sulfatase modifying factor 1 (SUMF1) - coding DNA reference sequence

(used for variant description)

(last modified November 4, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_182760.3 in the SUMF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering SUMF1 transcript NM_182760.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5037
                        cacgtgaccaaccgggtcacatggcccgcgggacaac       c.-1

          .         .         .         .         .         .       g.5097
 ATGGCTGCGCCCGCACTAGGGCTGGTGTGTGGACGTTGCCCTGAGCTGGGTCTCGTCCTC       c.60
 M  A  A  P  A  L  G  L  V  C  G  R  C  P  E  L  G  L  V  L         p.20

          .         .         .         .         .         .       g.5157
 TTGCTGCTGCTGCTCTCGCTGCTGTGTGGAGCGGCAGGGAGCCAGGAGGCCGGGACCGGT       c.120
 L  L  L  L  L  S  L  L  C  G  A  A  G  S  Q  E  A  G  T  G         p.40

          .         .         .         .         .         .       g.5217
 GCGGGCGCGGGGTCCCTTGCGGGTTCTTGCGGCTGCGGCACGCCCCAGCGGCCTGGCGCC       c.180
 A  G  A  G  S  L  A  G  S  C  G  C  G  T  P  Q  R  P  G  A         p.60

          .         .         .         .         .         .       g.5277
 CATGGCAGTTCGGCAGCCGCTCACCGATACTCGCGGGAGGCTAACGCTCCGGGCCCCGTA       c.240
 H  G  S  S  A  A  A  H  R  Y  S  R  E  A  N  A  P  G  P  V         p.80

          .         .         . | 02       .         .         .    g.19263
 CCCGGAGAGCGGCAACTCGCGCACTCAAAG | ATGGTCCCCATCCCTGCTGGAGTATTTACA    c.300
 P  G  E  R  Q  L  A  H  S  K   | M  V  P  I  P  A  G  V  F  T      p.100

          .         .         .         .         .         .       g.19323
 ATGGGCACAGATGATCCTCAGATAAAGCAGGATGGGGAAGCACCTGCGAGGAGAGTTACT       c.360
 M  G  T  D  D  P  Q  I  K  Q  D  G  E  A  P  A  R  R  V  T         p.120

          .         .         .         .         .         .       g.19383
 ATTGATGCCTTTTACATGGATGCCTATGAAGTCAGTAATACTGAATTTGAGAAGTTTGTG       c.420
 I  D  A  F  Y  M  D  A  Y  E  V  S  N  T  E  F  E  K  F  V         p.140

          .         .     | 03   .         .         .         .    g.22978
 AACTCAACTGGCTATTTGACAGAG | GCTGAGAAGTTTGGCGACTCCTTTGTCTTTGAAGGC    c.480
 N  S  T  G  Y  L  T  E   | A  E  K  F  G  D  S  F  V  F  E  G      p.160

          .         .         .          | 04        .         .    g.52157
 ATGTTGAGTGAGCAAGTGAAGACCAATATTCAACAGGCA | GTTGCAGCTGCTCCCTGGTGG    c.540
 M  L  S  E  Q  V  K  T  N  I  Q  Q  A   | V  A  A  A  P  W  W      p.180

          .         .         .         .         .         .       g.52217
 TTACCTGTGAAAGGCGCTAACTGGAGACACCCAGAAGGGCCTGACTCTACTATTCTGCAC       c.600
 L  P  V  K  G  A  N  W  R  H  P  E  G  P  D  S  T  I  L  H         p.200

    | 05     .         .         .         .         .         .    g.54208
 AG | GCCGGATCATCCAGTTCTCCATGTGTCCTGGAATGATGCGGTTGCCTACTGCACTTGG    c.660
 R  |  P  D  H  P  V  L  H  V  S  W  N  D  A  V  A  Y  C  T  W      p.220

          .         .         .         .         .         .       g.54268
 GCAGGGAAGCGGCTGCCCACGGAAGCTGAGTGGGAATACAGCTGTCGAGGAGGCCTGCAT       c.720
 A  G  K  R  L  P  T  E  A  E  W  E  Y  S  C  R  G  G  L  H         p.240

       | 06  .         .         .         .         .         .    g.55095
 AATAG | ACTTTTCCCCTGGGGCAACAAACTGCAGCCCAAAGGCCAGCATTATGCCAACATT    c.780
 N  R  |  L  F  P  W  G  N  K  L  Q  P  K  G  Q  H  Y  A  N  I      p.260

          .         .         .         .         .         .       g.55155
 TGGCAGGGCGAGTTTCCGGTGACCAACACTGGTGAGGATGGCTTCCAAGGAACTGCGCCT       c.840
 W  Q  G  E  F  P  V  T  N  T  G  E  D  G  F  Q  G  T  A  P         p.280

  | 07       .         .         .         .         .         .    g.61364
  | GTTGATGCCTTCCCTCCCAATGGTTATGGCTTATACAACATAGTGGGGAACGCATGGGAA    c.900
  | V  D  A  F  P  P  N  G  Y  G  L  Y  N  I  V  G  N  A  W  E      p.300

          .         .         .         .         .     | 08   .    g.95899
 TGGACTTCAGACTGGTGGACTGTTCATCATTCTGTTGAAGAAACGCTTAACCCA | AAAGGT    c.960
 W  T  S  D  W  W  T  V  H  H  S  V  E  E  T  L  N  P   | K  G      p.320

          .         .         .         .         .     | 09   .    g.110034
 CCCCCTTCTGGGAAAGACCGAGTGAAGAAAGGTGGATCCTACATGTGCCATAGG | TCTTAT    c.1020
 P  P  S  G  K  D  R  V  K  K  G  G  S  Y  M  C  H  R   | S  Y      p.340

          .         .         .         .         .         .       g.110094
 TGTTACAGGTATCGCTGTGCTGCTCGGAGCCAGAACACACCTGATAGCTCTGCTTCGAAT       c.1080
 C  Y  R  Y  R  C  A  A  R  S  Q  N  T  P  D  S  S  A  S  N         p.360

          .         .         .         .                           g.110139
 CTGGGATTCCGCTGTGCAGCCGACCGCCTGCCCACTATGGACTGA                      c.1125
 L  G  F  R  C  A  A  D  R  L  P  T  M  D  X                        p.374

          .         .         .         .         .         .       g.110199
 caaccaaggaaagtcttccccagtccaaggagcagtcgtgtctgacctacattgggcttt       c.*60

          .         .         .         .         .         .       g.110259
 tctcagaactttgaacgatcccatgcaaagaattcccaccctgaggtgggttacatacct       c.*120

          .         .         .         .         .         .       g.110319
 gcccaatggccaaaggaaccgccttgtgagaccaaattgctgacctgggtcagtgcatgt       c.*180

          .         .         .         .         .         .       g.110379
 gctttatggtgtggtgcatctttggagatcatcaccatattttacttttgagagtcttta       c.*240

          .         .         .         .         .         .       g.110439
 aagaggaaggggagtggagggaaccctgagctaggcttcaggaggcccgcgtcctacgca       c.*300

          .         .         .         .         .         .       g.110499
 ggctctgccacaggggttagaccccaggtccgacgcttgaccttcctgggcctcaagtgc       c.*360

          .         .         .         .         .         .       g.110559
 cctcccctatcaaatgaagggatggacagcatgacctctgggtgtctctccaactcacca       c.*420

          .         .         .         .         .         .       g.110619
 gttctaaaaagggtatcagattctattgtgacttcatagtgagaatttattatagattat       c.*480

          .         .         .         .         .         .       g.110679
 tttttagctattttttccatgtgtgaaccttgagtgatactaatcatgtaaagtaagagt       c.*540

          .         .         .         .         .         .       g.110739
 tctcttatgtattattttcggaagaggggtgtggtgactcctttatattcgtactgcact       c.*600

          .         .         .         .         .         .       g.110799
 ttgtttttccaaggaaatcagtgtcttttacgttgttatgatgaatcccacatggggccg       c.*660

          .         .         .         .         .         .       g.110859
 gtgatggtatgctgaagttcagccgttgaacacataggaatgtctgtggggtgactctac       c.*720

          .         .         .         .         .         .       g.110919
 tgtgctttatcttttaacattaagtgcctttggttcagaggggcagtcataagctctgtt       c.*780

          .         .         .         .         .         .       g.110979
 tccccctctccccaaagccttcagcgaacgtgaaatgtgcgctaaacggggaaacctgtt       c.*840

          .         .         .         .         .         .       g.111039
 taattctagatatagggaaaaaggaacgaggaccttgaatgagctatattcagggtatcc       c.*900

          .         .         .         .         .         .       g.111099
 ggtattttgtaatagggaataggaaaccttgttggctgtggaatatccgatgctttgaat       c.*960

          .         .         .                                     g.111138
 catgcactgtgttgaataaacgtatctgctaaatcaggc                            c.*999

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sulfatase modifying factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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