca       c.*600

          .         .         .         .         .         .       g.136491
 aatgcttgctcttcatcatatatatagttatgcatacatacacacacacacatacagtat       c.*660

          .         .         .         .         .         .       g.136551
 attctttcctcaaaagggttaagatgtctaaaatagggacctagaagcttaacactattt       c.*720

          .         .         .         .         .         .       g.136611
 aagtaaatacagtagaagctcacaaatagatttctttgcacaatgattttttgcaaaatt       c.*780

          .         .         .         .         .         .       g.136671
 ttacagtaataataatcccaaggcaaatctctcctgaactgctttccattccataatttg       c.*840

          .         .         .         .         .         .       g.136731
 tagtataattcttggattccactgttttctttggggaatggaagttctgaattaaaagcc       c.*900

          .         .         .         .         .         .       g.136791
 cactgtggagatgctgtggttcatggaatctcttccagtgtaattcagaatcattggcct       c.*960

          .         .         .         .         .         .       g.136851
 agaaagtctctgatatttggaggggaacaaaaatcactcacaagcaatccatgatctata       c.*1020

          .         .         .         .         .         .       g.136911
 cacataagcataatttcctttagttctagttagtcatcagagaacagtcatgtatgcaag       c.*1080

          .         .         .         .         .         .       g.136971
 ttttgtgactgagaaatttctgtgcttccaatccacaatgagatgcatgattttgttttc       c.*1140

          .         .         .         .         .         .       g.137031
 atcccatttcccccaagcccctgtaaatcagggaaaatgcgcaactgatcgcctaggaga       c.*1200

          .         .         .         .         .         .       g.137091
 gggcctcgtagtggcacagctggagatagtttcaaagtctaaaccaccagcccatcctga       c.*1260

          .         .         .         .         .         .       g.137151
 ggaaagcctcctatggaatgtaaagtgcaatcatttcttcagatataagactttccccaa       c.*1320

          .         .         .         .         .         .       g.137211
 caatgtgattggattcctttatggcaaaatcgagagaagctgccatccacctgcttatgc       c.*1380

          .         .         .         .         .         .       g.137271
 atttatctcttttgtggacttgtctgaccaccttctatttgcccagagtttgctcaattc       c.*1440

          .         .         .         .         .         .       g.137331
 caagacagtgcccatgaatgggacacctgtaatgtaacccacacagcggtttgcagagaa       c.*1500

          .         .         .         .         .         .       g.137391
 tgttagccatgacttgggctttctgaaagttggctataatttctctatccctacccacaa       c.*1560

          .         .         .         .         .         .       g.137451
 ccctgggaagttggagcaagaggggcatactattgggctgggaggatttgacagcatttc       c.*1620

          .         .         .         .         .         .       g.137511
 cccagttgccctttaagttcttctatttcaaacgttaattttgcttctctttctaaaaaa       c.*1680

          .         .         .         .         .         .       g.137571
 aaaaaaaaaaaagaaagagaagaaagaagtgattcctaccccctacctccagagttgttg       c.*1740

          .         .         .         .         .         .       g.137631
 aaagctgaaaagcatacaagattcttccttttaacttggatttctcgttccagaaattgt       c.*1800

          .         .         .         .         .         .       g.137691
 gggataatctgtattcttgctttagaaaacattcttagagagggtactagcttactgatg       c.*1860

          .         .         .         .         .         .       g.137751
 atgtgttaggattgctactgatgctgtcatgtggaaactatttaaaggcactattataaa       c.*1920

          .         .         .         .         .         .       g.137811
 tttatcctataagatgacaatgtttactcaaagtctaacatattcaatgcaagtaagact       c.*1980

          .         .         .         .         .         .       g.137871
 ttctgaaaacacttgatgatgtggaaatgctgcaggattaaataacttgaagagccttta       c.*2040

          .         .         .         .         .         .       g.137931
 tagattatatgaatgcctatttgtgtctagaaccagttatttaacctgtaaaatgtcaat       c.*2100

          .         .         .         .         .         .       g.137991
 agcaaatgaaggatgaagtatatctctagatgcaaatacattgagtttaaaagtgcctca       c.*2160

          .         .         .         .         .         .       g.138051
 aaataattgagatcacatttcaggacatttggaaatcaggtcgatttgtggtaactgtag       c.*2220

          .         .         .         .         .         .       g.138111
 tcatcttaaatttcaaaccatttaccatctgaaagttttgatttgaatgtaaaacaggaa       c.*2280

          .         .         .         .         .         .       g.138171
 attggaattcctttgtccaggagaaacctcacaaaccttctttaaggcatagttttgttg       c.*2340

          .         .         .         .         .         .       g.138231
 tttgtttgcttgtttgttgcaggctgtaaggcatggctgcttgtttacaaagcatctcat       c.*2400

          .         .         .         .         .         .       g.138291
 tcatattacctgtggagttgcatatccaaaccttagtgagttttgaagctttaagcaaat       c.*2460

          .         .         .         .         .         .       g.138351
 tcttttaaaaaattcttgtatttctagcattactagatattaaaagttaagcaaatagat       c.*2520

          .         .         .         .         .         .       g.138411
 taatgacgtatacataggcatcatttcacaaggtcagtaatgctgcaggaaaagcaaaat       c.*2580

          .         .         .         .         .         .       g.138471
 tgcaatctacgtatctatggtactaaggaagtcctgtttttcaaaaatggaagcccactt       c.*2640

          .         .         .         .         .         .       g.138531
 ctcagatttttctgaagggcatacaatgaaaagtgaaggggaaacacacacacacaaaaa       c.*2700

          .         .         .         .         .         .       g.138591
 aacaagtatttggcttgtcacaggaatctgattgcattaagtgaaaggattatttagaat       c.*2760

          .         .         .         .         .         .       g.138651
 atgttaatgcaaagctaaaataaaattttccttggcaattaaaaatgctgtgcgctaata       c.*2820

          .         .         .         .         .         .       g.138711
 ccctgctttctatcgtgactcaattcaacaatgtggggaatgtttactacatttccaact       c.*2880

          .         .         .         .         .         .       g.138771
 tgatgtcaagcaatggggaatacaagttccagttctgcaaagattcgtcaactttcttag       c.*2940

          .         .         .         .         .         .       g.138831
 ctcaagagagaggctgagaaatgcagagaagaataagacataaaatagctccgacctcca       c.*3000

          .         .         .         .         .         .       g.138891
 tgatccgagagtgggaaaaggcccgattattacccataaggcacactctctaaggccttt       c.*3060

          .         .         .         .         .         .       g.138951
 taaggggcctacaaaaatgttttattttataatcagaagaaaaggaaatgaacattgggg       c.*3120

          .         .         .         .         .         .       g.139011
 attgaaaatcatattggtatttgcaccaacatagtcataaaatagtatgttaatatgttt       c.*3180

          .         .         .         .         .         .       g.139071
 ttactttatatatttatatattaaaatatatttaatatgttttgcctttgtggcccatga       c.*3240

          .         .         .         .         .         .       g.139131
 aagtcttactgggccctggggaaggtatcctaccctggtgaagcagctgctttgctctac       c.*3300

          .         .         .         .         .         .       g.139191
 aaatacctggggcagaaatttgatttgaaaagtattattctctcttctctttgtttcaac       c.*3360

          .         .         .         .         .         .       g.139251
 tggattcctttggaaaaccaaactagtatcagaacaaaccccgaaacagtaagaaattgg       c.*3420

          .         .         .         .         .         .       g.139311
 agtgagaagggcatggtattgggactaggatcggctctcattcgatcgagctattctctt       c.*3480

          .         .         .         .         .         .       g.139371
 aaaatgacaaaaagtgtccataaagaggctgctggagagtgcgtggccatagggagccga       c.*3540

          .         .         .         .         .         .       g.139431
 catgcccgggaggaaaggtgttgattacatggatacttctaaaagctaaagccttgttgc       c.*3600

          .         .         .         .         .         .       g.139491
 cttctctttaatgcctagagaatgggatgtgtgatgcaaatgctcaaaacctcttaaatc       c.*3660

          .         .         .         .         .         .       g.139551
 atagctgtctgacctctacggacctcacatccatctgaggcttcatggacaaagattctc       c.*3720

          .         .         .         .         .         .       g.139611
 cacttggccaaactttagccaagctcctcaaccttctcccaggcccaatctgggcacttc       c.*3780

          .         .         .         .         .         .       g.139671
 cttgtaaaatctagttttggcaagaagtctattaggtcagtttagcaagaacacctaacc       c.*3840

          .         .         .         .         .         .       g.139731
 cccccatatctgttcaacctcagtatctgatcaggctcctcagcctccaccatcccccag       c.*3900

          .         .         .         .         .         .       g.139791
 gtgatgtctggtcaactggcctgccttcagctagaatcctgttaggtcggtttagatgaa       c.*3960

          .         .         .         .         .         .       g.139851
 tgctccctgatatttcctcttggtaatcttccatccactgcccctgaccctgttccctgt       c.*4020

          .         .         .         .         .         .       g.139911
 ctataaatccccagttttccatggtgtattcagagctgagtccagtctctctcccctact       c.*4080

          .         .         .         .         .         .       g.139971
 acaagtccccattgctgtggtccccgtacctgtcatgatggtcctaaataaagtcttact       c.*4140

          .         .         .         .         .         .       g.140031
 gtgctttaataggtagcattgaaaaatttttttctttgacatcattcatgacaacatgaa       c.*4200

          .         .         .         .         .         .       g.140091
 acctattgggacagcatgactgtgcagggtctttagagctcagctttctgaggccctgag       c.*4260

          .         .         .         .         .         .       g.140151
 cattcttggttttccgacatcgtgaacctgttctgtgttgcaagatatcactcaagccag       c.*4320

          .         .         .         .         .         .       g.140211
 tgttgcttaataccatctctttgtgtaatagatctgaataaagtaattgtaatacaccaa       c.*4380

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Steroid sulfatase (microsomal), isozyme S protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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