syntaxin binding protein 1 (STXBP1) - coding DNA reference sequence

(used for variant description)

(last modified December 22, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_003165.3 in the STXBP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016623.1, covering STXBP1 transcript NM_003165.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            cccgcgcgcgccggcgg       c.-181

 .         .         .         .         .         .                g.5077
 cggggcagcctcgctctggctcgcgccgcgcccccgcgcccagtccgcgcgtcagtcggt       c.-121

 .         .         .         .         .         .                g.5137
 ccctagcgcggctgcggggcggagagctgcggctggcccagcgcgcccacctgaggaggc       c.-61

 .         .         .         .         .         .                g.5197
 ggcggggtccgcaggcgtcgcgggacgaggagatcggagccgggagactcgcgcagcgcc       c.-1

          .         .         .        | 02.         .         .    g.44419
 ATGGCCCCCATTGGCCTCAAAGCTGTTGTCGGAGAGA | AGATTATGCATGATGTGATAAAG    c.60
 M  A  P  I  G  L  K  A  V  V  G  E  K |   I  M  H  D  V  I  K      p.20

          .         .        | 03.         .         .         .    g.46541
 AAGGTCAAGAAGAAGGGGGAATGGAAG | GTGCTGGTGGTGGATCAGTTAAGCATGAGGATG    c.120
 K  V  K  K  K  G  E  W  K   | V  L  V  V  D  Q  L  S  M  R  M      p.40

          .         .         .         .          | 04        .    g.51179
 CTGTCCTCCTGCTGCAAGATGACAGACATCATGACCGAGGGCATAACGA | TTGTGGAAGAT    c.180
 L  S  S  C  C  K  M  T  D  I  M  T  E  G  I  T  I |   V  E  D      p.60

          .         .         .         .         .         .       g.51239
 ATCAATAAGCGCAGAGAGCCGCTCCCCAGCCTGGAGGCTGTGTATCTCATCACTCCATCC       c.240
 I  N  K  R  R  E  P  L  P  S  L  E  A  V  Y  L  I  T  P  S         p.80

        | 05 .         .         .         .         .         .    g.52877
 GAGAAG | TCCGTCCACTCTCTCATCAGTGACTTTAAGGACCCGCCGACTGCTAAATACCGG    c.300
 E  K   | S  V  H  S  L  I  S  D  F  K  D  P  P  T  A  K  Y  R      p.100

          .         .      | 06  .         .         .         .    g.53930
 GCTGCACACGTCTTCTTCACTGACT | CTTGTCCAGATGCCCTGTTTAATGAACTGGTAAAA    c.360
 A  A  H  V  F  F  T  D  S |   C  P  D  A  L  F  N  E  L  V  K      p.120

          .         .         .         .         .         .       g.53990
 TCCCGAGCAGCCAAAGTCATCAAAACTCTGACGGAAATCAATATTGCATTTCTCCCGTAT       c.420
 S  R  A  A  K  V  I  K  T  L  T  E  I  N  I  A  F  L  P  Y         p.140

           | 07        .         .         .         .         .    g.56049
 GAATCCCAG | GTCTATTCCTTGGACTCTGCTGACTCTTTCCAAAGCTTCTACAGTCCCCAC    c.480
 E  S  Q   | V  Y  S  L  D  S  A  D  S  F  Q  S  F  Y  S  P  H      p.160

          .         .         .         .         .         .       g.56109
 AAGGCTCAGATGAAGAATCCTATACTGGAGCGCCTGGCAGAGCAGATCGCGACCCTTTGT       c.540
 K  A  Q  M  K  N  P  I  L  E  R  L  A  E  Q  I  A  T  L  C         p.180

          .         .         .         | 08         .         .    g.58062
 GCCACCCTGAAGGAGTACCCGGCTGTGCGGTATCGGGG | GGAATACAAGGACAATGCCCTG    c.600
 A  T  L  K  E  Y  P  A  V  R  Y  R  G  |  E  Y  K  D  N  A  L      p.200

          .         .         .         .         .         .       g.58122
 CTGGCTCAGCTAATCCAGGACAAGCTCGATGCCTATAAAGCTGATGATCCAACAATGGGG       c.660
 L  A  Q  L  I  Q  D  K  L  D  A  Y  K  A  D  D  P  T  M  G         p.220

     | 09    .         .         .         .         .         .    g.59016
 GAG | GGCCCAGACAAGGCACGCTCCCAGCTCCTGATCCTGGATCGAGGCTTTGACCCCAGC    c.720
 E   | G  P  D  K  A  R  S  Q  L  L  I  L  D  R  G  F  D  P  S      p.240

          .         .         .         .         .         .       g.59076
 TCCCCTGTGCTCCATGAATTGACTTTTCAGGCTATGAGTTATGATCTGCTGCCTATCGAA       c.780
 S  P  V  L  H  E  L  T  F  Q  A  M  S  Y  D  L  L  P  I  E         p.260

          .     | 10   .         .         .         .         .    g.60919
 AATGATGTATACAA | GTATGAGACCAGCGGCATCGGGGAGGCACGGGTGAAGGAGGTGCTC    c.840
 N  D  V  Y  K  |  Y  E  T  S  G  I  G  E  A  R  V  K  E  V  L      p.280

          .         .         .         .         .         .       g.60979
 CTGGACGAGGACGACGACCTGTGGATAGCACTGCGCCACAAGCACATCGCAGAGGTGTCC       c.900
 L  D  E  D  D  D  L  W  I  A  L  R  H  K  H  I  A  E  V  S         p.300

    | 11     .         .         .         .         .         .    g.62749
 CA | GGAAGTCACCCGGTCTCTGAAAGATTTTTCTTCTAGCAAGAGAATGAATACTGGAGAG    c.960
 Q  |  E  V  T  R  S  L  K  D  F  S  S  S  K  R  M  N  T  G  E      p.320

     | 12    .         .         .         .         .         .    g.64901
 AAG | ACCACCATGCGGGACCTGTCCCAGATGCTGAAGAAGATGCCTCAGTACCAGAAAGAG    c.1020
 K   | T  T  M  R  D  L  S  Q  M  L  K  K  M  P  Q  Y  Q  K  E      p.340

           | 13        .         .         .         .         .    g.66025
 CTCAGCAAG | TACTCCACCCACCTGCACCTTGCTGAGGACTGTATGAAGCATTACCAAGGC    c.1080
 L  S  K   | Y  S  T  H  L  H  L  A  E  D  C  M  K  H  Y  Q  G      p.360

          .         .         . | 14       .         .         .    g.68627
 ACCGTAGACAAACTCTGCCGAGTGGAGCAG | GACCTGGCCATGGGCACAGATGCTGAGGGA    c.1140
 T  V  D  K  L  C  R  V  E  Q   | D  L  A  M  G  T  D  A  E  G      p.380

          .         .         .         .         .         .       g.68687
 GAGAAGATCAAGGACCCTATGCGAGCCATCGTCCCCATTCTGCTGGATGCCAATGTCAGC       c.1200
 E  K  I  K  D  P  M  R  A  I  V  P  I  L  L  D  A  N  V  S         p.400

          .         .         .         .          | 15        .    g.69448
 ACTTATGACAAAATCCGCATCATCCTTCTCTACATCTTTTTGAAGAATG | GCATCACGGAG    c.1260
 T  Y  D  K  I  R  I  I  L  L  Y  I  F  L  K  N  G |   I  T  E      p.420

          .         .         .         .         .         .       g.69508
 GAAAACCTGAACAAACTGATCCAGCACGCCCAGATACCCCCGGAGGATAGTGAGATCATC       c.1320
 E  N  L  N  K  L  I  Q  H  A  Q  I  P  P  E  D  S  E  I  I         p.440

          .         .         .          | 16        .         .    g.71245
 ACCAACATGGCTCACCTCGGCGTGCCCATCGTCACCGAT | TCCACGCTGCGTCGCCGGAGC    c.1380
 T  N  M  A  H  L  G  V  P  I  V  T  D   | S  T  L  R  R  R  S      p.460

          .         .         .         .         .         .       g.71305
 AAGCCGGAGCGGAAGGAACGCATCAGCGAGCAGACCTACCAGCTCTCACGGTGGACTCCG       c.1440
 K  P  E  R  K  E  R  I  S  E  Q  T  Y  Q  L  S  R  W  T  P         p.480

          .         .  | 17      .         .         .         .    g.72989
 ATTATCAAGGACATCATGGAG | GACACTATTGAGGACAAACTTGACACCAAACACTACCCT    c.1500
 I  I  K  D  I  M  E   | D  T  I  E  D  K  L  D  T  K  H  Y  P      p.500

          .         .         .         .        | 18.         .    g.75212
 TATATCTCTACCCGTTCCTCTGCCTCCTTCAGCACCACCGCCGTCAG | CGCCCGCTATGGG    c.1560
 Y  I  S  T  R  S  S  A  S  F  S  T  T  A  V  S  |  A  R  Y  G      p.520

          .         .         .         .         .         .       g.75272
 CACTGGCATAAGAACAAGGCCCCAGGCGAGTACCGCAGTGGCCCCCGCCTCATCATTTTC       c.1620
 H  W  H  K  N  K  A  P  G  E  Y  R  S  G  P  R  L  I  I  F         p.540

          .         .         .         .         .         .       g.75332
 ATCCTTGGGGGTGTGAGCCTGAATGAGATGCGCTGCGCCTACGAGGTGACCCAGGCCAAC       c.1680
 I  L  G  G  V  S  L  N  E  M  R  C  A  Y  E  V  T  Q  A  N         p.560

          .         .   | 19     .         .         .         .    g.77199
 GGAAAGTGGGAGGTGCTGATAG | GTTCTACTCACATTCTTACTCCCACCAAATTTCTCATG    c.1740
 G  K  W  E  V  L  I  G |   S  T  H  I  L  T  P  T  K  F  L  M      p.580

          .         .         .         .         .         .       g.77259
 GACCTGAGACACCCCGACTTCAGGGAGTCCTCTAGGGTATCTTTTGAGGATCAGGCTCCA       c.1800
 D  L  R  H  P  D  F  R  E  S  S  R  V  S  F  E  D  Q  A  P         p.600

          .                                                     g.77271
 ACAATGGAGTGA |                                                    c.1813
 T  M  E  X                                                      p.603

          .       | 20 .         .         .         .         .    g.83612
 gagccaaagaaacaaa | gatccacacacatcctcaccccacagaaactgctggacacactg    c.*60

          .         .         .         .         .         .       g.83672
 aagaaactgaataaaacagatgaagaaataagcagttaaaaaaataagtcgcccctccaa       c.*120

          .         .         .         .         .         .       g.83732
 aacacgcccccatcccacagcgctccgcagcttcccaccaccgcccgcctcagttccttt       c.*180

          .         .         .         .         .         .       g.83792
 gcgtctgttgcctccccagccctgcacgccctggctggcactgttgccgctgcattctcg       c.*240

          .         .         .         .         .         .       g.83852
 tgttcagtgatgccctcttcttgtttgaaacaaaagaaaataatgcattgtgttttttaa       c.*300

          .         .         .         .         .         .       g.83912
 aaagagtatcttatacatgtatcctaaaaagagaagctcatgtgcaattggtgcacagca       c.*360

          .         .         .         .         .         .       g.83972
 ggagaaatttctggactgttaggatgaatggacgccttctccccgttatttaagatttgt       c.*420

          .         .         .         .         .         .       g.84032
 gaccttgtacataaccctgggtgacgtgcacattgcttgggtatggaacggtagaaattt       c.*480

          .         .         .         .         .         .       g.84092
 gggtgtttttaaaaccttgtttggggttgttcctgtccttgttgagaatcatagagatgt       c.*540

          .         .         .         .         .         .       g.84152
 ctgtgttcttggagtatttcacactgaggactaatctgctatcttcattccagtccctac       c.*600

          .         .         .         .         .         .       g.84212
 ccctcagtgcctgctctcatccaaataacctgggaggtgacaatcaggatatctcaggag       c.*660

          .         .         .         .         .         .       g.84272
 gtccaaggtggaacagacctctttgcctttcccagcgtctcatacccccggtagtgcagc       c.*720

          .         .         .         .         .         .       g.84332
 tgtgggtggaggctggggtgtctgcacgaagtcaggccagcgtcctcctccacagcctgt       c.*780

          .         .         .         .         .         .       g.84392
 cactgccccctccccagcctgtgtccacagtgctgtgatcccgagggaagtcctccagtc       c.*840

          .         .         .         .         .         .       g.84452
 taagtcacagtgccctgacaggtgagaagcaaactcccgctggaagcctccatctctttg       c.*900

          .         .         .         .         .         .       g.84512
 gaaaaacagttagtctggagcctgtggcccaggcccttctgtccccaggcatcatcccaa       c.*960

          .         .         .         .         .         .       g.84572
 cagctcattttccctagtccgccttcgttcaagggtcaggaatggaccagaacagatggg       c.*1020

          .         .         .         .         .         .       g.84632
 ttctggaggcccctgaacagagggctatggctgtggagaaggttcttggcccgttggact       c.*1080

          .         .         .         .         .         .       g.84692
 cacacagaccctgtaccctctcggcaagcatcttcagtcagattatcctcagtttcagat       c.*1140

          .         .         .         .         .         .       g.84752
 acttcataataccttgtgttgtgtggggtcatacatcatcgtgtttgtaagagaagatgg       c.*1200

          .         .         .         .         .         .       g.84812
 tcattttattctctgtataaaacttagctctaaagcagaaactaaagcagcaaatgcagg       c.*1260

          .         .         .         .         .         .       g.84872
 aaggctgtctcgccatcctcaagactcagcagctctcattctccagtggtgagcacacca       c.*1320

          .         .         .         .         .         .       g.84932
 tttgtgctgctgctgttgtcgtgaaatataataacagtggaagtcacaaaaatgtcccct       c.*1380

          .         .         .         .         .         .       g.84992
 gcccagccccctcgccgcccttgacctcctgcaggccatgtgtgtattacttgtctagtg       c.*1440

          .         .         .         .         .         .       g.85052
 atgtcctctcaaagtgctgtacgcgagctcggcgccacctccgcctccctttcagagcct       c.*1500

          .         .         .         .         .         .       g.85112
 gctccccgccctctctgctcgctgcattgtggtgttctcttctcaaggctttgaaatctc       c.*1560

          .         .         .         .         .         .       g.85172
 cccttgcactgagattagtcgtcagatctctccccgtctccctcccaacttatacgacct       c.*1620

          .         .         .         .         .         .       g.85232
 gatttccttaggacggaaccgcaggcacctgcgccgggcgtcttactcccgctgcttgtt       c.*1680

          .         .         .         .         .         .       g.85292
 ctgtcccctccctcggaccaaacagtgctcatgcttcaggaccttgtttgtcgaagatgt       c.*1740

          .         .         .         .         .         .       g.85352
 tggtttccctttctctgttatttatataaaaataatttatcaaaaggatattttaaaaaa       c.*1800

          .         .         .         .         .         .       g.85412
 gctagtctgtcttgaaacttgtttaccttaaaattatcagaatctcagtgtttgaaagta       c.*1860

          .         .         .         .         .         .       g.85472
 ctgaagcacaaacatatatcatctctgtaccattctgtactaaagcacttgagtctaata       c.*1920

          .         .         .                                     g.85510
 aataaagaaatcagcaccccttcccggtgtccaggggg                             c.*1958

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Syntaxin binding protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 20c
©2004-2017 Leiden University Medical Center