synapsin I (SYN1) - coding DNA reference sequence

(used for variant description)

(last modified July 11, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_006950.3 in the SYN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008437.1, covering SYN1 transcript NM_006950.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    agtctgcgg       c.-121

 .         .         .         .         .         .                g.5069
 tgggcagcggaggagtcgtgtcgtgcctgagagcgcagctgtgctcctgggcaccgcgca       c.-61

 .         .         .         .         .         .                g.5129
 gtccgcccccgcggctcctggccagaccacccctaggaccccctgccccaagtcgcagcc       c.-1

          .         .         .         .         .         .       g.5189
 ATGAACTACCTGCGGCGCCGCCTGTCGGACAGCAACTTTATGGCCAATCTGCCAAATGGG       c.60
 M  N  Y  L  R  R  R  L  S  D  S  N  F  M  A  N  L  P  N  G         p.20

          .         .         .         .         .         .       g.5249
 TACATGACAGACCTGCAGCGTCCGCAGCCGCCCCCACCGCCGCCCGGTGCCCACAGCCCC       c.120
 Y  M  T  D  L  Q  R  P  Q  P  P  P  P  P  P  G  A  H  S  P         p.40

          .         .         .         .         .         .       g.5309
 GGAGCCACGCCCGGTCCCGGGACCGCCACTGCCGAGAGGTCCTCCGGGGTCGCCCCAGCG       c.180
 G  A  T  P  G  P  G  T  A  T  A  E  R  S  S  G  V  A  P  A         p.60

          .         .         .         .         .         .       g.5369
 GCCTCTCCGGCCGCCCCTAGCCCCGGGTCCTCGGGGGGCGGTGGCTTCTTCTCGTCGCTG       c.240
 A  S  P  A  A  P  S  P  G  S  S  G  G  G  G  F  F  S  S  L         p.80

          .         .         .         .         .         .       g.5429
 TCCAACGCGGTCAAGCAGACCACGGCGGCGGCAGCTGCCACCTTCAGCGAGCAGGTGGGC       c.300
 S  N  A  V  K  Q  T  T  A  A  A  A  A  T  F  S  E  Q  V  G         p.100

          .         .         .         .         .         .       g.5489
 GGCGGCTCTGGGGGCGCAGGCCGCGGGGGAGCCGCCTCCAGGGTGCTGCTGGTCATCGAC       c.360
 G  G  S  G  G  A  G  R  G  G  A  A  S  R  V  L  L  V  I  D         p.120

          .        | 02.         .         .         .         .    g.17702
 GAGCCGCACACCGACTG | GGCAAAATACTTCAAAGGGAAAAAGATCCATGGAGAAATTGAC    c.420
 E  P  H  T  D  W  |  A  K  Y  F  K  G  K  K  I  H  G  E  I  D      p.140

          .      | 03  .         .         .         .         .    g.17866
 ATTAAAGTAGAACAG | GCCGAATTCTCTGATCTCAACCTTGTGGCCCATGCCAATGGTGGA    c.480
 I  K  V  E  Q   | A  E  F  S  D  L  N  L  V  A  H  A  N  G  G      p.160

          .         .         .         .        | 04.         .    g.19491
 TTCTCTGTGGATATGGAAGTTCTTCGGAATGGGGTGAAGGTCGTGCG | GTCTCTGAAGCCG    c.540
 F  S  V  D  M  E  V  L  R  N  G  V  K  V  V  R  |  S  L  K  P      p.180

          .         .         .         .         .         .       g.19551
 GATTTTGTGCTGATCCGCCAGCACGCCTTCAGCATGGCACGCAACGGAGACTACCGCAGT       c.600
 D  F  V  L  I  R  Q  H  A  F  S  M  A  R  N  G  D  Y  R  S         p.200

          .         .         .         .         .         .       g.19611
 TTGGTCATTGGGCTGCAGTATGCTGGAATCCCCAGTGTTAACTCCTTGCATTCTGTCTAC       c.660
 L  V  I  G  L  Q  Y  A  G  I  P  S  V  N  S  L  H  S  V  Y         p.220

          .         .     | 05   .         .         .         .    g.19826
 AACTTCTGTGACAAGCCCTGGGTG | TTTGCCCAGATGGTTCGACTGCATAAGAAACTGGGG    c.720
 N  F  C  D  K  P  W  V   | F  A  Q  M  V  R  L  H  K  K  L  G      p.240

          .         .         .         .         .     | 06   .    g.47362
 ACAGAAGAATTCCCTCTAATTGATCAGACCTTCTACCCCAATCACAAAGAAATG | CTCAGC    c.780
 T  E  E  F  P  L  I  D  Q  T  F  Y  P  N  H  K  E  M   | L  S      p.260

          .         .         .         .         .        | 07.    g.48220
 AGTACAACGTACCCCGTGGTTGTGAAGATGGGGCACGCACACTCTGGGATGGGCAAG | GTC    c.840
 S  T  T  Y  P  V  V  V  K  M  G  H  A  H  S  G  M  G  K   | V      p.280

          .         .         .         .         .         .       g.48280
 AAGGTTGACAACCAGCATGACTTCCAGGACATCGCAAGTGTCGTGGCACTGACCAAGACG       c.900
 K  V  D  N  Q  H  D  F  Q  D  I  A  S  V  V  A  L  T  K  T         p.300

          .         .         .         .         .         .       g.48340
 TATGCCACTGCCGAGCCCTTCATCGATGCCAAATATGACGTGCGTGTCCAGAAGATTGGG       c.960
 Y  A  T  A  E  P  F  I  D  A  K  Y  D  V  R  V  Q  K  I  G         p.320

          .         . | 08       .         .         .         .    g.48491
 CAGAACTACAAGGCCTACAT | GAGGACGTCAGTGTCAGGGAACTGGAAGACCAATACTGGC    c.1020
 Q  N  Y  K  A  Y  M  |  R  T  S  V  S  G  N  W  K  T  N  T  G      p.340

          .         .         .      | 09  .         .         .    g.48649
 TCTGCGATGCTGGAGCAAATTGCCATGTCTGACAG | ATACAAGCTGTGGGTGGACACGTGC    c.1080
 S  A  M  L  E  Q  I  A  M  S  D  R  |  Y  K  L  W  V  D  T  C      p.360

          .         .         .         .         .         .       g.48709
 TCAGAGATTTTTGGGGGACTGGACATCTGCGCAGTGGAAGCGCTACATGGCAAGGACGGA       c.1140
 S  E  I  F  G  G  L  D  I  C  A  V  E  A  L  H  G  K  D  G         p.380

          .         | 10         .         .         .         .    g.49625
 AGGGATCACATCATTGAG | GTGGTGGGTTCCTCCATGCCGCTCATTGGTGACCACCAGGAT    c.1200
 R  D  H  I  I  E   | V  V  G  S  S  M  P  L  I  G  D  H  Q  D      p.400

          .         .         .         .         .         .       g.49685
 GAAGACAAACAGCTCATCGTAGAGCTCGTGGTCAACAAGATGGCTCAGGCCCTGCCCCGG       c.1260
 E  D  K  Q  L  I  V  E  L  V  V  N  K  M  A  Q  A  L  P  R         p.420

          .         .         .         .      | 11  .         .    g.50097
 CAGCGACAGCGGGATGCCTCCCCTGGCAGGGGCTCCCATGGCCAG | ACTCCGTCCCCAGGG    c.1320
 Q  R  Q  R  D  A  S  P  G  R  G  S  H  G  Q   | T  P  S  P  G      p.440

          .         .         .         .         .         .       g.50157
 GCCCTGCCCTTGGGCCGCCAGACCTCCCAGCAGCCCGCAGGGCCCCCGGCTCAGCAGCGA       c.1380
 A  L  P  L  G  R  Q  T  S  Q  Q  P  A  G  P  P  A  Q  Q  R         p.460

          .    | 12    .         .         .         .         .    g.50314
 CCCCCACCACAGG | GCGGCCCTCCACAGCCGGGTCCAGGCCCCCAGCGCCAGGGACCCCCA    c.1440
 P  P  P  Q  G |   G  P  P  Q  P  G  P  G  P  Q  R  Q  G  P  P      p.480

          .         .         .         .         .         .       g.50374
 TTGCAGCAGCGCCCGCCCCCGCAGGGCCAGCAGCACCTTTCAGGCCTTGGACCCCCAGCT       c.1500
 L  Q  Q  R  P  P  P  Q  G  Q  Q  H  L  S  G  L  G  P  P  A         p.500

          .         .         .         .         .         .       g.50434
 GGCAGCCCCCTGCCCCAGCGCCTTCCAAGTCCCACCTCAGCGCCCCAGCAGCCCGCGTCC       c.1560
 G  S  P  L  P  Q  R  L  P  S  P  T  S  A  P  Q  Q  P  A  S         p.520

          .         .         .         .         .         .       g.50494
 CAGGCCGCGCCGCCGACCCAGGGTCAAGGCCGCCAATCCCGGCCAGTGGCGGGAGGCCCC       c.1620
 Q  A  A  P  P  T  Q  G  Q  G  R  Q  S  R  P  V  A  G  G  P         p.540

          .         .         .         .         .         .       g.50554
 GGGGCGCCTCCAGCAGCCCGCCCGCCCGCCTCTCCGTCTCCCCAGCGCCAGGCGGGCCCC       c.1680
 G  A  P  P  A  A  R  P  P  A  S  P  S  P  Q  R  Q  A  G  P         p.560

          .         .         .         .         .         .       g.50614
 CCACAGGCTACCCGTCAGACATCCGTCTCTGGCCCGGCTCCGCCAAAGGCCTCTGGGGCC       c.1740
 P  Q  A  T  R  Q  T  S  V  S  G  P  A  P  P  K  A  S  G  A         p.580

          .         .         .         .         .         .       g.50674
 CCACCGGGCGGGCAGCAGCGCCAGGGCCCGCCCCAGAAACCCCCAGGCCCAGCCGGCCCC       c.1800
 P  P  G  G  Q  Q  R  Q  G  P  P  Q  K  P  P  G  P  A  G  P         p.600

          .         .         .         .         .         .       g.50734
 ACACGCCAGGCCAGCCAGGCGGGTCCCGTGCCCCGCACTGGGCCACCCACCACGCAGCAG       c.1860
 T  R  Q  A  S  Q  A  G  P  V  P  R  T  G  P  P  T  T  Q  Q         p.620

          .         .         .         .         .         .       g.50794
 CCTCGGCCCAGCGGCCCGGGCCCCGCTGGACGTCCCAAACCACAGCTGGCCCAGAAACCC       c.1920
 P  R  P  S  G  P  G  P  A  G  R  P  K  P  Q  L  A  Q  K  P         p.640

          .         .         .         .         .         .       g.50854
 AGCCAGGACGTGCCGCCACCCGCCACCGCCGCTGCAGGGGGACCTCCGCACCCCCAGCTC       c.1980
 S  Q  D  V  P  P  P  A  T  A  A  A  G  G  P  P  H  P  Q  L         p.660

    | 13     .         .         .         .         .         .    g.51916
 AA | CAAATCCCAGTCTCTGACCAATGCCTTCAACCTTCCAGAGCCAGCCCCGCCCAGGCCC    c.2040
 N  |  K  S  Q  S  L  T  N  A  F  N  L  P  E  P  A  P  P  R  P      p.680

          .         .         .         .         .         .       g.51976
 AGCCTTAGCCAGGACGAGGTGAAAGCTGAGACCATCCGCAGCCTGAGGAAGTCTTTCGCC       c.2100
 S  L  S  Q  D  E  V  K  A  E  T  I  R  S  L  R  K  S  F  A         p.700

          .                                                         g.51994
 AGCCTCTTCTCCGACTGA                                                 c.2118
 S  L  F  S  D  X                                                   p.705

          .         .         .         .         .         .       g.52054
 taccccactctgagaaccccaaaatccctgggcaacccttctctgggccctgaatccatt       c.*60

          .         .         .         .         .         .       g.52114
 tctcacttttggagtctccaaatcccttgagaacccatctcccggttctccaagattcca       c.*120

          .         .         .         .         .         .       g.52174
 cctctcattcctcaagatccccgagtaccttgagaaacctgactcctcctggccctaaat       c.*180

          .         .         .         .         .         .       g.52234
 ccggttctcacatgtggaatccccaagtccttttagaaccccactcgtggtcacttcagg       c.*240

          .         .         .         .         .         .       g.52294
 atctacttctgttttagaacctccacattcctgaagacctccgcccctggtttccccaga       c.*300

          .         .         .         .         .         .       g.52354
 gggcgttttccttcctggaagtgcccaaataccaggcaacccattgcagaatcccttcct       c.*360

          .         .         .         .         .         .       g.52414
 ggagccctgaagttcctggaaaaccctatttttggtcccaaatctctccagcacacctat       c.*420

          .         .         .         .         .         .       g.52474
 ttcccatcataattttccaaatcctcaagaaacccctactgttgagccccttcccatgga       c.*480

          .         .         .         .         .         .       g.52534
 tcttccatccctctgaagatccacatcttcaaatgccacccaacacctagccccacaagg       c.*540

          .         .         .         .         .         .       g.52594
 atttcccttcaccagctcccctcaacctcattcaataccttgggagcccctcccacttcc       c.*600

          .         .         .         .         .         .       g.52654
 aggacccctcggttcccccagggaccccctccccagtttcctgcctctgacagctgtctt       c.*660

          .         .         .         .         .         .       g.52714
 taaatatgcaaactccacccatcttcccagaatcctttgcacacggaaggccagtggtct       c.*720

          .         .         .         .         .         .       g.52774
 ccgcttccccacctttgctgtggtgtctgtgtctgtgactgacgtggcctccttttgtgc       c.*780

          .         .         .         .         .         .       g.52834
 cgtgcttggcatatgtggtcctcgttcatcgtgccgcctgtggtgatgcgtgcagtgacg       c.*840

          .         .         .         .         .         .       g.52894
 ctgtttatgtggtccgcacctccccctgaccttcactccttgcctggactcaccccaccc       c.*900

          .         .         .         .         .         .       g.52954
 ctcagcggctctgaaccccaagagaagagtcgggaaacaaaataaacaagcaaaggccca       c.*960

                                                                    g.52957
 gca                                                                c.*963

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Synapsin I protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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