suppressor of zeste 12 homolog (Drosophila) (SUZ12) - coding DNA reference sequence

(used for variant description)

(last modified October 26, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_015355.2 in the SUZ12 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009237.1, covering SUZ12 transcript NM_015355.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   ggtgagcggcctccgaagcggagcggggctctgaggagacac       c.-181

 .         .         .         .         .         .                g.5102
 tttttttttcctccctccttccctcctctcctcctcccttcccttcccctctcctcccct       c.-121

 .         .         .         .         .         .                g.5162
 ctctcctccttcccccctcggtccgccggagcctgctggggcgagcggttggtattgcag       c.-61

 .         .         .         .         .         .                g.5222
 gcgcttgctctccggggccgcccggcgggtagctggcggggggaggaggcaggaaccgcg       c.-1

          .         .         .         .         .         .       g.5282
 ATGGCGCCTCAGAAGCACGGCGGTGGGGGAGGGGGCGGCTCGGGGCCCAGCGCGGGGTCC       c.60
 M  A  P  Q  K  H  G  G  G  G  G  G  G  S  G  P  S  A  G  S         p.20

          .         .         .         .         .         .       g.5342
 GGGGGAGGCGGCTTCGGGGGTTCGGCGGCGGTGGCGGCGGCGACGGCTTCGGGCGGCAAA       c.120
 G  G  G  G  F  G  G  S  A  A  V  A  A  A  T  A  S  G  G  K         p.40

          .         .         .         .         .         .       g.5402
 TCCGGCGGCGGGAGCTGTGGAGGGGGTGGCAGTTACTCGGCCTCCTCCTCCTCCTCCGCG       c.180
 S  G  G  G  S  C  G  G  G  G  S  Y  S  A  S  S  S  S  S  A         p.60

          .         .         .         .         .         .       g.5462
 GCGGCAGCGGCGGGGGCTGCGGTGTTACCGGTGAAGAAGCCGAAAATGGAGCACGTCCAG       c.240
 A  A  A  A  G  A  A  V  L  P  V  K  K  P  K  M  E  H  V  Q         p.80

          .         .         .     | 02   .         .         .    g.8287
 GCTGACCACGAGCTTTTCCTCCAGGCCTTTGAGA | AGCCAACACAGATCTATAGATTTCTT    c.300
 A  D  H  E  L  F  L  Q  A  F  E  K |   P  T  Q  I  Y  R  F  L      p.100

          .         .  | 03      .         .         .         .    g.8436
 CGAACTCGGAATCTCATAGCA | CCAATATTTTTGCACAGAACTCTTACTTACATGTCTCAT    c.360
 R  T  R  N  L  I  A   | P  I  F  L  H  R  T  L  T  Y  M  S  H      p.120

          .         .       | 04 .         .         .         .    g.15626
 CGAAACTCCAGAACAAACATCAAAAG | GAAAACATTTAAAGTTGATGATATGTTATCAAAA    c.420
 R  N  S  R  T  N  I  K  R  |  K  T  F  K  V  D  D  M  L  S  K      p.140

          .         .         .      | 05  .         .         .    g.34147
 GTAGAGAAAATGAAAGGAGAGCAAGAATCTCATAG | CTTGTCAGCTCATTTGCAGCTTACG    c.480
 V  E  K  M  K  G  E  Q  E  S  H  S  |  L  S  A  H  L  Q  L  T      p.160

          .         .      | 06  .         .         .         .    g.41156
 TTTACTGGTTTCTTCCACAAAAATG | ATAAGCCATCACCAAACTCAGAAAATGAACAAAAT    c.540
 F  T  G  F  F  H  K  N  D |   K  P  S  P  N  S  E  N  E  Q  N      p.180

          .         .         .         .         .  | 07      .    g.43466
 TCTGTTACCCTGGAAGTCCTGCTTGTGAAAGTTTGCCACAAAAAAAGAAAG | GATGTAAGT    c.600
 S  V  T  L  E  V  L  L  V  K  V  C  H  K  K  R  K   | D  V  S      p.200

          .         .         .         .         .         .       g.43526
 TGTCCAATAAGGCAAGTTCCCACAGGTAAAAAGCAGGTGCCTTTGAATCCTGACCTCAAT       c.660
 C  P  I  R  Q  V  P  T  G  K  K  Q  V  P  L  N  P  D  L  N         p.220

          .         .         .         .         .         .       g.43586
 CAAACAAAACCCGGAAATTTCCCGTCCCTTGCAGTTTCCAGTAATGAATTTGAACCTAGT       c.720
 Q  T  K  P  G  N  F  P  S  L  A  V  S  S  N  E  F  E  P  S         p.240

          .         .         .         .         .         .       g.43646
 AACAGCCATATGGTGAAGTCTTACTCGTTGCTATTTAGAGTGACTCGTCCAGGAAGAAGA       c.780
 N  S  H  M  V  K  S  Y  S  L  L  F  R  V  T  R  P  G  R  R         p.260

          .         .         .         .    | 08    .         .    g.44513
 GAGTTTAATGGAATGATTAATGGAGAAACCAATGAAAATATTG | ATGTCAATGAAGAGCTT    c.840
 E  F  N  G  M  I  N  G  E  T  N  E  N  I  D |   V  N  E  E  L      p.280

          .         .         .         .         .         .       g.44573
 CCAGCCAGAAGAAAACGAAATCGTGAGGATGGGGAAAAGACATTTGTTGCACAAATGACA       c.900
 P  A  R  R  K  R  N  R  E  D  G  E  K  T  F  V  A  Q  M  T         p.300

          .        | 09.         .         .         .         .    g.51017
 GTATTTGATAAAAACAG | GCGCTTACAGCTTTTAGATGGGGAATATGAAGTAGCCATGCAG    c.960
 V  F  D  K  N  R  |  R  L  Q  L  L  D  G  E  Y  E  V  A  M  Q      p.320

          .         .         .         .         .         .       g.51077
 GAAATGGAAGAATGTCCAATAAGCAAGAAAAGAGCAACATGGGAGACTATTCTTGATGGG       c.1020
 E  M  E  E  C  P  I  S  K  K  R  A  T  W  E  T  I  L  D  G         p.340

     | 10    .         .         .         .         .         .    g.56352
 AAG | AGGCTGCCTCCATTCGAAACATTTTCTCAGGGACCTACGTTGCAGTTCACTCTTCGT    c.1080
 K   | R  L  P  P  F  E  T  F  S  Q  G  P  T  L  Q  F  T  L  R      p.360

          .         .         .         .         .         .       g.56412
 TGGACAGGAGAGACCAATGATAAATCTACGGCTCCTATTGCCAAACCTCTTGCCACTAGA       c.1140
 W  T  G  E  T  N  D  K  S  T  A  P  I  A  K  P  L  A  T  R         p.380

          .         .         .         .         .         .       g.56472
 AATTCAGAGAGTCTCCATCAGGAAAACAAGCCTGGTTCAGTTAAACCTACTCAAACTATT       c.1200
 N  S  E  S  L  H  Q  E  N  K  P  G  S  V  K  P  T  Q  T  I         p.400

   | 11      .         .         .         .         .         .    g.61276
 G | CTGTTAAAGAATCATTGACTACAGATCTACAAACAAGAAAAGAAAAGGATACTCCAAAT    c.1260
 A |   V  K  E  S  L  T  T  D  L  Q  T  R  K  E  K  D  T  P  N      p.420

          .         .         .    | 12    .         .         .    g.61867
 GAAAACCGACAAAAATTAAGAATATTTTATCAG | TTTCTCTATAACAACAATACAAGGCAA    c.1320
 E  N  R  Q  K  L  R  I  F  Y  Q   | F  L  Y  N  N  N  T  R  Q      p.440

          .         .         .         .         .         .       g.61927
 CAAACTGAAGCAAGAGATGACCTGCATTGCCCTTGGTGTACTCTGAACTGCCGCAAACTT       c.1380
 Q  T  E  A  R  D  D  L  H  C  P  W  C  T  L  N  C  R  K  L         p.460

          .         .         .         .         .        | 13.    g.62542
 TATAGTTTACTCAAGCATCTTAAACTCTGCCATAGCAGATTTATCTTCAACTATGTT | TAT    c.1440
 Y  S  L  L  K  H  L  K  L  C  H  S  R  F  I  F  N  Y  V   | Y      p.480

          .         .         .         .         .         .       g.62602
 CATCCAAAAGGTGCTAGGATAGATGTTTCTATCAATGAGTGTTATGATGGCTCCTATGCA       c.1500
 H  P  K  G  A  R  I  D  V  S  I  N  E  C  Y  D  G  S  Y  A         p.500

          .         .         .         .         .         .       g.62662
 GGAAATCCTCAGGATATTCATCGCCAACCTGGATTTGCTTTTAGTCGCAACGGACCAGTT       c.1560
 G  N  P  Q  D  I  H  R  Q  P  G  F  A  F  S  R  N  G  P  V         p.520

          .         .         .      | 14  .         .         .    g.63564
 AAGAGAACACCTATCACACATATTCTTGTGTGCAG | GCCAAAACGAACAAAAGCAAGCATG    c.1620
 K  R  T  P  I  T  H  I  L  V  C  R  |  P  K  R  T  K  A  S  M      p.540

          .         .         .         .         .         .       g.63624
 TCTGAATTTCTTGAATCTGAAGATGGGGAAGTAGAACAGCAAAGAACATATAGTAGTGGC       c.1680
 S  E  F  L  E  S  E  D  G  E  V  E  Q  Q  R  T  Y  S  S  G         p.560

          .         .         .         .         .         .       g.63684
 CACAATCGTCTGTATTTCCATAGTGATACCTGCTTACCTCTCCGTCCACAAGAAATGGAA       c.1740
 H  N  R  L  Y  F  H  S  D  T  C  L  P  L  R  P  Q  E  M  E         p.580

          .         .         .         .         .     | 15   .    g.64779
 GTAGATAGTGAAGATGAAAAGGATCCTGAATGGCTAAGAGAAAAAACCATTACA | CAAATT    c.1800
 V  D  S  E  D  E  K  D  P  E  W  L  R  E  K  T  I  T   | Q  I      p.600

          .         .         .         .         .         .       g.64839
 GAAGAGTTTTCTGATGTTAATGAAGGAGAGAAAGAAGTGATGAAACTCTGGAATCTCCAT       c.1860
 E  E  F  S  D  V  N  E  G  E  K  E  V  M  K  L  W  N  L  H         p.620

          .     | 16   .         .         .         .         .    g.66679
 GTCATGAAGCATGG | GTTTATTGCTGACAATCAAATGAATCATGCCTGTATGCTGTTTGTA    c.1920
 V  M  K  H  G  |  F  I  A  D  N  Q  M  N  H  A  C  M  L  F  V      p.640

          .         .         .         .         .         .       g.66739
 GAAAATTATGGACAGAAAATAATTAAGAAGAATTTATGTCGAAACTTCATGCTTCATCTA       c.1980
 E  N  Y  G  Q  K  I  I  K  K  N  L  C  R  N  F  M  L  H  L         p.660

          .         .         .         .         .         .       g.66799
 GTCAGCATGCATGACTTTAATCTTATTAGCATAATGTCAATAGATAAAGCTGTTACCAAG       c.2040
 V  S  M  H  D  F  N  L  I  S  I  M  S  I  D  K  A  V  T  K         p.680

          .         .         .         .         .         .       g.66859
 CTCCGTGAAATGCAGCAAAAATTAGAAAAGGGGGAATCTGCTTCCCCTGCAAACGAAGAA       c.2100
 L  R  E  M  Q  Q  K  L  E  K  G  E  S  A  S  P  A  N  E  E         p.700

          .         .         .         .         .         .       g.66919
 ATAACTGAAGAACAAAATGGGACAGCAAATGGATTTAGTGAAATTAACTCAAAAGAGAAA       c.2160
 I  T  E  E  Q  N  G  T  A  N  G  F  S  E  I  N  S  K  E  K         p.720

          .         .         .         .         .         .       g.66979
 GCTTTGGAAACAGATAGTGTCTCAGGGGTTTCAAAACAGAGCAAAAAACAAAAACTCTGA       c.2220
 A  L  E  T  D  S  V  S  G  V  S  K  Q  S  K  K  Q  K  L  X         p.739

          .         .         .         .         .         .       g.67039
 aaagctctaaccccatgttatggacaaacactgaaattacattttagggaattcatcctc       c.*60

          .         .         .         .         .         .       g.67099
 taagaattatgtttttgtttttaatcatatgttccaaacaggcactgttagatgaagtaa       c.*120

          .         .         .         .         .         .       g.67159
 atgatttcaacaaggatatttgtatcagggttctacttcacttcattatgcagcattaca       c.*180

          .         .         .         .         .         .       g.67219
 tgtatatcacttttattgatgtcattaaaacattctgtactttaagcatgaaaagcaata       c.*240

          .         .         .         .         .         .       g.67279
 tttcaaagtatttttaaactcaacaaatgtcatcaaatatgttgaattgatctagaaatt       c.*300

          .         .         .         .         .         .       g.67339
 atttcatatataaatcagaatttttttgcatttatgaacggctgtttttctactttgtaa       c.*360

          .         .         .         .         .         .       g.67399
 ttgtgagacattttcttggggagggaaaattggaatggttcccttttttagaaattgaag       c.*420

          .         .         .         .         .         .       g.67459
 tggtcttcatatgtcaactacagaaaaggaaaaaaatagaaattgaaggatttttatgaa       c.*480

          .         .         .         .         .         .       g.67519
 attatattgcattactatttgcagtcaaactttgatccttgtttttgaaatcatttgtca       c.*540

          .         .         .         .         .         .       g.67579
 attcggaatgaaaaattataatgtaattttacattacataagttccttttacaattaaaa       c.*600

          .         .         .         .         .         .       g.67639
 aatagcacttcttcatcttatgcctgtttgagaagatattaaattttcacattgttgaca       c.*660

          .         .         .         .         .         .       g.67699
 gtgaaatgctatgttggtttataagattacagaccatttgttttcatgtggataatttta       c.*720

          .         .         .         .         .         .       g.67759
 gtgcattgctcacccggtatgttttttttttttaacttgaacattttgcttgttttgttt       c.*780

          .         .         .         .         .         .       g.67819
 ttcttttttaattagataatcacacggaaaattaagctgttcatatctttaaattaggat       c.*840

          .         .         .         .         .         .       g.67879
 tgcaaaccaaggaaagaacgcatttgagattttaagatgtcacttataaggggagaagtg       c.*900

          .         .         .         .         .         .       g.67939
 ttcttaaaaagtcaaccagaaaactgttatgccttttatttgtttgcaaggatgtctttg       c.*960

          .         .         .         .         .         .       g.67999
 taatgtgtttcatgaatagaatatccaatagagataagctgacttgaatcattttgagca       c.*1020

          .         .         .         .         .         .       g.68059
 attttgccctgtgttatatgtgtttcacgcacatatttgcagttggattttctccaacag       c.*1080

          .         .         .         .         .         .       g.68119
 aaagtggattcactactggcacattaacaagcaccaataggtttttattccaactccgag       c.*1140

          .         .         .         .         .         .       g.68179
 cactgtggttgagtaacatcacctcaattttttattatccttaaagatattgcattttca       c.*1200

          .         .         .         .         .         .       g.68239
 tattctttatttataaaggatcaatgctgctgtaaatacaggtatttttaattttaaaat       c.*1260

          .         .         .         .         .         .       g.68299
 ttcattccaccaccatcagatgcagttccctattttgtttaatgaagggatatataagct       c.*1320

          .         .         .         .         .         .       g.68359
 ttctaatggtgtcttcagaaatttataaaatgtaaatactgatttgactggtctttaaga       c.*1380

          .         .         .         .         .         .       g.68419
 tgtgtttaactgtgaggctatttaacgaatagtgtggatgtgatttgtcatccagtatta       c.*1440

          .         .         .         .         .         .       g.68479
 agttcttagtcattgatttttgtgtttaaaaaaaaataggaaagagggaaactgcagctt       c.*1500

          .         .         .         .         .         .       g.68539
 tcattacagattccttgattggtaagctctccaaatgatgagttctagtaaactctgatt       c.*1560

          .         .         .         .         .         .       g.68599
 tttgcctctggatagtagatctcgagcgtttatctcgggctttaatttgctaaagctgtg       c.*1620

          .         .         .         .         .         .       g.68659
 cacatatgtaaaaaaaaaaaaaaaaagattattttaggggagatgtaggtgtagaattat       c.*1680

          .         .         .         .         .         .       g.68719
 tgcttatgtcatttcttaagcagttatgctcttaatgcttaaaagaaggctagcattgtt       c.*1740

          .         .         .         .         .         .       g.68779
 tgcacaaaaagttggtgattcccaccccaaatagtaataaaattacttctgttgagtaaa       c.*1800

          .         .         .         .         .         .       g.68839
 ctttttatgtcatcgtaaaagctgaaaaaatccctttgtttctatttataaaaaaagtgc       c.*1860

          .         .         .         .         .         .       g.68899
 ttttctatatgtacccttgataacagattttgaagaaatcctgtaagatgataaagcatt       c.*1920

          .         .         .         .         .         .       g.68959
 tgaatggtacagtagatgtaaaaaaaattcagtttaaaagaacatttgtttttacattaa       c.*1980

          .         .         .         .         .                 g.69014
 atgtttatttgaaatcaaatgattttgtacataaagttcaataatataaaagctg            c.*2035

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Suppressor of zeste 12 homolog (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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