spectrin repeat containing, nuclear envelope family member 4 (SYNE4) - coding DNA reference sequence

(used for variant description)

(last modified March 23, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001039876.1 in the SYNE4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering SYNE4 transcript NM_001039876.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                tccagcggaggagctctgggacacccttg       c.-61

 .         .         .         .         .         .                g.5089
 tctagggaagaggtcttactggctgccctcacctgactttgtgtccccaggcccccagcc       c.-1

          .         .         .         .         .         .       g.5149
 ATGGCCCTGTCCCTGCCTCTGGGCCCTAGACTTGGCTCAGAGCCCCTCAACCACCCACCG       c.60
 M  A  L  S  L  P  L  G  P  R  L  G  S  E  P  L  N  H  P  P         p.20

          .         .         .         .         .         .       g.5209
 GGAGCACCTAGAGAGGCGGACATTGTTGGATGCACCGTCTGCCCCGCGTCCGGAGAGGAG       c.120
 G  A  P  R  E  A  D  I  V  G  C  T  V  C  P  A  S  G  E  E         p.40

          | 02         .         .         .         .         .    g.5455
 AGCACGAG | CCCAGAGCAGGCCCAGACCCTGGGACAGGACTCCTTGGGCCCTCCTGAGCAC    c.180
 S  T  S  |  P  E  Q  A  Q  T  L  G  Q  D  S  L  G  P  P  E  H      p.60

          .         .         .         .         .         .       g.5515
 TTCCAGGGTGGGCCAAGGGGCAATGAGCCTGCCGCTCACCCCCCGAGATGGTCAACACCC       c.240
 F  Q  G  G  P  R  G  N  E  P  A  A  H  P  P  R  W  S  T  P         p.80

          .         .         .          | 03        .         .    g.6523
 TCTTCCTACGAGGACCCAGCTGGGGGCAAACACTGTGAG | CACCCCATTTCTGGCCTGGAG    c.300
 S  S  Y  E  D  P  A  G  G  K  H  C  E   | H  P  I  S  G  L  E      p.100

          .         .         .         .         .         .       g.6583
 GTACTAGAGGCTGAGCAGAACAGCCTGCACCTGTGCCTGCTGGGGCTGGGCCGCCGGCTG       c.360
 V  L  E  A  E  Q  N  S  L  H  L  C  L  L  G  L  G  R  R  L         p.120

          .         .         .         .         .         .       g.6643
 CAGGACCTGGAGCAAGGCCTGGGGCACTGGGCATTGGCCCAGAGTGGGATGGTGCAGCTG       c.420
 Q  D  L  E  Q  G  L  G  H  W  A  L  A  Q  S  G  M  V  Q  L         p.140

     | 04    .         .         .         .         .         .    g.6883
 CAG | GCCCTCCAGGTGGACCTACGAGGGGCAGCTGAGCGTGTGGAGGCGCTGCTAGCGTTT    c.480
 Q   | A  L  Q  V  D  L  R  G  A  A  E  R  V  E  A  L  L  A  F      p.160

          .         .         .         .         .         .       g.6943
 GGTGAGGGGCTGGCACAGCGGAGTGAGCCCAGGGCCTGGGCAGCCCTGGAGCAGATCCTG       c.540
 G  E  G  L  A  Q  R  S  E  P  R  A  W  A  A  L  E  Q  I  L         p.180

          .         .         .         .         .         .       g.7003
 CGGGCCCTGGGAGCTTACCGAGACTCCATCTTCCGGCGGCTCTGGCAGCTGCAGGCCCAG       c.600
 R  A  L  G  A  Y  R  D  S  I  F  R  R  L  W  Q  L  Q  A  Q         p.200

          .         | 05         .         .         .         .    g.7141
 CTGGTCAGCTACAGCCTG | GTGTTCGAGGAGGCCAACACGCTGGACCAGGACTTGGAGGTC    c.660
 L  V  S  Y  S  L   | V  F  E  E  A  N  T  L  D  Q  D  L  E  V      p.220

          .         .         .         .         .         .       g.7201
 GAGGGAGACTCGGACTGGCCAGGACCTGGTGGGGTCTGGGGGCCCTGGGCACCCAGTAGC       c.720
 E  G  D  S  D  W  P  G  P  G  G  V  W  G  P  W  A  P  S  S         p.240

          .         .         .         .         .         .       g.7261
 CTCCCCACTTCCACAGAGTTGGAGTGGGATCCGGCGGGGGACATTGGGGGCCTTGGGCCC       c.780
 L  P  T  S  T  E  L  E  W  D  P  A  G  D  I  G  G  L  G  P         p.260

          .         .         .         .         .         .       g.7321
 TTGGGACAAAAGACAGCCCGGACACTAGGAGTGCCCTGTGAGCTGTGTGGCCAGAGGGGG       c.840
 L  G  Q  K  T  A  R  T  L  G  V  P  C  E  L  C  G  Q  R  G         p.280

          .         .        | 06.         .         .         .    g.8366
 CCCCAGGGCAGGGGACAAGGCCTTGAG | GAAGCAGACACCTCTCACTCCCGACAGGACATG    c.900
 P  Q  G  R  G  Q  G  L  E   | E  A  D  T  S  H  S  R  Q  D  M      p.300

          .         .         .         .         .         .       g.8426
 CTGGAGTCTGGCCTCGGCCACCAGAAACGCTTAGCACGTCACCAAAGACACTCCCTGCTC       c.960
 L  E  S  G  L  G  H  Q  K  R  L  A  R  H  Q  R  H  S  L  L         p.320

          .   | 07     .         .         .         .         .    g.10147
 CGGAAGCCTCAG | GACAAGAAGAGGCAAGCATCTCCTCATCTCCAGGATGTGAGGCTGGAG    c.1020
 R  K  P  Q   | D  K  K  R  Q  A  S  P  H  L  Q  D  V  R  L  E      p.340

          .  | 08      .         .         .         .         .    g.10299
 GGGAATCCAGG | GGCCCCCGATCCTGCATCCAGGCAGCCTCTGACCTTCCTCCTTATCCTC    c.1080
 G  N  P  G  |  A  P  D  P  A  S  R  Q  P  L  T  F  L  L  I  L      p.360

          .         .         .         .         .         .       g.10359
 TTCCTCCTCTTCCTCCTCCTGGTGGGTGCCATGTTTCTCCTGCCCGCGTCAGGAGGCCCC       c.1140
 F  L  L  F  L  L  L  V  G  A  M  F  L  L  P  A  S  G  G  P         p.380

          .         .         .         .         .         .       g.10419
 TGCTGCTCTCATGCCCGAATACCCAGGACACCCTACCTGGTGCTCAGCTATGTCAATGGT       c.1200
 C  C  S  H  A  R  I  P  R  T  P  Y  L  V  L  S  Y  V  N  G         p.400

          .                                                         g.10434
 CTTCCCCCAGTCTGA                                                    c.1215
 L  P  P  V  X                                                      p.404

          .         .         .         .         .         .       g.10494
 tgtgtgtaataaatggtcactgtcaaaggatgtgtgaagatactaggtgccttcataccc       c.*60

          .         .         .         .         .         .       g.10554
 ggaatctaggatgtggcctggatatgtctggatggacccttttgccttgagaacagaata       c.*120

          .         .         .         .         .         .       g.10614
 cagaactgcatcagcccatcttgggtggggctgccccagaccctgacacaaagagtcaag       c.*180

          .         .         .         .         .                 g.10671
 caccagttctttatttaggcgtggcaggggagccaggacgtgagctcaggaagggag          c.*237

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Spectrin repeat containing, nuclear envelope family member 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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