synapsin III (SYN3) - coding DNA reference sequence

(used for variant description)

(last modified April 22, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001135774.1 in the SYN3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029545.1, covering SYN3 transcript NM_001135774.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       gttgaggggcagaggctgagct       c.-241

 .         .         .         .         .         .                g.5082
 cccgggacccggagcggatcgactggcgggcgccgcgccgaggcaccaccgggcgccgag       c.-181

 .         .        | 02.         .         .         .             g.56610
 ttcctggcggctcgcacg | caggtaaataaaggcagctaaagctgactgctggttgcgcaa    c.-121

 .         .         .         .         .         .                g.56670
 aatccccctggctcttctggctaaagtcctaccactccctgtacctggcagcagcctgtc       c.-61

 .         .         .         .         .         .                g.56730
 ttctgggcctcacctacacacgtctgggtaggagccagtcatctccatccatccacagcc       c.-1

          .         .         .         .         .         .       g.56790
 ATGAATTTCCTCCGGCGACGTCTCTCTGACAGCAGCTTCATGGCCAACCTGCCTAATGGC       c.60
 M  N  F  L  R  R  R  L  S  D  S  S  F  M  A  N  L  P  N  G         p.20

          .         .         .         .         .         .       g.56850
 TATATGACGGACCTGCAACGCCCAGATAGCTCCACCAGCTCACCTGCTTCCCCCGCCATG       c.120
 Y  M  T  D  L  Q  R  P  D  S  S  T  S  S  P  A  S  P  A  M         p.40

          .         .         .         .         .         .       g.56910
 GAGAGGAGGCACCCCCAGCCCCTGGCTGCCTCCTTCTCCTCTCCAGGATCCAGCCTTTTT       c.180
 E  R  R  H  P  Q  P  L  A  A  S  F  S  S  P  G  S  S  L  F         p.60

          .         .         .         .         .         .       g.56970
 AGCTCCCTCTCCAGTGCCATGAAGCAGGCCCCTCAGGCCACCTCAGGACTGATGGAGCCT       c.240
 S  S  L  S  S  A  M  K  Q  A  P  Q  A  T  S  G  L  M  E  P         p.80

          .         .         .         .         .         .       g.57030
 CCAGGTCCCTCCACGCCCATTGTTCAAAGACCCAGGATCCTGTTGGTGATCGATGATGCC       c.300
 P  G  P  S  T  P  I  V  Q  R  P  R  I  L  L  V  I  D  D  A         p.100

          .  | 03      .         .         .         .         .    g.82739
 CATACAGACTG | GTCGAAGTATTTCCATGGGAAGAAGGTGAATGGAGAGATTGAGATCCGA    c.360
 H  T  D  W  |  S  K  Y  F  H  G  K  K  V  N  G  E  I  E  I  R      p.120

           | 04        .         .         .         .         .    g.131962
 GTGGAGCAG | GCTGAATTCTCAGAGTTGAACCTAGCTGCCTATGTGACCGGGGGCTGCATG    c.420
 V  E  Q   | A  E  F  S  E  L  N  L  A  A  Y  V  T  G  G  C  M      p.140

          .         .         .         .  | 05      .         .    g.194287
 GTGGACATGCAGGTCGTGAGAAATGGGACCAAAGTGGTGAG | ATCCTTCAAGCCAGACTTC    c.480
 V  D  M  Q  V  V  R  N  G  T  K  V  V  R  |  S  F  K  P  D  F      p.160

          .         .         .         .         .         .       g.194347
 ATCCTGGTCCGCCAGCATGCCTACAGCATGGCCCTGGGGGAAGACTACCGCAGCCTGGTC       c.540
 I  L  V  R  Q  H  A  Y  S  M  A  L  G  E  D  Y  R  S  L  V         p.180

          .         .         .         .         .         .       g.194407
 ATCGGCCTGCAGTATGGAGGGCTGCCTGCTGTCAACTCTCTCTACTCCGTCTACAACTTC       c.600
 I  G  L  Q  Y  G  G  L  P  A  V  N  S  L  Y  S  V  Y  N  F         p.200

          .         | 06         .         .         .         .    g.198428
 TGCAGCAAGCCCTGGGTG | TTCTCTCAGCTCATTAAGATCTTCCATTCCCTGGGTCCTGAG    c.660
 C  S  K  P  W  V   | F  S  Q  L  I  K  I  F  H  S  L  G  P  E      p.220

          .         .         .         .         | 07         .    g.466667
 AAGTTCCCGCTTGTGGAGCAAACATTTTTCCCCAACCATAAGCCAATG | GTCACAGCCCCA    c.720
 K  F  P  L  V  E  Q  T  F  F  P  N  H  K  P  M   | V  T  A  P      p.240

          .         .         .         .         .  | 08      .    g.521687
 CACTTCCCGGTGGTAGTCAAGCTGGGACATGCCCACGCTGGAATGGGAAAG | ATCAAAGTG    c.780
 H  F  P  V  V  V  K  L  G  H  A  H  A  G  M  G  K   | I  K  V      p.260

          .         .         .         .         .         .       g.521747
 GAAAACCAGCTTGACTTCCAGGACATCACCAGCGTGGTCGCCATGGCCAAAACCTACGCC       c.840
 E  N  Q  L  D  F  Q  D  I  T  S  V  V  A  M  A  K  T  Y  A         p.280

          .         .         .         .         .         .       g.521807
 ACCACCGAGGCCTTCATCGACTCCAAGTACGACATCCGCATCCAGAAAATTGGATCCAAC       c.900
 T  T  E  A  F  I  D  S  K  Y  D  I  R  I  Q  K  I  G  S  N         p.300

          .     | 09   .         .         .         .         .    g.525327
 TACAAGGCTTACAT | GAGAACCTCCATCTCTGGGAACTGGAAGGCCAACACAGGCTCTGCC    c.960
 Y  K  A  Y  M  |  R  T  S  I  S  G  N  W  K  A  N  T  G  S  A      p.320

          .         .          | 10        .         .         .    g.529527
 ATGCTGGAGCAGGTGGCCATGACAGAGAG | GTACAGGCTGTGGGTGGACAGCTGCTCGGAA    c.1020
 M  L  E  Q  V  A  M  T  E  R  |  Y  R  L  W  V  D  S  C  S  E      p.340

          .         .         .         .         .         .       g.529587
 ATGTTTGGCGGCCTGGACATCTGTGCCGTCAAGGCTGTCCACAGCAAGGATGGCAGAGAT       c.1080
 M  F  G  G  L  D  I  C  A  V  K  A  V  H  S  K  D  G  R  D         p.360

          .   | 11     .         .         .         .         .    g.534430
 TACATCATCGAG | GTAATGGACAGCTCAATGCCGCTGATTGGAGAGCATGTGGAAGAGGAC    c.1140
 Y  I  I  E   | V  M  D  S  S  M  P  L  I  G  E  H  V  E  E  D      p.380

          .         .         .         .         .         .       g.534490
 AGACAGCTGATGGCCGACCTTGTTGTCTCCAAAATGAGCCAGCTCCCGATGCCAGGAGGC       c.1200
 R  Q  L  M  A  D  L  V  V  S  K  M  S  Q  L  P  M  P  G  G         p.400

          .         .        | 12.         .         .         .    g.535418
 ACAGCGCCCTCCCCCCTCAGACCTTGG | GCTCCACAGATTAAATCAGCGAAATCCCCAGGG    c.1260
 T  A  P  S  P  L  R  P  W   | A  P  Q  I  K  S  A  K  S  P  G      p.420

          .         .         .         .         .      | 13  .    g.545061
 CAAGCCCAGCTGGGGCCTCAGCTAGGCCAGCCCCAGCCACGCCCACCTCCGCAAG | GAGGC    c.1320
 Q  A  Q  L  G  P  Q  L  G  Q  P  Q  P  R  P  P  P  Q  G |   G      p.440

          .         .         .         .         .         .       g.545121
 CCTCGCCAAGCTCAGTCTCCTCAGCCCCAGAGATCTGGAAGCCCCTCCCAACAGAGGCTC       c.1380
 P  R  Q  A  Q  S  P  Q  P  Q  R  S  G  S  P  S  Q  Q  R  L         p.460

          .         .         .         .         .         .       g.545181
 TCCCCACAAGGCCAGCAGCCCCTGAGCCCCCAGTCCGGATCTCCACAGCAGCAAAGGTCA       c.1440
 S  P  Q  G  Q  Q  P  L  S  P  Q  S  G  S  P  Q  Q  Q  R  S         p.480

          .         .         .         .         .         .       g.545241
 CCAGGCTCTCCGCAGCTATCCCGGGCATCCAGTGGCAGCTCCCCAAACCAGGCCTCCAAG       c.1500
 P  G  S  P  Q  L  S  R  A  S  S  G  S  S  P  N  Q  A  S  K         p.500

          .         .         .         .         .         .       g.545301
 CCAGGTGCCACCCTCGCCTCACAGCCCCGGCCCCCTGTGCAGGGCCGTAGTACCTCCCAG       c.1560
 P  G  A  T  L  A  S  Q  P  R  P  P  V  Q  G  R  S  T  S  Q         p.520

          .         .         .         .        | 14.         .    g.549579
 CAGGGTGAAGAGTCCAAGAAGCCAGCACCACCCCATCCGCATCTCAA | CAAATCTCAGTCC    c.1620
 Q  G  E  E  S  K  K  P  A  P  P  H  P  H  L  N  |  K  S  Q  S      p.540

          .         .         .         .         .         .       g.549639
 CTGACTAACAGCCTCAGCACATCCGACACCTCCCAGCGTGGGACCCCAAGTGAAGACGAG       c.1680
 L  T  N  S  L  S  T  S  D  T  S  Q  R  G  T  P  S  E  D  E         p.560

          .         .         .         .         .         .       g.549699
 GCCAAGGCTGAAACCATCCGCAACCTGAGGAAGTCTTTTGCCAGCCTGTTCTCTGACTAA       c.1740
 A  K  A  E  T  I  R  N  L  R  K  S  F  A  S  L  F  S  D  X         p.579

          .         .         .         .         .         .       g.549759
 cgccatccaggctgggaggggaagagtgctctgctacactcgtccccctcctgcctcatc       c.*60

          .         .         .         .         .         .       g.549819
 ttccttctcagccttggttcctgatgggaacagaatggagggcctgagaacatactttct       c.*120

          .         .         .         .         .         .       g.549879
 aaatgcctttgacccaggaaccgattatctatatttgttcccattttccttcaccgtgac       c.*180

          .         .         .         .         .         .       g.549939
 attccagcattgtctgactgtgaggtgggcctttgagagcctccaggttcctcaaaacag       c.*240

          .         .         .         .         .         .       g.549999
 gcctgagcgatgggcatcacaccctctgcctacccacgtgcctgcttacctgccagataa       c.*300

          .         .         .         .         .         .       g.550059
 ccaagtgagatgtctgcgagtggctagttttcacattcttactagtgtttggctcacctt       c.*360

          .         .         .         .         .         .       g.550119
 tgggcaaaggccccctctaggccttgccccacctccatcaaacgcagacactgtagtcag       c.*420

          .         .         .         .         .         .       g.550179
 acctcagcaatataggaggcaataatcttttaacagtgttttgcaaacaaacaaaaagag       c.*480

          .         .         .         .         .         .       g.550239
 aaaaatcccagccaggggaactcgccacctgcccacgctagttccatccacgctcaagac       c.*540

          .         .         .         .         .         .       g.550299
 ccgcccttagaccaggcaggcaaaggcccccatcacactcggccactagtggggtcctga       c.*600

          .         .         .         .         .         .       g.550359
 ggccaagaaagaaaccagaccctgtatgacaagtggggtctttcagaacacgacagaaac       c.*660

          .         .         .         .         .         .       g.550419
 aggggggcccttgtaatgccactcatactcagagcattattcttatttggacagccaagg       c.*720

          .         .         .         .         .         .       g.550479
 gcagatcacaggttattgtaggaataaagactagtttacaaaggagaaagaggccctgga       c.*780

          .         .         .         .         .         .       g.550539
 cttcccaaggaaagggtcaggttagggctcctgtacccattctgttccaccactgtttga       c.*840

          .         .         .         .         .         .       g.550599
 tctctctggcctcccaccaggaatgccgtttcctttttatggatctgttgggaaccagag       c.*900

          .         .         .         .         .         .       g.550659
 agaatcaacagatcaatgacataggatccgaagtgcaatgatagtcacttctagtttggc       c.*960

          .         .         .         .         .         .       g.550719
 atttcacaaactctgtacagcaaggtattggtaggttactcaatttcaaaagggccccat       c.*1020

          .         .         .         .         .         .       g.550779
 ggccaaatatgtttaggaaccgctgtttgtatttctttttttggagacgcattgtatata       c.*1080

          .         .         .         .         .         .       g.550839
 atatatgtcaaaggctttcggaattcctgcaggaaagaaatcagctttgttaaatccaaa       c.*1140

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Synapsin III protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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