suppressor of fused homolog (Drosophila) (SUFU) - coding DNA reference sequence

(used for variant description)

(last modified May 3, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_016169.3 in the SUFU gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021338.1, covering SUFU transcript NM_016169.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  accctctggca       c.-181

 .         .         .         .         .         .                g.5071
 gactcggcggcggcgacagcctgggcggacagtgcgccgtgcgcaggcgcggagctagac       c.-121

 .         .         .         .         .         .                g.5131
 ctcgctgcagcccccatcgcctcggggagtctcacccaccgagtccgcccgctggcccgt       c.-61

 .         .         .         .         .         .                g.5191
 cagtgctctccccgtcgtttgccctctccagttcccccagtgcctgccctacgcaccccg       c.-1

          .         .         .         .         .         .       g.5251
 ATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCG       c.60
 M  A  E  L  R  P  S  G  A  P  G  P  T  A  P  P  A  P  G  P         p.20

          .         .         .         .         .         .       g.5311
 ACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCACGCCATCTACGGAGAG       c.120
 T  A  P  P  A  F  A  S  L  F  P  P  G  L  H  A  I  Y  G  E         p.40

          .         .         .         .         .         .       g.5371
 TGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTAC       c.180
 C  R  R  L  Y  P  D  Q  P  N  P  L  Q  V  T  A  I  V  K  Y         p.60

    | 02     .         .         .         .         .         .    g.10265
 TG | GTTGGGTGGCCCAGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCT    c.240
 W  |  L  G  G  P  D  P  L  D  Y  V  S  M  Y  R  N  V  G  S  P      p.80

          .         .         .         .         .         .       g.10325
 TCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCTGAGTGATCTCTATGGT       c.300
 S  A  N  I  P  E  H  W  H  Y  I  S  F  G  L  S  D  L  Y  G         p.100

          .        | 03.         .         .         .         .    g.51051
 GACAACAGAGTCCATGA | GTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTG    c.360
 D  N  R  V  H  E  |  F  T  G  T  D  G  P  S  G  F  G  F  E  L      p.120

          .         .         .         .         .         .       g.51111
 ACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTA       c.420
 T  F  R  L  K  R  E  T  G  E  S  A  P  P  T  W  P  A  E  L         p.140

          .         .         .     | 04   .         .         .    g.93646
 ATGCAGGGCTTGGCACGATACGTGTTCCAGTCAG | AGAACACCTTCTGCAGTGGGGACCAT    c.480
 M  Q  G  L  A  R  Y  V  F  Q  S  E |   N  T  F  C  S  G  D  H      p.160

          .         .         .         .         .         .       g.93706
 GTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACA       c.540
 V  S  W  H  S  P  L  D  N  S  E  S  R  I  Q  H  M  L  L  T         p.180

          .         .         .         .         .        | 05.    g.94677
 GAGGACCCACAGATGCAGCCCGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAG | ATC    c.600
 E  D  P  Q  M  Q  P  V  Q  T  P  F  G  V  V  T  F  L  Q   | I      p.200

          .         .         .         .         .         .       g.94737
 GTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAACGGGCAGGGCATCCTG       c.660
 V  G  V  C  T  E  E  L  H  S  A  Q  Q  W  N  G  Q  G  I  L         p.220

          .         .    | 06    .         .         .         .    g.95068
 GAGCTGCTGCGGACAGTGCCTAT | TGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGG    c.720
 E  L  L  R  T  V  P  I  |  A  G  G  P  W  L  I  T  D  M  R  R      p.240

          .         .         .       | 07 .         .         .    g.98202
 GGAGAGACCATATTTGAGATCGATCCACACCTGCAA | GAGAGAGTTGACAAAGGCATCGAG    c.780
 G  E  T  I  F  E  I  D  P  H  L  Q   | E  R  V  D  K  G  I  E      p.260

          .         .         .         .         .         .       g.98262
 ACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGGGATGACCTGAGCCGG       c.840
 T  D  G  S  N  L  S  G  V  S  A  K  C  A  W  D  D  L  S  R         p.280

          .         .         .         .         .         .       g.98322
 CCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTC       c.900
 P  P  E  D  D  E  D  S  R  S  I  C  I  G  T  Q  P  R  R  L         p.300

          . | 08       .         .         .         .         .    g.100521
 TCTGGCAAAG | ACACAGAGCAGATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGC    c.960
 S  G  K  D |   T  E  Q  I  R  E  T  L  R  R  G  L  E  I  N  S      p.320

          .         .         .         .         .         .       g.100581
 AAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTCGCCCACGACCGGGCC       c.1020
 K  P  V  L  P  P  I  N  P  Q  R  Q  N  G  L  A  H  D  R  A         p.340

    | 09     .         .         .         .         .         .    g.116364
 CC | GAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTG    c.1080
 P  |  S  R  K  D  S  L  E  S  D  S  S  T  A  I  I  P  H  E  L      p.360

          .         .         .         .         .         .       g.116424
 ATTCGCACGCGGCAGCTTGAGAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTC       c.1140
 I  R  T  R  Q  L  E  S  V  H  L  K  F  N  Q  E  S  G  A  L         p.380

          .        | 10.         .         .         .         .    g.118371
 ATTCCTCTCTGCCTAAG | GGGCAGGCTCCTGCATGGACGGCACTTTACATATAAAAGTATC    c.1200
 I  P  L  C  L  R  |  G  R  L  L  H  G  R  H  F  T  Y  K  S  I      p.400

          .         .         .         .         .         .       g.118431
 ACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAG       c.1260
 T  G  D  M  A  I  T  F  V  S  T  G  V  E  G  A  F  A  T  E         p.420

          .         .         .       | 11 .         .         .    g.128237
 GAGCATCCTTACGCGGCTCATGGACCCTGGTTACAA | ATTCTGTTGACCGAAGAGTTTGTA    c.1320
 E  H  P  Y  A  A  H  G  P  W  L  Q   | I  L  L  T  E  E  F  V      p.440

          .         .         .         .      | 12  .         .    g.131119
 GAGAAAATGTTGGAGGATTTAGAAGATTTGACTTCTCCAGAGGAA | TTCAAACTTCCCAAA    c.1380
 E  K  M  L  E  D  L  E  D  L  T  S  P  E  E   | F  K  L  P  K      p.460

          .         .         .         .         .         .       g.131179
 GAGTACAGCTGGCCTGAAAAGAAGCTGAAGGTCTCCATCCTGCCTGACGTGGTGTTCGAC       c.1440
 E  Y  S  W  P  E  K  K  L  K  V  S  I  L  P  D  V  V  F  D         p.480

          .                                                         g.131194
 AGTCCGCTACACTAG                                                    c.1455
 S  P  L  H  X                                                      p.484

          .         .         .         .         .         .       g.131254
 cctgggctgggccctgcaggggccagcagggagcccagctgctccccagtgacttccagt       c.*60

          .         .         .         .         .         .       g.131314
 gtaacagttgtgtcaacgagatctccacaaataaaaggacaagtgtgaggaagactgcgc       c.*120

          .         .         .         .         .         .       g.131374
 agtgccaccccgcagcccagtggggtgccatgcacaggccacaggccctccacctcacct       c.*180

          .         .         .         .         .         .       g.131434
 ccagctcaggggccgcaccccgccgctggctaagccttgtgacccatcaggccagtgagt       c.*240

          .         .         .         .         .         .       g.131494
 gggcaaatgcggaccctccctgcctgcagcctgcacagattctggtttgaggtttgactc       c.*300

          .         .         .         .         .         .       g.131554
 tggaccctggctgtgcccctaggtggagacagccctctttctcacctaccccctgccgca       c.*360

          .         .         .         .         .         .       g.131614
 cagcccagcaggagggaggcggacagccagatgcagagcgagtggatgcacttcccagct       c.*420

          .         .         .         .         .         .       g.131674
 catctctggaagcctttgctactcaagctcctctggccgcggaacaattcctctgatcat       c.*480

          .         .         .         .         .         .       g.131734
 gtttggttttcttcttccttattttattttgtagaaaccgggtggtattttattgctctg       c.*540

          .         .         .         .         .         .       g.131794
 caaagatgtccagaagccatgtatataatgttttttaaacagaacttcattccccgttga       c.*600

          .         .         .         .         .         .       g.131854
 actttcgcattctctgacagaggcctagggctgtatctctccctgggctgccaccagaga       c.*660

          .         .         .         .         .         .       g.131914
 aggtgcttggtgttcgcctgccagcccagagccctggaggagccggctgcacagagaggc       c.*720

          .         .         .         .         .         .       g.131974
 ttttcttcccagctgggcctggtggagcccggggcagggggagagtagagacactccctt       c.*780

          .         .         .         .         .         .       g.132034
 gtgcagctttgagcctagtttagctggggccagggaggggtgctactgttttccaagtga       c.*840

          .         .         .         .         .         .       g.132094
 atgggtctcaaagacttggtgaccccagcctcatcttctaggccttttccacccaaccag       c.*900

          .         .         .         .         .         .       g.132154
 gcctacctgggagagggtgaggttcagcacatcacacaccatccccactgtcattcaggg       c.*960

          .         .         .         .         .         .       g.132214
 cctgggtctccagctctgtaaccagtcctgtcccatttcctcagtccctgggcctcccag       c.*1020

          .         .         .         .         .         .       g.132274
 ccttcaggctgtagggctgccttactaaaattgaaaaatccacctcttaacatctctttc       c.*1080

          .         .         .         .         .         .       g.132334
 actttggttttgctaacactgctctctgctgccctcccatcctccctgtatccattcatg       c.*1140

          .         .         .         .         .         .       g.132394
 ccctatctttcattctccactcctaatccctctcctttctggcatcctggcctctcgtgg       c.*1200

          .         .         .         .         .         .       g.132454
 tcctcagcccctcacccccagtactgcagatctcacagtttgccttccagaagccagcct       c.*1260

          .         .         .         .         .         .       g.132514
 atctctagcccatggttttggagttcctctcgggttatctcccacgcctgacctggaacc       c.*1320

          .         .         .         .         .         .       g.132574
 agcaagcccctttcctgccttcttacccccaactctagggatgggactgttacaatactt       c.*1380

          .         .         .         .         .         .       g.132634
 caagatcactctttacacctcttcaaagcaaagtcatgacaatgcagggctcctcattgc       c.*1440

          .         .         .         .         .         .       g.132694
 tcccatctgcctctgctgcacacacaggcaccagcagggatgccacaggagtgcccacag       c.*1500

          .         .         .         .         .         .       g.132754
 ggtgcaggactccactgatgagagatccagccaaagagctgcccccaggggtatgagggc       c.*1560

          .         .         .         .         .         .       g.132814
 accagctgggttctccagggagcaggagttggacctccatggagccactaggcctggcct       c.*1620

          .         .         .         .         .         .       g.132874
 cctctacacatccccagggctatctggttaattccatcaagctcagagttaaaaggcata       c.*1680

          .         .         .         .         .         .       g.132934
 tcagcctggagtatttgggagagactggctgcagatccccgccagccaagatgcaagcca       c.*1740

          .         .         .         .         .         .       g.132994
 ctcgggacctgatgtcggcagctgtgcctctactgccctgaggacttaccagagggagcc       c.*1800

          .         .         .         .         .         .       g.133054
 ctactggccttcccccaccacagcagccctgcctgtgaagctcttgtttctgacatttca       c.*1860

          .         .         .         .         .         .       g.133114
 caggcagagaggtgccatcagttcgcctccattccttgccaccatgaccagcctctccct       c.*1920

          .         .         .         .         .         .       g.133174
 gaactctctcttgctcgggacctgcctgagggctccctgctgcagttcgccgtacttcca       c.*1980

          .         .         .         .         .         .       g.133234
 tctgctgggtgcctccatcgttggttgggtggggatggggcattttctgagctaagcttt       c.*2040

          .         .         .         .         .         .       g.133294
 gtcattagtttgtgaagcacctggtcagcaacctgccccagacctggagggtctttgtgg       c.*2100

          .         .         .         .         .         .       g.133354
 actgaaggtagacaccagccagcatggtggccctgttctgggggagcagggtaaggcagg       c.*2160

          .         .         .         .         .         .       g.133414
 aggaagtgggtgagctccgagatgatgagcacatgaagcctgtggccccttcgtacctgc       c.*2220

          .         .         .         .         .         .       g.133474
 aatatgtcaggagcctcacgctcacccaagatcctgcaggggccaggctccatctcactg       c.*2280

          .         .         .         .         .         .       g.133534
 gctctgagggcaggacagggtatcacacatttctcaccaggcctcctttcctatgggcat       c.*2340

          .         .         .         .         .         .       g.133594
 tggtgcctcccagaggtttcttgggctgctggctggtgagagaggacccttaaagaagat       c.*2400

          .         .         .         .         .         .       g.133654
 caagccaagctgaccttggaccctgtccagcacagcttctggcacaggatgcttggtgaa       c.*2460

          .         .         .         .         .         .       g.133714
 tgtaccctttctttccctccctgcagctctgagggagcccctgaccttgtagtgggtgga       c.*2520

          .         .         .         .         .         .       g.133774
 ggaggtaaggggcctccctccctaaatctgcctcttctgcaagctacttggagacttgcc       c.*2580

          .         .         .         .         .         .       g.133834
 tagttgtacccacccctccaggtccctggtgctagagcttctgagaagggcctttccctt       c.*2640

          .         .         .         .         .         .       g.133894
 tcctctttgcctgctatataaggcaggctcctgtggctctgctggctcagtgtgggctgc       c.*2700

          .         .         .         .         .         .       g.133954
 aggaggactgcagactcagctgcaattctgaggggggtttgggaggcttgtgcgaggtct       c.*2760

          .         .         .         .         .         .       g.134014
 caggcctgtgtggggagctggtgcctcttcctgcccgtatctttctcttccaagggcagt       c.*2820

          .         .         .         .         .         .       g.134074
 gctccaaggcagggactggagaagccaaggggagagtctaaaagggctagagcattttta       c.*2880

          .         .         .         .         .         .       g.134134
 aaaatagacacagggtcttgggactggggtttcggattgagttgcaagcagggagaaaac       c.*2940

          .         .         .         .         .         .       g.134194
 ctgaaggtcggtgcccctatggggctgaccagtagagaatttcctttactgtatttttgt       c.*3000

          .         .         .         .         .         .       g.134254
 gtctggtcttccctttctggcttctaggacatccatgccaggtgaggtgcctgggtccct       c.*3060

          .         .         .         .         .         .       g.134314
 gttacaagtcaggagccctgtagggagacccctccttttgtacaagtacctgaatgctgc       c.*3120

          .         .         .         .         .         .       g.134374
 gacaagcagatttttgtaaaattttatattagtttttaatgtcagtggcgactcggttcc       c.*3180

          .         .         .         .         .         .       g.134434
 tggggctgcagccagcctgggacttttgtaagaatttttgggtgactcacttagatgtcg       c.*3240

          .         .         .         .         .         .       g.134494
 tttccttcttgccccctcttcctctctgtaatctaagtgcattaaacatctttgcagaag       c.*3300

                                                                    g.134496
 tg                                                                 c.*3302

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Suppressor of fused homolog (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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