succinate-CoA ligase, ADP-forming, beta subunit (SUCLA2) - coding DNA reference sequence

(used for variant description)

(last modified February 2, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_003850.2 in the SUCLA2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000013.10, covering SUCLA2 transcript NM_003850.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    ccgcctgtcgcctgtgcgcctgcgcgcggcgccgaggggacggggtccgactcagaa       c.-1

          .         .         .         .         .         .       g.5117
 ATGGCGGCCTCCATGTTCTACGGCAGGCTAGTGGCCGTGGCCACCCTTCGGAACCACCGG       c.60
 M  A  A  S  M  F  Y  G  R  L  V  A  V  A  T  L  R  N  H  R         p.20

          .         .         . | 02       .         .         .    g.9334
 CCTCGGACGGCCCAGCGGGCTGCTGCTCAG | GTTCTGGGAAGTTCTGGATTGTTTAATAAC    c.120
 P  R  T  A  Q  R  A  A  A  Q   | V  L  G  S  S  G  L  F  N  N      p.40

          .         .         .         .         .         .       g.9394
 CATGGACTCCAAGTACAGCAGCAACAGCAAAGGAATCTCTCACTACATGAATACATGAGT       c.180
 H  G  L  Q  V  Q  Q  Q  Q  Q  R  N  L  S  L  H  E  Y  M  S         p.60

          .         .         .         .         .         .       g.9454
 ATGGAATTATTGCAAGAAGCTGGTGTCTCCGTTCCCAAAGGATATGTGGCAAAGTCACCA       c.240
 M  E  L  L  Q  E  A  G  V  S  V  P  K  G  Y  V  A  K  S  P         p.80

          .         .         .  | 03      .         .         .    g.17375
 GATGAAGCTTATGCAATTGCCAAAAAATTAG | GTTCAAAAGATGTCGTGATAAAGGCACAG    c.300
 D  E  A  Y  A  I  A  K  K  L  G |   S  K  D  V  V  I  K  A  Q      p.100

          .         .         .         .         .         .       g.17435
 GTTTTAGCTGGTGGTAGAGGAAAAGGAACATTTGAAAGTGGCCTCAAAGGAGGAGTGAAG       c.360
 V  L  A  G  G  R  G  K  G  T  F  E  S  G  L  K  G  G  V  K         p.120

          .  | 04      .         .         .         .         .    g.17673
 ATAGTTTTCTC | TCCAGAAGAAGCAAAAGCTGTTTCTTCACAAATGATTGGGAAAAAATTG    c.420
 I  V  F  S  |  P  E  E  A  K  A  V  S  S  Q  M  I  G  K  K  L      p.140

          .         .         .         .         .         .       g.17733
 TTTACCAAGCAAACGGGAGAAAAGGGCAGAATATGCAATCAAGTATTGGTCTGTGAGCGA       c.480
 F  T  K  Q  T  G  E  K  G  R  I  C  N  Q  V  L  V  C  E  R         p.160

          .         .         .         .         .     | 05   .    g.32941
 AAATATCCCAGGAGAGAATACTACTTTGCAATAACAATGGAAAGGTCATTTCAA | GGTCCT    c.540
 K  Y  P  R  R  E  Y  Y  F  A  I  T  M  E  R  S  F  Q   | G  P      p.180

          .         .         .         .         .         .       g.33001
 GTATTAATAGGAAGTTCACATGGTGGTGTCAACATTGAAGATGTTGCTGCTGAGTCTCCT       c.600
 V  L  I  G  S  S  H  G  G  V  N  I  E  D  V  A  A  E  S  P         p.200

          .         .         .         .         .         .       g.33061
 GAAGCAATAATTAAAGAACCTATTGATATTGAAGAAGGCATCAAAAAGGAACAAGCTCTC       c.660
 E  A  I  I  K  E  P  I  D  I  E  E  G  I  K  K  E  Q  A  L         p.220

     | 06    .         .         .         .         .         .    g.37651
 CAG | CTTGCACAGAAGATGGGATTTCCACCTAATATTGTGGAATCAGCAGCAGAAAACATG    c.720
 Q   | L  A  Q  K  M  G  F  P  P  N  I  V  E  S  A  A  E  N  M      p.240

          .         .         .         .         .         .       g.37711
 GTCAAGCTTTACAGCCTTTTTCTGAAATACGATGCAACCATGATAGAAATAAATCCAATG       c.780
 V  K  L  Y  S  L  F  L  K  Y  D  A  T  M  I  E  I  N  P  M         p.260

          .         .   | 07     .         .         .         .    g.51808
 GTGGAAGATTCAGATGGAGCTG | TATTGTGTATGGATGCAAAGATCAATTTTGACTCTAAT    c.840
 V  E  D  S  D  G  A  V |   L  C  M  D  A  K  I  N  F  D  S  N      p.280

          .         .         .         .         .         .       g.51868
 TCAGCCTATCGCCAAAAGAAAATCTTTGATCTACAGGACTGGACCCAGGAAGATGAAAGG       c.900
 S  A  Y  R  Q  K  K  I  F  D  L  Q  D  W  T  Q  E  D  E  R         p.300

          .         .         .         .         .         .       g.51928
 GACAAAGATGCTGCTAAGGCAAATCTCAACTACATTGGCCTCGATGGAAATATAGGCTGC       c.960
 D  K  D  A  A  K  A  N  L  N  Y  I  G  L  D  G  N  I  G  C         p.320

      | 08   .         .         .         .         .         .    g.52101
 CTAG | TAAATGGTGCTGGTTTGGCTATGGCCACAATGGATATAATAAAACTTCATGGAGGG    c.1020
 L  V |   N  G  A  G  L  A  M  A  T  M  D  I  I  K  L  H  G  G      p.340

          .         .         .         .         .         .       g.52161
 ACTCCAGCCAACTTCCTTGATGTTGGTGGTGGTGCTACAGTCCATCAAGTAACAGAAGCA       c.1080
 T  P  A  N  F  L  D  V  G  G  G  A  T  V  H  Q  V  T  E  A         p.360

          .         .        | 09.         .         .         .    g.56757
 TTTAAGCTTATCACTTCAGATAAAAAG | GTACTGGCTATTCTGGTCAACATTTTTGGAGGA    c.1140
 F  K  L  I  T  S  D  K  K   | V  L  A  I  L  V  N  I  F  G  G      p.380

          .         .         .         .         .         .       g.56817
 ATCATGCGCTGTGATGTTATTGCACAGGGTATAGTCATGGCAGTAAAAGACTTGGAAATT       c.1200
 I  M  R  C  D  V  I  A  Q  G  I  V  M  A  V  K  D  L  E  I         p.400

          .         .         | 10         .         .         .    g.57331
 AAAATACCTGTTGTGGTACGGTTACAAG | GTACACGAGTCGATGATGCTAAGGCACTGATA    c.1260
 K  I  P  V  V  V  R  L  Q  G |   T  R  V  D  D  A  K  A  L  I      p.420

          .         .         .         .         .        | 11.    g.62885
 GCGGACAGTGGACTTAAAATACTTGCTTGTGATGACTTGGATGAAGCTGCTAGAATG | GTT    c.1320
 A  D  S  G  L  K  I  L  A  C  D  D  L  D  E  A  A  R  M   | V      p.440

          .         .         .         .         .         .       g.62945
 GTAAAGCTCTCTGAAATAGTGACCTTAGCGAAGCAAGCACATGTGGATGTGAAATTTCAG       c.1380
 V  K  L  S  E  I  V  T  L  A  K  Q  A  H  V  D  V  K  F  Q         p.460

          .                                                         g.62957
 TTGCCAATATGA                                                       c.1392
 L  P  I  X                                                         p.463

          .         .         .         .         .         .       g.63017
 tctgaaaacccagtggatggctgaaggtgttaaatgtgctataatcattaagaatactgt       c.*60

          .         .         .         .         .         .       g.63077
 gttctgtgttattgttctttttctttttagtgtgtggagattgtaattgccatctaggca       c.*120

          .         .         .         .         .         .       g.63137
 cacaaacatttaaaaggatttggactgcatttaattgtaccattcagaatggactgtttg       c.*180

          .         .         .         .         .         .       g.63197
 tacgaagcatgtataatgcagttatcttctttcttttgtcgcagccagtcttttttgctt       c.*240

          .         .         .         .         .         .       g.63257
 ctcctacaaaacgtaacttgcaatttgccagtttattattgttggatacaaagttcttca       c.*300

          .         .         .         .         .         .       g.63317
 ttgataagagtcctataaataagataaatacgaagataaagctttattctttagtgttaa       c.*360

          .         .         .         .         .         .       g.63377
 aatacagtatatctaataactagcctcattagtagagcagtatattaaaacaatgtttta       c.*420

          .         .         .         .         .         .       g.63437
 tgtaaaaagtgtttatcttcagcaccaaatacatgataaatgtatcaatcactatttata       c.*480

          .         .         .         .         .         .       g.63497
 aacagagctttcaaacactcctcagaatattcttctaagtattttgatgaagtaactttg       c.*540

          .         .         .         .         .         .       g.63557
 taattatttgaacattgttttaatcattaggaaacactgattaactgcaagtcttcatga       c.*600

          .         .         .         .         .         .       g.63617
 ttctgtcatattaagaaacacctgtaggtttgcttcaaataaaggcatatataccaagga       c.*660

          .         .         .         .         .                 g.63672
 cttacagacaaaattaagaatgtcaatttaagttaataaaaatctcccaatatga            c.*715

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Succinate-CoA ligase, ADP-forming, beta subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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